- ongoing, recruitingTherapeutic exploratory (Phase II)
CONCISE COlchicine iN Circulating Inflammatory markers after StrokE
The CONCISE study is looking into whether a medicine called colchicine can help reduce swelling and inflammation in people after a stroke. Researchers want to see if it changes certain markers in the blood related to inflammation.
Ireland - enrolling by invitation
Co-designing a Stroke Rehabilitation Trial Toolkit
This study aims to create a 'toolkit' to help future stroke rehabilitation trials run smoothly. We're working with stroke survivors, families, and healthcare staff to design it. The goal is to make sure trials are effective, leading to better recovery for stroke survivors.
United Kingdom - active not recruitingNA
Physical Activity Maintenance Intervention for People With Stroke
This study aims to help people who have had a stroke stay active long-term. Many stroke survivors struggle to keep up physical activity after initial programmes. Researchers want to create a new programme with input from patients and staff to make it helpful and easy to stick with.
United Kingdom - recruiting
Vascular mEchanisms in, Stroke, dePression, dementiA, and deliRum: The VESPAR Project
This study, called VESPAR, looks at how blood flow in the brain affects thinking problems like dementia, depression, and stroke. Researchers want to find better ways to measure brain blood flow and understand how it changes in different conditions to help plan future research.
United Kingdom - active not recruitingNA
CHAMPION-AF Clinical Trial
This study compares a small heart device (WATCHMAN FLX) with standard blood-thinning medicines (such as DOACs) for people with an irregular heartbeat called atrial fibrillation. It aims to see if the device can prevent strokes just as well as the medicines.
United States · Australia · Belgium - recruiting
Clinical Outcome Modelling of Rapid Dynamics in Acute Stroke
This study looks at how people recover from a stroke by tracking their movements. Using a special system called MoCat, it aims to understand changes in movement over time. This could help doctors predict recovery better and improve stroke care for future patients.
United Kingdom - recruitingNA
Awareness Detection and Communication in Disorders of Consciousness
This study explores how brain-computer technology can help people with severe conditions like disorders of consciousness or paralysis communicate. It aims to see if they can use their thoughts to answer yes/no questions, offering a new way to understand their awareness.
Ireland · United Kingdom - recruitingNA
Investigating the Effects of Transcranial Stimulation to Advance Stroke Rehabilitation
This study looks at whether a gentle electrical brain stimulation, given while doing arm exercises, can help people recover better after a stroke. It aims to make the brain more open to learning new movements, helping improve how well the arm works.
United Kingdom - active not recruitingNA
Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion
This study compares a new device (Occlutech Flex II) for closing a small hole in the heart called a PFO, often linked to strokes, with existing standard devices. It checks if the new device is as safe and effective at closing the hole and preventing future strokes.
United States · Canada · Denmark - active not recruitingNA
Acceptance and Commitment Therapy for Post-Stroke Adjustment Via Telerehabilitation
This study looks at how a talking therapy called Acceptance and Commitment Therapy (ACT) can help people adjust to life after a stroke. It's done online in group sessions.
United Kingdom - recruiting
INflammation and Small Vessel Disease Study
This study looks at whether inflammation in the body affects brain damage and memory in people with a condition called cerebral small vessel disease. It aims to understand if changes in inflammation can predict future problems.
Netherlands · United Kingdom - recruiting
Safety and Efficacy of Aneurysms Treated With Endovascular Devices
This study looks at how safe and effective the newest devices are for treating brain aneurysms. Doctors want to see if these treatments work well and are safe for people with this condition, which can sometimes lead to a stroke or bleeding in the brain.
United Kingdom - recruitingPHASE3
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG
This study looks at how best to prevent blood clots and bleeding in people who develop an irregular heartbeat (atrial fibrillation) after bypass surgery. It compares different common blood-thinning treatments.
United States · Canada · Germany - recruiting
The Origin and Role of Thromboembolism in the Pathogenesis of Ischaemic Stroke
This study looks at how blood clots cause strokes. We're using a special scan to find these clots and see where they come from. The aim is to better understand different types of stroke, especially when the cause isn't clear, to improve future treatments.
United Kingdom - recruitingPHASE4
Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Atrial Fibrillation Occurring Transiently With Stress
This study looks at whether blood-thinning medicines (anticoagulants) can prevent strokes and other heart-related problems in people who have had temporary episodes of an irregular heartbeat called atrial fibrillation (AF) during stressful times like surgery or serious illness.
