- recruitingTherapeutic confirmatory (Phase III)
Randomised, double-blind, placebo-controlled study to evaluate the effect of metformin, an AMPK activator, on cognitive measures of progression in Huntington's disease patients.
This study is looking at whether a common diabetes medicine called metformin could help people with Huntington's disease with their thinking and memory. It compares metformin to a dummy pill to see if it makes a difference to how the disease progresses.
Spain - recruitingPHASE2, PHASE3
Study to Evaluate the Pharmacodynamics, Safety and Efficacy of SKY-0515 in Participants With Huntington's Disease
This study is testing a new oral drug, SKY-0515, for Huntington's disease. Researchers want to see if it can reduce harmful proteins in the brain and improve symptoms. It's for adults aged 25 and over with a confirmed diagnosis of Huntington's.
United States · Argentina · Brazil - recruitingPHASE3
Pridopidine Phase 3 Study in Huntington's Disease
This study looks at whether a drug called pridopidine can slow down Huntington's disease (HD) in adults. It also checks if the drug is safe. Participants will take pridopidine or a dummy pill for a year, with regular check-ups, to see if it helps with HD symptoms.
United States · Belgium · Canada - not yet recruitingNA
Autobiographical Memory, Future Thought, and Eye Movements in Huntington's Disease
This study looks at how Huntington's disease affects memory, especially remembering personal life events and thinking about the future. It uses special eye-tracking technology and standard memory tests to better understand these changes.
France - recruitingPHASE3
A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease
This study is looking into a new medicine called Votoplam for people with early Huntington's disease. Researchers want to see if it's safe, how well people tolerate it, and if it can slow down the disease’s progress compared to a dummy medicine.
United States · Argentina · Australia - recruiting
Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers
This study looks at tiny genetic differences in people with Huntington’s disease to understand more about the condition. It involves one visit to a clinic, answering questions about your health, and giving a blood sample. This research could help us learn more about Huntington's.
United States · Argentina · Australia - active not recruitingPHASE1, PHASE2
A Study to Evaluate AB-1001 Striatal Administration in Adults With Early Manifest Huntington's Disease
This study is testing a new gene therapy, AB-1001, for early Huntington's disease. Researchers want to see if it's safe and if it helps people. The treatment is given directly into the brain, and the study will look at different doses.
France - active not recruitingPHASE2
An Extension Study to Evaluate the Long-Term Safety and Efficacy of Votoplam in Participants With Huntington's Disease (HD)
This study is looking into the long-term safety and effects of a medicine called Votoplam for people with Huntington's disease. Participants who were already in a previous study with Votoplam will continue to take it to see how it works over a longer time.
Australia · Austria · Canada - active not recruitingPHASE1, PHASE2
Safety and Efficacy of AMT-130 in European Adults With Early Manifest Huntington's Disease
This study is testing a new treatment called AMT-130 for early Huntington's disease in adults across Europe. It aims to see if the treatment is safe and helps with the condition. Some participants will also receive medication to help with the treatment.
Poland · United Kingdom - recruitingPHASE1, PHASE2
A Safety and Pharmacokinetics Trial of VO659 in SCA1, SCA3 and HD
This study is testing a new drug called VO659 for people with certain genetic conditions affecting movement: Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 3, and Huntington's Disease. It's looking at how safe the drug is and how the body handles it. This is a very early stage trial.
Denmark · France · Germany - active not recruitingPHASE2
GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease
This study, GENERATION HD2, is looking at a new drug called tominersen for Huntington's disease. Researchers want to see how safe it is, how it affects the body, and if it helps people in the early stages of the condition. It's comparing tominersen to a dummy drug.
United States · Argentina · Australia - recruiting
IMarkHD: in Vivo Longitudinal Imaging of HD Pathology
This study uses special brain scans (PET and MRI) to understand how Huntington's disease (HD) changes the brain over time. Researchers are looking at what causes symptoms and how the disease progresses, hoping to find better ways to diagnose and treat HD.
United Kingdom