Longitudinal Investigation of I2BS in PD
Researchers are conducting a study to better understand Parkinson's disease and find ways to measure its changes in the brain. They are looking for a 'biomarker' – a measurable sign that shows if the disease is present, how severe it is, or how it's progressing. To do this, they will use special brain scans, including PET, SPECT, and MRI, which help them see chemical changes and structures in the brain. Some participants might also have a lumbar puncture to collect spinal fluid for analysis. The information gathered from this study will help scientists develop new medicines that could slow down the symptoms and progression of Parkinson's disease. The study involves visits to research centres in London over a period of 12 months.
At a glance
What is this study about?
Parkinson's disease is a condition that affects the brain and can cause problems with movement, such as slowness, stiffness, and shaking. It tends to get worse over time. In this study, scientists are trying to find new ways to understand and measure these changes in the brain. They are looking for what's called a 'biomarker'. Think of a biomarker as a measurable clue, like a specific reading from a test, that tells doctors more about a disease, how it's developing, or how severe it is.
To find these biomarkers, the study will use several types of special brain scans: PET (Positron Emission Tomography), SPECT (Single-photon Emission Computed Tomography), and MRI (Magnetic Resonance Imaging). PET and SPECT scans use tiny, safe amounts of a special substance to show active processes and chemical changes in the brain that other tests can't see. MRI scans, on the other hand, use strong magnets and radio waves to create detailed pictures of the brain's structure and how it's working.
The main goal of getting this detailed information is to gain a deeper understanding of how Parkinson's disease affects the brain. This knowledge is incredibly important because it can help researchers discover and develop new treatments. Ultimately, the hope is that these new medicines could help to slow down the progression of Parkinson's disease symptoms, improving the lives of those affected.
Key takeaways
- This study aims to find new ways to measure Parkinson's disease in the brain.
- It uses special brain scans (PET, SPECT, MRI) and possibly spinal fluid tests.
- The goal is to help develop new medicines to slow down Parkinson's disease.
- Participation involves multiple visits over a 12-month period in London.
- You won't receive new treatments, but you'll help advance medical knowledge.
Who may be eligible?
To join this study, you need to be at least 25 years old and be able to travel to the research sites in London. You also need to be able to fully understand what the study involves and agree to take part by signing a consent form.
For women who might be able to have children, you must show that you are not pregnant or breastfeeding. You must also agree to use very effective birth control methods throughout the study. This includes methods like combined birth control pills, implants, certain injections, an IUD, or sterilisation, or if your partner has had a vasectomy. Men who are sexually active must agree to use condoms to prevent pregnancy and ensure their partner is also using birth control during the study and for 3 months after the last scan.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you 25 years old or older?
- Can you travel to research sites in London?
- Are you able to understand and sign a consent form?
- If you are a woman of childbearing potential, are you willing to use highly effective birth control and confirm you are not pregnant or breastfeeding?
- If you are a sexually active man, are you willing to use condoms and ensure your partner uses birth control during and after the study?
What does participation involve?
If you decide to take part, you'll have two main sets of visits, spaced out 12 months apart. You'll start with an initial check-up and discussion where you'll learn all about the study and give your consent. After that, you'll have an MRI scan, and a PET scan which involves a special tracer called BU99008 that helps highlight certain cells in the brain.
Later, you'll have a SPECT scan. There's also an optional fourth visit for a lumbar puncture, where a small amount of fluid from your spine is collected for testing. These exact same visits will then be repeated about 12 months later. This means you could have up to 8 visits in total, though two of these (the lumbar punctures) are optional.
Potential risks and benefits
Locations (1)
- University Of ExeterVerified postcodeExeter, United Kingdom· Recruiting
Common questions
What is a 'biomarker'?
A biomarker is like a measurable sign in your body, like a score from a blood test or a change seen on a scan, that helps doctors understand more about a disease.
Will I receive treatment for my Parkinson's in this study?
No, this study is about research and understanding Parkinson's better, not about providing treatment. You will continue to receive your usual medical care.
Do the scans use a lot of radiation?
The PET and SPECT scans use tiny, safe amounts of radiation, similar to what you might experience from natural sources over a year.
What is a lumbar puncture?
A lumbar puncture is a procedure where a small needle is used to collect a sample of fluid from around your spine, which can give doctors clues about what's happening in your brain.
How long will I be involved in the study?
Your involvement will be over a period of about 12 months, with multiple visits during that time and then again 12 months later.
How to find out more
Marios Politis, Professor
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
Discussion
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