- authorisedHuman Pharmacology (Phase I)- Other
[¹⁸F]MC225 PET Analysis of Blood–Brain Barrier Function in Glioblastomas
This early-stage study uses a new scanning dye, called [¹⁸F]MC225, with PET scans in adults with glioblastoma brain tumours. Researchers want to see how the brain's natural protective shield works in and around the tumour. This could help doctors design better ways to deliver cancer medicines in the future.
Netherlands - authorisedHuman Pharmacology (Phase I)- First administration to humans
First study evaluating the safety and dosage of YG-01 in patients with a malignant brain tumor
This clinical trial is testing a new experimental medicine called YG-01 in adults with glioblastoma, a fast-growing brain tumour. Because this is the first time YG-01 has been given to people, doctors want to find out if it is safe, identify side effects, and discover the best dose.
Austria - recruitingPhase I and Phase II (Integrated)- Other
A Phase I/II open label study to assess safety and preliminary evidence of a therapeutic effect of Azeliragon combined with conventional concurrent radiation and temozolomide in patients with newly diagnosed glioblastoma.
This study is looking at a new medicine called Azeliragon for people recently diagnosed with glioblastoma, a type of brain tumour. It's an early-stage study to see if the medicine is safe and if it helps when given alongside standard treatments like radiation and other medication.
Spain - recruitingTherapeutic exploratory (Phase II)
Evaluation of the feasibility of PD L 506 for stereotactic interstitial photodynamic therapy (iPDT) in adult patients with newly diagnosed supratentorial IDH wild-type glioblastoma
This study is looking at a new way to treat a type of brain cancer called glioblastoma. It uses a special light treatment to target cancer cells. Researchers want to see if this treatment is safe and practical for adult patients who have recently been diagnosed.
Germany - recruitingHuman Pharmacology (Phase I)- Other
Phase Ib Clinical Trial to Evaluate the Safety Profile of the Combination Tilray FS Oral Solution T10:C10 with Temozolomide and Radiotherapy in Patients With Newly Diagnosed Glioblastoma.
This study is looking at a new combination treatment for people with a type of brain cancer called glioblastoma. It combines a cannabis-based medicine with standard treatments (chemotherapy and radiotherapy) to see if it's safe to use together.
Spain - authorisedPhase I and Phase II (Integrated)- Other
A study to evaluate the safety and efficacy of the tumor-targeting human antibody-cytokine fusion protein L19TNF plus standard temozolomide chemoradiotherapy in patients with newly diagnosed glioblastoma.
This study is testing a new antibody treatment, L19TNF, along with standard brain cancer medication, temozolomide. It aims to see if combining them is safe and helps people with a type of brain tumour called glioblastoma live longer and feel better.
Germany · Italy - recruitingHuman Pharmacology (Phase I)- Other
A study to determine how BI 907828 (Brigimadlin) is taken up in the tumor (Phase 0) and to determine the highest dose of BI 907828 (Brigimadlin) that could be tolerated (Phase Ia) in combination with radiation therapy in people with a brain tumor called glioblastoma
This study looks at a new drug, Brigimadlin, for people with glioblastoma, a type of brain tumour. It aims to see how the drug works in the tumour and find the safest dose when given with radiotherapy. It's an early-stage study to understand the drug better.
Belgium · Spain - completed
PreOperative Brain Irradiation in Glioblastoma
This study looks at treating glioblastoma, a fast-growing brain tumour, with radiotherapy before surgery. Researchers want to see if this early treatment can slow down tumour growth and find the safest way to deliver it without affecting the operation.
United Kingdom · England - recruitingPhase I/II
5G: A next generation agile genomically guided glioma modular platform for proof-of-concept molecular hypothesis testing in patients with malignant brain tumours
This study is testing a new drug called paxalisib with a standard treatment (temozolomide) for glioblastoma, a type of brain tumour. It aims to see if this combination is safe and effective, especially for patients whose tumours might respond well to paxalisib.
United Kingdom · England · Scotland - active not recruitingPHASE2
ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids
This study looks at adding a cannabis-based medicine (Nabiximols) to standard treatment (Temozolomide) for a type of brain tumour called glioblastoma that has come back. It aims to see if this combination works better than standard treatment alone.
