Cerebral Small Vessel Disease research hub
50 indexed studies · 38 currently recruiting
- recruitingNA
Neurophysiological and Behavioral Study of the Cognitive Deficits Associated With Cerebral Small Vessel Disease in the SHIVA Cohort. SHIVA-CogNeurophys
This study looks at how a condition called Cerebral Small Vessel Disease (cSVD) affects thinking skills. We want to find new ways to spot these changes early using brainwave tests (EEG) and see if brain training or gentle electrical brain stimulation can help improve them.
France - not yet recruitingNA
Evaluation of the NEUROSWING Orthosis on Walking Speed in a Population With Dorsal and/or Plantar Flexor Deficits, With a View to a Reimbursement Application
This study looks at a new ankle support, the NEUROSWING orthosis, to see if it helps people with walking difficulties caused by conditions like stroke or MS. Researchers will compare it to a standard carbon ankle support to see if it improves walking speed.
France - recruiting
Evolution of Walking Abilities in Subacute Stroke Patients Hospitalized in Neurorehabilitation Center
This study looks at how walking improves in people recovering from a stroke. It follows stroke patients in rehabilitation centers for up to six months to see changes in their walking abilities. The aim is to better understand their recovery jouney.
France - recruitingNA
Neural Mechanisms of Music Intervention Chronic Arm Hemiparesis Following Stroke: A Single Case Series EEG Study
This study looks at how playing music might help people recover arm movement after a stroke. Researchers want to see if music therapy can reorganise the brain and improve arm function for stroke survivors. It involves home-based music sessions and brain wave measurements.
United Kingdom - active not recruitingNA
Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion
This study compares a new device (Occlutech Flex II) for closing a small hole in the heart called a PFO, often linked to strokes, with existing standard devices. It checks if the new device is as safe and effective at closing the hole and preventing future strokes.
United States · Canada · Denmark - active not recruiting
Systematic Assessment of Treatment Effectiveness for Long-Term Management of Stable Atrial Tachycardia in Inpatient and Outpatient Environments
This study looks at how well treatments work over a long time for people with a fast or irregular heartbeat called atrial tachycardia. Researchers want to see the long-term effects of these treatments on people's health, including their risk of stroke and even how long they live.
Germany - recruitingNA
Pilot Study: Home Use of Wearable Grasping Neuroprosthesis in Vascular Hemiparesis
This study looks at a special device called a Grasp Neuroprosthesis (GNP) that helps people who've had a stroke open and close their hand. It's already been tested in hospitals, and now researchers want to see how well it works when used at home for a whole year.
France - recruiting
The Origin and Role of Thromboembolism in the Pathogenesis of Ischaemic Stroke
This study looks at how blood clots cause strokes. We're using a special scan to find these clots and see where they come from. The aim is to better understand different types of stroke, especially when the cause isn't clear, to improve future treatments.
United Kingdom - recruiting
Prediction of Post-stroke Motor Recovery
This study looks at how well we can predict arm recovery after a stroke. It uses information like a patient's age and initial arm movement to guess how much their arm will improve three months later. This helps doctors plan the best care.
France - ongoing, recruitingHuman Pharmacology (Phase I)- Other
DMT in healthy subjects
This study is looking for healthy people over 18 to test a new medicine (DMT). It's an early-stage study to see how safe the medicine is and how it works in the body, not to treat a specific illness. It's an important first step towards understanding potential future treatments for conditions like stroke.
Netherlands - recruitingNA
MUSic Therapy In Complex Specialist Neurorehabilitation
This study looks at whether adding music therapy to standard rehabilitation helps people recover better after serious brain or spinal cord injuries. It compares music therapy to usual care to see if it improves daily activities and well-being in patients aged 16-80.
United Kingdom - recruitingPHASE3
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG
This study looks at how best to prevent blood clots and bleeding in people who develop an irregular heartbeat (atrial fibrillation) after bypass surgery. It compares different common blood-thinning treatments.
