Randomised, double-blind, placebo-controlled study to evaluate the effect of metformin, an AMPK activator, on cognitive measures of progression in Huntington's disease patients.
This research is investigating if a widely used diabetes drug, metformin, might help with thinking and memory problems in people who have Huntington's disease. Participants will take either metformin or a dummy pill (placebo) without knowing which one they have, and researchers will compare their progress. The main goal is to see if metformin can slow down changes in brain functions like memory and problem-solving, which are often affected by Huntington's disease. This is a large study (Phase 3), meaning it's one of the final steps to see if the medicine really works and is safe for this particular use. The findings could potentially offer a new way to help manage some symptoms of Huntington's.
At a glance
What is this study about?
This study is trying to understand if a medicine called metformin, which is usually given to people with diabetes, could also help those living with Huntington's disease. Huntington's disease can affect many parts of the body, including how people think, remember, and process information. Researchers believe that metformin might have properties that could help protect brain cells and improve some of these thinking skills.
To find out if metformin works, the study uses a careful method. Some people will receive metformin, while others will receive a 'dummy pill' (called a placebo) that looks exactly the same but contains no active medicine. Neither the participants nor their doctors will know who is getting which pill until the study is over. This helps to make sure the results are fair and accurate, as it removes any bias that knowing might create.
The main thing the researchers will be looking at is how participants' thinking and memory skills change over time. They will use a set of specific tests that measure things like how quickly you can process information, your verbal fluency (how easily you can find words), and your ability to concentrate. By comparing the scores of those who took metformin with those who took the dummy pill, the study aims to see if metformin can slow down the natural progression of these cognitive (thinking) changes in people living with Huntington's disease.
Key takeaways
- This study is testing a diabetes drug (metformin) for Huntington's symptoms.
- It aims to see if metformin can improve thinking and memory.
- Participants will take either metformin or a dummy pill.
- The study is a Phase 3 trial, a later stage of research.
- Regular brain function tests will be performed.
- You can withdraw from the study at any time.
Who may be eligible?
To join this study, people need to be at least 18 years old. There's no upper age limit, meaning older adults can also take part.
This study is open to everyone, regardless of whether they are male or female. The main requirement is that you have a diagnosis of Huntington's disease.
There might be other health requirements or medicines you are currently taking that could affect whether you can join, so it's important to discuss your full medical history with the study team.
- Are you 18 years old or older?
- Do you have a diagnosis of Huntington's disease?
- Are you prepared to take a tablet daily?
- Are you able to attend regular clinic appointments for tests?
- Are you comfortable with the possibility of taking a dummy pill instead of the active drug?
This is a guide only — the research team will confirm whether you can take part.
What does participation involve?
If you decide to take part, you'll be given either the metformin tablet or a dummy tablet, both orally. You'll take these coated tablets daily. You won't know which one you are taking, and neither will the study doctor. The study will involve a series of regular visits to the clinic. At these visits, you'll have specific tests to check your thinking and memory (like puzzles and word games) and other health checks. These assessments will help the researchers track any changes over time. We expect the study will run over a significant period, involving regular follow-ups to monitor your progress and ensure your safety. The total duration of your involvement will be clearly explained by the study team.
Potential risks and benefits
Locations (1)
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Common questions
What is metformin normally used for?
Metformin is a common medicine usually prescribed to help people with type 2 diabetes control their blood sugar levels.
What does 'double-blind' mean?
It means neither you nor your doctor will know if you're taking the actual metformin medicine or a dummy pill (placebo) until the study is over. This helps make the results fair.
What is a 'dummy pill'?
A dummy pill, or 'placebo,' looks exactly like the real medicine but doesn't contain any active drug. It's used to compare against the real medicine.
Will I have to pay to be in the study?
No, you will not have to pay for the study medication or the tests related to the study.
What is the main thing the study is looking for?
The main goal is to see if metformin can help to slow down changes in thinking, memory, and other brain functions in people with Huntington's disease.
How to find out more
Always speak to your GP or specialist before deciding to take part in a study.
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