Low Anterior Resection Syndrome research hub
19 indexed studies · 14 currently recruiting
- active not recruitingNA
Transanal Irrigation for the Management of LARS
This study looks at how a special bowel management method called Transanal Irrigation (TAI) can help people who have had rectal cancer surgery and are experiencing bowel problems. It aims to see if TAI, taught online with nurse support, improves their quality of life.
Canada - not yet recruitingNA
Clinical and BIOgical Analyses of RECtal Tumors
This study looks at samples from people treated for rectal cancer to better understand the disease. We want to find ways to predict who will respond best to different treatments, especially those that might help avoid surgery, and develop new ways to fight the cancer effectively.
France - recruiting
Advanced Pelvic Surgical Oncology Database - Prospective Observational Study
This study looks at people in Glasgow having complex surgery for cancers in the tummy and pelvis, like bowel or gynaecological cancers. We're observing their recovery and health over time to understand common problems and improve future care.
United Kingdom - recruiting
Interest of PET-MRI in the Evaluation of the Response After Neoadjuvant Treatment of Locally Advanced Rectal Adenocarcinoma
This study looks at using a special scan called PET-MRI for people with advanced rectal cancer. We want to see if these scans can predict how well treatments work early on, helping doctors make better decisions about care.
France - not yet recruitingPHASE2
Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent Tumors
This study looks at using heat treatment (hyperthermia) with repeat radiation therapy for certain cancers that have come back after earlier radiation. It checks if this combined approach works as well as the first treatment for preventing the cancer from returning locally.
Germany - recruitingNA
Prospective Monocentric Study Evaluating the Circulating NK Cells Phenotype and the ImmunoScore® in Patients With Non Metastatic Rectal Cancer
This study looks at new ways to treat non-spreading bowel cancer by using blood tests and special scores. It aims to see if we can better predict who will respond well to treatment and potentially avoid major surgery, improving life quality.
France - authorisedTherapeutic use (Phase IV)
Next Generation StaR TREC - Save the rectum by watchful waiting after (chemo)Radiotherapy or Total mesorectal excision for early REctal Cancer?
This study is for people with early rectal cancer. It's looking at whether some patients can avoid a major operation by having chemotherapy and then being closely watched, instead of surgery. It aims to see how many patients respond well to this 'watch and wait' approach.
Sweden - completedPhase II
Improving diagnosis and treatment for patients with rectal cancer
This study is looking at new ways to diagnose and treat bowel cancer in the back passage (rectal cancer). We're testing if special MRI scans can give doctors better information about the cancer, which could help guide your treatment and improve care for future patients.
United Kingdom · England - recruitingNA
Pre-therapeutic MRI Assessment of Early-Stage Rectal Cancer and Significant Rectal Polyps to Avoid Major Resectional Surgery
This study aims to improve how MRI scans identify early bowel cancer. By training doctors to spot these cancers better, more patients could have a simpler local procedure, avoiding major surgery and helping them keep their bowel.
United Kingdom - recruitingPHASE3
Preoperative FOLFOX Versus Postoperative Risk-adapted Chemotherapy in Patients With Locally Advanced Rectal Cancer
This study compares different ways to treat advanced rectal cancer. It looks at giving chemotherapy before surgery versus after, to see which approach works best for certain patients, aiming to reduce the cancer coming back in other parts of the body.
Germany - recruitingNA
Hyperthermia With Chemoradiotherapy in Rectal Cancer
This study looks at adding heat treatment (hyperthermia) to standard therapy for advanced bowel cancer (rectal cancer). It aims to see if this helps more people avoid surgery and improve recovery.
Germany - recruitingPHASE3
Interest of Early Erectile Rehabilitation With Sildenafil After Radiotherapy and Proctectomy for Rectal Cancer
This study looks at whether an early treatment with Sildenafil (Viagra) can help men avoid long-term erection problems after having surgery and radiotherapy for bowel cancer. It compares Sildenafil to a dummy pill (placebo).
France - not yet recruiting
Robotic vs. TaTME Rectal Surgery (ROTA STUDY)
This study compares two advanced surgical methods for rectal cancer (keyhole and robotic surgery) in patients with cancer in the lower bowel. It aims to see which is better in terms of recovery and long-term results, using experienced surgeons.
Denmark · United Kingdom - not yet recruiting
Use of a Novel Camera to Check the Bowel After Polyp or Tumour Removal
This study is testing a new, smaller camera called a 'rectoscope' to check the lower bowel after polyps or small cancers have been removed. It aims to make these important checks easier and quicker, using a simple enema instead of strong bowel preparation, to help reduce waiting lists.
United Kingdom - authorisedTherapeutic exploratory (Phase II)
Colonic Intramural Injections of Botulin toxin versus placebo to treat fragmented defecation and urgency after restorative total mesorectal excision (TME) for rectal cancer
This study is looking at whether a special injection, similar to Botox, can help people who have problems with their bowel movements after surgery for rectal cancer. It compares the injection to a dummy treatment to see if it makes a difference.
Belgium - recruitingNA
Magnetic Resonance Tumour Regression Grade (mrTRG) as a Novel Biomarker - Phase III Non CTIMP Trial
This study looks at a new way to check how well rectal cancer treatment works using special MRI scans. It aims to see if some patients can avoid surgery and instead be carefully watched, improving their quality of life.
United Kingdom - authorisedTherapeutic use (Phase IV)
Systemic Neoadjuvant and adjuvant Control by Precision medicine in rectal cancer (SYNCOPE) – approach on high-risk group to reduce metastases
This study, called SYNCOPE, looks at new ways to treat advanced bowel cancer (rectal cancer) to stop it from coming back. It uses special medicine combinations for people at high risk to improve their chances of staying cancer-free.
Finland - recruiting
Circulating Tumour DNA (ctDNA) in Patients With Colorectal Cancer and the Relationship to Imaging Features of Extramural Venous Invasion
This study looks at a new way to understand bowel cancer spread. We're taking blood samples from patients having surgery for bowel cancer to see if blood changes can tell us more about how the cancer might spread through blood vessels. This could help improve how we treat bowel cancer in the future.
United Kingdom - recruiting
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
The MOMENTUM Study is tracking how a new type of advanced radiotherapy, called MR-Linac, works for people with different cancers. It aims to see if this treatment improves survival, controls cancer better, and enhances quality of life by using highly precise radiation guidance.
United States · Australia · Belgium