United Kingdom - recruitingEARLY_PHASE1
Pilot Trial for Treatment of Recurrent Glioblastoma
This early trial aims to test new, personalised treatments for people with an aggressive type of brain tumour called glioblastoma that has come back. It will check if these treatments are safe and if this type of study can be done on a larger scale.
Canada - recruitingPHASE2
Daily Temozolomide for Elderly Patients With Unmethylated MGMT- Promoter Newly Diagnosed GliOblatoma
This study looks at a new way to give an existing chemotherapy, Temozolomide, to older patients with a specific type of aggressive brain cancer called glioblastoma. The aim is to see if this modified treatment can help slow the disease and improve survival when standard chemotherapy might not work as well.
Canada - recruitingPHASE3
Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM
This study is looking at a new way to treat glioblastoma brain tumours that have come back. It combines a special ultrasound device called SonoCloud-9 with an anti-cancer drug, carboplatin, to see if it works better than standard treatments.
United States · Austria · Belgium - active not recruitingPHASE3
Treatment Intensification With Temozolomide in Adults With a Glioblastoma
This study compares two ways to give chemotherapy (temozolomide) to adults with a type of brain tumour called glioblastoma. One way is the standard treatment, and the other is a more intense plan, given earlier and for longer, to see if it works better.
France - recruitingPHASE2, PHASE3
A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma
This study is testing different treatments for a type of brain cancer called glioblastoma. It's for people who have been recently diagnosed or whose cancer has come back. The aim is to find better ways to treat this cancer.
United States · Australia · Canada - recruitingPHASE1
A Study Assessing if it is Safe and Possible to Treat Brain Cancer Patients With Immunotherapy Before They Receive the Standard Treatment.
This study looks at giving a new cancer drug called ipilimumab to people with a type of brain cancer (glioblastoma) before their usual treatment. It aims to check if the drug is safe and if it helps control the cancer at this early stage.
United Kingdom - active not recruitingPHASE1, PHASE2
Glioblastoma Treatment With Irradiation and Olaptesed Pegol (NOX-A12) in MGMT Unmethylated Patients
This study looks at new ways to treat a serious type of brain cancer called glioblastoma. It combines a new drug (olaptesed pegol) with standard treatments like radiotherapy, aiming to improve outcomes for patients where usual chemotherapy isn't expected to work as well.
Germany - active not recruitingNA
A Study to Test a New Fluid to Improve the Quality of Images Obtained by Using Sound Waves (Ultrasound) During Surgery
This study is testing a new fluid called SonoClear®. It aims to improve ultrasound images during brain tumour surgery. Clearer images could help surgeons remove more of the tumour. We want to see if SonoClear® is safe and works better than standard fluids.
Germany - recruitingPHASE2
Protective VEGF Inhibition for Isotoxic Dose Escalation in Glioblastoma
This study looks at a new way to treat glioblastoma, a type of brain cancer. It uses a higher dose of radiation while also giving a drug called bevacizumab to help protect healthy tissues. The goal is to improve treatment without increasing side effects.
Germany - authorisedTherapeutic use (Phase IV)
Unravelling the invisiBle infiltRating cOmponeNT Of glioblaStomA Using mRi USpio (BRONTOSAURUS)
This study looks at how best to use a special iron-based dye called USPIO with MRI scans. Researchers want to find the right amount of USPIO to help get clearer images of brain tumours, specifically glioblastoma, to improve diagnosis and understanding of this cancer.
Netherlands - not yet recruiting
MRinRT: Swansea University and SWWCC Collaboration Study.
This study looks at using MRI scans to make radiotherapy for cancers like brain, stomach, and gullet cancer more accurate. It aims to see if MRI can help doctors better plan and adjust treatment, potentially reducing side effects.
United Kingdom - active not recruitingPHASE4
Pediatric Long-Term Follow-up and Rollover Study
This study looks at the long-term well-being of children and young people who have been treated with specific medications (dabrafenib and/or trametinib) for certain brain cancers in previous clinical trials. It aims to understand the lasting effects of these treatments.
United States · Argentina · Australia - recruitingPHASE3
EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma
This study looks at a new combination treatment for a type of brain cancer called glioblastoma. It combines a device called Optune, a chemotherapy drug called temozolomide, and a new drug called pembrolizumab, comparing it to Optune, temozolomide, and a dummy drug.
