- not yet recruiting
Ultrasonic COmparison of Salivary Glands in Autoimmune Diseases (COUGAR)
This study looks at how ultrasound scans of spit glands can help understand conditions like Sjögren's, lupus, and rheumatoid arthritis. Researchers want to see if these scans can tell the difference between these diseases and how they affect people with dry mouth.
France - recruitingPHASE1
An Ascending Dose Study of PIT565 in Participants With Rheumatoid Arthritis
This study is testing a new medicine, PIT565, for people with rheumatoid arthritis. We want to see if it's safe, how well the body handles it, and if it could help. It's an early stage study, focusing on finding the right dose.
Argentina · Bulgaria · China - active not recruitingNA
Cemented TrendHip® - Multicenter PMCF Study on Total Indications
This study is checking how well a specific type of hip replacement part, called the TrendHip® stem, works and if it's safe. It's for people who've had or are having a hip replacement using this part, to see how they're doing over time.
Germany - active not recruitingPHASE4
Effect of Proactive Therapeutic Drug Monitoring on Maintenance of Sustained Disease Control in Adults With Rheumatoid Arthritis on a Subcutaneous TNF Inhibitor: The Rheumatoid Arthritis Therapeutic DRUg Monitoring Trial (RA-DRUM)
This study looks at how best to manage rheumatoid arthritis for people taking a common treatment called adalimumab. Researchers will check drug levels in the blood to see if this helps keep the condition under control better than usual care and prevents flare-ups.
Austria · Italy · Norway - active not recruiting
Deciphering Rheumatoid Arthritis-associated Interstitial Lung Disease Pathogenesis 2
This study looks into why some people with rheumatoid arthritis (RA) also get a lung condition called interstitial lung disease (ILD). Researchers want to understand the causes and how ILD progresses in RA patients to improve care.
France - recruiting
Characterisation of Intestinal Microbiota of Patients With Spondyloarthritis or Rheumatoid Arthritis
This study looks at the gut bacteria in people with spondyloarthritis or rheumatoid arthritis to see if it's different from healthy people. Researchers want to understand if specific gut bacteria are linked to these conditions and could help find new ways to detect or treat them.
France - active not recruiting
Comprehensive Nano - Post Market Clinical Follow-Up Study
This study looks at how well a shoulder replacement system, called Comprehensive Nano, works for people with shoulder pain from conditions like arthritis. Doctors will check on patients who have had this surgery to see how they recover and how the new shoulder helps them.
Austria · Canada · South Korea - not yet recruitingPHASE4
Tdose Binding and Tocilizumab
This study looks at different ways to give a medicine called tocilizumab for rheumatoid arthritis. We want to see if a standard dose works as well as a dose based on a person's weight, for patients whose arthritis is already well-controlled.
France - active not recruitingNA
The Medacta International GMK Sphere Post-Marketing Surveillance Study
This study is checking how well a new knee replacement, called the GMK Sphere, works for people with arthritis. Doctors will follow patients after their surgery to see how they recover and if the new knee joint helps them get back to their daily lives.
Belgium · United Kingdom - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Placebo-Controlled, Double-Blind, Parallel Group, Phase 3 Study to Evaluate the Efficacy and Safety of Subcutaneous CT-P13 in Patients with Moderately to Severely Active Rheumatoid Arthritis
This study is looking at a new medicine called CT-P13 for adults with moderate to severe rheumatoid arthritis. Researchers want to see if it helps reduce symptoms and is safe to use. Some people will get the new medicine, and others will get a dummy medicine to compare.
Poland - recruitingPHASE2
A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)
This study is looking into a new medication called Afimkibart for adults with moderate to severe rheumatoid arthritis. It's for those who haven't found enough relief from or can't take other common treatments. The aim is to see how well it works and if it's safe.
United States · Argentina · Belgium - active not recruiting
The CCP Study: Coordinated Programme to Prevent Arthritis - Can We Identify Arthritis at a Pre-clinical Stage ?
This study looks for early signs of arthritis, especially rheumatoid arthritis, before people even have noticeable symptoms. By closely watching people who might be at risk, researchers hope to learn how to identify the condition earlier and potentially treat it sooner.
United Kingdom - recruiting
Evaluation of the PHENO4U Data Platform in Patients Undergoing Total Knee Arthroplasty
This study looks at how a new digital platform, Pheno4U, helps patients who have had total knee replacement surgery. It collects information about their recovery and how well their knee works.
