Surgery for Recurrent Glioblastoma

This study is looking for adults aged 18 or over. To be considered, you must have been previously diagnosed with glioblastoma that has been confirmed by a lab test, and you must have already had standard treatments like surgery and radiotherapy.

Your glioblastoma must have started to grow back (this is called 'recurrence' or 'progression'), but not within the first 3 months after finishing your radiotherapy. Importantly, scans of your brain must show that it's possible to safely remove the new tumour growth without causing significant problems with your speech or movement. A team of experts will review your scans to confirm this.

You cannot have features on your brain scan that suggest the tumour is too widespread, such as extending to the other side of the brain, or problems that make surgery too risky, like the tumour being too close to major blood vessels or important brain areas for speech and movement. You also need to be generally well and able to carry out most daily activities, as measured by a score called KPS of 70 or higher.

If you join this study, you will be randomly assigned to one of two groups, like flipping a coin. One group will have a second surgery to remove the tumour, followed by further treatments (like medication). The other group will go straight to receiving further treatments, without another surgery.

You'll have regular check-ups and brain scans (MRIs) throughout the study to monitor your health and the tumour's growth. Doctors will also check your neurological function (like speech and movement) and ask you questions about your quality of life to understand how you are feeling. The exact number of visits and tests will be explained in detail by the study team, along with the total length of time you'll be part of the study. All treatments, assessments, and follow-ups will be closely managed by the clinical team.