United States · Canada · Czechia - recruiting
The PALSUR-study: Palliative Care Versus Surgery in High-grade Glioma Patients (ENCRAM 2203)
This study looks at the best way to care for people with a serious type of brain tumour called high-grade glioma. It compares palliative care, a small operation (biopsy), or a larger operation (resection) to see which approach offers the best quality of life and survival.
United States · Belgium · Germany - enrolling by invitationNA
Triggered Imaging in Glioblastoma Based on Clinical Outcome Evaluation Compared to Routine: a Feasibility Study
This study looks at whether checking for changes in glioblastoma based on a patient's symptoms is better than regular scans. It wants to see if patients noticing serious symptoms might trigger earlier imaging, helping with care.
United Kingdom - recruitingNA
Preoperative Preradiotherapy TTFields
This study looks at using a device called Optune for glioblastoma brain tumours. We're testing if using Optune before surgery and before radiotherapy is safe and helps prevent the tumour from growing quickly in that time, which we call 'rapid early progression'.
United Kingdom - active not recruitingPHASE1
A Dose Finding Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed Glioblastoma in Combination With Standard of Care and in Recurrent Glioblastoma as a Single Agent.
This study looks at a new treatment called [177Lu]Lu-DOTA-TATE for glioblastoma, a type of brain tumour. It's testing different doses and how well it works, both on its own and with usual treatments, in people recently diagnosed or whose cancer has come back.
United States · France · Portugal - authorisedHuman Pharmacology (Phase I)- Other
Phase I/IIa study of concomitant radiotherapy with olaparib and temozolomide in unresectable high grade gliomas patients
This study is testing a new way to treat an aggressive brain tumour called glioblastoma. It combines radiation therapy with two drugs, olaparib and temozolomide, to see if this treatment is safe and if it helps people with tumours that can't be removed by surgery.
France - recruiting
The RESBIOP-study: Resection Versus Biopsy in High-grade Glioma Patients (ENCRAM 2202)
This study compares two ways to treat serious brain tumours (high-grade gliomas) in older patients or those who are not very active: having surgery to remove the tumour (resection) or taking a small tissue sample (biopsy). It looks at survival, quality of life, and if patients can then have other treatments.
United States · Belgium · Germany - recruitingPHASE2
Surgery for Recurrent Glioblastoma
This study looks at whether a second surgery for recurrent glioblastoma brain cancer, followed by treatment, is better than just having treatment alone. It aims to see if surgery helps people live longer, feel better, and have a good quality of life.
Austria · France · Germany - recruitingNA
Amplitude Modulated Radiofrequency Electromagnetic Field Treatment Combined With Radiochemotherapy and Maintenance Chemotherapy in Patients With Glioblastoma (Brain-RF)
This study is looking at a new way to treat glioblastoma, a type of brain tumour. It combines standard chemotherapy and radiation with a special radiofrequency treatment. The aim is to see if this combination is safe and effective.
Germany - active not recruitingPHASE1, PHASE2
AGuIX Nanoparticles With Radiotherapy Plus Concomitant Temozolomide in the Treatment of Newly Diagnosed Glioblastoma
This study looks at a new treatment for a type of brain cancer called glioblastoma. It combines standard treatments (radiotherapy and other medicine) with special ‘nanoparticles’ called AGuIX. The aim is to see if this new combination is safe and effective.
France - recruiting
The PROGRAM-study: Awake Mapping Versus Asleep Mapping Versus No Mapping for Glioblastoma Resections
This study compares different ways to remove brain tumours called glioblastoma. It looks at whether using special brain mapping techniques during surgery, or not using them, affects how well the surgery goes and how patients recover. The goal is to find the safest and most effective method.
United States · Belgium · Germany - recruitingPHASE2
Contribution From PET-DOPA in Glioblastoma Re-irradiation - A Randomized Phase II Study
This study looks at a new way to treat recurrent glioblastoma, a tough brain cancer. It uses advanced radiation mapping to target tumors more precisely, aiming to improve treatment where cancer has returned.
