- recruitingPhase III
Oral versus intramuscular glucocorticoids in rheumatoid arthritis
The LEADER trial looks at the best way to give short-term steroid treatment to people with rheumatoid arthritis. It compares steroid tablets against a single injection into the muscle, testing both higher and lower doses to find out which option provides the best relief with the fewest side effects.
United Kingdom - recruitingPhase IV
The 3TR-PARTNER-RA study: Are RNA signatures (biomarkers) in the tissue which surrounds the joints (synovial tissue) from patients with early Rheumatoid Arthritis (symptoms <12 months) predictive of response to biologic drug treatments?
This UK clinical study investigates whether testing a tiny sample of joint tissue can help doctors choose the most effective treatment for early rheumatoid arthritis. Researchers want to see if specific biological markers can predict whether a modern medicine called abatacept works well for newly diagnosed patients.
United Kingdom · England · Belgium - authorisedTherapeutic use (Phase IV)
Optimising Arthritis Strategies in Elderly patients (≥70 years) with rheumatoid arthritis in sustained low disease activity (the OASE study): A Prospective Target Trial Emulation Study Evaluating Tapering of Disease-Modifying Anti-Rheumatic Drugs vs. Usual Care Based on Patient Preference
This study looks at adults aged 70 and over with well-controlled rheumatoid arthritis. It tests whether slowly lowering their arthritis medication is safe compared to staying on their usual dose. The goal is to find out if reducing medication can lower side effects while keeping arthritis symptoms under control.
Denmark - authorisedTherapeutic use (Phase IV)
Tapering optimisation with placebo-based mechanisms in rheumatoid arthritis: the TOP-RA trial
This study explores whether psychological techniques, such as positive expectation training and sensory cues like scents, can help adults with rheumatoid arthritis safely reduce their biologic injections. Researchers want to see if these tools help people lower their medication doses without their joint pain and swelling returning over nine months.
Netherlands - recruitingHuman Pharmacology (Phase I)- Other
RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTIPLE ASCENDING DOSE STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF IA-14069 IN HEALTHY SUBJECTS, WITH AN EXTENSION TO EXPLORE ANY DRUG-DRUG INTERACTION POTENTIAL WITH METHOTREXATE (PART 1), AND IN PATIENTS WITH RHEUMATOID ARTHRITIS, WITH PRELIMINARY ASSESSMENT OF EFFICACY IN PATIENTS (PART 2)
This study is testing a new medicine, IA-14069, for rheumatoid arthritis. It first checks if the medicine is safe and how it works in healthy people, then looks at its effects in people with rheumatoid arthritis.
Romania - recruitingTherapeutic confirmatory (Phase III)
A Multicenter, Open-label, Long Term Extension Study to Assess the Safety and Efficacy of Filgotinib in Subjects with Rheumatoid Arthritis
This study is looking at the long-term safety and effectiveness of a medicine called Jyseleca for people with rheumatoid arthritis. Participants will take Jyseleca tablets, and doctors will monitor their health carefully over time.
Bulgaria · Hungary · Germany - recruitingTherapeutic confirmatory (Phase III)
A Prospective, Randomized, Double-blind, Parallel-group Study to Compare the Efficacy, Safety, Pharmacokinetics, and Immunogenicity of MB04 and EU-sourced Enbrel® in Patients with Moderate to Severe Rheumatoid Arthritis.
This study is comparing a new medication called MB04 with a standard medicine, Enbrel, for people with moderate to severe rheumatoid arthritis. We want to see if MB04 works just as well and is as safe as Enbrel. This will help us understand if it's a good treatment option.
Poland · Hungary · Bulgaria - recruitingTherapeutic confirmatory (Phase III)
A MULTICENTER, PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF SPIRONOLACTONE FOR THE TREATMENT OF ACTIVE RHEUMATOID ARTHRITIS (RA) - ALDORA
This study, called ALDORA, is looking at whether a common medicine called spironolactone could help people with rheumatoid arthritis (RA). It’s comparing spironolactone to a dummy pill to see if it reduces RA symptoms and improves heart health without causing too many side effects.
