- recruitingTherapeutic confirmatory (Phase III)
A 96-Week, Prospective, Multicenter, Randomised, Double-Blind, Placebo-Controlled, Phase 3 Study to Compare Efficacy and Safety of Masitinib Dose Titration to 4.5 mg/kg/day versus Placebo in the Treatment of Patients with Primary Progressive or Secondary Progressive Multiple Sclerosis Without Relapse
This study tests whether a medicine called masitinib can help slow down disability in people living with progressive forms of multiple sclerosis (MS). Researchers will compare masitinib to a dummy pill (placebo) over 96 weeks to see if it safely keeps physical and memory symptoms from getting worse.
Greece · Spain · Poland - recruitingHuman Pharmacology (Phase I)- Other
A Phase 1, drug-drug interaction trial of IMU-838 with oral contraceptives in women
This early-stage study looks at how a potential new multiple sclerosis medication, called IMU-838, interacts with oral contraceptive pills in women. Researchers want to make sure the two medications can be taken safely together without stopping birth control pills from working properly.
Belgium - recruitingTherapeutic exploratory (Phase II)
A controlled phase II clinical trial evaluating the safety and efficacy of myelin peptide-loaded tolDC as treatment for Multiple Sclerosis
This study is looking into a new treatment called 'tolDC' for multiple sclerosis (MS). Researchers want to see if it's safe and helps reduce new changes in the brain that are often seen in people with MS.
Spain · Belgium - recruitingTherapeutic exploratory (Phase II)
Dendritic cells therapy combined with immunomodulatory treatment in multiple sclerosis
This study is looking at a new treatment called TolDec for multiple sclerosis (MS). It combines a special cell therapy with other medicines to see if it can reduce new MS lesions and is safe for patients.
Spain - recruitingHuman Pharmacology (Phase I)- Other
A Phase 1, Single-Center, Open-Label, Fixed-Sequence, 2-Part Study to Assess the Pharmacokinetics of IMU-838 Administered Alone and in Combination with Multiple Doses of Gemfibrozil as CYP2C8 Inhibitor, or Rifampicin as CYP2C8 Inducer, in Healthy Subjects
This study is looking at how a new drug, IMU-838, moves through the body. We're testing it on its own and with other medicines in healthy volunteers. This helps us understand if other drugs affect how IMU-838 works, which is important for people with conditions like multiple sclerosis.
Netherlands - authorisedTherapeutic exploratory (Phase II)
TARGET-EBV in MS: A prospective randomized controlled parallel group phase 2b double blinded study to investigate if targeting Epstein Barr Virus with Tenofovir Alafenamide Fumarate compared to placebo as add-on treatment to anti-CD20 therapy reduces neuronal damage in multiple sclerosis
This study looks into whether a drug called Tenofovir Alafenamide, given alongside a standard MS treatment, can help reduce nerve damage in people with multiple sclerosis by targeting the Epstein-Barr virus. It compares the drug to a dummy pill.
Norway · Finland - recruitingHuman Pharmacology (Phase I)- Other
A study investigating the effect of curcumin on the absorption and elimination of IMU 838, a new compound that may potentially be used in the treatment of multiple sclerosis, and the effect of IMU 838 on the absorption and elimination of rosuvastatin.
This study is looking at how a new drug called IMU 838, which might help people with multiple sclerosis, works in the body. Researchers want to see how IMU 838 interacts with curcumin (found in turmeric) and a cholesterol medicine called rosuvastatin.
Netherlands - active not recruitingPHASE3
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (PPMS)
This study looks at a new, higher dose of ocrelizumab for people with primary progressive multiple sclerosis (PPMS). Researchers want to see if this dose is safe and works better than the current approved dose to slow down the disease.
United States · Argentina · Belgium - active not recruitingPHASE3
A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis
This study looks at the long-term safety and effectiveness of a medicine called ocrelizumab for people with Multiple Sclerosis (MS). It's for people already taking part in other ocrelizumab studies, to see how the treatment works over a longer time.
United States · Argentina · Australia - recruiting
Neuropsychological evaluation and rehabilitation in multiple sclerosis – definitive randomised controlled trial (RCT) and implementation study
Up to seven in ten people with multiple sclerosis (MS) experience memory and concentration problems. The NEuRoMS study tests a new NHS pathway. It screens people for thinking difficulties and offers practical, therapist-led support sessions to help manage everyday challenges alongside standard NHS care.
United Kingdom · England · Wales - completed
Changing physical activity behaviour in people with MS: the iStep-MS trial
The iStep-MS trial explores whether a physiotherapy coaching programme helps people with multiple sclerosis (MS) move more and sit less. Researchers want to find out if four support sessions, step counters, and personal goal-setting are safe, enjoyable, and practical before planning a larger nationwide study.
