- recruitingTherapeutic confirmatory (Phase III)
A Randomized, Double-Blind, Phase 3 Trial of Maintenance with Selinexor/ Placebo After Combination Chemotherapy for Patients with Advanced or Recurrent Endometrial Cancer
This study looks at a new treatment called Selinexor for advanced womb cancer. It aims to see if Selinexor helps patients live longer without their cancer growing after chemotherapy, compared to a dummy pill. It's a key stage of research.
Italy · Germany · Belgium - recruitingPHASE2
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
This study is looking at a new treatment called HER3-DXd for people with certain advanced solid tumours that haven't responded to other treatments. It aims to see how well it works and if it's safe for different types of cancer, like melanoma, lung cancer, and breast cancer.
United States · Australia · Belgium - active not recruitingPHASE3
Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005)
This study compares a new medicine, sacituzumab tirumotecan, with standard chemotherapy for endometrial cancer. It's for people whose cancer has returned or progressed after previous treatments (platinum-based chemotherapy and immunotherapy). Researchers want to see if the new medicine helps people live longer and keeps the cancer from getting worse.
United States · Argentina · Australia - recruitingPHASE3
Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)
This study compares a new drug, Puxitatug Samrotecan, with standard chemotherapy for advanced endometrial cancer that has returned after previous treatments. It aims to see if the new drug can help patients live longer or stop their cancer from getting worse.
United States · Argentina · Australia - recruitingPHASE1, PHASE2
Phase I/IIa Study of AZD5335 as Monotherapy and Combination Therapy in Participants With Solid Tumors
This study is testing a new cancer medicine, AZD5335, on its own and with other treatments for various solid tumors. Researchers want to see if it's safe, tolerable, and if it can shrink tumors or stop them from growing. It's for people with advanced cancer.
United States · Australia · Canada - recruitingPHASE3
A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)
This study looks at new treatments for a type of womb cancer that has spread or returned. It compares a new drug combination (sac-TMT with pembrolizumab) against pembrolizumab alone to see if it helps patients live longer and keeps the cancer from growing.
United States · Argentina · Australia - recruitingPHASE3
DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer
This study looks at new drug combinations for advanced or returning endometrial cancer that has a specific HER2 marker. It aims to see if these new treatments work better than standard chemotherapy by slowing down cancer growth.
United States · Australia · Austria - active not recruitingPHASE3
Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Participants With Endometrial Cancer After Platinum-Based Chemotherapy and Immunotherapy (ASCENT-GYN-01/GOG-3104/ENGOT-en26)
This study looks at a new drug, sacituzumab govitecan, for women with endometrial cancer that has come back or hasn't responded to earlier treatments. It compares this new drug to standard treatments chosen by doctors, aiming to see if it helps women live longer or keeps cancer from growing.
United States · Australia · Brazil - recruitingPHASE1, PHASE2
A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies
This study is testing a new medicine called AZD8205, by itself or with other cancer drugs. It's for people with advanced cancers like breast, ovarian, or lung cancer, to see if it's safe and helps shrink tumours.
United States · Australia · Belgium - recruitingPHASE3
A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer
This study is looking at a new treatment (BNT323) for women with advanced womb cancer that has come back. It compares BNT323 to standard chemotherapy to see if it works better at shrinking tumours and keeping the cancer from growing.
United States · Argentina · Australia - completedPhase III
DOMENICA: Randomized phase III trial in MMR deficient endometrial cancer patients comparing chemotherapy alone versus dostarlimab in a first-line advanced/metastatic setting
The DOMENICA trial tests whether a newer immunotherapy drug, dostarlimab, works better than standard chemotherapy for advanced womb (endometrial) cancer. It is for people whose tumours have a specific genetic feature called MMR deficiency. The goal is to see if dostarlimab can stop the cancer returning or spreading for longer.
United Kingdom · England · Scotland - recruitingTherapeutic confirmatory (Phase III)
BIOMarkers in Endometrial Cancer - A phase III open label randomized trial to determine the efficacy of biomarker staging as compared to conventional staging in women with presumed early-stage endometrial cancer (The BIOMEC trial)
This study, called BIOMEC, is for women with early-stage womb cancer. It compares two ways of checking the cancer's spread – standard methods versus using special markers. The aim is to see which approach helps women live longer and better. It might involve chemotherapy drugs, paclitaxel and carboplatin.
