- recruiting
Pilot study of safety and efficacy of unilateral MRI-guided focused ultrasound thalamotomy in tremor-dominant Parkinson’s disease
This Scottish study tests a non-invasive treatment for Parkinson’s tremors. Using sound waves guided by an MRI scanner, doctors create a tiny heat spot in the brain to calm shaking. The trial checks whether this single-session treatment is safe and effective for people whose tremors do not improve with medicine.
United Kingdom · Scotland - authorisedHuman Pharmacology (Phase I)- First administration to humans
First-in-human evaluation of [11C]UCB-1A as imaging marker for synaptic vesicle glycoprotein 2C (SV2C): a PET study in healthy volunteers and participants with Parkinson’s disease
This early-stage study tests a new brain imaging tracer called [11C]UCB-1A. Researchers want to see if this tracer can safely show a specific brain protein on PET scans in both healthy volunteers and people with Parkinson’s disease. It aims to improve how doctors study and track brain health.
Sweden - recruitingNA
Ginger-PD: Ginger as a Modifier of Ghrelin Levels and Gut Function in Parkinson's Disease
Researchers in Cambridge are testing whether daily ginger capsules can increase a natural stomach hormone called ghrelin in people with Parkinson's disease. Ghrelin helps with gut health and may protect brain cells. This 12-week trial aims to see if ginger is safe, easy to take, and helpful for digestion.
United Kingdom - recruitingTherapeutic exploratory (Phase II)
Effect of Exenatide on disease progression in early Parkinson’s disease.
This clinical trial is testing whether a medicine called exenatide can slow down early Parkinson's disease. Normally used for diabetes, researchers want to see if weekly injections of this drug can protect brain cells over a 21-month period, using specialised brain scans and regular movement checks.
Sweden - authorisedTherapeutic exploratory (Phase II)
Interventional, randomized, double-blind, parallel-group, placebo-controlled, flexible-dose trial of Lu AF28996 in adults with Parkinson’s disease experiencing motor fluctuations.
This clinical trial is testing a new experimental medicine called Lu AF28996 for adults with Parkinson's disease. Researchers want to see if this treatment can increase daily 'good ON time'—the hours when symptoms are well controlled without causing troublesome, involuntary movements—compared to a dummy pill (placebo).
Czechia · France · Spain - authorisedTherapeutic confirmatory (Phase III)
Evaluating the effect of inhaled levodopa (Inbrija®) for early morning off in Parkinson’s disease
This clinical study tests whether an inhaled Parkinson's medicine, called Inbrija, helps people wake up and get moving faster than standard dissolvable tablets. Researchers want to see if breathing in levodopa directly into the lungs shortens morning stiffness and helps people start their day more easily.
Denmark - recruitingHuman Pharmacology (Phase I)- First administration to humans
To investigate the safety and efficacy of a novel investigational compound against neurological diseases such as Parkinson's disease in healthy men and women and patients with Parkinson's disease.
This early-stage clinical trial tests a brand-new medicine for conditions like Parkinson's disease. Researchers want to see if the treatment is safe and how it behaves in the human body. It is open to both healthy volunteers and people living with Parkinson's disease who are aged 18 and older.
Netherlands - recruitingHuman Pharmacology (Phase I)- Other
Phase I, Open-Label Study to Evaluate the Pharmacokinetics, Safety and Tolerability of BIA 28-6156 in Participants with Varying Degrees of Renal Impairment
This early-stage study tests a potential new Parkinson's drug called BIA 28-6156. Researchers want to find out how the body processes the medicine and whether it is safe for adults who have different levels of kidney health, ranging from normal kidney function to reduced kidney function.
Hungary - not yet recruitingPHASE1, PHASE2
Study to Test Effects and Safety of RO7568282 in Early Parkinson's Disease
This clinical trial is testing a new experimental medicine, called RO7568282, for people with early-stage Parkinson’s disease. Researchers want to see if the medicine is safe and if it helps improve movement and daily symptoms better than a dummy pill (placebo) when taken alongside usual levodopa treatment.
United Kingdom - recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Randomised, bioequivalence clinical trial of rasagiline 1 mg capsules vs rasagiline 1 mg tablets, after a single oral dose administration to healthy volunteers under fasting conditions in crossover replicated design.
This study is checking if a new capsule version of a Parkinson's medicine, rasagiline, works the same as the tablet form already available. Healthy volunteers will take a single dose of each to see how the body absorbs them.
Spain - recruitingHuman Pharmacology (Phase I)- Other
Lu AF28996 in Patients With Parkinson's Disease
This study is looking into a new medicine called Lu AF28996 for people with Parkinson's disease. It's an early-stage study to check how safe the medicine is and how it works in the human body. Anyone over 18 can potentially join.