United States · Brazil · Canada - not yet recruitingNA
Potential for Recovery of Voluntary Finger Extension After Stroke
This study looks at how some stroke survivors might regain finger movement, even years after their stroke. It tests a home exercise program with electrical stimulation to see who benefits and why.
United Kingdom - not yet recruitingNA
Volunteer Facilitated Discharge Assistance and Supports at Home (DASH) for People With Stroke
This study looks at whether a volunteer visiting stroke survivors at home can help them cope better. Researchers want to see if this support, alongside usual care, improves recovery for people who have recently left the hospital after a stroke.
Canada - not yet recruitingNA
Telerehabilitation of Balance Clinical and Economic Decision Support System
This study looks at a new way to help people with balance problems caused by stroke, memory issues, inner ear problems, or Long Covid. It uses a virtual coach at home to guide exercises and improve balance and well-being.
Germany · Greece · Portugal - recruitingNA
Somatosensory Stimulation for Unilateral Neglect Post Stroke (SSUN)
This study looks at a hands-on therapy called Mobilisation and Tactile Stimulation (MTS) for people who have had a stroke. It aims to see if MTS can help with 'neglect,' where people aren't aware of one side of their body, after at least 20 weeks post-stroke.
United Kingdom - recruitingNA
B2AD-Risk AFDAS Evolution of Burden of AF
This study looks at people who have had a stroke and then found out they have an irregular heartbeat called atrial fibrillation (AF). We want to understand how this AF changes over time to help improve treatments and prevention for future strokes.
Canada - recruiting
Falls in stroke survivors
This study looks at a new programme, called SAF, to help stroke survivors avoid falls after leaving hospital. It compares SAF with usual care to see if it reduces falls over 12 months. SAF involves a checklist and action plan to manage fall risks.
United Kingdom · England · Wales - active not recruitingNA
Amplatzer Amulet LAAO vs. NOAC
This study compares a device that closes off a small pouch in the heart (Amplatzer Amulet) with standard blood-thinning medicines (NOACs). It aims to see which is safer and better at preventing strokes in people with an irregular heartbeat called atrial fibrillation.
United States · Australia · Canada - active not recruiting
Electrical Impedance Tomography of Stroke and Brain Injury
This study is looking at a new, quick, and safe scanning method called Electrical Impedance Tomography (EIT) to image the brain after a stroke or head injury. We want to see if it can produce good images that match current scans like MRI or CT, potentially helping doctors give faster treatment.
United Kingdom - recruitingNA
Comparing Digitally and Traditionally Made Ankle Foot Orthoses
This study compares how two types of ankle-foot supports (AFOs) are made: the traditional plaster cast method and a new digital 3D printing method. We want to see if the digital AFOs work just as well for people with leg weakness, potentially making them faster and cheaper to produce.
Canada - recruitingNot Specified
Spatial inattention grasping therapy for neglect post-stroke
This study looks at a new therapy, SIGHT, for people who've had a stroke and have spatial inattention. This condition makes it hard to notice things on one side. SIGHT uses special rods to help the brain relearn how to pay attention. We want to see if it helps and for whom.
United Kingdom · England - active not recruitingNA
AMPLATZER PFO Occluder Post Approval Study
This study is looking at how well a small device, the AMPLATZER™ PFO Occluder, works to close a small hole in the heart (PFO) after someone has had a stroke. It's checking its safety and effectiveness in many patients across different hospitals.
United States · Canada · Germany - recruiting
Magnesium and Cognition After Stroke
This study looks into how magnesium levels might be linked to memory and thinking problems after a stroke. Researchers want to see if magnesium levels affect how well people recover their mental abilities after a stroke.
Germany - recruitingNA
Evaluation of the Effect of Music During Nursing Care on the Confort of Patient Hospitalized in Intensive Care Unit During the Acute Phase of a Stroke
This study looks at whether playing music during routine nursing care, like washing, can make stroke patients in intensive care feel more comfortable. Researchers want to see if music helps with physical, mental, and environmental well-being.
