RecruitingNAINTERVENTIONAL

grouP O wholE blooD : storagE leSion impacT And infLammation

This research study is looking at different types of blood products used for transfusions. Normally, blood donations are separated into red blood cells, plasma, and platelets. However, in emergency situations, like for soldiers in combat, getting all these separate components can be difficult, especially platelets. A special kind of whole blood, called LTOWB, provides all three parts together. While LTOWB is good at stopping bleeding, researchers don't fully understand its effect on inflammation in the body. This study aims to compare how LTOWB affects inflammation and other body processes compared to the standard blood products. The goal is to figure out the best and safest blood products to use, especially in challenging environments where quick and effective transfusions are crucial.

At a glance

Status

Recruiting

Phase

Sponsor

Etablissement Français du Sang

Enrolment target

Start

12 Mar 2025

Estimated completion

01 Feb 2028

Blood Donation Blood Platelets Blood Donors Inflammation Transfusion

What is this study about?

Imagine you're in a situation where someone has lost a lot of blood. Usually, doctors give them separate blood parts like red blood cells, plasma, and platelets, depending on what they need most. These are called 'blood components'. This study is looking at a different approach, especially for emergencies, like when soldiers are injured in remote areas where it's hard to store and transport individual blood parts.

There's a special type of blood product called Low Titer O Whole Blood (LTOWB). This combines red blood cells, plasma, and platelets all in one go, which can be very useful when quick and complete blood replacement is needed. While we know LTOWB is good at stopping bleeding, we don't fully understand if it might cause more inflammation (the body's response to injury or infection) compared to regular blood components. Platelets, which are in LTOWB, are known to play a role in inflammation, not just in clotting blood.

This study aims to carefully compare LTOWB with the standard separate blood components. Researchers want to see if LTOWB causes more inflammation and to understand the other effects it has on the body. By doing this, they hope to find out which blood product is safest and most effective in different situations, especially in places where medical supplies and facilities might be limited. The information from this study will help doctors make the best decisions about how to save lives when every second counts.

Key takeaways

Researchers are comparing standard blood products with a special 'whole blood' product (LTOWB).
The study focuses on how these different blood products might affect inflammation in recipients.
This research could help improve how blood transfusions are given in emergency situations.
Participation involves donating blood if you are an eligible donor.
The goal is to find the safest and most effective blood products for patients.

Who may be eligible?

This study is looking for healthy volunteers who regularly donate blood. You can take part if you meet the usual requirements for giving blood. This includes being in good health and weighing at least 50 kilograms.

For most blood donations, you need to be between 18 and 70 years old. If you're donating only platelets or plasma through a special process called apheresis, you need to be between 18 and 65 years old.

You cannot take part in this study if you are already unable to donate blood for any reason.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you generally in good health?
Do you weigh at least 50 kilograms (about 7 stone 12 pounds)?
Are you between 18 and 70 years old for whole blood donation?
Are you between 18 and 65 years old if you donate plasma or platelets?
Are you currently eligible to donate blood (meaning no reasons that prevent you from donating)?

Answer every question to see your result.

What does participation involve?

The information provided does not detail what participation involves beyond being a blood donor. Generally, for a study like this, it would involve giving a blood donation, similar to a standard donation at a blood bank. Researchers would then study your donated blood. It's likely there would be no additional visits or follow-up required beyond your regular donation.

Potential risks and benefits

The main benefit of participating in this study is contributing to important medical research that could help save lives, particularly in emergency situations. The risks are the same as those associated with a standard blood donation, such as slight discomfort during the needle insertion, bruising, or feeling a little faint. You always have the right to withdraw from donating blood at any point, even if you have initially agreed to participate.

Locations (1)

Maison du don de l'EFS Auvergne Rhônes-Alpes
Verified postcode
Saint-Etienne, France· Recruiting

Common questions

What is whole blood and why is it important?

Whole blood contains all parts of your blood (red cells, white cells, platelets, and plasma). It's important for transfusions, especially in emergencies, because it can replace all the blood components a person has lost.

What is inflammation?

Inflammation is your body's natural response to protect itself from infection or injury. It can cause swelling, redness, and pain, but sometimes too much inflammation can be harmful.

What is the study hoping to achieve?

The study aims to compare different types of blood products to see how they affect inflammation in the body. This will help doctors decide which blood product is best and safest for transfusions, especially in critical situations.

Will I have to take any new medication?

No, this study does not involve taking any new medications. It's about studying blood donations.

Who is running this study?

This study is being conducted by Etablissement Français du Sang (EFS) and the Centre de Transfusion Sanguine des Armées (CTSA), which are French blood establishments.

How to find out more

Hind HAMZEH-COGNASSE, PhD, HDR

hind.hamzeh@univ-st-etienne.fr +33 477 421 400 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.