Germany · United Kingdom - active not recruiting
Prospective Observational Study of Filgotinib in Subjects With Rheumatoid Arthritis
This study looks at how a medicine called filgotinib works for people with rheumatoid arthritis in everyday life. Researchers want to see if it makes a difference to symptoms, side effects, and how patients feel, simply by observing those already taking the medication.
Belgium · Germany · Italy - authorisedTherapeutic exploratory (Phase II)
A Multicentre, Parallel-group, Phase II, Randomised, Double-blind, 4 Arm Study to Evaluate Efficacy and Safety of AZD1163 in Participants with Moderately-to-Severely Active Rheumatoid Arthritis (LaunchPAD-RA)
This study is testing a new medicine, AZD1163, for people with moderate to severe rheumatoid arthritis. We want to see if it helps reduce joint pain and swelling, and if it's safe to use. Half the participants will receive the new medicine and half will receive a dummy medicine.
Hungary · Spain · Bulgaria - recruitingNA
The Role of Cytokines and Regulatory T Lymphocytes in Migraine Pathophysiology.
This study looks into why some people get migraines, especially those with other health conditions like autoimmune diseases. Researchers are examining how chemicals in the body, called cytokines, and special immune cells, called Treg cells, might be linked to migraine pain. They hope to better understand migraine causes.
France - recruitingNA
Safety of Splenic Stimulation for RA
This study looks at a new device for people with rheumatoid arthritis (RA) who haven't found relief with other treatments. It will see if stimulating a nerve near the spleen is safe and helps reduce RA symptoms. Five people will have the device implanted for 12 weeks.
Netherlands · United Kingdom - active not recruiting
Real World Use of Tocilizumab Biosimilar studY
This study looks at how a new medicine called Tyenne, used for rheumatoid arthritis (RA), works for people in their everyday lives. It checks how long patients continue using the treatment over 12 months.
Germany - recruiting
Biobank for Inflammatory Chronic Diseases and Osteoporosis
This study aims to create a collection of blood samples from people with certain types of arthritis (rheumatoid, psoriatic, spondyloarthritis) or osteoporosis. Researchers hope to find markers in the blood that can help doctors choose the best treatments for these conditions.
France - recruitingPHASE1
Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants
This study is testing a new medicine, surovatamig, for rheumatoid arthritis (RA) and lupus (SLE). We want to see if it's safe, how it works in the body, and what dose is best. It's an early-stage study in adults.
United States · Australia · Belgium - active not recruitingPHASE3
A Study to Compare the Response to Treatment With Abatacept vs Adalimumab, on Background Methotrexate, in Adults With Early, Seropositive, and Shared Epitope-positive Rheumatoid Arthritis and an Inadequate Response to Methotrexate
This study compares two treatments, abatacept and adalimumab, for adults with early, severe rheumatoid arthritis who haven't responded well to methotrexate. It aims to see which treatment is better at reducing arthritis symptoms and improving quality of life.
United States · Argentina · Australia - ongoing, recruitingTherapeutic use (Phase IV)
I4V-MC-JAJA (RA-BRIDGE): A Randomized, Active-Controlled, Parallel-Group, Phase 3b/4 Study of Baricitinib in Patients with Rheumatoid Arthritis
This study looks at how safe and effective a medicine called baricitinib is for people with rheumatoid arthritis, compared to other common treatments. It will see how long it takes for a blood clot to happen. This is a long-term study that will last over five years.
Hungary · Slovakia · Lithuania - recruitingNA
Stand UP to Rheumatoid Arthritis (SUPRA)
This study aims to find the best treatment for people with Rheumatoid Arthritis (RA). RA is a condition causing painful, swollen joints. Doctors want to discover which medication works best for each person, helping them live a better life without years of trial-and-error.
Canada - active not recruitingPHASE3
A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate and Who Have an Inadequate Response to Methotrexate
This study compares a new medicine, upadacitinib, with a sugar pill (placebo) and an existing medicine, adalimumab, for adults with rheumatoid arthritis. It looks at how well these treatments work and if they are safe when methotrexate isn't enough on its own.
United States · Argentina · Australia - active not recruitingNA
Post Market Clinical Follow-up (PMCF) Study of the A.L.P.S. Proximal Humerus Plating System
This study looks at a new surgical plate, the A.L.P.S. Proximal Humerus Plating System, used for broken upper arm bones. It aims to confirm the plate is safe and works well after it's been made available for use.
