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RecruitingNAINTERVENTIONAL

Vulnerability and Risk of Neuropathic Pain in Cancer

Many cancer patients experience ongoing nerve pain, which can be hard to treat and significantly impact their lives. This study explores why some people are more likely to develop this pain after cancer treatments like surgery, chemotherapy, or radiotherapy. Researchers want to understand the different factors that might increase this risk, such as pre-existing pain, sleep problems, emotional well-being, and social circumstances. The main goal is to create a simple tool that doctors can use to predict a patient's risk of developing long-lasting nerve pain early on. This could help tailor care and potentially prevent pain from becoming a long-term issue, ultimately improving quality of life for cancer patients.

At a glance

Status
Recruiting
Phase
NA
Sponsor
University Hospital, Clermont-Ferrand
Enrolment target
625
Start
28 Oct 2024
Estimated completion
30 Jun 2028

What is this study about?

When people are treated for cancer, for example with surgery, chemotherapy, or radiotherapy, these treatments can sometimes cause pain. For many, this pain goes away, but for some, it can turn into long-lasting pain, often called neuropathic pain. This is a special type of pain that comes from damage to nerves.

This long-lasting nerve pain is common, affecting about half of all cancer patients. It can be very difficult to treat, often appearing slowly and sometimes lasting even after the cancer has gone. This can make everyday life much harder. Doctors currently use general guidelines to treat this pain, but these treatments don't always work, and sometimes they can have side effects.

Researchers understand that many different things can affect whether someone gets this long-lasting pain. These include how much pain they had before treatment, how old they are, if they have trouble sleeping, and their general emotional and mental state. This study aims to bring all this information together to better understand why some people are more vulnerable. The big goal is to develop a tool that healthcare teams can use early on to spot patients who might be at a higher risk of developing persistent nerve pain. This way, they can offer more targeted support and potentially prevent the pain from becoming a long-term problem.

Key takeaways

  • Many cancer patients get long-lasting nerve pain.
  • This study wants to find out why some people are more at risk.
  • It aims to create a tool to predict this risk early on.
  • Understanding these risks could lead to better pain prevention.
  • Participation involves assessments, not new treatments.

Who may be eligible?

This study is looking for two main groups of people: adults (over 18) who have cancer, and healthy volunteers. If you have cancer, you might be able to join if you are going through treatment for breast, gynaecological, bowel (colorectal), or lung cancer, and you're having treatments like chemotherapy, surgery, hormone therapy, or radiotherapy.

However, you wouldn't be able to join if you've had cancer or cancer treatment in the past, or if you have certain brain tumours or other serious neurological conditions like Parkinson's or Alzheimer's. You also can't take part if you are pregnant or breastfeeding, or if your doctor thinks there's another medical reason why it wouldn't be safe for you.

For healthy volunteers, you need to be over 18 and generally in good health with no history of cancer. You shouldn't be taking any medication, especially painkillers, in the week before joining, unless the study doctor says it's okay. Everyone taking part needs to be able to understand the study requirements and give their permission to join, and also be part of the French social security system, as the study is based there.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

  1. Are you over 18 years old?
  2. Are you currently being treated for breast, gynaecological, bowel, or lung cancer?
  3. Have you *not* had cancer or cancer treatment in the past?
  4. Do you *not* have certain brain tumours or conditions like Parkinson's or Alzheimer's?
  5. Are you able to understand and cooperate with study instructions?
  6. Are you not pregnant or breastfeeding?
Answer every question to see your result.

What does participation involve?

As this study is focused on assessments and doesn't involve new treatments, taking part would primarily involve attending appointments for detailed assessments. These assessments would focus on your thoughts and feelings about pain, as well as your general pain levels. The study is designed to gather information to understand vulnerability, so you wouldn't be given any new medications or specific treatments as part of the study itself. The exact number and duration of visits aren't specified but typically these involve a few appointments over a period to track changes.

Potential risks and benefits

The main benefit of taking part in this study is contributing to important research that could help future cancer patients by leading to better ways to predict and manage nerve pain. There are no direct medical benefits to you from participating, as you won't receive new treatments. Potential risks are generally low, mainly involving the time commitment for assessments and any discomfort from discussing pain or emotional states. You are always free to withdraw from the study at any time, for any reason, without it affecting your usual medical care.

Locations (19)

  • Centre Hospitalier d'Ajaccio
    Verified postcode
    Ajaccio, France· Recruiting
  • Centre de Lutte contre le Cancer - Institut de Cancérologie de l'Ouest
    Verified postcode
    Angers, France· Recruiting
  • Centre Hospitalier Henri Mondor d'Aurillac
    Verified postcode
    Aurillac, France· Recruiting
  • Centre de Lutte contre le Cancer - Institut Bergonié
    Verified postcode
    Bordeaux, France· Recruiting
  • Centre de Lutte contre le Cancer - Centre François Baclesse
    Verified postcode
    Caen, France· Recruiting
  • Centre Hospitalier Universitaire Caen Normandie
    Verified postcode
    Caen, France· Recruiting
  • Centre de Lutte contre le Cancer - Jean Perrin
    Verified postcode
    Clermont-Ferrand, France· Recruiting
  • CHU de Clermont-Ferrand
    Verified postcode
    Clermont-Ferrand, France· Recruiting
  • Hôpitaux civils de Colmar
    Verified postcode
    Colmar, France· Recruiting
  • Centre Régional de Lutte contre le Cancer - Georges Francois Leclerc
    Verified postcode
    Dijon, France· Recruiting
  • Hôpital privé le Bois
    Verified postcode
    Lille, France· Recruiting
  • Centre Hospitalier de Montluçon
    Verified postcode
    Montluçon, France· Not yet recruiting

Common questions

What is nerve pain?

Nerve pain, or neuropathic pain, is a type of long-lasting pain caused by damage or injury to the nerves.

Why is this study important?

It's important because it aims to help doctors predict which cancer patients are most likely to get long-lasting nerve pain, so they can offer better support and potentially prevent it.

Will I get new treatment in this study?

No, this study is about understanding pain and predicting risk, not about giving new treatments. Your current cancer treatment will continue as planned.

How long will I need to be involved?

The study description doesn't specify the exact length, but it mentions looking at how pain develops over time, so it would involve a series of assessments over a period.

Can I stop taking part if I change my mind?

Yes, you can choose to leave the study at any point, and it won't affect your ongoing medical care.

How to find out more

Lise LACLAUTRE

Always speak to your GP or specialist before deciding to take part in a study.

Interested in taking part?

Register your interest

Share your details and the research team for "Vulnerability and Risk of Neuropathic Pain in Cancer…" will contact you if you may be eligible. Always speak to your GP before agreeing to take part.

Discussion

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