France - active not recruitingPHASE2
Efficiency of Vaccination with Lysate-loaded Dendritic Cells in Patients with Newly Diagnosed Glioblastoma
This study looks at a new vaccine to treat a serious type of brain tumour called glioblastoma. It combines a special vaccine made from your own tumour cells with standard treatments to see if it helps people live longer.
Germany - authorisedHuman Pharmacology (Phase I)- First administration to humans
RIVKAL clinical trial for the first-in-human administration of BIM2b in participants with Glioblastoma
This study, called RIVKAL, is the very first time a new medicine called BIM2b is being tested in people with glioblastoma. Doctors want to see if it's safe and how the body handles it. It's an early-stage study to learn more about this potential treatment.
France - authorisedHuman Pharmacology (Phase I)- First administration to humans
An open-label dose escalation study to estimate maximum tolerated dose (MTD), identify dose-limiting toxicities (DLTs) and study pharmacokinetics following a single dose of intracranially administered temozolomide-based SI-053 as an add-on to the current standard of care (SoC), in adult patients with newly diagnosed glioblastoma (GBM).
This study is testing a new way to give a existing medicine, temozolomide, directly into the brain for adults with newly diagnosed glioblastoma, a type of brain cancer. It aims to find the safest dose when given alongside standard treatments.
Germany · Netherlands - active not recruitingPHASE1, PHASE2
A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors
This study is testing a new drug, ST101, for people with advanced cancers like breast cancer, melanoma, and glioblastoma. It aims to see if the drug is safe, how much to give, and if it could help shrink tumors. It's for adults whose cancer hasn't responded to other treatments.
United States · United Kingdom - authorisedTherapeutic exploratory (Phase II)
MATVAC-1 : EVALUATION OF UCPVAX VACCINE +/- PEMBROLIZUMAB COMBINED WITH STANDARD TREATMENT AS ADJUVANT THERAPY IN PATIENTS WITH UNMETHYLATED MGMT GLIOBLASTOMA
This study is looking at new treatments for a type of brain cancer called glioblastoma. It's testing a vaccine called UCPVAX, sometimes with another drug called pembrolizumab, alongside standard care, to see if it helps people live longer after treatment.
France - active not recruitingPHASE3
A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma
This study compares a new drug (niraparib) with standard treatment (temozolomide) for a type of brain tumour called glioblastoma. We want to see if niraparib can help people live longer. Participants will take medication daily alongside radiotherapy.
United States · Australia · Canada - recruiting
Ex VIvo DEtermiNed Cancer Therapy
This study, called EVIDENT, wants to see if we can test a tiny piece of your tumour in the lab to predict how well cancer treatments will work for you. It's for people with various solid cancers, like bladder or kidney cancer, who are having surgery or a biopsy.
United Kingdom - recruiting
Targeted Pediatric High-Grade Glioma Therapy
This study aims to understand childhood brain tumours better by looking at their genes. For children, teenagers, and young adults with newly diagnosed high-grade gliomas, including DIPG, doctors will check their tumour's genetic makeup to see if they might be suitable for specific new treatments in future trials.
United States · Australia · Canada - recruitingPHASE2
Irinotecan-ChemoSeed in Surgically Resectable Glioblastoma
This study is testing a new way to treat an aggressive type of brain tumour called glioblastoma. After surgery, small implants containing a cancer drug are placed where the tumour was removed. This aims to kill any remaining cancer cells and stop the tumour from growing back.
United Kingdom - active not recruitingPHASE3
Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma Multiforme
This study is looking at a new way to treat a type of brain tumour called glioblastoma. It compares standard treatment with adding a special type of radiation given during surgery. The aim is to see if this new approach can help people live longer without their cancer growing back.
United States · Brazil · Canada - recruitingPHASE2
Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant
This study is looking at new drug combinations to treat certain types of brain tumours in children and young adults. It aims to see if combining ribociclib with either everolimus or temozolomide can help patients live longer and improve their health.
United States · Australia · Canada - active not recruiting
Surgically Induced Neurological Deficits in Glioblastomas (SIND Study)
This study looks at how brain surgery for glioblastoma affects your vision, thinking, and daily life. Researchers use scans and tests before and after surgery to understand how changes in the brain link to your well-being.
United Kingdom