Sweden - recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2 Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of BLU-222 as a Single Agent and in Combination Therapy for Patients with Advanced Solid Tumors
This study is testing a new drug, BLU-222, for people with certain advanced cancers, including breast, ovarian, and stomach cancers. It aims to see how safe the drug is, how it moves through the body, and if it helps shrink tumors, both on its own and with other treatments.
France · Italy · Belgium - active not recruiting
Methylated Biomarkers Predictive of Endometrial Cancer Risk
This study looks for early signs of womb cancer in women aged 45-70 who are having a hysterectomy. Researchers hope to find new ways to detect cancer risk using simple tests, making diagnosis easier and less invasive in the future.
United Kingdom - recruitingPHASE1
A Phase 1 Study of CTIM-76 in Patients With Recurring Ovarian Cancer and Other Advanced Solid Tumors
This study is testing a new drug, CTIM-76, for some difficult-to-treat cancers like ovarian, testicular, and endometrial cancer. It's an early-stage study to check for safety and find the right dose. The drug works by helping your immune system fight the cancer.
United States · United Kingdom - recruitingPHASE3
Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing (IHC 3+/2+) Endometrial Cancer
This study compares a new drug, trastuzumab deruxtecan, with standard chemotherapy for women with early-stage HER2-positive womb cancer. It aims to see which treatment works better after surgery to stop the cancer from coming back.
United States · Argentina · China - recruitingPHASE2
Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER
This study looks at new, gentler treatments for early womb cancer. We want to see if these new approaches, which involve less intensive treatment, work as well as the usual care for patients with specific types of early-stage womb cancer.
United States · Australia · Canada - recruitingPHASE1
A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors
This study is testing a new drug, PF-08046054/SGN-PDL1V, alone and with an existing medicine called pembrolizumab, for various advanced cancers. Researchers want to see how safe it is and if it has any effect on the cancer. It's a very early stage study.
United States · Belgium · Canada - recruitingPHASE1
A Phase 1 First-In-Human Study of the Anti-CD73 IPH5301 Alone or in Combination With Chemotherapy and Trastuzumab in Patients With Advanced Solid Tumors
This study is testing a new drug called IPH5301 for advanced cancers like breast, stomach, and lung. It's a first-time-in-human study, meaning it's the very first time this drug is being given to people. Researchers want to find a safe dose, either alone or with other treatments.
France - recruiting
Cancer Loyalty Card Study 2 (CLOCS-2)
This study looks at shopping habits using loyalty card data from Tesco or Boots to see if certain purchases might hint at cancer earlier. It aims to help doctors diagnose pancreatic, bowel, oesophageal, stomach, liver, bladder, womb, vulval, and ovarian cancers sooner.
United Kingdom - recruitingPHASE1, PHASE2
A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas
This study is testing a new medicine, Tulmimetostat, for people with advanced cancers like solid tumours and lymphomas. It's looking at how safe it is, any side effects, and if it helps to shrink tumours.
United States · France · Italy - not yet recruiting
Measurement of Urinary Hormones in Patients With Abnormal Uterine Bleeding to Study Uterine Cancer Progression
This study looks at hormones in urine from women with unusual bleeding to understand uterine cancer better. It also tests a monitoring device and checks how well people understand their menstrual health.
Canada - authorisedTherapeutic confirmatory (Phase III)
A Phase 3 Randomized, Open-label Study of Rinatabart Sesutecan (Rina-S) Versus Treatment of Investigator’s Choice (IC) in Patients With Endometrial Cancer After Platinum-Based Chemotherapy and PD(L)-1 Therapy
This study is testing a new drug, Rinatabart Sesutecan (Rina-S), for people with advanced endometrial cancer. It compares Rina-S to standard treatments to see if it works better at slowing down or stopping the cancer's growth and helping people live longer after previous treatments.
Poland · Denmark · Finland - recruitingPHASE2
A Study of Lorigerlimab in Participants With Advanced Solid Tumors
This study is testing a new medicine called lorigerlimab for some women with advanced ovarian or gynaecological cancers that have not responded well to certain other treatments. The aim is to see if it's safe and helps shrink the cancer.