Germany · France - recruitingTherapeutic exploratory (Phase II)
A randomized, double blind, placebo-controlled, dose response, phase II, multicentre trial to evaluate the efficacy and safety of oral AP1189 administered at the doses of 40, 70, or 100 mg for 12 weeks in combination with methotrexate, in DMARD-naïve participants with early rheumatoid arthritis and active inflammation.
This study is testing a new tablet, AP1189, for people recently diagnosed with rheumatoid arthritis who haven't tried other strong medicines yet. It aims to see how well different doses of AP1189 lower inflammation and improve symptoms when taken with another common arthritis medicine.
Bulgaria · Czechia · Poland - recruitingHuman Pharmacology (Phase I)- Other
A clinical study of MK-2420 in healthy men (MK-2420-003)
This study is looking into a new potential medicine, called MK-2420. It's being tested in healthy adult men to see how it works in the body and if it's safe. The goal is to find better ways to treat conditions like rheumatoid arthritis in the future.
Belgium - recruitingTherapeutic confirmatory (Phase III)
A Randomized, Placebo-Controlled, Double-Blind, Parallel Group, Phase 3 Study to Evaluate the Efficacy and Safety of Subcutaneous CT-P13 in Patients with Moderately to Severely Active Rheumatoid Arthritis
This study is looking at a new medicine called CT-P13 for adults with moderate to severe rheumatoid arthritis. Researchers want to see if it helps reduce symptoms and is safe to use. Some people will get the new medicine, and others will get a dummy medicine to compare.
Poland - recruitingHuman Pharmacology (Phase I)- Other
A clinical study of MK-2420 in healthy people (MK-2420-002)
This study is testing a new medicine, MK-2420, in healthy adults. It's an early-stage study to understand how the medicine works in the body and if it's safe. While the medicine might eventually help people with rheumatoid arthritis, this study is about testing its basic effects.
Belgium - active not recruitingPHASE3
A Study to Compare the Response to Treatment With Abatacept vs Adalimumab, on Background Methotrexate, in Adults With Early, Seropositive, and Shared Epitope-positive Rheumatoid Arthritis and an Inadequate Response to Methotrexate
This study compares two treatments, abatacept and adalimumab, for adults with early, severe rheumatoid arthritis who haven't responded well to methotrexate. It aims to see which treatment is better at reducing arthritis symptoms and improving quality of life.
United States · Argentina · Australia - completedPhase II
A single-site study to understand the best route of delivery for a new cell-based treatment created from patient's own white blood cells for rheumatoid arthritis
Researchers in Newcastle are testing a personalised treatment for rheumatoid arthritis made from a patient's own white blood cells. This early-stage study aims to find the best way to give the treatment: injected into a knee joint, into the skin of the thigh, or directly into an immune gland.
United Kingdom · England - completed
Study of patients with early rheumatoid arthritis: The TACERA (Towards a Cure for Early Rheumatoid Arthritis) Study
The TACERA study looks at adults newly diagnosed with rheumatoid arthritis. Researchers want to understand how standard NHS treatments work for different people. By studying blood and urine samples over 18 months, the team hopes to develop tests that help doctors choose the best medication for each individual patient in the future.
United Kingdom · England · Scotland - completedNot Applicable
Stratification of biologic therapies for rheumatoid arthritis by pathobiology
This study looks at adults with rheumatoid arthritis whose standard medicines have not worked well. Researchers take a small sample of joint tissue to see if they can match each person to the biologic medicine that suits them best, rather than relying on trial and error to find relief.
United Kingdom · England · Scotland - recruitingPhase IV
Are RNA signatures (biomarkers) in the tissue which surrounds the joints (synovial tissue) from patients with rheumatoid arthritis predictive of response to drug treatments?
This UK clinical study tests whether examining a small sample of joint tissue can help doctors pick the best medicine for rheumatoid arthritis. Adults with active arthritis will have a minor joint biopsy and receive one of two standard biologic medicines to see if tissue tests improve treatment success.
United Kingdom · England · Belgium - recruitingTherapeutic use (Phase IV)
I4V-MC-JAJA (RA-BRIDGE): A Randomized, Active-Controlled, Parallel-Group, Phase 3b/4 Study of Baricitinib in Patients with Rheumatoid Arthritis
This study looks at how safe and effective a medicine called baricitinib is for people with rheumatoid arthritis, compared to other common treatments. It will see how long it takes for a blood clot to happen. This is a long-term study that will last over five years.