France - recruitingNA
Improving Sleep and Learning in Rehabilitation After Stroke, Part 2
This study looks at whether a digital programme called Sleepio, which helps with sleep problems, can improve sleep in people who have had a stroke. We also want to see if better sleep helps them learn new movements better after their stroke.
United Kingdom - recruitingNA
VIrtual Reality Glasses Use to Improve Lateropulsion and the Post-stroke Postural Vertical
This study looks at how virtual reality glasses might help people who have had a stroke and are struggling with balance and feeling aware of where straight up is. We're testing if special VR glasses can help them stand straighter and feel more stable.
France - recruitingNA
Implementation of an App-based Walking Aid Skills Training Program
This study looks at a new app called 'ICanWALK' designed to help people who use walking aids like crutches or walkers. It aims to teach them how to use these aids safely and effectively, hoping to reduce falls and improve their confidence.
Canada - not yet recruitingNA
Clinical Feasibility & Validation of the Augmented Reality GlenxRose Acquired Brain Injury Rehabilitation Programs
This study looks at using fun, game-like virtual reality activities for people recovering from brain injury. It explores if these engaging new therapies help people stick with their exercises, enjoy their recovery more, and get better results than standard care alone.
Canada - recruitingNA
Impact of Atrial Fibrosis Surface Area on the Occurrence of Atrial Fibrillation in Patients With Ischemic Stroke of Undetermined Origin: a Prospective Cardiac MRI Pilot Study.
This study looks at using heart scans (MRI) after an unexplained stroke. We want to see if these scans can help identify people at higher risk of an irregular heartbeat called atrial fibrillation, potentially guiding who needs a small heart monitor implanted.
France - not yet recruitingNA
YOGA-FIT: Protocol for a Crossover Trial Investigating the Feasibility and Impact of Yoga for People With Stroke
This study looks at whether a special yoga programme, called LoveYourBrain Yoga, can help stroke survivors in Nova Scotia. It checks if the programme is easy to do, safe, and if it could improve balance, walking, mood, and overall well-being for people who have had a stroke.
Canada - recruiting
Clinical Outcome Modelling of Rapid Dynamics in Acute Stroke
This study looks at how people recover from a stroke by tracking their movements. Using a special system called MoCat, it aims to understand changes in movement over time. This could help doctors predict recovery better and improve stroke care for future patients.
United Kingdom - not yet recruitingNA
WSO BEAT STROKE Initiative
This study looks at whether a special learning program for doctors can help them better follow guidelines for preventing future strokes, especially those caused by heart problems. It checks if bringing heart and brain specialists together improves care for people who've had a stroke.
Canada - recruitingNA
Stroke Motor Recovery for the Hand and Fingers
This study compares two ways to improve hand and finger movement after a stroke: focusing on reaching goals versus improving movement technique. We also look at brain changes and who benefits most. Patients will have piano training and MRI scans to understand which method works best.
Canada - recruitingPHASE2
The Canadian Maraviroc Randomized Controlled Trial To Augment Rehabilitation Outcomes After Stroke
This study looks at whether a drug called Maraviroc, combined with exercise, can help people recover better after a stroke. It focuses on improving movement in arms and legs, especially in the first few months after a stroke.
Canada - not yet recruiting
New Rear Anti-tip Device for Manual Wheelchairs: Subjective Input (RAD-SI)
This study looks at a new and improved anti-tip device for manual wheelchairs. Researchers want to know what wheelchair users and service providers think about current anti-tip devices and if this new design could make wheelchairs safer and easier to use.
Canada - active not recruitingNA
Fine Motor Skills and Post-Stroke Swallowing
This study looks at how fine hand movements might help improve swallowing problems after a stroke. Researchers want to see if special exercises that combine hand and mouth movements can help people swallow better, as swallowing issues can cause other health problems.
France - recruitingNA
Stimulating Postural Control to Augment Rehabilitation After Cerebral Stroke (SPARC): a Pilot Trial
This study looks at new ways to help stroke survivors improve their balance and prevent falls. It tests whether combining balance exercises with a gentle electrical stimulation can make rehabilitation more effective for people who have had a stroke.