United States · Australia · Canada - active not recruitingPHASE2
Two-period Crossover Study to Demonstrate the Comparability of Pharmacokinetics of Subcutaneous Ianalumab Between 2mL Auto-injector/2mL PFS with1mL Pre-filled Syringe in Adult Participants With Autoimmune Disease
This study is testing a new way to give a drug called ianalumab for autoimmune diseases like lupus, Sjögren's, and rheumatoid arthritis. We are comparing different devices (pre-filled syringes and auto-injectors) to make sure they deliver the drug in the same way and are safe.
United States · Argentina · Canada - recruiting
ROLE of PLATELETS in the PATHOPHYSIOLOGY of SYSTEMIC LUPUS
This study looks at how tiny blood cells called platelets might be involved in conditions like lupus and arthritis. Researchers want to understand if platelets make these conditions worse and if targeting them could lead to new treatments. It could help us find better ways to diagnose and treat these illnesses.
France - recruitingNA
Neurofeedback for Nociplastic Pain in Rheumatoid Arthritis (NECTAR)
This study looks at a new way to help people with rheumatoid arthritis who still have pain even after their inflammation is treated. It uses a technique called neurofeedback to see if it can reduce this specific type of pain, as well as helping with tiredness and sleep problems.
United Kingdom - authorisedTherapeutic use (Phase IV)
DISCO-RA:DIScontinuation of COncomitant disease modifying anti-rheumatic drugs (DMARDs) in rheumatoid arthritis patients also using TNF inhibitors - a randomized long-term non-inferiority strategy trial
This study looks at whether people with rheumatoid arthritis who are doing well on a combination of medicines can safely stop one of their drugs (the DMARD) while continuing their TNF inhibitor. It aims to see if stopping the DMARD makes a difference to their condition over two years.
Netherlands - recruitingPHASE3
Efficacy of a Sequential Treatment Strategy in Rheumatoid Arthritis
This study looks at a new way to treat rheumatoid arthritis (RA) using two different medicines. It aims to see if starting with one medicine, then switching to another, works better for people whose current treatment isn't enough to control their RA.
France · Monaco - active not recruitingPHASE2
A Study to Evaluate the Efficacy, Safety, and Tolerability of IMVT-1402 in Adult Participants With Active, Difficult to Treat Rheumatoid Arthritis
This study is testing a new medicine, IMVT-1402, for adults with a type of rheumatoid arthritis that's been hard to treat. It checks if the medicine works and is safe compared to a dummy treatment.
United States · Argentina · Bulgaria - active not recruiting
Outcomes Study of the Trabecular Metal (TM) Reverse Shoulder System
This study looks at how well a new type of shoulder replacement, called the Trabecular Metal Reverse Shoulder System, works for people with severe shoulder problems. It aims to see how long it lasts, if it reduces pain, and improves movement.
United States · United Kingdom - active not recruitingNA
Zimmer Trabecular Metal Total Ankle PMCF
This study looks at how well a new type of ankle replacement, called the Zimmer Trabecular Metal Total Ankle, works in people with different kinds of arthritis. It checks how long the ankle replacement lasts, how much pain people have, and how well they can move after the surgery.
United States · Canada · Finland - active not recruiting
G7 BiSpherical Acetabular Shell PMCF Study
This study looks at how well a new part for hip replacements, called the G7 BiSpherical Acetabular Shell, works for people with certain hip problems like arthritis. It checks if it reduces pain and improves movement after surgery.
France · Germany · Netherlands - recruitingPHASE1
A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)
This study is testing a new cell therapy called CC-97540 for severe autoimmune diseases like lupus and rheumatoid arthritis. It aims to see if it's safe, how well it works, and how the body handles it, especially when other treatments haven't helped.
United States · Belgium · France - recruitingPHASE2
A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis
This study is testing a new medicine, AZD1163, for people with rheumatoid arthritis (RA) who haven't found enough relief from other treatments. It aims to see if the new medicine is safe and helps reduce RA symptoms.
United States · Argentina · Brazil - recruitingNA
RhEumatoid Arthritis MEDIcation Adherence
This study looks at how working closely with pharmacists and doctors might help people with rheumatoid arthritis take their medicines more consistently. The goal is to see if this team approach improves their health compared to usual care.
France - ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomised, double-blind, multicentre study comparing the efficacy, safety and immunogenicity of proposed Abatacept biosimilar (DRL_AB) with Orencia® administered by the intravenous route as an add-on to methotrexate in the treatment of patients with moderate to severe rheumatoid arthritis
This study is comparing a new version of a rheumatoid arthritis medicine, called DRL_AB, with an existing one, Orencia. It aims to see if the new medicine works as well, is safe, and causes a similar immune response in people with moderate to severe rheumatoid arthritis.