United States · Canada · South Korea - recruitingNA
Bariatric Surgery for Fertility-Sparing Treatment of Atypical Hyperplasia and Grade 1 Cancer of the Endometrium
This study looks at whether weight-loss surgery, combined with standard hormone treatment, can better help young women with early womb cancer or a pre-cancerous condition. The aim is to help them preserve their fertility, as obesity is a key risk factory for this type of cancer.
Canada - recruitingNA
ImpRoving hEalth behaviourS for LIfe After ENdometrial CancEr Trial
This study looks at how a digital healthy living platform, with online support, can help women who have had womb cancer. It aims to improve their health, especially around fitness and waist size, to help them stay healthier long-term.
Canada - recruitingNA
Assessing Uterine Cancer Risk in Lynch Syndrome Carriers Using Vaginal Self-sampling and a Health Questionnaire
This study looks at whether women with Lynch syndrome can use a simple home test to check for early signs of womb cancer. It also asks if they find this self-testing easy and helpful. The goal is to find better ways to spot cancer risk sooner.
Canada - active not recruitingPHASE2
Safety and Efficacy of Retifanlimab (INCMGA00012) Alone or in Combination With Other Therapies in Participants With Advanced or Metastatic Endometrial Cancer Who Have Progressed on or After Platinum-based Chemotherapy.
This study is for women with advanced womb cancer that has returned or worsened after chemotherapy. It tests a new drug called retifanlimab, sometimes alone and sometimes with other medicines, to see how safe and effective they are.
United States · Belgium · France - not yet recruitingPHASE2
Adaptive Radiotherapy for Safe Hypofractionation
This study compares a new, more flexible way of giving radiotherapy called 'adaptive radiotherapy' with the standard treatment for certain cancers. It aims to see if this new method, which uses fewer, stronger doses, is just as safe and effective.
Canada - recruitingPHASE1
Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors
This study is testing a new medicine called XmAb541 for people with certain advanced cancers that haven't responded to other treatments. Doctors want to see if it's safe, what dose works best, and if it can help shrink or control the cancer. It's a very early-stage trial.
United States · Belgium · Denmark - active not recruitingPHASE3
Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma
This study looks at a medicine called selinexor for people with advanced or recurring womb cancer (endometrial carcinoma). It's for patients whose cancer responded well to previous platinum-based treatment, to see if selinexor can help keep the cancer from coming back.
United States · Australia · Belgium - recruiting
European Collaborative Multicenter Observational Study: Modular Treatment With PMMR and Targeted Compartmental Pelvic Lymphadenectomy Followed by Therapeutic Pelvic and Paraaortic Lymphadenectomy in Node Positive Disease for Locoregional Control in Endometrial Cancer FIGO Stages I-III
This study looks at new ways to treat womb cancer that hasn't spread far. It compares a special surgery with standard care to see if the new surgery can reduce cancer coming back and help people live longer without cancer, while avoiding strong radiation treatment.
Germany - recruitingNA
Fertility Sparing Management of EndomeTrial Cancer and Hyperplasia
This study looks at a new treatment for womb lining changes or early womb cancer in women who want to have children. It uses a keyhole procedure to remove problem areas if hormone therapy hasn't worked.
Canada - recruitingPHASE1
A Study of MGC026 in Participants With Advanced Solid Tumors
This study is testing a new medicine called MGC026 for people with advanced cancers that have come back or spread. Doctors want to see if it's safe, what side effects it causes, and if it can help slow down or shrink tumors.
United States · Australia · United Kingdom - active not recruitingPHASE1
Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors
This study is testing two anti-cancer drugs, cabozantinib and atezolizumab, alone and together, for various advanced cancers. It aims to find a safe combination dose and see how well it works and any side effects.
United States · Australia · Belgium - active not recruitingPHASE1
A Study to Learn About Study Medicine ALTA2618 in Adults With AKT1 E17K-Mutant Solid Tumors
This study is looking into a new medication called ALTA2618 for adults with certain advanced cancers that have a specific genetic change (AKT1 E17K mutation). The main goal is to check its safety and find the right dose.
