Triple Negative Breast Cancer research hub
27 indexed studies · 12 currently recruiting
- recruitingPHASE1, PHASE2
Modi-1 Moditope in Breast, Head and Neck, Ovarian, or Renal Cancer
This study is testing a new vaccine called Modi-1 Moditope for advanced cancers like breast, head and neck, ovarian, or kidney cancer. It aims to see if it's safe, and if it can help the body fight cancer, alone or with other treatments.
United Kingdom - recruitingPHASE1
ASTEROID: A Trial of ASTX660 in Combination With Pembrolizumab
This study is testing a new combination of two drugs, ASTX660 and pembrolizumab, for people with advanced cancers like cervical cancer and a type of breast cancer. It's a first step to see if this new approach can boost the body's own immune system to fight cancer.
United Kingdom - recruitingPHASE1
A Study of MOv18 IgE in Patients With Solid Tumours That Express Folate Receptor Alpha
This study is testing a new medicine called MOv18 IgE for women with advanced ovarian, endometrial, or triple-negative breast cancer. It aims to find a safe dose and see how well it works, especially in cancers that have a specific marker called Folate Receptor Alpha.
United Kingdom - active not recruitingPHASE1, PHASE2
Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression
This study is testing a new drug, BT5528, for advanced cancers like ovarian, lung, and breast cancer. We want to find a safe dose, understand side effects, and see how well it works, sometimes given with another drug called nivolumab.
United States · Belgium · South Korea - active not recruitingPHASE3
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer
This study is for people with a specific type of advanced breast cancer (PD-L1 positive triple-negative) that hasn't been treated yet. It compares two different drug combinations to see which one works better at stopping the cancer from growing.
United States · Argentina · Australia - recruiting
Breast Cancer Evolution During Neoadjuvant Systemic Therapy
This study, called BELIEVE, collects tissue and blood samples from people with breast cancer before surgery. Researchers want to understand why some cancers respond well to treatment and others don't, how to better measure treatment success, and predict if cancer might return. It helps improve future breast cancer care.
United Kingdom - recruitingPHASE1
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
This study is testing a new drug, LY4052031, for people with advanced cancers like bladder, breast, and lung cancer. It aims to see if the drug is safe, what dose works best, and if it helps shrink tumors. It's an early-stage study to gather important information.
United States · Australia · China - authorisedTherapeutic confirmatory (Phase III)
PembroLizumab Adjuvant in patients with early-stage Triple NEgaTive breast cancer with residual disease after neoadjuvant pembrolizumab plus chemotherapy – the multicenter, randomized phase III, pragmatic PLANET trial
This study looks at new treatments for early-stage triple-negative breast cancer that hasn't completely gone away after initial treatment. It compares different medicines to see if they can stop the cancer from coming back, helping people live longer and healthier lives.
Netherlands - authorisedPhase I and Phase II (Integrated)- First administration to humans
CELL-BASED IMMUNOTHERAPY FOR TREATMENT OF TRIPLE NEGATIVE BREAST CANCER STAGES II AND III
This study is testing a new cell-based treatment for breast cancer that doesn't respond to usual hormone therapies or targeted drugs (called triple-negative breast cancer). It's an early-stage trial trying to find out if the treatment is safe and if it works for patients with stages II and III of this type of cancer.
Slovenia - active not recruitingPHASE3
Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician's Choice in Patients With Previously Untreated Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer
This study looks at a new drug, Sacituzumab Govitecan-hziy, for people with an aggressive type of breast cancer called triple-negative breast cancer that has spread or can't be operated on. It compares this new drug to standard treatments to see which works better at stopping the cancer from growing.
United States · Argentina · Australia - recruitingPHASE1, PHASE2
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
This study is testing a new drug, rezatapopt, for advanced cancers with a specific gene change (TP53 Y220C). It's also looking at rezatapopt with another drug, pembrolizumab, to see how safe and effective they are. It’s for people who have already had cancer treatment.
United States · Australia · France - recruitingPHASE3
Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)
This study looks at a new drug combination, sacituzumab tirumotecan and pembrolizumab, for a type of breast cancer called triple-negative. It's for patients who had initial treatment but still have some cancer cells after surgery. We want to see if this new combination helps prevent the cancer from coming back better than standard care.
United States · Argentina · Australia - active not recruitingPHASE2
Safety and Preliminary Effectiveness of BNT327, an Investigational Therapy for Breast Cancer, When Given in Combination With Chemotherapy
This study is testing a new drug, BNT327, for advanced breast cancer (called triple-negative). Researchers want to see if it's safe and works well when given with chemotherapy. It's for people whose cancer has spread or is difficult to treat.