Germany · France · Spain - recruitingTherapeutic exploratory (Phase II)
283PD201 (LUMA): A Phase 2b, multicenter, randomized, double-blind, placebo-controlled study to determine the efficacy and safety of BIIB122 in participants with Parkinson’s Disease
This study is looking into a new medication called BIIB122 for Parkinson's disease. We want to see if it helps slow down the disease's effects on movement and daily activities, compared to a dummy pill. It's an important step in finding new ways to manage Parkinson's.
France · Germany · Austria - recruitingTherapeutic confirmatory (Phase III)
58-week Open-Label Trial of Tavapadon in Parkinson’s Disease (Tempo-4 Trial)
This study is looking at a new medication called Tavapadon for people with Parkinson's disease. Researchers want to see if it's safe and how well it helps with symptoms over 58 weeks. It's a Phase 3 trial, meaning it's a big step towards potentially becoming a new treatment.
France · Germany · Italy - recruitingTherapeutic exploratory (Phase II)
A Proof of Concept, Phase IIa, Open Label Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients with Early Parkinson's Disease
This study is testing a new medicine, Afamelanotide, for people with early Parkinson's disease. Researchers want to see if it's safe and how well it works. They'll be checking for any side effects and looking at changes in the body and brain over about eight weeks.
Spain - recruitingHuman Pharmacology (Phase I)- Other
A Phase I, open-label, non-randomized study to evaluate the absorption, distribution, metabolism and excretion and pharmacokinetics of DLX313 (minzasolmin) following a single oral dose of [14C]DLX313 in healthy male participants
This study is giving a new medicine called DLX313 to healthy male volunteers. It's the first time humans will take this drug. Researchers want to see how the body absorbs, uses, and gets rid of it, hoping to learn more about treating Parkinson's Disease in the future.
Netherlands - recruitingHuman Pharmacology (Phase I)- Other
Phase Ib Safety, Tolerability and Pharmacokinetic Study of Subcutaneously Administered HER-096 in Healthy Volunteer Subjects and Patients with Parkinson’s Disease
This early-stage study is looking at a new medicine called HER-096 for Parkinson's disease. Researchers want to check if it's safe and how the body handles it. It involves healthy volunteers and people with Parkinson's to see if it could be a helpful future treatment.
Finland - recruitingTherapeutic exploratory (Phase II)
A 17-week, Phase 2, Randomized, Double-blind, Placebo-controlled, Flexible-dosing, Parallel-group, Multicenter Study of the Efficacy and Safety of Suvecaltamide in the Treatment of Moderate to Severe Residual Tremor in Participants with Parkinson’s Disease
This study is testing a new medicine, suvecaltamide, for people with Parkinson's disease who have shaking (tremor) that's affecting their daily life. It aims to see if the medicine can make their tremor better and is safe to use over 17 weeks.
Spain · Germany · Poland - recruitingHuman Pharmacology (Phase I)- Other
A study of the safety, absorption and effects of investigational drug ARV-102 in patients with Parkinson's disease.
This study is looking at a new medicine called ARV-102 for people with Parkinson's disease. Researchers want to see if it's safe, how the body uses it, and what effects it has. It's an early-stage study, open to adults.
Netherlands - recruitingPhase I and Phase II (Integrated)- First administration to humans
Evaluation of the safety and efficacy of Continuous Dopaminergic Stimulation by intracerebroventricular administration of anaerobically conserved dopamine in Parkinson's disease at the motor fluctuation stage: Single-center pilot study
This study is testing a new way to give medicine for Parkinson's disease. It involves giving a special dopamine medicine directly into the brain. Researchers want to see if it's safe and helps people whose Parkinson's symptoms change a lot throughout the day.
France - recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A study to compare the absorption of two tablet strengths with the absorption of a solution.
This study is looking at how well two different strengths of a tablet are absorbed by the body compared to a liquid version. It's for people with Parkinson's disease and is a very early stage trial to understand how the medicine works in the body.
Netherlands - recruitingTherapeutic exploratory (Phase II)
Comparative, randomized, open, crossover clinical trial to investigate adhesiveness of a newly developed Rotigotine 12 mg/24 h transdermal patch in patients with Parkinson’s disease
This study is looking at how well a new patch for Parkinson's disease sticks to the skin compared to an existing patch. It's an early-stage trial focusing on how well the patches stay on for nearly a full day.
Germany - recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease
This study is looking into a new medicine called prasinezumab for people with early-stage Parkinson's disease. We want to see if it's safe and helps improve symptoms compared to a dummy drug. Participants will be on a stable dose of existing Parkinson's medication.
United States · Australia · Austria - completed
Personalised Acceptance and Commitment Therapy (PACT) for Parkinson's Disease
This study tests a smartphone app designed to support mental wellbeing in people with Parkinson’s disease. It uses short, daily activities based on Acceptance and Commitment Therapy (ACT) to help users build practical coping skills. Researchers want to see if this app helps reduce emotional distress from the comfort of home.