Hungary · Slovakia · Lithuania - recruitingTherapeutic confirmatory (Phase III)
A randomised, double-blind, multicentre study comparing the efficacy, safety and immunogenicity of proposed Abatacept biosimilar (DRL_AB) with Orencia® administered by the intravenous route as an add-on to methotrexate in the treatment of patients with moderate to severe rheumatoid arthritis
This study is comparing a new version of a rheumatoid arthritis medicine, called DRL_AB, with an existing one, Orencia. It aims to see if the new medicine works as well, is safe, and causes a similar immune response in people with moderate to severe rheumatoid arthritis.
Czechia · Hungary · Poland - recruitingHuman Pharmacology (Phase I)- First administration to humans
A placebo-controlled safety and tolerability study of intravenous (IV) and subcutaneous (SC) AZD1163 in healthy volunteers
This early-stage study is looking at a new medicine called AZD1163 for rheumatoid arthritis. Researchers want to see if it's safe and how well healthy people tolerate it when given through a vein or under the skin. It’s the first time this medicine is being tested in humans.
Germany - recruitingTherapeutic exploratory (Phase II)
J1A-MC-KDAF: A Phase 2b, Double-Blind, Placebo-Controlled Study to Evaluate Peresolimab in Adult Participants with Moderately-to-Severely Active Rheumatoid Arthritis
This study is testing a new medicine, peresolimab, for adults with moderate to severe rheumatoid arthritis. It aims to see if the medicine can reduce arthritis symptoms, like joint pain and swelling, better than a dummy treatment.
Hungary · Spain · Italy - recruitingTherapeutic exploratory (Phase II)
J3P-MC-FTAF: An Adaptive Phase 2a/2b, Randomized, Double-Blind, Placebo-Controlled Study of LY3871801 in Adult Participants With Moderately-to-Severely Active Rheumatoid Arthritis
This study is testing a new medicine, LY3871801, for adults with rheumatoid arthritis. It's a research study to see how well the medicine works and if it's safe compared to a dummy pill. We hope to find new ways to help people with this condition.
France · Czechia · Slovakia - recruitingPhase II and Phase III (Integrated)
Thiamine against chronic rheumatoid arthritis fatigue
This study looks at whether a high dose of vitamin B1 (thiamine) can help reduce tiredness in people with rheumatoid arthritis. We want to see if fatigue levels change after four weeks of treatment.
Denmark - recruitingTherapeutic exploratory (Phase II)
A Phase 2a Multicenter, Randomized, Double Blind, Parallel-group, Proof of Concept Study Evaluating the Efficacy and Safety of Nipocalimab and Certolizumab Combination Therapy in Subjects with Active Rheumatoid Arthritis despite Prior Treatment with Advanced Therapies (bDMARD or tsDMARD)
This study is looking at a new combination of two medicines, nipocalimab and certolizumab (Cimzia), for adults with rheumatoid arthritis that hasn't improved with other strong treatments. We want to see if this combination helps reduce symptoms and is safe after 12 weeks.
Germany · Poland · Hungary - recruitingTherapeutic use (Phase IV)
RCT part: CareRA2020: Effectiveness of a combination of Methotrexate and a step down glucocorticoid regimen (COBRA-Slim) for remission induction in patients with early Rheumatoid Arthritis (RA), with or without fast access to 24 weeks of Tumor Necrosis Factor (TNF) blockade in insufficient responders, a randomized, multicenter, pragmatic trial. LTE part: CareRA2020 LTE: a 3 year longitudinal observational, multicenter, follow-up of early RA patients after participation in the CareRA2020 RCT.
This study looks at how well a treatment for early rheumatoid arthritis (RA) works over a long time. It compares a standard approach with one that offers quicker access to a stronger medicine for those who aren't improving enough.
Belgium - recruitingHuman Pharmacology (Phase I)- Other
A Phase 1b Study of Imvotamab in Moderate to Severe Rheumatoid Arthritis
This study is looking into a new treatment called Imvotamab for people with moderate to severe rheumatoid arthritis. It's an early-stage study to understand how safe the treatment is and if it has any effects on the body.
