- ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A study to Evaluate AB308 in Combination with AB122 in Participants with Advanced Malignancies (ARC-12)
This early-stage study is testing a new combination of medicines, AB308 and AB122, for people with several types of advanced cancer, including blood cancers and solid tumours. It aims to see if the treatment is safe and how the body reacts to it.
Spain · Poland - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
Optical PD-L1 imaging using Quantitative Fluorescence Endoscopy in locally advanced esophageal cancer using durvalumab-680LT: a phase I multicenter feasibility and safety study
This study looks at a new way to see if a particular treatment might work for advanced oesophageal cancer. It uses a special camera and a small amount of a drug to get a clearer picture inside the body, helping doctors understand the cancer better.
Netherlands - recruitingNA
Stereotactic Body Radiotherapy in Patients With Rare Oligometastatic Cancers (OligoRARE)
This study looks at adding special radiation to standard care for rare cancers that have spread a little. It wants to see if this addition helps people live longer compared to standard care alone.
Belgium · France · Germany - recruitingPHASE2
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
This study is looking at a new treatment called HER3-DXd for people with certain advanced solid tumours that haven't responded to other treatments. It aims to see how well it works and if it's safe for different types of cancer, like melanoma, lung cancer, and breast cancer.
United States · Australia · Belgium - recruitingPHASE1, PHASE2
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
This study is looking at a new drug called MCLA-158 for advanced cancers like bowel and head and neck cancer. It aims to find the safest dose and see how well it works alone or with other treatments. It's for patients whose cancer has spread or come back.
United States · Belgium · France - recruitingPHASE3
PROton Versus Photon Therapy for Esophageal Cancer - a Trimodality Strategy
This study compares standard radiotherapy (photon therapy) with a newer type (proton therapy) for oesophageal cancer. It aims to see if proton therapy reduces side effects, especially lung problems, while still treating the cancer effectively.
Belgium · Denmark · France - recruitingPHASE1
A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
This study is looking at a new medicine called PF-08046876 for people with advanced cancers like bladder, lung, head & neck, oesophageal, or pancreatic cancer. It checks how safe the medicine is and how well it works. The medicine is given through a drip.
United States · Canada · Puerto Rico - recruiting
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
The MOMENTUM Study is tracking how a new type of advanced radiotherapy, called MR-Linac, works for people with different cancers. It aims to see if this treatment improves survival, controls cancer better, and enhances quality of life by using highly precise radiation guidance.
United States · Australia · Belgium - recruiting
Oesophagectomy and Chest Wall and Respiratory Function
This study looks at how removing a part of the food pipe (oesophagectomy) for cancer affects breathing and chest movement. It aims to find better ways to measure chest movement and breathing capacity using new technologies, which could lead to improved physiotherapy after surgery.
United Kingdom - recruitingPHASE1
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
This study is testing a new drug, LY4052031, for people with advanced cancers like bladder, breast, and lung cancer. It aims to see if the drug is safe, what dose works best, and if it helps shrink tumors. It's an early-stage study to gather important information.
United States · Australia · China - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Safety and Efficacy Study of PRT3789 in Combination with Pembrolizumab in Patients with Advanced or Metastatic Solid Tumors with a SMARCA4 Mutation
This study looks at a new drug, PRT3789, with an existing cancer treatment, Pembrolizumab, for advanced solid tumours like lung cancer. It checks how safe and effective this combination is for people whose cancer has a specific change called a SMARCA4 mutation.
Spain · Germany · France - authorisedTherapeutic exploratory (Phase II)
Optimizing Lymph Node Staging in Esophageal Cancer with USPIO-enhanced MRI
This study is comparing a new MRI scan using a special tracer called USPIO to standard PET-CT scans for finding cancer in the lymph nodes of people with oesophageal cancer. We want to see which one works better and is easier for patients.
Netherlands - recruitingPHASE3
Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2
This study is testing new combinations of medicines (sonesitatug vedotin, rilvegostomig, and capecitabine) for advanced stomach, gastroesophageal junction, or oesophageal cancers. It aims to see how well they work and if they are safe for people whose cancer has a specific marker called Claudin18.2.
United States · Australia · Austria