United Kingdom · England · Northern Ireland - completedNot Applicable
Assessment of electrical stimulation to improve movement for people who have Parkinson’s disease
This UK clinical trial is testing whether a gentle electrical stimulation device, called FES, can improve walking for people with Parkinson's disease. Small electrical pulses help lift the foot to make walking easier and faster. Researchers want to see if this safe treatment reduces falls and improves everyday life.
United Kingdom · England · Wales - completed
Live well with Parkinson's
This UK study tests whether a self-management toolkit can help people with Parkinson’s disease live well at home. Participants receive a guide—online or on paper—and up to six one-to-one sessions with a trained supporter to help manage everyday symptoms, build confidence, and maintain their independence.
United Kingdom - completedPhase I
A study in patients with Parkinson’s disease to evaluate a novel delayed-release, dual-pulse carbidopa and levodopa tablet, CP-012
This early-stage clinical study tests a new delayed-release tablet for people with Parkinson’s disease. The tablet is designed to release medication during the night. Researchers want to see if it reduces morning stiffness and makes it easier for patients to turn over in bed and move freely when waking up.
United Kingdom · Scotland - completedPhase III
A trial of rivastigmine to prevent falls in Parkinson's
Parkinson’s disease can affect balance and walking, leading to frequent falls. This UK clinical study is testing whether a skin patch containing a medicine called rivastigmine can improve steadiness and prevent falls. Around 600 people with Parkinson's will use either the real medicine patch or a dummy patch for one year.
United Kingdom · England · Scotland - completedNot Applicable
Understanding how increasing some of the brain's chemicals can help thinking and behaviour in people with Parkinson’s disease
Researchers in Cambridge are studying whether a medicine called atomoxetine can improve thinking, attention, and decision-making in people with Parkinson’s disease. The medicine works by temporarily raising a brain chemical called noradrenaline. Volunteers attend two hospital visits to compare a single dose of the medicine against a dummy pill.
United Kingdom · England - recruiting
Power-PD: Empowering people with Parkinson’s Disease (PD) through flexible exercise
Power-PD is a UK research study testing a flexible, 12-week exercise programme for people with Parkinson’s disease. Participants can choose each week whether to join classes in person or online from home. The goal is to make regular exercise easier to access, helping people stay active and manage their symptoms.
United Kingdom · England - recruiting
High-intensity functional training in Parkinson's disease
This study looks at a type of exercise called High-Intensity Functional Training (HIFT) for people with Parkinson's. Researchers want to see if it's practical, enjoyable, and safe. The goal is to learn if HIFT could help manage Parkinson's symptoms.
United Kingdom · England - completed
Evaluating the feasibility of a samba percussion intervention for people with Parkinson’s disease
This study looks at a fun samba drumming activity for people with Parkinson's disease. It wants to see if weekly drumming sessions can help with movement, thinking, and mood. The aim is to check if a future, bigger study would be possible.
United Kingdom · Wales - recruitingTherapeutic exploratory (Phase II)
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in Subjects With Parkinson’s Disease With a Pathogenic Variant in the Glucocerebrosidase (GBA1) Gene
This study is looking into a new medicine, BIA 28-6156, for people with Parkinson's disease linked to a specific gene change (GBA1). It wants to see if the medicine can slow down how the disease affects everyday activities and movement.
Germany · Netherlands · Sweden - recruiting
A pilot study to develop a new treatment for people living with Parkinson’s who have difficulties with producing and understanding language
This study looks into developing a new online therapy for people with Parkinson's disease who struggle with language. It's a pilot project to see if the therapy helps with daily conversations and if it's practical to offer more widely.
United Kingdom · Scotland - recruitingHuman Pharmacology (Phase I)- Other
Effects of NT-0796 in Healthy Volunteers and Patients with Parkinson’s Disease
This study is looking for healthy volunteers and people with Parkinson's disease. Researchers want to see how a new medicine, called NT-0796, works in the body and if it's safe. It's an early-stage study to understand the medicine better.
Netherlands - completed
Home-based trunk intervention training to improve rigidity and functionality in people with Parkinson's disease
This study looks at how specific exercises for your body's core muscles might help people with Parkinson's disease. We want to see if these exercises can improve stiffness and make daily activities easier, compared to general exercise.
United Kingdom · England - recruiting
The LITE study: shining LIGHT on Parkinson’s disease
The LITE study is looking into Parkinson's disease (PD) to better understand its causes and how it affects people. We need volunteers, with and without PD, to help us collect important information that could lead to new treatments.
United Kingdom · Scotland - completed
Exploring the potential for ENGAGE-PD physical activity coaching in the NHS for people newly diagnosed with Parkinson’s: perspectives of people with lived experience of Parkinson’s
This study asks people with Parkinson's and their carers in the UK about an exercise coaching programme. It aims to adapt the American 'ENGAGE-PD' programme for the NHS to help newly diagnosed people stay active, independent, and manage their condition better.