Poland - recruitingTherapeutic exploratory (Phase II)
A Phase 2a multi-center, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of Burfiralimab (hzVSF-v13) added to disease-modifying antirheumatic drugs in patient with moderate to severe Rheumatoid Arthritis
This study is testing a new medicine, Burfiralimab, for people with moderate to severe rheumatoid arthritis. We want to see if it helps reduce joint pain and swelling when added to their usual arthritis medicines. Participants will receive either the new medicine or a dummy treatment.
Spain · Austria · Czechia - recruitingHuman Pharmacology (Phase I)- First administration to humans
MK-2420 SAD Study
This early-stage study is looking at a new medicine called MK-2420 for rheumatoid arthritis. It's the first time this medicine is being given to people, to check how safe it is and how the body handles it. Only adult men can take part.
Belgium - recruitingPhase II
Repair effects of leramistat in participants with rheumatoid arthritis
This study is looking at a new medicine called leramistat for people with rheumatoid arthritis. It wants to see what effects leramistat has on muscles. It's an early-stage study, meaning we're still learning if the medicine works and is safe.
United Kingdom · England - recruitingTherapeutic exploratory (Phase II)
A Phase 2 Randomized, Double-blind, Placebo-controlled, Dose-ranging, Efficacy and Safety study of SAR441566 plus Methotrexate in Adults with Moderate to Severe Rheumatoid Arthritis
This study is testing a new medicine, SAR441566, for people with moderate to severe rheumatoid arthritis who are already taking methotrexate. It aims to see if the new medicine helps reduce arthritis symptoms and if it's safe to use. Patients will either get the new medicine or a dummy medicine.
Slovakia · Czechia · Germany - recruitingPHASE1
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
This study looks at a new treatment called AZD5492 for lupus, myositis, and rheumatoid arthritis. It checks how safe it is, how well the body handles it, and how it works in adults.
United States · Canada · China - recruitingPHASE2
A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)
This study is looking into a new medication called Afimkibart for adults with moderate to severe rheumatoid arthritis. It's for those who haven't found enough relief from or can't take other common treatments. The aim is to see how well it works and if it's safe.
United States · Argentina · Belgium - active not recruitingPHASE3
A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate and Who Have an Inadequate Response to Methotrexate
This study compares a new medicine, upadacitinib, with a sugar pill (placebo) and an existing medicine, adalimumab, for adults with rheumatoid arthritis. It looks at how well these treatments work and if they are safe when methotrexate isn't enough on its own.
United States · Argentina · Australia - authorisedTherapeutic use (Phase IV)
Non-inferiority study of TOCILIZUMAB in dose-banding versus dose-weight in rheumatoid arthritis with low activity or clinical remission
This study looks at a different way to give RoActemra (tocilizumab) for rheumatoid arthritis. We want to see if giving a standard dose based on how well you're doing, rather than your weight, works just as well for patients with low disease activity or who are in remission.
France - authorisedHuman Pharmacology (Phase I)- Other
Phase 1b study to assess the safety and tolerability of SR-878 in patients with rheumatoid arthritis
This study is testing a new medicine, SR-878, for people with rheumatoid arthritis. It's a very early study to check if the medicine is safe and if people can tolerate it well. Researchers want to see how the body reacts to this new treatment.
Romania - active not recruitingPHASE1, PHASE2
Comparison of B-cell Depletion by Rituximab and Anti-CD 19 CAR-T Therapy in Patients With Rheumatoid Arthritis
This study compares a new cell therapy (KYV101) with an existing medicine (Rituximab) for severe rheumatoid arthritis that hasn't responded to other treatments. It checks how safe and effective they are at reducing disease activity and certain antibodies.
Germany - active not recruiting
A Study to Evaluate the Safety of Remsima® SC in the Treatment of RA, AS, PsA and Ps
This study looks at how safe a medicine called Remsima® SC is for people with certain long-term conditions like rheumatoid arthritis, a type of spinal arthritis, psoriatic arthritis, and psoriasis. It aims to see if there are any unwelcome side effects.
France - not yet recruiting
Ultrasonic COmparison of Salivary Glands in Autoimmune Diseases (COUGAR)
This study looks at how ultrasound scans of spit glands can help understand conditions like Sjögren's, lupus, and rheumatoid arthritis. Researchers want to see if these scans can tell the difference between these diseases and how they affect people with dry mouth.