United Kingdom · England - recruitingPhase III
To test artificial intelligence (AI)-assisted magnetic resonance imaging (MRI) in detecting disease activity in Multiple Sclerosis, and to determine whether AI impacts MRI review, treatment decisions, costs, and follow-up care
This study looks at using clever computer programs (AI) to help doctors interpret MRI scans for people with Multiple Sclerosis (MS). It aims to see if this technology, called icobrain ms, can better spot MS activity, guide treatment, and improve care in the NHS.
United Kingdom · England - completedNot Applicable
REFUEL-MS: Clinical and Cost-Effectiveness RCT
This study looks into an app called REFUEL-MS to help people with Multiple Sclerosis (MS) manage fatigue. The app offers exercises and coping strategies. We want to see if it reduces tiredness more than usual care and if it's safe.
United Kingdom · England · Scotland - recruitingTherapeutic exploratory (Phase II)
A Phase 2 double blind, randomized, placebo controlled study evaluating the effect of SAR443820 on serum neurofilament levels in participants with multiple sclerosis, followed by an open-label long-term extension period
This study looks at a new drug, SAR443820, for multiple sclerosis (MS). Researchers want to see if it lowers a marker in the blood called neurofilament, which can show nerve damage. It's a Phase 2 trial, meaning it's still in earlier stages of testing.
Spain · Belgium · Germany - recruitingTherapeutic exploratory (Phase II)
Tenofovir Alafenamide Fumarate and Epstein-Barr virus activity in people with MS – The TAF-MS study
This study, called TAF-MS, is looking into how a medicine called Tenofovir Alafenamide Fumarate (TAF) affects the Epstein-Barr virus (EBV) in people with Multiple Sclerosis (MS). Researchers want to see if this treatment can help reduce EBV activity, which may be linked to MS.
Norway - completed
Changing physical activity and sedentary behaviour in people with MS to reduce fatigue: the iStep-MS study
This study, iStep-MS, looks at how a new activity program helps people with Multiple Sclerosis (MS) feel less tired. It hopes to find better ways for people with MS to be more active and sit less, improving their daily lives.
United Kingdom · England - recruitingHuman Pharmacology (Phase I)- Other
Safety Study to Compare the Gastrointestinal Tolerability of Oral Tegomil Fumarate and Dimethyl Fumarate (Tecfidera®) in Healthy Volunteers.
This study is looking at a new medicine called Tegomil Fumarate. It's compared to an existing medicine, Tecfidera®, to see which is easier on the stomach and gut. This is a very early study in healthy people, not people with a specific illness.
Portugal - not yet recruitingNA
FIT-ATOMIC Exercise Feasibility Trial
This study looks at a 20-week home exercise programme for young people aged 11-25 with Multiple Sclerosis (MS). It aims to see if this type of exercise is a good way to help manage MS and improve their health, preparing for a larger study.
United States · Canada - recruitingNA
EMG Biofeedback Training to Improve Balance in Individuals with Multiple Sclerosis
This study looks at a new training method called EMG Biofeedback, using sensors, to help people with multiple sclerosis improve their balance. It compares it to traditional exercises to see which works best and if the improvements last.
Canada - active not recruiting
Validation and Standardization of Paramagnetic Rim Lesion (PRL) Identification in Multiple Sclerosis Across MAGNIMS Centers
This study looks at how consistently special brain scans (MRIs) are read across different hospitals for people with Multiple Sclerosis (MS). It aims to make sure everyone agrees on identifying specific 'rim lesions' in MS to help improve diagnosis and treatment plans for patients, using existing scan data only.
Austria · Czechia · Denmark - not yet recruiting
Early Prediction of Outcomes Following Optic Neuritis: Development and Acceptability of a Prognostic Tool
This study looks at how your genes and health information after optic neuritis might help predict if you'll develop multiple sclerosis (MS). It also checks your vision and quality of life.
United Kingdom - not yet recruitingPHASE1
Transcranial Magnetic Stimulation for Depression in Multiple Sclerosis
This study looks at a new way to treat depression and extreme tiredness (fatigue) in people with Multiple Sclerosis (MS). It uses magnetic pulses to gently stimulate the brain. Researchers want to see if it's safe and helps improve mood and energy levels.
Canada - recruiting
Measuring Silent Disease Progression in Multiple Sclerosis With a Multimodal Approach
This study looks at how multiple sclerosis (MS) progresses slowly, even without new attacks, in people on certain treatments. It uses regular check-ups, scans, blood tests, and optional smartphone/smartwatch data to understand these changes better.
