RecruitingOBSERVATIONAL

Detection of Spinal Cord Lesions Using the MP2RAGE Sequence in Inflammatory Diseases of the Neuraxis

This research aims to improve how doctors find changes in the spinal cord of people with Multiple Sclerosis (MS) using a special type of MRI scan. Currently, it can be tricky to see these small changes, especially in the neck area. This study will compare a new MRI technique, called MP2RAGE, with the standard MRI scans doctors usually use. The goal is to see if the MP2RAGE scan is more effective at spotting these spinal cord changes. Finding these early and clearly can help doctors make a more accurate diagnosis and better understand each person's MS.

At a glance

Status

Recruiting

Sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Enrolment target

196

Start

31 Jul 2024

Estimated completion

01 Jul 2026

Multiple Sclerosis

What is this study about?

This study is about making it easier for doctors to spot specific changes in the spinal cord of people who have, or might have, a condition called Multiple Sclerosis (MS). In MS, it's important to find these changes, often called 'lesions,' because they help doctors diagnose the condition and understand how it's affecting someone. However, these changes, especially in the neck part of the spine, can be very small and hard to see clearly with current MRI scans.

At the moment, doctors use a few different types of MRI scans to look at the spinal cord. Our team and other researchers have found that some newer MRI techniques might be better. This study is focusing on one particular new MRI method called MP2RAGE. We want to see if this MP2RAGE scan is better than the usual MRI scans at finding these important spinal cord changes in people with MS.

If the MP2RAGE scan proves to be more effective, it could help doctors get a clearer picture of MS activity in the spinal cord. This could lead to earlier and more accurate diagnoses, better monitoring of the condition, and potentially help in making more informed decisions about treatment plans for people living with MS.

Key takeaways

The study aims to improve how doctors detect spinal cord lesions in MS patients.
It compares a new MRI technique (MP2RAGE) with standard MRI scans.
Participation involves one extra MRI scan during your already scheduled appointment.
No new medications or additional hospital visits are required.
Results could lead to more accurate and earlier MS diagnosis.

Who may be eligible?

To join this study, you need to be at least 18 years old. You should also be scheduled to have an MRI scan of your spinal cord as part of checking for or reviewing an inflammatory condition that affects your nervous system, like MS.

It's important that you understand and agree to take part in the study, and that you are covered by a social security plan, which most people in the UK are.

However, some people can't join. This includes anyone under the age of 18 or those who are pregnant. Also, if your doctor says you can't have an MRI scan for medical reasons, or if you are under certain legal protections, you won't be able to participate.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Are you scheduled for a spinal cord MRI for an inflammatory condition like MS?
Can you give your permission to take part?
Are you NOT pregnant?
Do you have no medical reasons preventing you from having an MRI scan?

Answer every question to see your result.

What does participation involve?

This study involves you having one additional type of MRI scan during your already scheduled MRI appointment for your spinal cord. You won't need any extra visits to the hospital just for this study. There are no new medications involved, and you won't have any extra follow-up appointments directly related to the study. The total duration of your involvement will just be the time it takes for that extra MRI sequence during your routine scan.

Potential risks and benefits

Taking part in this study could help advance our understanding of Multiple Sclerosis detection, potentially leading to better diagnosis in the future. As you are already scheduled for an MRI, the main extra element is a slightly longer scan time. The MP2RAGE sequence uses the same MRI equipment, so the risks are generally the same as a standard MRI. You have the right to change your mind and withdraw from the study at any time without affecting your medical care.

Locations (1)

Hopital Fondation Adolphe de Rothschild
Verified postcode
Paris, France· Recruiting

Common questions

What is the study trying to find out?

The study wants to see if a newer type of MRI scan (MP2RAGE) is better at finding changes in the spinal cord for people with MS compared to the usual MRI scans.

Do I need to take any new medicine for this study?

No, this study only involves having an MRI scan. There are no new medications to take.

Will I have more hospital visits?

No, you'll still have your planned MRI scan. The study will just add an extra scan to that same appointment.

What is 'MP2RAGE'?

MP2RAGE is just a name for a specific kind of MRI scanning technique that creates a very detailed picture.

Will this study change my medical treatment?

The study itself won't directly change your current medical treatment. It's about improving how we see MS in the future.

How to find out more

Yavchitz

ayavchitz@for.paris 33 + 148036454 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.