France - recruitingPHASE1
An Ascending Dose Study of PIT565 in Participants With Rheumatoid Arthritis
This study is testing a new medicine, PIT565, for people with rheumatoid arthritis. We want to see if it's safe, how well the body handles it, and if it could help. It's an early stage study, focusing on finding the right dose.
Argentina · Bulgaria · China - active not recruitingNA
Cemented TrendHip® - Multicenter PMCF Study on Total Indications
This study is checking how well a specific type of hip replacement part, called the TrendHip® stem, works and if it's safe. It's for people who've had or are having a hip replacement using this part, to see how they're doing over time.
Germany - active not recruitingPHASE4
Effect of Proactive Therapeutic Drug Monitoring on Maintenance of Sustained Disease Control in Adults With Rheumatoid Arthritis on a Subcutaneous TNF Inhibitor: The Rheumatoid Arthritis Therapeutic DRUg Monitoring Trial (RA-DRUM)
This study looks at how best to manage rheumatoid arthritis for people taking a common treatment called adalimumab. Researchers will check drug levels in the blood to see if this helps keep the condition under control better than usual care and prevents flare-ups.
Austria · Italy · Norway - active not recruiting
Deciphering Rheumatoid Arthritis-associated Interstitial Lung Disease Pathogenesis 2
This study looks into why some people with rheumatoid arthritis (RA) also get a lung condition called interstitial lung disease (ILD). Researchers want to understand the causes and how ILD progresses in RA patients to improve care.
France - recruiting
Characterisation of Intestinal Microbiota of Patients With Spondyloarthritis or Rheumatoid Arthritis
This study looks at the gut bacteria in people with spondyloarthritis or rheumatoid arthritis to see if it's different from healthy people. Researchers want to understand if specific gut bacteria are linked to these conditions and could help find new ways to detect or treat them.
France - active not recruiting
Comprehensive Nano - Post Market Clinical Follow-Up Study
This study looks at how well a shoulder replacement system, called Comprehensive Nano, works for people with shoulder pain from conditions like arthritis. Doctors will check on patients who have had this surgery to see how they recover and how the new shoulder helps them.
Austria · Canada · South Korea - not yet recruitingPHASE4
Tdose Binding and Tocilizumab
This study looks at different ways to give a medicine called tocilizumab for rheumatoid arthritis. We want to see if a standard dose works as well as a dose based on a person's weight, for patients whose arthritis is already well-controlled.
France - active not recruitingNA
The Medacta International GMK Sphere Post-Marketing Surveillance Study
This study is checking how well a new knee replacement, called the GMK Sphere, works for people with arthritis. Doctors will follow patients after their surgery to see how they recover and if the new knee joint helps them get back to their daily lives.
Belgium · United Kingdom - active not recruiting
The CCP Study: Coordinated Programme to Prevent Arthritis - Can We Identify Arthritis at a Pre-clinical Stage ?
This study looks for early signs of arthritis, especially rheumatoid arthritis, before people even have noticeable symptoms. By closely watching people who might be at risk, researchers hope to learn how to identify the condition earlier and potentially treat it sooner.
United Kingdom - active not recruiting
Prospective Observational Study of Filgotinib in Subjects With Rheumatoid Arthritis
This study looks at how a medicine called filgotinib works for people with rheumatoid arthritis in everyday life. Researchers want to see if it makes a difference to symptoms, side effects, and how patients feel, simply by observing those already taking the medication.
Belgium · Germany · Italy - recruiting
Evaluation of the PHENO4U Data Platform in Patients Undergoing Total Knee Arthroplasty
This study looks at how a new digital platform, Pheno4U, helps patients who have had total knee replacement surgery. It collects information about their recovery and how well their knee works.
Germany · United Kingdom - authorisedTherapeutic exploratory (Phase II)
A Multicentre, Parallel-group, Phase II, Randomised, Double-blind, 4 Arm Study to Evaluate Efficacy and Safety of AZD1163 in Participants with Moderately-to-Severely Active Rheumatoid Arthritis (LaunchPAD-RA)
This study is testing a new medicine, AZD1163, for people with moderate to severe rheumatoid arthritis. We want to see if it helps reduce joint pain and swelling, and if it's safe to use. Half the participants will receive the new medicine and half will receive a dummy medicine.
Hungary · Spain · Bulgaria