- recruitingPHASE3
Long-Term Safety and Efficacy of Plozasiran in Adults With Hypertriglyceridemia
This study is testing a new injection called Plozasiran for adults with very high triglyceride levels. Participants have already been in related studies and will receive the injection every three months for two years, while following a low-fat diet.
United States · Argentina · Australia - recruitingPHASE1
A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias
This study is testing a new medicine called CTX310 for people in the UK with high cholesterol and fats in their blood that haven't improved with usual treatments. It will check if the medicine is safe and how well people tolerate different doses. It's an early-stage study.
United States · Australia · New Zealand - ongoing, recruitingTherapeutic confirmatory (Phase III)
ISIS 678354-CS9: A Randomized, Double-blind, Placebo-Controlled, Phase 3 Study of Olezarsen (ISIS 678354) in Patients with Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease (Established or at Increased Risk for), or with Severe Hypertriglyceridemia
This study is testing a new medicine, Olezarsen, for people with high 'triglycerides' (a type of fat in the blood) and heart problems. It aims to see if the medicine can lower these fats and is safe to use.
Denmark · Spain · France - active not recruitingPHASE3
Phase 3 Study of Plozasiran in Adults With Hypertriglyceridemia
This study looks at a new injection called plozasiran for adults with high triglycerides. We want to see if it's safe and helps lower triglyceride levels compared to a dummy injection.
United States · Argentina · Australia - recruitingPHASE1
Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia
This study is testing a new treatment, VERVE-201, for people with very high cholesterol and fats in their blood that haven't responded to other medicines. Scientists want to see if it's safe and how it affects these blood fats by altering a specific gene in the liver.
Australia · Canada · South Africa