Canada - recruitingNA
Evaluation of Percutaneous Cryoneurotomy Compared to Surgical Open Neurotomy for the Management of Equinovarus Foot Deformity in Patients With Refractory Lower Limb Spasticity After Stroke
This study compares two treatments for foot problems after a stroke: a traditional surgery and a newer, less invasive freezing method. It aims to see which is safer and more effective for people with stiff, turned-in feet (equinovarus foot) due to spasticity after a stroke.
France - recruitingNA
Standardized Goal-Directed vs. Self-Directed Valsalva Maneuver for the Assessment of Patent Foramen Ovale
This study compares two ways of doing a special breathing test (Valsalva maneuver) to find a small hole in the heart called a PFO. We want to see if a guided breathing test is better at finding PFOs, which can cause strokes.
Canada - recruitingPHASE4
International Care Bundle Evaluation in Cerebral Hemorrhage Research
This study, called I-CATCHER, is looking into whether a special care package helps people who have a stroke caused by bleeding in the brain (intracerebral haemorrhage). It aims to improve recovery for these patients by testing a new approach to treatment.
United States · Australia · Canada - recruiting
The Imperial Comprehensive Cognitive Assessment in Cerebrovascular Disease (IC3)
This study is developing a new, easy-to-use digital test (IC3) to better understand how stroke affects memory and thinking skills. It aims to help doctors give the right support to stroke survivors, using brain scans and blood tests alongside the new cognitive assessment.
United Kingdom - recruitingNA
Optimizing Recruitment to Drive Equitable Research Opportunity in Stroke Rehabilitation Trials in Canada
This study aims to make it easier for all stroke survivors, especially women and those with speaking difficulties, to join rehabilitation research. It's testing new ways to explain studies, so more people can take part and help develop better stroke treatments.
Canada - recruiting
INflammation and Small Vessel Disease Study
This study looks at whether inflammation in the body affects brain damage and memory in people with a condition called cerebral small vessel disease. It aims to understand if changes in inflammation can predict future problems.
Netherlands · United Kingdom - active not recruitingNA
Carotid Artery Implant for Preventing Stroke in Atrial Fibrillation Patients Taking Oral Anticoagulants
This study is looking at a new device called the Vine™ Embolic Protection System. It's like a tiny filter placed in the neck arteries to help prevent strokes in people with atrial fibrillation who are already taking blood thinners but are still at high risk.
Belgium · Czechia · Germany - recruitingNA
Investigating the Effects of Transcranial Stimulation to Advance Stroke Rehabilitation
This study looks at whether a gentle electrical brain stimulation, given while doing arm exercises, can help people recover better after a stroke. It aims to make the brain more open to learning new movements, helping improve how well the arm works.
United Kingdom - active not recruitingNA
Focused Ultrasound Stimulation of the Cerebellum to Induce Changes in Cognition and Brain Activity
This study is looking into whether using gentle sound waves on a part of the brain called the cerebellum can change how we think and how our brain works. It's for healthy volunteers aged 18-40 and aims to understand if these sound waves can affect memory and other thought processes.
United Kingdom - recruitingPHASE3
The Role of Peripheral Afferents in Modulating Post-stroke Central Pain
This study is looking into new ways to treat ongoing pain after a stroke, called central post-stroke pain. It will test if nerve blocks using two different medicines (lidocaine or levobupivacaine) or a dummy treatment can help reduce this type of pain.
France - recruitingNA
Understanding Motor Function in Stroke Patients and Their Functional Brain Reorganization Using Ultra High-field MRI
This study uses advanced MRI scans to understand brain changes in stroke patients with arm weakness. We want to create a detailed map of these changes to help develop better treatments and possibly a new device for arm rehabilitation.
France - active not recruiting
Impact of Door-to-Needle Time on Stroke Outcomes at Gonesse Hospital
This study at Gonesse Hospital looks at how quickly stroke patients get clot-busting treatment after arriving. Researchers want to see if faster treatment improves recovery and find ways to make stroke care better. They'll check the time from hospital arrival to treatment.
France