Pre-therapeutic MRI Assessment of Early-Stage Rectal Cancer and Significant Rectal Polyps to Avoid Major Resectional Surgery
This project is about improving how doctors read MRI scans for early-stage bowel cancer or polyps. When doctors can accurately see how far a cancer has grown into the bowel wall, it helps them decide the best treatment. Currently, many early cancers are missed, leading to unnecessary major surgery. We've developed a new, more accurate way for radiologists to read these scans. Our goal is to teach this method to radiologists in 20 hospitals. We'll then check if this training leads to more accurate scan reports and, importantly, helps more patients choose a simpler local procedure that preserves their bowel and avoids the risks of major operations. If successful, we hope to roll this out across the NHS.
At a glance
What is this study about?
When someone is diagnosed with a lump (polyp) or cancer in their bowel, doctors use MRI scans to understand how deeply it has grown. This is really important because it helps them decide the best way to treat it. If a cancer is very early and has only grown a little way into the bowel wall, it can often be removed with a much simpler local procedure. This type of surgery only takes out the lump and leaves most of the bowel untouched, helping patients recover faster and avoid the bigger risks and lifestyle changes associated with major surgery.
However, it's quite common for scans to not clearly show these early cancers. This means some patients end up having bigger operations or treatments like radiotherapy that they might not actually need. Our team has created a new, more precise way for the doctors who read MRI scans (called radiologists) to spot these early cancers. We've found that this new method is much better at identifying early bowel cancers – it can find about 9 out of 10, compared to only 3 out of 10 with current methods. We've also proven that we can teach other radiologists this new skill.
In this first step, we're going to train radiologists in 20 different hospitals across the UK. We'll then look at their scan reports before and after the training to see if the new method leads to better, more accurate information for patients. Most importantly, we want to see if more patients are then offered and choose these simpler, local procedures. The information we gather will be key to helping us get funding to make this training available to all NHS hospitals, helping many more patients get the right treatment from the start.
Key takeaways
- The study aims to improve how doctors spot early bowel cancer on MRI scans.
- Better scan reading could mean more patients avoid major surgery.
- A new training method helps radiologists identify early cancers more accurately.
- The goal is to increase the use of simpler, local bowel-preserving procedures.
- Your care won't change, but your scan data might help improve care for others.
Who may be eligible?
To be considered for this study, you would generally need to be at least 16 years old. You must have either a known growth or suspected growth in your bowel that looks like it could be an early cancer on an MRI scan, or is confirmed as an early cancer after it's been removed.
There are some reasons why you might not be able to join. For example, if the cancer has already spread to other parts of your body, or if you have a type of bowel cancer that isn't adenocarcinoma (which is the most common type). Also, if you can't have an MRI scan for any medical reason, you wouldn't be able to take part.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you 16 years old or older?
- Do you have a growth or suspected growth in your bowel?
- Is it thought to be an early-stage cancer or polyp?
- Can you have an MRI scan?
- Has the cancer not spread to other parts of your body?
What does participation involve?
This study is focused on training doctors and improving MRI reports; it doesn't involve you directly doing anything different to your usual care. You would receive your standard MRI scans and appointments. The doctors reading your scans would be part of the training program. There are no extra visits, assessments, or medications required from you as a patient. The study primarily involves comparing the accuracy of MRI reports before and after the radiologists receive the special training, and looking at treatment choices made based on those reports. Your participation is about your medical information being part of this review.
Potential risks and benefits
Locations (23)
- Royal Berkshire HospitalVerified postcodeReading, United Kingdom· Not yet recruiting
- Buckinghamshire Healthcare Nhs TrustVerified postcodeAmersham, United Kingdom· Recruiting
- University College London Hospitals Nhs Foundation TrustVerified postcodeLondon, United Kingdom· Not yet recruiting
- King'S College Hospital Nhs Foundation TrustVerified postcodeLondon, United Kingdom· Not yet recruiting
- West Middlesex HospitalVerified postcodeLondon, United Kingdom· Not yet recruiting
- Imperial College Healthcare Nhs TrusVerified postcodeLondon, United Kingdom· Not yet recruiting
- The Hillingdon Hospitals Nhs Foundation TrustVerified postcodeUxbridge, United Kingdom· Not yet recruiting
- Hampshire Hospitals Nhs Foundation TrustVerified postcodeBasingstoke, United Kingdom· Not yet recruiting
- Southampton General HospitalVerified postcodeSouthampton, United Kingdom· Not yet recruiting
- Kent & Canterbury HospitalVerified postcodeCanterbury, United Kingdom· Not yet recruiting
- Maidstone HospitalVerified postcodeMaidstone, United Kingdom· Not yet recruiting
- Westmorland General HospitalVerified postcodeKendal, United Kingdom· Not yet recruiting
Common questions
What is 'early-stage rectal cancer'?
This means the cancer has only grown a small way into the wall of your bowel, making it easier to treat with a less invasive procedure.
What is an 'MRI scan'?
It's a type of scan that uses strong magnets and radio waves to create detailed pictures of the inside of your body, helping doctors see where a cancer is located.
What is 'local excision'?
This is a smaller operation where only the cancer or polyp is removed, leaving most of your bowel intact. It's often preferred for early-stage cancers.
Will I have to do anything extra if I take part?
No, this study is about training doctors and reviewing existing information. You would continue with your usual medical care and appointments.
What is a 'radiologist'?
A radiologist is a doctor who specialises in reading X-rays, MRI scans, and other medical images to help diagnose illnesses.
How to find out more
Caroline Martin
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
Discussion
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