United States · Argentina · Australia - active not recruitingNA
Focused Ultrasound Stimulation of the Cerebellum to Induce Changes in Cognition and Brain Activity
This study is looking into whether using gentle sound waves on a part of the brain called the cerebellum can change how we think and how our brain works. It's for healthy volunteers aged 18-40 and aims to understand if these sound waves can affect memory and other thought processes.
United Kingdom - not yet recruitingNA
Piloting the Attention Training Technique for Post-Stroke Emotionalism
This study looks at a new technique called Attention Training (ATT) to help people who have had a stroke and experience uncontrollable crying or laughing (emotionalism). It aims to see if ATT can improve these symptoms and how it works.
United Kingdom - not yet recruitingNA
Telerehabilitation Decision Support System: Pilot Testing Protocol
This study tests a new online exercise system for people with conditions like stroke or long COVID. It uses special technology, including holograms, to help improve balance and movement from home. We want to see how well it works and if it's easy to use before a larger study.
Germany · Greece · Portugal - active not recruitingNA
Amplatzer Amulet LAAO vs. NOAC
This study compares a device that closes off a small pouch in the heart (Amplatzer Amulet) with standard blood-thinning medicines (NOACs). It aims to see which is safer and better at preventing strokes in people with an irregular heartbeat called atrial fibrillation.
United States · Australia · Canada - not yet recruitingNA
Activity-based Mirror Therapy for Lower Limb Motor Recovery, Balance, Gait, and Mobility in Acute Inpatient Stroke: A Feasibility Study
This study looks at a special mirror therapy for people who recently had a stroke and are in hospital. It explores if this therapy can help improve movement, balance, and walking in their legs, alongside their usual treatment.
United Kingdom - active not recruiting
Preventing Recurrent Cardioembolic Stroke (The PRECISE Study)
This study aims to improve how we check for a heart condition called atrial fibrillation (AF) after a stroke. By finding better ways to identify who needs checking, we hope to prevent more second strokes for people in the UK.
United Kingdom - recruitingPHASE2, PHASE3
Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)
This study is testing a new medicine, DM199, for people who have had a type of stroke called an ischaemic stroke. It aims to see if the medicine is safe and helps people recover better, especially those with fewer treatment options.
United States · Belgium · Canada - recruiting
Neurofrailty: A Study of Late-onset Epilepsy and Its Associations
This study looks at adults who have their first seizure later in life. We want to see if there's a link between these seizures and conditions like stroke or memory problems (dementia) that might happen years later. We'll observe people's health over time to learn more.
United Kingdom - not yet recruitingNA
Virtual Reality in Occupational Therapy Upper Limb Stroke Rehabilitation
This study looks at using a virtual reality (VR) system called Resynk to help stroke survivors improve movement in their arm and hand. We want to see if it's practical and helpful for patients both in hospital and at home.
United Kingdom - recruiting
The South London Stroke Register: Improving the Lives of Stroke Survivors With Data
This study, the South London Stroke Register, collects information from people in South London who have had a stroke. It helps us understand how stroke affects people over many years and how different types of care can help them recover.
United Kingdom - recruiting
Monitoring Arm Recovery After Stroke (MARS)
This study is testing a new phone app to help people recover arm movement after a stroke. It compares the app's accuracy to special lab cameras when measuring arm movements. The goal is to create a simple, affordable way to track recovery and improve treatments using video of everyday movements.
United Kingdom - active not recruiting
Outcomes of Patients Who Survived Treatment on an Intensive Care Unit for COVID-19 in England and Wales
This study looks at the health of people in England and Wales one year after they left intensive care for COVID-19. Researchers will compare their health to people who were in intensive care for other reasons. The aim is to understand long-term health effects.
United Kingdom - not yet recruitingNA
Potential for Recovery of Voluntary Finger Extension After Stroke
This study looks at how some stroke survivors might regain finger movement, even years after their stroke. It tests a home exercise program with electrical stimulation to see who benefits and why.
United Kingdom - active not recruitingNA
AMPLATZER PFO Occluder Post Approval Study
This study is looking at how well a small device, the AMPLATZER™ PFO Occluder, works to close a small hole in the heart (PFO) after someone has had a stroke. It's checking its safety and effectiveness in many patients across different hospitals.
