Generalized Myasthenia Gravis research hub

Evaluating the Pharmacokinetics, Pharmacodynamics, and Safety of Efgartigimod Administered Intravenously in Children With Generalized Myasthenia Gravis

This study is looking at a new treatment called efgartigimod for children and teenagers aged 2 to 18 with a muscle condition called generalized myasthenia gravis (gMG). It will examine how the treatment works in the body and its safety.

A Study to Investigate the Efficacy, Safety and Tolerability of Remibrutinib Versus Placebo in Adult Patients With Generalized Myasthenia Gravis

This study is looking at a new medicine called Remibrutinib for adults with a condition called Generalized Myasthenia Gravis. It compares Remibrutinib to a dummy medicine (placebo) to see how well it works and if it's safe, alongside their usual treatment.

A Phase III Study to Investigate Efficacy, Safety and Tolerability of Iptacopan Compared With Placebo in Participants Aged 18 to 85 Years With gMG.

This study is testing a new medicine called iptacopan for people aged 18-85 with a type of muscle weakness called generalized Myasthenia Gravis (gMG). It's compared to a dummy medicine to see if it's safe and helps improve symptoms while continuing usual care.

An Open-label Extension Study to Evaluate Subcutaneous Zilucoplan in Pediatric Participants With Generalized Myasthenia Gravis

This study looks at the long-term effects of a medicine called Zilucoplan for children and teenagers with a muscle weakness condition called myasthenia gravis. It checks if the medicine is safe and if people can tolerate it well over an extra year.

A Study to Evaluate Subcutaneous Zilucoplan in Pediatric Participants With Generalized Myasthenia Gravis

This study is testing a new medicine, Zilucoplan, for young people with a muscle condition called generalised myasthenia gravis (gMG). We want to understand how it works, if it's safe, and if it helps improve symptoms in children and teenagers.

Phase 3 Study to Assess the Efficacy and Safety of Batoclimab as Induction and Maintenance Therapy in Adult Participants With Generalized Myasthenia Gravis

This study is looking at a new medicine called batoclimab for adults with a condition called generalized Myasthenia Gravis (gMG). It wants to see how well it works and if it's safe. Participants will receive batoclimab or a dummy medicine (placebo) to see if it helps relieve their symptoms.

Study to Assess the Efficacy and Safety of IMVT-1402 in Participants With Mild to Severe Generalized Myasthenia Gravis

This study is testing a new medicine, IMVT-1402, for adults with a condition called myasthenia gravis. The aim is to see if it's safe and helps improve daily life for those with mild to severe symptoms.

Efficacy and Safety of a New Formulation of Oral Cladribine Compared With Placebo in Participants With Generalized Myasthenia Gravis (MyClad)

This study is testing a new medicine, cladribine, in pill form for people with a muscle weakening condition called myasthenia gravis. We want to see if it helps and if it's safe compared to a dummy pill. We're also looking at its long-term effects and how the body uses the medicine.

A Phase 3 Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Patients With Acetylcholine Receptor Binding Antibody Seronegative Generalized Myasthenia Gravis

This study is testing a new medicine called efgartigimod for people with a type of Myasthenia Gravis (MG). It checks how well it works and if it's safe compared to a dummy medicine. Some people will then get the new medicine openly.

A Study of Efgartigimod PH20 SC in Children Between 2 and Less Than 18 Years of Age With Generalized Myasthenia Gravis

This study is testing a new medicine, efgartigimod PH20 SC, for children aged 2 to 17 with a muscle weakness condition called generalised Myasthenia Gravis. We want to find the best dose and make sure it's safe. Participants will get injections and be monitored.

Evaluating Long-term Safety of Efgartigimod Administered Intravenously and Efgartigimod PH20 Administered Subcutaneously in Children With Generalized Myasthenia Gravis

This study looks at the long-term safety of two forms of a drug called efgartigimod for children and teenagers with a muscle weakness condition called generalised Myasthenia Gravis (gMG). Participants are those who have previously taken part in other efgartigimod studies.

A Study to Test How Safe Pozelimab and Cemdisiran Combination Therapy and Cemdisiran Alone Are and How Well They Work in Adult Patients With Generalized Myasthenia Gravis

This study is testing new drug combinations, pozelimab and cemdisiran, for adults with a muscle-weakening condition called generalised myasthenia gravis (gMG). It looks at how safe these drugs are and how well they help improve muscle function.

Open-Label Extension of Zilucoplan in Subjects With Generalized Myasthenia Gravis

This study is for people with a muscle condition called generalized myasthenia gravis (gMG) who have already been in a zilucoplan trial. It checks how safe and effective zilucoplan is over a longer time, helping us understand its long-term benefits.

Study to Assess Safety, Efficacy, and Cellular Kinetics of YTB323 in Generalized Myasthenia Gravis

This study is looking at a new cell therapy called YTB323 for people with a severe type of myasthenia gravis, a muscle weakening condition. It aims to see if it's safe and effective for patients who haven't responded well to other treatments.

Efficacy and Safety of Nipocalimab vs Efgartigimod in a Randomized, Open-label, Phase 3b, Interventional Trial Including Within Class Switching From Efgartigimod to Nipocalimab

This study compares two existing treatments, nipocalimab and efgartigimod, for a muscle weakness condition called generalised myasthenia gravis. It aims to see how well they work and if one is better than the other, especially when people switch from one drug to the other.

A Double-Blind, Randomized, Placebo-Controlled Study to Investigate the Safety and Efficacy of Aritinercept, a Dual BAFF/APRIL Inhibitor, in Patients with Generalized Myasthenia Gravis

This study is testing a new medicine called Aritinercept for people with a muscle weakness condition called Myasthenia Gravis. Researchers want to see if it's safe, how well it works, and how your body reacts to it over time. This is an early-stage study.

A MULTICENTER, OPEN-LABEL, OUTPATIENT STUDY TO EVALUATE THE SAFE AND EFFECTIVE USE OF A ZILUCOPLAN AUTO INJECTOR COMBINATION PRODUCT FOR SUBCUTANEOUS SELF-ADMINISTRATION BY STUDY PARTICIPANTS WITH GENERALIZED MYASTHENIA GRAVIS

Safety and Efficacy of ALXN1720 in Adults With Generalized Myasthenia Gravis

This study is looking into a new medicine, ALXN1720, for adults with generalised myasthenia gravis (gMG). We want to see if it's safe and helps improve symptoms for people whose gMG is caused by certain antibodies. It's compared against a dummy treatment.