Frontotemporal dementia (FTD) research hub
4 indexed studies · 0 currently recruiting
- ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
SAD and MAD study of VES001
This early-stage study is looking at a new medicine called VES001 for a condition called Frontotemporal Dementia (FTD). It's the first time this medicine is being given to people, to check its safety and how it works in the body. Researchers want to see if it could help people with FTD in the future.
Netherlands - ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
Phase 1b Study to Assess the Safety, Tolerability and Pharmacodynamics of PBFT02 in Adult Participants with Frontotemporal Dementia (FTD) and GRN or C9orf72 Mutations
This study is testing a new medicine, PBFT02, for people with a type of dementia called Frontotemporal Dementia (FTD). Researchers want to see if it's safe, how well people tolerate it, and how it affects the body, specifically for those with certain gene changes (GRN or C9orf72).
Portugal · Spain - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of AL001 in Individuals at Risk For or With Frontotemporal Dementia Due to Heterozygous Mutations in the Progranulin Gene
This study is testing a new medicine, latozinemab, for a type of frontotemporal dementia linked to a specific gene change. It aims to see if the medicine can slow down the disease and is safe to use. Half the people will get the medicine, and half will get a dummy treatment.
Greece · Germany · Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to find how well VES001 works and how safe it is in participants with GRN -frontotemporal dementia (GRN-FTD) showing no symptoms
Researchers are looking into a new medicine, VES001, for a type of dementia called Frontotemporal Dementia (FTD) linked to a specific gene (GRN). This early study wants to see if the medicine is safe and if it works for people who have this gene but don't yet have symptoms of the disease.
Netherlands