Germany - recruitingNA
Remediation Program Via a "Serious Game" for the Cognitive Functions of Multiple Sclerosis Patients
This study is looking at a fun, computer-based 'serious game' to help people with multiple sclerosis (MS) improve their memory and how quickly they think. It aims to see if this game can be more helpful than usual care.
France - not yet recruitingNA
Evaluation of the NEUROSWING Orthosis on Walking Speed in a Population With Dorsal and/or Plantar Flexor Deficits, With a View to a Reimbursement Application
This study looks at a new ankle support, the NEUROSWING orthosis, to see if it helps people with walking difficulties caused by conditions like stroke or MS. Researchers will compare it to a standard carbon ankle support to see if it improves walking speed.
France - active not recruitingPHASE1
A Study to Evaluate the Safety, Tolerability, Efficacy, and Drug Levels of CC-97540 in Participants With Relapsing Forms of Multiple Sclerosis, Progressive Forms of Multiple Sclerosis or Refractory Myasthenia Gravis (MG) (Breakfree-2)
This study is looking at a new drug called CC-97540 for people with certain types of Multiple Sclerosis (MS) or a muscle weakness condition called Myasthenia Gravis (MG). We want to see if it's safe, how well people can handle it, and if it helps their condition.
United States · Belgium · France - recruiting
Pregnancy Exposure Registry for Vumerity (Diroximel Fumarate)
This study looks at how babies born to mothers with multiple sclerosis (MS) are affected by a medication called Vumerity (diroximel fumarate) during pregnancy. It compares these babies to those whose mothers either didn't take MS medicines or took other similar treatments.
United States · Australia · Germany - recruiting
Detection of Spinal Cord Lesions Using the MP2RAGE Sequence in Inflammatory Diseases of the Neuraxis
This study looks at a new MRI scan (called MP2RAGE) to see if it's better at finding changes in the spinal cord for people with Multiple Sclerosis (MS). Finding these changes early can help doctors understand and manage MS better.
France - active not recruitingNA
Improving Cognitive Recovery in Multiple Sclerosis
This study looks at a new program, CIRCuiTS-MS, to help people with Multiple Sclerosis (MS) improve their thinking skills. It will check if the program is practical and helpful, paving the way for a larger trial to improve daily life for those with MS.
United Kingdom - recruitingNA
Study of Ovarian Reserve Concerning Patients With Multiple Sclerosis (MS), Compared to a Control Group
This study looks at the egg reserve in women with multiple sclerosis (MS) compared to healthy women. Researchers want to see if MS affects a woman's ability to have children, focusing on women aged 25-35.
France - authorisedTherapeutic use (Phase IV)
Effects of CLADribine tablets on the Immune Synapse, in Relapsing Multiple Sclerosis (RMS) patients_CLADIS.
This study looks at how a medicine called MAVENCLAD affects the body's defence system in people with a type of multiple sclerosis. Researchers want to see if it changes how immune cells communicate and how this affects their MS over one year.
Greece - recruiting
Cognitive Performance, Sleep Disturbances and Fatigue in Multiple Sclerosis
This study looks at how sleep problems and tiredness (fatigue) affect people with Multiple Sclerosis (MS). Researchers want to understand if poor sleep makes MS-related fatigue and thinking problems worse, and how different types of MS are affected. They are also using AI to help analyse sleep data.
Germany - recruitingNA
Deployment o the Multidisciplinary Prospective Cohort Imminent
This study aims to better understand long-term inflammatory diseases like lupus and severe asthma. Researchers will collect information and samples to find new ways to treat these conditions, reduce side effects, and improve daily life for patients. It's about finding better treatments for the future.
France - authorisedTherapeutic exploratory (Phase II)
A Phase 2a Study of SUN-627 to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Impact on Measures of Neuroinflammation in the Central Nervous System in Participants With Non-Active Progressive Multiple Sclerosis (SPMS/PPMS)
This study is looking at a new medicine called SUN-627 for people with certain types of Multiple Sclerosis (MS). Researchers want to see if it's safe, how the body uses it, and if it helps reduce inflammation in the brain over 16 weeks.
Finland - not yet recruiting
Screening for Cognitive Disorders in Multiple Sclerosis
This study looks at how MS affects memory and thinking skills. We will use simple tests to see if people with MS have these difficulties and how it impacts their daily lives. The aim is to better understand these challenges in adults with MS.
France - recruiting
Longitudinal Assessment of Iron Rims in MS Lesions
This study looks at how 'iron rims' around MS lesions on brain scans might affect the disease. We're also checking blood samples for genetic links. Some participants might get another special MRI scan to see how these iron rims change over time.
United Kingdom - active not recruitingPHASE3
Safety and Efficacy of Fingolimod in Pediatric Patients With Multiple Sclerosis
This study looks at how safe and effective two medicines, fingolimod and interferon beta-1a, are for young people aged 10-17 with multiple sclerosis (MS). It compares them to see which works best and is safest.
