Zimmer POLAR Persona - TKA (EMEA Study)

This study is looking for adults aged between 18 and 75 who need a total knee replacement because of severe knee pain and difficulty moving. This pain might be caused by various types of arthritis, like osteoarthritis or rheumatoid arthritis, or other knee problems that have led to significant damage.

You would need to be well enough for the operation and willing to attend follow-up appointments. It's also important that you haven't had a partial or total knee replacement on the same knee before and aren't currently involved in other studies that focus on surgery or pain management.

However, you wouldn't be able to join if you have certain conditions like an active infection in the knee, very weak bones (osteoporosis), uncontrolled health problems, or if you're pregnant. Also, if you have known allergies to the materials used in the knee implant, you wouldn't be suitable.

If you decide to take part, you'll first have a full conversation with the study team to make sure you understand everything involved before giving your consent. Before your knee replacement surgery, you'll have a check-up. After the operation, you'll have several follow-up appointments with the study team. These check-ups will usually happen around 5 days to 6 weeks after your surgery, then again at 3 to 6 months, and annually for the next five years. During these visits, the team will check how you're doing, ask about your pain and daily activities, and take X-rays of your knee. Some participants might also be asked to come back for voluntary visits at 7 and 10 years. You won't receive any specific study medication, as this study is observing an already approved knee replacement.