Glioblastoma research hub

RIVKAL clinical trial for the first-in-human administration of BIM2b in participants with Glioblastoma

This study, called RIVKAL, is the very first time a new medicine called BIM2b is being tested in people with glioblastoma. Doctors want to see if it's safe and how the body handles it. It's an early-stage study to learn more about this potential treatment.

Phase I/IIa study of concomitant radiotherapy with olaparib and temozolomide in unresectable high grade gliomas patients

This study is testing a new way to treat an aggressive brain tumour called glioblastoma. It combines radiation therapy with two drugs, olaparib and temozolomide, to see if this treatment is safe and if it helps people with tumours that can't be removed by surgery.

Unravelling the invisiBle infiltRating cOmponeNT Of glioblaStomA Using mRi USpio (BRONTOSAURUS)

This study looks at how best to use a special iron-based dye called USPIO with MRI scans. Researchers want to find the right amount of USPIO to help get clearer images of brain tumours, specifically glioblastoma, to improve diagnosis and understanding of this cancer.

A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors

This study is testing a new drug, ST101, for people with advanced cancers like breast cancer, melanoma, and glioblastoma. It aims to see if the drug is safe, how much to give, and if it could help shrink tumors. It's for adults whose cancer hasn't responded to other treatments.

EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma

ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids

MRinRT: Swansea University and SWWCC Collaboration Study.

This study looks at using MRI scans to make radiotherapy for cancers like brain, stomach, and gullet cancer more accurate. It aims to see if MRI can help doctors better plan and adjust treatment, potentially reducing side effects.

Pediatric Long-Term Follow-up and Rollover Study

This study looks at the long-term well-being of children and young people who have been treated with specific medications (dabrafenib and/or trametinib) for certain brain cancers in previous clinical trials. It aims to understand the lasting effects of these treatments.

A Study Assessing if it is Safe and Possible to Treat Brain Cancer Patients With Immunotherapy Before They Receive the Standard Treatment.

This study looks at giving a new cancer drug called ipilimumab to people with a type of brain cancer (glioblastoma) before their usual treatment. It aims to check if the drug is safe and if it helps control the cancer at this early stage.

Preoperative Preradiotherapy TTFields

This study looks at using a device called Optune for glioblastoma brain tumours. We're testing if using Optune before surgery and before radiotherapy is safe and helps prevent the tumour from growing quickly in that time, which we call 'rapid early progression'.

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

This study is looking at new drug combinations to treat certain types of brain tumours in children and young adults. It aims to see if combining ribociclib with either everolimus or temozolomide can help patients live longer and improve their health.

Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma Multiforme

This study is looking at a new way to treat a type of brain tumour called glioblastoma. It compares standard treatment with adding a special type of radiation given during surgery. The aim is to see if this new approach can help people live longer without their cancer growing back.

Targeted Pediatric High-Grade Glioma Therapy

This study aims to understand childhood brain tumours better by looking at their genes. For children, teenagers, and young adults with newly diagnosed high-grade gliomas, including DIPG, doctors will check their tumour's genetic makeup to see if they might be suitable for specific new treatments in future trials.

Surgically Induced Neurological Deficits in Glioblastomas (SIND Study)

This study looks at how brain surgery for glioblastoma affects your vision, thinking, and daily life. Researchers use scans and tests before and after surgery to understand how changes in the brain link to your well-being.

Ex VIvo DEtermiNed Cancer Therapy

This study, called EVIDENT, wants to see if we can test a tiny piece of your tumour in the lab to predict how well cancer treatments will work for you. It's for people with various solid cancers, like bladder or kidney cancer, who are having surgery or a biopsy.

A study to evaluate the safety and efficacy of the tumor-targeting human antibody-cytokine fusion protein L19TNF plus standard temozolomide chemoradiotherapy in patients with newly diagnosed glioblastoma.

This study is testing a new antibody treatment, L19TNF, along with standard brain cancer medication, temozolomide. It aims to see if combining them is safe and helps people with a type of brain tumour called glioblastoma live longer and feel better.

MATVAC-1 : EVALUATION OF UCPVAX VACCINE +/- PEMBROLIZUMAB COMBINED WITH STANDARD TREATMENT AS ADJUVANT THERAPY IN PATIENTS WITH UNMETHYLATED MGMT GLIOBLASTOMA

This study is looking at new treatments for a type of brain cancer called glioblastoma. It's testing a vaccine called UCPVAX, sometimes with another drug called pembrolizumab, alongside standard care, to see if it helps people live longer after treatment.

A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma

This study compares a new drug (niraparib) with standard treatment (temozolomide) for a type of brain tumour called glioblastoma. We want to see if niraparib can help people live longer. Participants will take medication daily alongside radiotherapy.

A study to determine how BI 907828 (Brigimadlin) is taken up in the tumor (Phase 0) and to determine the highest dose of BI 907828 (Brigimadlin) that could be tolerated (Phase Ia) in combination with radiation therapy in people with a brain tumor called glioblastoma

A Phase I/II open label study to assess safety and preliminary evidence of a therapeutic effect of Azeliragon combined with conventional concurrent radiation and temozolomide in patients with newly diagnosed glioblastoma.

Evaluation of the feasibility of PD L 506 for stereotactic interstitial photodynamic therapy (iPDT) in adult patients with newly diagnosed supratentorial IDH wild-type glioblastoma

Phase Ib Clinical Trial to Evaluate the Safety Profile of the Combination Tilray FS Oral Solution T10:C10 with Temozolomide and Radiotherapy in Patients With Newly Diagnosed Glioblastoma.

An open-label dose escalation study to estimate maximum tolerated dose (MTD), identify dose-limiting toxicities (DLTs) and study pharmacokinetics following a single dose of intracranially administered temozolomide-based SI-053 as an add-on to the current standard of care (SoC), in adult patients with newly diagnosed glioblastoma (GBM).