Long-Term Safety and Efficacy of Plozasiran in Adults With Hypertriglyceridemia

This study is specifically for adults who have already taken part in one of several previous related studies on the medication Plozasiran and completed all the required visits in those studies. You would also need to meet other health criteria to be included.

Key health requirements include having your blood sugar (HbA1c) at or below 10% within a month before starting this study. If you were in a specific previous study (AROAOC3-2003), you also needed to have completed another study before that and met certain very high triglyceride levels at the start of the first study, particularly if you had a history of pancreatitis.

Beyond these specific previous study requirements, for all participants, women must not be pregnant or breastfeeding and must use highly effective contraception if they could become pregnant. Men must also use contraception. Everyone must be on their usual medications for managing cholesterol and triglycerides, unless their doctor says they cannot take them. If you have heart disease or a high risk of it, you must be on appropriate cholesterol-lowering treatment as well. If you have diabetes, it must be well-managed according to your doctor's advice.

If you join this study, you will receive Plozasiran as an injection under the skin approximately every three months for a total of two years. You will have regular appointments where study staff will check your health, take blood samples, and monitor how you are responding to the treatment. You will also be strongly advised to continue following a low-fat diet throughout the two-year study period. The exact schedule of visits and assessments will be provided by the study team, but typically involves regular check-ups to monitor your safety and the effectiveness of the treatment.