United States · Canada · Germany - recruitingNA
MUSic Therapy In Complex Specialist Neurorehabilitation
This study looks at whether adding music therapy to standard rehabilitation helps people recover better after serious brain or spinal cord injuries. It compares music therapy to usual care to see if it improves daily activities and well-being in patients aged 16-80.
United Kingdom - active not recruiting
Electrical Impedance Tomography of Stroke and Brain Injury
This study is looking at a new, quick, and safe scanning method called Electrical Impedance Tomography (EIT) to image the brain after a stroke or head injury. We want to see if it can produce good images that match current scans like MRI or CT, potentially helping doctors give faster treatment.
United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
Long-term iron chelation in the prevention of secondary remote degeneration after stroke
This study looks at whether a medicine called Ferriprox can help prevent further problems after a stroke. It checks if the medicine reduces iron levels in specific brain areas. Researchers want to see if this could protect against long-term brain damage.
France - authorisedTherapeutic exploratory (Phase II)
Upper-limb Active Function and Botulinum Toxin A
This study looks at how a medicine called Dysport, similar to Botox, might help people who have had a stroke and have stiff or tight arm muscles. Researchers want to see if it improves arm movement and reduces muscle co-contraction (muscles working against each other).
France - authorisedHuman Pharmacology (Phase I)- First administration to humans
Regenerative Stem Cell Therapy for Stroke in Europe 1
This study is looking at a new type of treatment using special cells, called stem cells, for people who have had a stroke. It's an early stage trial to see if the treatment is safe for humans and how it works. Adults of any age can take part.
France - recruiting
Sleep and Motor Learning in Stroke
This study looks at how sleep after a stroke affects how well people regain movement. It explores if poor sleep stops the brain from 'learning' movements overnight, which could slow down recovery of arm function.
United Kingdom - recruitingNA
Improving Sleep and Learning in Rehabilitation After Stroke, Part 2
This study looks at whether a digital programme called Sleepio, which helps with sleep problems, can improve sleep in people who have had a stroke. We also want to see if better sleep helps them learn new movements better after their stroke.
United Kingdom - recruiting
Visual Perception Difficulties After Stroke
This study looks at how well a new test called OxVPS can find vision problems in people who have had a stroke. It compares OxVPS to older, trusted tests to see if it's accurate and helpful for identifying visual difficulties after a stroke.
United Kingdom - recruitingNA
Neural Mechanisms of Music Intervention Chronic Arm Hemiparesis Following Stroke: A Single Case Series EEG Study
This study looks at how playing music might help people recover arm movement after a stroke. Researchers want to see if music therapy can reorganise the brain and improve arm function for stroke survivors. It involves home-based music sessions and brain wave measurements.
United Kingdom - recruiting
The Imperial Comprehensive Cognitive Assessment in Cerebrovascular Disease (IC3)
This study is developing a new, easy-to-use digital test (IC3) to better understand how stroke affects memory and thinking skills. It aims to help doctors give the right support to stroke survivors, using brain scans and blood tests alongside the new cognitive assessment.
United Kingdom - recruitingNA
Somatosensory Stimulation for Unilateral Neglect Post Stroke (SSUN)
This study looks at a hands-on therapy called Mobilisation and Tactile Stimulation (MTS) for people who have had a stroke. It aims to see if MTS can help with 'neglect,' where people aren't aware of one side of their body, after at least 20 weeks post-stroke.
United Kingdom - not yet recruitingNA
Telerehabilitation of Balance Clinical and Economic Decision Support System
This study looks at a new way to help people with balance problems caused by stroke, memory issues, inner ear problems, or Long Covid. It uses a virtual coach at home to guide exercises and improve balance and well-being.
Germany · Greece · Portugal - authorisedTherapeutic use (Phase IV)
Pilot randomized controlled trial of the prevention of early respiratory tract infections in intubated patients. Comparison of the safety and efficacy of a short course of systemic antibiotic, a cough simulator and aspiration of subglottic secretions
This study looks at ways to prevent lung infections in very sick patients on breathing machines. Researchers are testing a short course of antibiotics and special breathing treatments to see if they are safe and help reduce these infections.
Spain