Aortic Valve Calcification research hub

Does Colchicine Reduce Progression of Aortic Valve Stenosis? Colchicine and Inflammation in Aortic Stenosis (CHIANTI): A placebo-controlled, double-blind, multicenter randomized trial.

This study looks at whether a widely used medicine called colchicine can slow down the hardening of the heart's aortic valve. Researchers will compare people taking colchicine with those taking a dummy pill, to see if it helps keep the valve working better for longer. It's a big study to find out if this treatment could be useful.

Pilot Study on HA380 Column Use in Critically Ill Patients Receiving Extracorporeal Support.

This study looks at a special blood filter, HA380, for very sick patients in intensive care. It's connected to machines like dialysis or ECMO to see if it can help them recover faster by reducing the body's overreaction to illness.

Taxifolin/Ergothioneine and Immune Biomarkers in Healthy Volunteers (TaxEr)

This study looks at how natural substances, Taxifolin and Ergothioneine, found in foods like apples and mushrooms, might affect our immune system. We want to see if these substances can help improve how our body fights off illness, especially as we get older, by reducing stress on our cells.

Skin Inflammation in (Peri)Menopause: A Probiotic Intervention Proof of Concept Trial

This study looks at whether a daily probiotic drink can help women aged 40-60 with skin issues like eczema or rosacea. We want to see if it can reduce inflammation and improve their immune system during menopause.

axSEND: Exploring Immune and Microbiota Effects of a Partial Enteral Nutrition Diet in Axial Spondyloarthritis

This study looks into how a special liquid and food diet (Partial Enteral Nutrition or PEN) might affect gut health and inflammation in people with axial spondyloarthritis (axSpA). Researchers want to see if this diet can help improve gut bacteria and reduce inflammation, similar to how it works in some bowel conditions.

Barts Sex-CAD Database - Sex Hormones and Inflammatory Status in Coronary Artery Disease

This study looks at how hormones and inflammation affect heart artery disease in men and women, especially for women after menopause. Researchers at Barts Heart Centre hope to find better ways to treat heart conditions by understanding these differences.

Identification of New Biomarkers of Insulin Resistance

This study looks for new ways to spot insulin resistance early, a step before type 2 diabetes. We'll check how a special protein called Rab3 changes with diet and exercise, and also look at gut health. This helps us understand and prevent type 2 diabetes.

Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk

This study, called LEADER-PAD, is looking into whether a low dose of colchicine, a common anti-inflammatory medicine, can help people with a condition called Peripheral Artery Disease (PAD) reduce their risk of serious heart and circulation problems.

INflammation and Small Vessel Disease Study

This study looks at whether inflammation in the body affects brain damage and memory in people with a condition called cerebral small vessel disease. It aims to understand if changes in inflammation can predict future problems.

Comorbid Obesity and Depression With an Anti-inflammatory Medication

This study looks into using a medicine called minocycline for people who have both obesity and depression. It's for those with signs of body inflammation. The aim is to see if this treatment can help improve depression symptoms by reducing inflammation.

Prospective Study of White Blood Cells

This study looks at white blood cells from healthy volunteers to help create new treatments for serious conditions like autoimmune diseases and organ transplant rejection. By understanding these cells better, scientists hope to develop new medicines that can regulate the body's immune system.

Collection of Blood Samples for New Diagnostic Devices 2

This study helps develop new tests for conditions like blood clots, heart problems, kidney issues, and infections. It involves giving blood samples (from a vein or finger-prick) to help create quick, accurate tests that can be used at clinics, offering faster results to improve patient care.

Mechanisms of Acute Inflammation Following Periodontal Treatment

This study looks at how treating gum disease affects your body's inflammation and blood vessel health. We want to see if a special light treatment (photodynamic therapy) with regular gum treatment can reduce inflammation better than regular treatment alone.

ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation

This study investigates if a new drug, ziltivekimab, can lower the risk of heart attacks and strokes in people with heart disease, kidney disease, and ongoing inflammation. Participants will receive either the drug or a dummy treatment to see if it makes a difference.

Focused Orticumab Research for Treating Inflammation in Coronary Arteries

This study looks at a new drug, Orticumab, to see if it can reduce inflammation in the heart's arteries after a heart attack. Researchers will compare it to a dummy drug (placebo) over 6 months to see its effects.

Residual Inflammation and Plaque Progression Long-term Evaluation

This study looks at how inflammation in blood vessels after a heart attack might lead to future problems. We use special scans to see inflammation and track changes in blood vessels over time. The goal is to understand how to better prevent future heart issues.

Investigation of the Distinct Mechanisms Involved in Inflammatory Resolution Between Healthy Men and Women

This study looks at how the body deals with inflammation differently in healthy men and women. We want to understand if these differences could explain why heart problems, like coronary artery disease, affect men and women differently. We'll use a special skin patch to create tiny, harmless blisters and study the fluid from them.

An Accessorised Prefilled Syringe to an Autoinjector Pharmacokinetic Bridging Study of Tozorakimab

This study is looking at a new way to give a medicine called Tozorakimab for people with breathing problems caused by inflammation. Researchers want to make sure a new pre-filled syringe works just as well as the current autoinjector device.

A Phase IIa, Randomized, Double-blind, Placebo-controlled Study to Evaluate Safety, Tolerability, and Pharmacodynamics of AZD4831 in Participants with Non-cirrhotic Non-alcoholic Steatohepatitis (NASH) with Fibrosis

The MISTRAL Study: Gut Microbiome Correlates of Serious AIDS and Non-AIDS Events

The MISTRAL study investigates how gut bacteria affect people living with HIV, especially those over 50. It aims to find ways to improve health, reduce complications like inflammation, and make treatments and vaccines work better by understanding the gut microbiome.