- recruitingPHASE2
A Trial of Polatuzumab Vedotin, Obinutuzumab and Glofitamab As a Peri-CAR-T Cell Treatment Strategy in Large B-cell Lymphoma
This study looks at new drug combinations for large B-cell lymphoma that has come back or not responded to past treatments. It checks how safe and effective these drugs are, both before and after a treatment called CAR-T cell therapy.
United Kingdom - recruitingPHASE1, PHASE2
A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies
This study is testing a new drug, surovatamig, for different types of B-cell blood cancers like leukaemia and lymphoma. Researchers want to see if it's safe and effective, either alone or with other cancer treatments.
United States · Australia · China - active not recruitingPHASE3
Study to Evaluate the Safety and Efficacy of Tafasitamab Plus Lenalidomide in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (firmMIND)
This study looks at a new combination of two drugs, tafasitamab and lenalidomide, for adults in the UK with a type of blood cancer called diffuse large B-cell lymphoma (DLBCL). It's for those whose cancer has returned or hasn't responded well to previous treatments and who can't have a stem cell transplant.
Bulgaria · Croatia · Czechia - active not recruitingPHASE3
An Open-Label Study Comparing Glofitamab and Polatuzumab Vedotin + Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone Versus Pola-R-CHP in Previously Untreated Patients With Large B-Cell Lymphoma
This study is looking at a new treatment called glofitamab for a type of cancer called large B-cell lymphoma. It compares this new treatment, along with other medicines, against a standard treatment for people who haven't had treatment before.
United States · Argentina · Australia - recruitingPHASE3
AZD0486 1L Therapy for Elderly or Unfit Participants With LBCL
This study is testing a new treatment, AZD0486, for older or less-fit people recently diagnosed with a type of blood cancer called Large B-cell Lymphoma. It compares the new treatment combined with standard therapy against the standard therapy alone.
Australia · Belgium · Brazil - ongoing, recruitingPhase II and Phase III (Integrated)
A phase 2 immunoPET imaging study with ZED88082A/CED88004S in patients with large B-cell lymphoma before and after CD19-directed CAR T-cell therapy
This study looks at how a special scan called a 'PET scan' can help us see large B-cell lymphoma before and after a treatment called CAR T-cell therapy. We're using a special dye to see how the therapy affects the cancer.
Netherlands - recruitingPHASE1, PHASE2
A Phase I/II Trial of ALETA-001 for the Treatment of Participants With B-cell Malignancies
This study is testing a new medicine, ALETA-001, for people with certain types of B-cell lymphoma. It's for those who have already had a specific CAR T-cell treatment. The study will look at how safe and effective ALETA-001 is.
United Kingdom