United States · Australia · France - recruitingPHASE1, PHASE2
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
This study is testing a new drug, rezatapopt, for advanced cancers with a specific gene change (TP53 Y220C). It's also looking at rezatapopt with another drug, pembrolizumab, to see how safe and effective they are. It’s for people who have already had cancer treatment.
United States · Australia · France - recruitingPHASE1, PHASE2
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
This study is testing a new drug, ART0380, for people with advanced cancer. It aims to find the safest dose, understand side effects, and see how well it works, both alone and with other treatments like gemcitabine or irinotecan.
United States · France · Spain - recruitingPHASE1
A Study of MOv18 IgE in Patients With Solid Tumours That Express Folate Receptor Alpha
This study is testing a new medicine called MOv18 IgE for women with advanced ovarian, endometrial, or triple-negative breast cancer. It aims to find a safe dose and see how well it works, especially in cancers that have a specific marker called Folate Receptor Alpha.
United Kingdom - active not recruitingPHASE1, PHASE2
Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
This study is looking into a new drug, AZD5305, by itself or with other cancer treatments, for advanced solid cancers like ovarian, breast, and lung cancer. It aims to see if it's safe, tolerable, and effective.
United States · Australia · Canada - recruitingPHASE1, PHASE2
Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers
This study is testing a new drug, ubamatamab, alone or with cemiplimab, for recurrent ovarian or endometrial cancer. It aims to see how safe it is, how it works in the body, and if it can help treat these cancers.
United States · Australia · Belgium - recruitingPHASE2, PHASE3
Refining Adjuvant Treatment IN Endometrial Cancer Based On Molecular Features
This study looks at new treatments for endometrial cancer based on specific cancer features. It aims to find better ways to treat patients after surgery, potentially leading to personalised care for different types of endometrial cancer.
Canada · France · Netherlands - active not recruitingPHASE1, PHASE2
A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid Tumours
This study is testing a new drug, HMBD-001, for advanced cancers where a protein called HER3 is active. We want to find the best dose, understand side effects, and see if it helps stop cancer growth, sometimes with another drug called enzalutamide.
United Kingdom - recruitingPHASE2
Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
This study looks at a new drug, Dato-DXd, by itself and with other treatments for different advanced cancers like those affecting the stomach, ovaries, and prostate. It checks if the treatment is safe and effective.
United States · Canada · China - active not recruitingPHASE1
Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced Cancer
This study is testing a new cancer medicine, botensilimab, sometimes with another drug, balstilimab. It's for people with advanced cancers that haven't responded to other treatments. Doctors want to see if it's safe, how it works, and find the best dose.
United States · United Kingdom - active not recruitingPHASE3
Endometrial Cancer Patientes MMR Deficient Comparing Chemotherapy vs Dostarlimab in First Line
This study is looking at a new treatment called dostarlimab for advanced or recurring endometrial cancer that has a specific genetic feature (MMR deficient). It compares dostarlimab with standard chemotherapy to see which works better and is safer for patients.
Australia · Canada · France - recruitingNA
Pipelle® Under Ultrasound Guidance (PUG) to Investigate Post-menopausal Bleeding.
This study looks at a new way to take a womb lining sample for women who have bleeding after menopause. It uses ultrasound to guide the doctor, hoping to get a better sample, cause less pain, and speed up treatment compared to the usual method.
United Kingdom - active not recruiting
Performance of Ultrasound in Women With Postmenopausal or Abnormal Uterine Bleeding Between White and Black Ethnic Groups- a Retrospective Cohort Study.
This study looks at how well ultrasound scans work for women with unusual vaginal bleeding, especially after menopause. It compares results between White and Black women to see if there are differences in how clear the scans are, which helps doctors check for womb cancer.
United Kingdom - recruitingPHASE3
Refining Adjuvant Treatment IN Endometrial Cancer Based On Molecular Features (RAINBO) - NSMP-ORANGE Trial: Comparing Radiotherapy With Oral Progestin Tablets vs. the Current Standard Care, Radiotherapy and Chemotherapy, in Patients With NSMP Endometrial Cancer
This study looks at a new way to treat womb cancer (endometrial cancer) after surgery. We're comparing standard treatment (radiotherapy and chemotherapy) with a new approach: radiotherapy plus hormone tablets, hoping to reduce side effects while being just as effective.
United Kingdom