- recruitingPhase II and Phase III (Integrated)
A phase 2 immunoPET imaging study with ZED88082A/CED88004S in patients with large B-cell lymphoma before and after CD19-directed CAR T-cell therapy
This study looks at how a special scan called a 'PET scan' can help us see large B-cell lymphoma before and after a treatment called CAR T-cell therapy. We're using a special dye to see how the therapy affects the cancer.
Netherlands - active not recruitingPHASE3
An Open-Label Study Comparing Glofitamab and Polatuzumab Vedotin + Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone Versus Pola-R-CHP in Previously Untreated Patients With Large B-Cell Lymphoma
This study is looking at a new treatment called glofitamab for a type of cancer called large B-cell lymphoma. It compares this new treatment, along with other medicines, against a standard treatment for people who haven't had treatment before.
United States · Argentina · Australia - recruitingPHASE1, PHASE2
A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies
This study is testing a new drug, surovatamig, for different types of B-cell blood cancers like leukaemia and lymphoma. Researchers want to see if it's safe and effective, either alone or with other cancer treatments.
United States · Australia · China - recruitingPhase II
Risk-adapted treatment for cancer of the immune system
Large B-cell lymphoma is a fast-growing blood cancer. Standard treatments work well for many people, but some need extra help. This clinical trial tests whether detailed scans and blood tests can spot patients at higher risk of relapse. High-risk patients will receive an additional targeted medicine called epcoritamab alongside standard care.
United Kingdom · England - active not recruitingPHASE3
Study to Evaluate the Safety and Efficacy of Tafasitamab Plus Lenalidomide in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (firmMIND)
This study looks at a new combination of two drugs, tafasitamab and lenalidomide, for adults in the UK with a type of blood cancer called diffuse large B-cell lymphoma (DLBCL). It's for those whose cancer has returned or hasn't responded well to previous treatments and who can't have a stem cell transplant.
Bulgaria · Croatia · Czechia - active not recruitingPHASE1, PHASE2
Phase I/II Study of Rapcabtagene Autoleucel in CLL, 3L+ DLBCL, r/r ALL and 1L HR LBCL
This study is testing a new cell therapy called rapcabtagene autoleucel for different types of blood cancers, including certain lymphomas and leukaemias. It aims to see if the treatment is safe, works well, and how best to give it, sometimes with another drug called ibrutinib.
United States · Australia · Austria - active not recruitingPHASE3
Study to Compare the Effectiveness and Safety of Golcadomide Plus R-CHOP vs Placebo Plus R-CHOP in Participants With Previously Untreated High-risk Large B-cell Lymphoma
This study looks at a new drug, Golcadomide, combined with standard chemotherapy (R-CHOP) for a type of blood cancer called large B-cell lymphoma. It wants to see if this new combination is safer and works better than R-CHOP alone for patients who haven't been treated before and have a high-risk form of the disease.
United States · Argentina · Australia - recruitingPHASE3
Acalabrutinib in Combination With R-miniCHOP in Older Adults With Untreated Diffuse Large B-Cell Lymphoma
This study looks at adding a new drug, acalabrutinib, to standard treatment (R-miniCHOP) for older adults with a type of blood cancer called diffuse large B-cell lymphoma (DLBCL). It wants to see if this addition can help people live longer without their cancer getting worse.
Germany - recruitingPHASE3
AZD0486 1L Therapy for Elderly or Unfit Participants With LBCL
This study is testing a new treatment, AZD0486, for older or less-fit people recently diagnosed with a type of blood cancer called Large B-cell Lymphoma. It compares the new treatment combined with standard therapy against the standard therapy alone.
Australia · Belgium · Brazil - recruiting
Glofitamab in Real Life
This study looks back at how well a treatment called Glofitamab worked and if it was safe for people in France with a type of blood cancer called Large B-cell Lymphoma. Researchers are especially interested in patients who had limited other treatment options.
France - recruitingPHASE2
A Trial of Polatuzumab Vedotin, Obinutuzumab and Glofitamab As a Peri-CAR-T Cell Treatment Strategy in Large B-cell Lymphoma
This study looks at new drug combinations for large B-cell lymphoma that has come back or not responded to past treatments. It checks how safe and effective these drugs are, both before and after a treatment called CAR-T cell therapy.
United Kingdom - recruitingPHASE1, PHASE2
A Phase I/II Trial of ALETA-001 for the Treatment of Participants With B-cell Malignancies
This study is testing a new medicine, ALETA-001, for people with certain types of B-cell lymphoma. It's for those who have already had a specific CAR T-cell treatment. The study will look at how safe and effective ALETA-001 is.
United Kingdom