- active not recruitingNA
Taxifolin/Ergothioneine and Immune Biomarkers in Healthy Volunteers (TaxEr)
This study looks at how natural substances, Taxifolin and Ergothioneine, found in foods like apples and mushrooms, might affect our immune system. We want to see if these substances can help improve how our body fights off illness, especially as we get older, by reducing stress on our cells.
United Kingdom - recruitingPHASE2
Focused Orticumab Research for Treating Inflammation in Coronary Arteries
This study looks at a new drug, Orticumab, to see if it can reduce inflammation in the heart's arteries after a heart attack. Researchers will compare it to a dummy drug (placebo) over 6 months to see its effects.
United States · Czechia · Hungary - recruitingNA
Skin Inflammation in (Peri)Menopause: A Probiotic Intervention Proof of Concept Trial
This study looks at whether a daily probiotic drink can help women aged 40-60 with skin issues like eczema or rosacea. We want to see if it can reduce inflammation and improve their immune system during menopause.
United Kingdom - active not recruitingEARLY_PHASE1
Investigation of the Distinct Mechanisms Involved in Inflammatory Resolution Between Healthy Men and Women
This study looks at how the body deals with inflammation differently in healthy men and women. We want to understand if these differences could explain why heart problems, like coronary artery disease, affect men and women differently. We'll use a special skin patch to create tiny, harmless blisters and study the fluid from them.
United Kingdom - active not recruitingPHASE3
ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation
This study investigates if a new drug, ziltivekimab, can lower the risk of heart attacks and strokes in people with heart disease, kidney disease, and ongoing inflammation. Participants will receive either the drug or a dummy treatment to see if it makes a difference.
United States · Argentina · Australia - recruiting
Collection of Blood Samples for New Diagnostic Devices 2
This study helps develop new tests for conditions like blood clots, heart problems, kidney issues, and infections. It involves giving blood samples (from a vein or finger-prick) to help create quick, accurate tests that can be used at clinics, offering faster results to improve patient care.
United Kingdom - active not recruiting
Residual Inflammation and Plaque Progression Long-term Evaluation
This study looks at how inflammation in blood vessels after a heart attack might lead to future problems. We use special scans to see inflammation and track changes in blood vessels over time. The goal is to understand how to better prevent future heart issues.
United Kingdom - active not recruiting
Meta-Analyses of the Effect of Plant Protein Versus Animal Protein on Cardiometabolic Risk
This study looks at lots of past research to see if swapping animal protein for plant protein makes a difference to health conditions like diabetes, heart problems, and kidney issues. They want to understand if eating more plant-based protein, like from beans or nuts, can be better for our health.
Canada - recruiting
Studying the Effects of Cannabis on Vasculature
This study looks at how long-term cannabis use affects your heart and blood vessels. Researchers will compare people who use cannabis regularly with those who don't, checking blood vessel health and signs of inflammation using simple tests and blood samples.
Canada - recruitingNA
Targeting Risk Factors for Diabetes in Subjects With Normal Blood Cholesterol Using Omega-3 Fatty Acids
This study looks at how omega-3 from fish oil might help prevent type 2 diabetes. Researchers are exploring if lowering 'bad cholesterol' in a certain way can increase diabetes risk, and if omega-3 can help counteract this in some people.
Canada - active not recruiting
Cognitive Changes After Major Joint Replacement - Full Trial (Cognigram 2)
This study looks at how memory and thinking skills (cognition) change after hip or knee replacement surgery. Researchers want to understand these changes better, identify who might be at higher risk, and find ways to improve recovery. It focuses on changes that might last longer than a few months.
Canada - recruitingNA
Flexi Band Resistance Training Versus EMS Exercise in Patients With the Diagnosis of Malignant Diseases
This study looks at how exercise, using either special resistance bands or a modern electrical muscle stimulation (EMS) method, can help cancer patients. We want to see if these exercises improve strength, body shape, fitness, and how patients feel overall during their treatment.
Germany - recruitingNA
Comparing a Healthy Beef-Centric Diet to a Healthy U.S.-Style Diet on Metabolic Health Outcomes in Pre-Diabetic Adults
This study looks at how two healthy diets affect health markers in people with pre-diabetes. One diet focuses on beef, and the other is a healthy US-style diet. Researchers want to see which one might reduce inflammation and improve blood sugar control.
Canada - recruitingNA
grouP O wholE blooD : storagE leSion impacT And infLammation
This study compares different ways to prepare blood for transfusions. Researchers are looking at regular blood products versus a special type of blood (LTOWB) for emergencies, especially for soldiers. They want to understand how each product affects the body and if one causes more inflammation than the other.
