- recruitingHuman Pharmacology (Phase I)- Other
A Randomized, double-blind, placebo-controlled, three-way cross-over study to assess the pharmacodynamic effects of an authorised and a new compound on nerve excitability threshold tracking in healthy male subjects.
This study is looking at how a new medicine, compared to an existing one and a dummy pill, affects nerve signals in healthy men. It aims to see if the new medicine could help with nerve pain in the future by understanding how it works in the body.
Netherlands - recruitingTherapeutic exploratory (Phase II)
J4F-MC-CYAB: A Phase 2, Randomized, Double-Blind, Placebo Controlled, Dose-Finding Study Evaluating LY3848575 in Chronic Neuropathic Pain Associated With Distal Sensory Polyneuropathy
This study is looking for better ways to manage long-term nerve pain, especially in the feet and hands. It's testing a new medicine, LY3848575, to see if it can reduce pain compared to a dummy pill. We want to find the right dose that works best to lessen pain.
Germany · Poland - active not recruitingPHASE2
Effects of LY3848575 Versus Placebo in Participants With Painful Distal Sensory Polyneuropathy
This study is testing a new treatment, LY3848575, for nerve pain that starts in the feet and moves up the legs. Researchers want to see if it's safe and helps reduce pain compared to a dummy treatment.
United States · Canada · Germany - active not recruiting
Global Registry: ExAblate Neuro MR Guided Focused Ultrasound (MRgFUS) of Neurological Disorders:
This study is gathering information on a new treatment called ExAblate Neuro. It uses sound waves to help people with conditions like essential tremor, Parkinson's disease, and certain types of pain. Doctors want to see how well it works and if it's safe after it's been approved for use.
United States · Canada · Israel - recruitingPHASE4
Capsaicin in Digital Osteoarthritis Versus Control
This study looks at a chilli pepper-based skin patch for painful hand osteoarthritis, especially when there's nerve pain. It compares a strong patch to a weaker one to see if the stronger one reduces finger pain more effectively after two months.
France - recruiting
Observational Study of the Use of 8% Capsaicin Patch in Children 0 to 18 Years Old
This study looks at how children and teenagers with long-lasting nerve pain get on when treated with an 8% capsaicin patch. Doctors want to understand how well it works and whether it causes any problems, by collecting information from patients and their families.
France - recruitingNA
Predictive and Impact of Pain After 6 Months of Radiotherapy, in Head and Neck Cancer
This study looks at why some people with head and neck cancer have ongoing pain after radiotherapy. It also checks if this pain is linked to continuing to smoke or drink alcohol, feeling low, very tired, or affecting their quality of life. Participants will answer questionnaires.
France - not yet recruitingNA
Midline Versus Dorsolateral Spinal Cord Stimulation for Post-surgical Neuropathic Pain
This study looks at a new way to use spinal cord stimulation (SCS) to treat long-lasting nerve pain after surgery. It compares two types of SCS to see which works best for pain that hasn't improved with other treatments, focusing on pain in a specific area.
Canada - recruitingPHASE3
Efficacy of an Intraoperative Periradicular Application of Platelet Rich Fibrin (PRF) on the Intensity of Residual Post-surgical Neuropathic Pain After a Surgery for Disc Herniation
This study looks at a new way to reduce long-lasting nerve pain after back surgery for a slipped disc. It tests if adding a special healing substance made from your own blood (PRF) during surgery helps ease pain better than surgery alone.
France - recruitingNA
Vulnerability and Risk of Neuropathic Pain in Cancer
This study looks at why some cancer patients get long-lasting nerve pain and how to predict who might be at risk. It aims to find better ways to understand and prevent this type of pain.
France