Czechia · Hungary · Poland - authorisedTherapeutic use (Phase IV)
Concentration guided dose reduction versus standard dosing in tocilizumab treated heumatoid arthritis patients:a randomised, international, multicenter, non-inferiority trial
This study compares two ways of giving tocilizumab for rheumatoid arthritis: adjusting the dose based on blood levels vs. standard dosing. We want to see if adjusting the dose works just as well and is safe, helping to find the best treatment plan for patients.
Netherlands - active not recruiting
BC Study of G7 Cup and Compatible Femoral Stems
This study looks at how well a new hip replacement cup, called the G7 Acetabular System, works for people needing hip surgery due to joint problems like arthritis. It helps ensure new implants are safe and effective.
United Kingdom - authorisedTherapeutic use (Phase IV)
A multicenter, randomized, open-label, blinded-assessor, phase 4 study in patients with early rheumatoid arthritis to compare active conventional therapy versus three biologic treatments, and two de-escalation strategies in patients who respond to treatment.
This study looks at different ways to treat early rheumatoid arthritis, comparing standard treatments with newer biologic medicines. It also explores if medicine doses can be lowered for people who are getting better, aiming to find the most effective and safe long-term approaches.
Iceland · Denmark · Norway - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A clinical study of MK-2420 in healthy men (MK-2420-003)
This study is looking into a new potential medicine, called MK-2420. It's being tested in healthy adult men to see how it works in the body and if it's safe. The goal is to find better ways to treat conditions like rheumatoid arthritis in the future.
Belgium - authorisedTherapeutic exploratory (Phase II)
A Phase 2, Randomized, Double-blind, Placebo-controlled Study to Investigate the Safety and Efficacy of ELV001 as Add-on Therapy in Patients with Active Rheumatoid Arthritis and Inadequate Response to Methotrexate and Tumor Necrosis Factor Inhibition (START SYNERGY)
This study is testing a new medicine, ELV001, for people with rheumatoid arthritis whose current treatments (methotrexate and another type of drug) aren't working well enough. We want to see if ELV001 is safe and helps reduce arthritis symptoms.
Czechia · Bulgaria · Hungary - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
MK-2420 SAD Study
This early-stage study is looking at a new medicine called MK-2420 for rheumatoid arthritis. It's the first time this medicine is being given to people, to check how safe it is and how the body handles it. Only adult men can take part.
Belgium - recruitingPHASE1
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
This study looks at a new treatment called AZD5492 for lupus, myositis, and rheumatoid arthritis. It checks how safe it is, how well the body handles it, and how it works in adults.
United States · Canada · China - ongoing, recruitingHuman Pharmacology (Phase I)- Other
RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTIPLE ASCENDING DOSE STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF IA-14069 IN HEALTHY SUBJECTS, WITH AN EXTENSION TO EXPLORE ANY DRUG-DRUG INTERACTION POTENTIAL WITH METHOTREXATE (PART 1), AND IN PATIENTS WITH RHEUMATOID ARTHRITIS, WITH PRELIMINARY ASSESSMENT OF EFFICACY IN PATIENTS (PART 2)
This study is testing a new medicine, IA-14069, for rheumatoid arthritis. It first checks if the medicine is safe and how it works in healthy people, then looks at its effects in people with rheumatoid arthritis.
Romania - active not recruiting
Zimmer POLAR Persona - TKA (EMEA Study)
This study looks at how well the Zimmer Persona knee replacement works for people with severe knee pain and disability. It tracks how long the implant lasts, its safety, and how much it improves patients' daily lives over several years.
Austria · France · Germany - active not recruiting
A Prospective, Clinical Investigation of the Vanguard 360 Revision Knee
This study looks at a new type of knee replacement system, called Vanguard 360, for people with knee problems like arthritis. It aims to see if this new system helps people move better, reduces pain, and lasts a long time after surgery.
United States · Belgium · Denmark - recruiting
Exactech Shoulder Post Market Clinical Follow-up Study
This study is looking at how well Exactech shoulder replacements work over a long time. It will follow people who have had this surgery to understand its safety and effectiveness for conditions like arthritis and rotator cuff tears, for at least 10 years.
United States · Canada · France - active not recruiting
Comprehensive Segmental Revision System
This study looks at how well a special shoulder and elbow replacement system works for people with joint problems, arthritis, or after surgery for cancer or injuries. It will track patients for at least 10 years to understand their long-term outcomes and improve future treatments.
Canada · Denmark · United Kingdom