United States · Australia · Austria - recruiting
Lorraine Registry of Multiple Sclerosis
The Lorraine Registry of Multiple Sclerosis (RelSEP) is a long-term study collecting information from people in the Lorraine region of France who have recently been diagnosed with MS. It aims to understand how MS progresses and is treated over time, helping researchers learn more about the condition.
France - recruitingNA
The Role of Cytokines and Regulatory T Lymphocytes in Migraine Pathophysiology.
This study looks into why some people get migraines, especially those with other health conditions like autoimmune diseases. Researchers are examining how chemicals in the body, called cytokines, and special immune cells, called Treg cells, might be linked to migraine pain. They hope to better understand migraine causes.
France - authorisedTherapeutic exploratory (Phase II)
An autologous and antigen-specific cell-based therapy of vitamin D3-treated and myelin-derived peptide loaded tolerogenic dendritic cells in subjects with progressive forms of multiple sclerosis: a phase IIa, open-label, self-controlled, multi-center clinical trial.
This study is testing a new cell therapy called tolDC for people with progressive forms of Multiple Sclerosis (MS). It aims to see if tolDC can slow down how MS affects your body and if it's safe to use.
Belgium · Spain - recruitingNA
Montpellier PROspective Cohort in Relapsing Remitting Multiple Sclerosis Using Imaging and Serologic
This study looks at people in France with Relapsing Remitting Multiple Sclerosis (RRMS) to compare how two types of MS treatments (standard vs. high-strength) affect brain shrinkage over three years, using MRI scans and other tests.
France - active not recruitingPHASE3
Efficacy and Safety Study of Frexalimab (SAR441344) in Adults With Nonrelapsing Secondary Progressive Multiple Sclerosis
This study is testing a new drug called frexalimab for people with a type of multiple sclerosis (MS) called non-relapsing secondary progressive MS (nrSPMS). Researchers want to see if it can slow down MS progression and if it's safe. It's compared to a dummy drug (placebo).
United States · Argentina · Australia - active not recruitingPHASE2
A Study of LY3541860 in Adult Participants With Relapsing Multiple Sclerosis
This study is testing a new drug, LY3541860, for adults with relapsing multiple sclerosis (MS). We want to see if it's safe and helps reduce MS flare-ups. The study will last about 9 months, with a 6-month follow-up.
United States · France · Italy - not yet recruitingNA
Implementation of Online Mindfulness-Based Stress Reduction Tailored for People with Multiple Sclerosis
This study looks at an 8-week online course called Mindfulness-Based Stress Reduction (MBSR) for people with Multiple Sclerosis (MS). It aims to see if MBSR helps reduce stress, anxiety, and improve quality of life.
Canada - recruitingNA
Implementation of an App-based Walking Aid Skills Training Program
This study looks at a new app called 'ICanWALK' designed to help people who use walking aids like crutches or walkers. It aims to teach them how to use these aids safely and effectively, hoping to reduce falls and improve their confidence.
Canada - active not recruiting
Assessment of NfL and GFAP Levels, Atrophy of the Macula GCC by OCT and Whole Brain Atrophy by MRI to Predict Evolution of Neurological Disability in MS Patients
This study looks at new ways to predict how Multiple Sclerosis (MS) might progress. Researchers will use special scans and blood tests to see if these can help understand future changes in a person's disability, hoping to find better ways to track the disease.
France - active not recruitingPHASE3
LONG-TERM EFFECTIVENESS AND SAFETY EVALUATION OF OCRELIZUMAB
This study looks at the long-term effects and safety of a medicine called ocrelizumab for people with multiple sclerosis (MS). It aims to see how well it helps prevent disability over time, especially for daily activities and arm and hand use.
France - active not recruiting
OFSEP High Definition Cohort
This study aims to understand what causes Multiple Sclerosis (MS) to worsen and to create tools to predict how the disease might progress for individuals. It uses a large French MS registry to collect detailed information and help improve care.
France · Martinique - recruitingNA
From Genetics to Transcriptomics to Unravel the Mechanisms Behind a Poor Outcome in Multiple Sclerosis
This study aims to understand why Multiple Sclerosis (MS) affects people so differently. Researchers are looking at blood samples from people with MS and healthy volunteers to find clues in their genes and cells that might explain why some MS is more aggressive than others.
France - not yet recruitingNA
Remote Ischemic Conditioning in PPMS
This study looks at a new, gentle treatment called Remote Ischemic Conditioning (RIC) for Primary Progressive Multiple Sclerosis (PPMS). It's a simple, non-drug method that uses arm cuffs to see if it can help stop walking problems from getting worse. It's a first step to see if RIC might help people with MS.
Canada