A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

To be considered for this study, you need to be at least 18 years old. You should have a type of advanced cancer that has either come back or spread, such as breast, ovarian, womb, bile duct, or a specific type of lung cancer. The doctors will also consider if you've already had standard treatments for your cancer, or if a research study is the best next step for you.

Before joining, doctors will check certain things through tests. For example, they'll look at your general health, how well your blood, liver, and kidneys are working, and make sure your cancer can be measured. You should also generally feel well enough to manage daily activities.

There are also some specific requirements depending on which part of the study you might join, but generally, having one of the specified advanced cancers and meeting the health requirements mentioned above are key for initial consideration.

If you decide to take part in this study, you would first go through a screening process to make sure you meet all the requirements. This might involve blood tests, scans, and other checks. If you're eligible, you would receive the study medicine, AZD8205, either by itself or with other anti-cancer drugs, depending on your specific situation and which part of the study you join. The medicine would be given regularly, and you would have planned visits to the hospital or clinic for assessments.

These visits would include regular check-ups, blood tests, and scans (like CT or MRI) to see how you are responding to the treatment and to monitor for any side effects. The frequency of visits might be more often at the beginning and then become less frequent as the study progresses. The total duration of your participation would depend on how your cancer responds to the treatment and if any side effects occur. You would be fully supported by the study team throughout your involvement.