France - active not recruiting
The MISTRAL Study: Gut Microbiome Correlates of Serious AIDS and Non-AIDS Events
The MISTRAL study investigates how gut bacteria affect people living with HIV, especially those over 50. It aims to find ways to improve health, reduce complications like inflammation, and make treatments and vaccines work better by understanding the gut microbiome.
Belgium · Croatia · Czechia - recruitingNA
Platelets Activation in Brain Neoplasms
This study looks at how tiny blood cells called platelets might affect brain tumours. We want to see if platelets are found inside these tumours and if they play a role in how the tumour grows or responds to treatment. The aim is to find new ways to improve anti-cancer therapies.
France - recruiting
Early Severe Illness TrAnslational BioLogy InformaticS in Humans
This study, called ESTABLISH, looks at how the body reacts to severe illnesses like sepsis in the Intensive Care Unit (ICU). Researchers want to find better ways to diagnose these conditions early and discover new treatments to help patients recover.
Canada - recruiting
INflammation and Small Vessel Disease Study
This study looks at whether inflammation in the body affects brain damage and memory in people with a condition called cerebral small vessel disease. It aims to understand if changes in inflammation can predict future problems.
Netherlands · United Kingdom - not yet recruitingNA
Mediterranean Diet Uptake and Nutrition on Child Health, Inflammation, and Early-life Symbiosis (MUNCHIES) Study
This study looks at how a Mediterranean diet affects toddlers' tummy health, body shape, and swelling (inflammation). It also checks if a special eating plan for parents helps teach healthy eating habits for their children aged 2-3.
Canada - recruitingNA
Comorbid Obesity and Depression With an Anti-inflammatory Medication
This study looks into using a medicine called minocycline for people who have both obesity and depression. It's for those with signs of body inflammation. The aim is to see if this treatment can help improve depression symptoms by reducing inflammation.
United Kingdom - recruitingNA
The ISAR InflEx Trial (Inflammation and Exercise)
This study looks at how different types of exercise (moderate, vigorous, and short bursts) affect inflammation in people who are overweight but otherwise healthy and don't exercise much. The aim is to see if exercise can help reduce inflammation and lower the risk of heart problems.
Germany - recruitingNA
Pilot Study on HA380 Column Use in Critically Ill Patients Receiving Extracorporeal Support.
This study looks at a special blood filter, HA380, for very sick patients in intensive care. It's connected to machines like dialysis or ECMO to see if it can help them recover faster by reducing the body's overreaction to illness.
United Kingdom - recruitingNA
axSEND: Exploring Immune and Microbiota Effects of a Partial Enteral Nutrition Diet in Axial Spondyloarthritis
This study looks into how a special liquid and food diet (Partial Enteral Nutrition or PEN) might affect gut health and inflammation in people with axial spondyloarthritis (axSpA). Researchers want to see if this diet can help improve gut bacteria and reduce inflammation, similar to how it works in some bowel conditions.
United Kingdom - recruiting
Barts Sex-CAD Database - Sex Hormones and Inflammatory Status in Coronary Artery Disease
This study looks at how hormones and inflammation affect heart artery disease in men and women, especially for women after menopause. Researchers at Barts Heart Centre hope to find better ways to treat heart conditions by understanding these differences.
United Kingdom - recruiting
Prospective Study of White Blood Cells
This study looks at white blood cells from healthy volunteers to help create new treatments for serious conditions like autoimmune diseases and organ transplant rejection. By understanding these cells better, scientists hope to develop new medicines that can regulate the body's immune system.
United Kingdom - recruitingPHASE3
Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk
This study, called LEADER-PAD, is looking into whether a low dose of colchicine, a common anti-inflammatory medicine, can help people with a condition called Peripheral Artery Disease (PAD) reduce their risk of serious heart and circulation problems.
United States · Australia · Belgium - active not recruitingNA
Identification of New Biomarkers of Insulin Resistance
This study looks for new ways to spot insulin resistance early, a step before type 2 diabetes. We'll check how a special protein called Rab3 changes with diet and exercise, and also look at gut health. This helps us understand and prevent type 2 diabetes.
United Kingdom - not yet recruitingNA
Mechanisms of Acute Inflammation Following Periodontal Treatment
This study looks at how treating gum disease affects your body's inflammation and blood vessel health. We want to see if a special light treatment (photodynamic therapy) with regular gum treatment can reduce inflammation better than regular treatment alone.
United Kingdom