United Kingdom · England - recruitingPhase II
DAPA-PD: a trial to test the use of dapansutrile, an anti-inflammatory medication, in people with Parkinson’s disease
This study is testing a new anti-inflammatory drug, dapansutrile, for people with early Parkinson's disease. We want to see if it can reduce brain inflammation and slow down Parkinson's progression. It's for people aged 50-80 in Cambridge, UK.
United Kingdom · England - recruiting
Augmented reality (Reality DTx®) compared to routine physiotherapy for patients with Parkinson's
This study looks at whether special augmented reality glasses (Reality DTx®) can help people with Parkinson's disease improve their balance and walking more than usual physiotherapy. It aims to make physiotherapy more accessible and effective for daily life.
United Kingdom · England - recruitingHuman Pharmacology (Phase I)- First administration to humans
Safety, tolerability, pharmacokinetics and pharmacodynamics of ARV-102 in healthy participants
This study is checking a new medicine called ARV-102 in healthy male volunteers. It's the first time this medicine is being given to people. Researchers want to see if it's safe, how the body handles it, and what effects it has, even though it's for Parkinson's disease.
Netherlands - recruitingTherapeutic exploratory (Phase II)
A DOSE-BLINDED EXTENSION STUDY TO EVALUATE THE LONG-TERM EFFICACY, SAFETY, AND TOLERABILITY OF UCB0599 IN STUDY PARTICIPANTS WITH PARKINSON’S DISEASE
This study is testing a new medicine, UCB0599, for Parkinson's disease. Researchers want to see if it's safe, how well it works long-term, and if it helps protect brain cells. They are comparing it to a dummy pill.
Netherlands · Germany · Spain - recruitingPHASE1
A Clinical Trial of LY3962681 in Healthy Volunteers and in Patients With Parkinson's Disease
This study is testing a new medicine, LY3962681, for Parkinson's disease. It aims to check if the medicine is safe, well-tolerated, and how it works in both healthy people and those with Parkinson's. The medicine is given into the fluid around the spine.
United States · Germany · Japan - active not recruiting
Noninterventional Study Evaluating Parkinson's Disease Diary Use
This study looks at the best way for people with Parkinson's disease to use a special diary. It checks if using the diary more often or less often makes a difference in how well it shows their symptoms. This helps understand how their Parkinson's changes over time.
United States · Canada · Germany - authorisedTherapeutic exploratory (Phase II)
Open-Label, Multi Stage Study to Optimize the Intraputaminal Administration of AB-1005 Using a Prescriptive Infusion Algorithm (PIA)
This study is looking at a new way to deliver a potential treatment, called AB-1005, for Parkinson's disease. Researchers want to make sure the delivery method is safe and works well. They'll also check if the treatment itself causes any side effects.
Poland - recruiting
Study to Assess Real Life Effectiveness of Foslevodopa/Foscarbidopa in Adult German Participants at Initial Stages of Advanced Parkinson's Disease (EARLY-FOS)
This study looks at how well an approved Parkinson's drug, foslevodopa/foscarbidopa, works in real life for adults in Germany who are in the early stages of advanced Parkinson's. It follows participants already prescribed this medication by their doctors.
Germany - recruiting
Serotonin Release in Premotor and Motor PD
This study aims to better understand Parkinson's disease by using special brain scans. Researchers hope to find a 'biomarker' – a sign of the disease – which could help develop new medicines to slow down Parkinson's symptoms.
United Kingdom - recruiting
Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry
This study looks at how well a device called the Vercise DBS System works for people with Parkinson's disease. Researchers are gathering information from around the world to see how it helps with symptoms and improves daily life.
United States · Argentina · Austria - active not recruiting
Global Registry: ExAblate Neuro MR Guided Focused Ultrasound (MRgFUS) of Neurological Disorders:
This study is gathering information on a new treatment called ExAblate Neuro. It uses sound waves to help people with conditions like essential tremor, Parkinson's disease, and certain types of pain. Doctors want to see how well it works and if it's safe after it's been approved for use.
United States · Canada · Israel - recruitingNA
Subthalamic Nucleus, Akinesia and Parkinson's Disease
This study looks into how a tiny brain area called the subthalamic nucleus (STN) affects movement in healthy people and those with Parkinson's disease. We want to understand why movement becomes difficult in Parkinson's and how stimulating the STN might help.
France - recruiting
Parkinson's Foundation PD GENEration Genetic Registry
This study aims to build a central collection of genetic information from people with Parkinson's disease. By understanding the genes linked to Parkinson's, researchers hope to learn more about the condition and how it develops. Participants will have genetic tests and share their results for future research.
United States · Canada · Israel