United States · Australia · Turkey (Türkiye) - recruitingPHASE1
PAveMenT: Palbociclib and Avelumab in Metastatic AR+ Triple Negative Breast Cancer
This study looks at combining two drugs, palbociclib and avelumab, for a specific type of advanced breast cancer called triple negative. We want to find the safest dose and see how well it works, especially for cancers with a particular marker called AR.
United Kingdom - ongoing, recruitingTherapeutic confirmatory (Phase III)
The GLORIA Study: A Phase 3, Randomized, Open-Label Study of the Anti-Globo H Vaccine Adagloxad Simolenin (OBI-822)/OBI-821 in the Adjuvant Treatment of Patients with High-Risk, Early-Stage Globo H-Positive Triple Negative Breast Cancer
The GLORIA study is looking at a new vaccine, Adagloxad Simolenin, for people with a type of breast cancer called triple-negative breast cancer that has a specific marker called Globo H. It aims to see if this vaccine, given after initial treatment, can help prevent the cancer from coming back.
Poland - ongoing, recruitingTherapeutic confirmatory (Phase III)
MOIO_Randomized phase III trial of standard immunotherapy (IO) by checkpoint inhibitors, versus reduced dose intensity of IO in patients with locally advanced or metastatic cancer in response after 6 months of standard IO
This study compares standard immunotherapy with a reduced dose for people whose cancer responded well after 6 months. It looks at how long they stay well and their quality of life. The aim is to see if a lower dose can be just as effective.
France - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Phase 1b, Open-Label, Dose-Escalation Trial of the Safety of and Antigen-Specific Immune Responses Elicited by VB.10 NEO in Combination With Atezolizumab in Subjects with Locally Advanced and Metastatic Tumors
This study is looking at a new treatment called VB.10 NEO combined with an existing medicine, atezolizumab, for people with advanced cancers. It aims to check if the combination is safe and how it affects the body's immune system to fight cancer.
Germany · Spain - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Study of SGN-B7H4V in Advanced Solid Tumors
Researchers are testing a new medicine called SGN-B7H4V for several advanced cancers, including certain breast, lung, and ovarian cancers. This early-stage study aims to find a safe dose and see what effects it has. It's for adults whose cancer has spread or come back.
France · Spain · Italy - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III Double-blind Randomised Study Assessing the Efficacy and Safety of Capivasertib + Paclitaxel Versus Placebo + Paclitaxel as First-line Treatment for Patients with Histologically Confirmed, Locally Advanced (Inoperable) or Metastatic Triple-Negative Breast Cancer (TNBC) (CAPItello-290)
This study is looking at a new combination of treatments for advanced triple-negative breast cancer. It compares a drug called capivasertib with paclitaxel, to paclitaxel alone, to see if the new combination improves survival and is safe.
Spain - authorisedTherapeutic exploratory (Phase II)
BARBICAN: A randomised, open-label Phase II study to determine the contribution of ipatasertib to neoadjuvant chemotherapy plus atezolizumab in women with triple-negative breast cancer
This study looks at new treatments for a specific type of breast cancer called triple-negative. It combines standard chemotherapy and Tecentriq with a new drug, Ipatasertib, to see if this combination helps shrink tumours more effectively before surgery.
Spain · Germany - active not recruitingPHASE1
Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors
This study is testing two anti-cancer drugs, cabozantinib and atezolizumab, alone and together, for various advanced cancers. It aims to find a safe combination dose and see how well it works and any side effects.
United States · Australia · Belgium - recruitingPHASE3
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
This study is looking at new treatments for triple-negative breast cancer that remains after surgery. It compares a new drug combination (sacituzumab govitecan-hziy and pembrolizumab) with standard treatments to see if it's more effective and safe for patients.
United States · Australia · Belgium - recruiting
Prospective Evaluation of AI R&D Tool for Patient Stratification - MoA Evaluation in Triple Negative Breast Cancer (PEAR-MET)
This study is testing a new tool for people with advanced triple-negative breast cancer. It uses a small sample of your tumour to see how it might react to different treatments. This helps researchers understand how to better choose treatments in the future, aiming to improve care for patients.
United Kingdom - active not recruitingPHASE2
Investigate the Contribution of Ipatasertib to Neoadjuvant Chemotherapy Plus Atezolizumab in TNBC
This study is looking into a new treatment for an aggressive type of breast cancer called triple-negative breast cancer. It combines standard chemotherapy with two newer drugs, Atezolizumab and Ipatasertib, to see if this mix can fight the cancer better before surgery.
United Kingdom - active not recruitingPHASE1, PHASE2
A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid Tumours
This study is testing a new drug, HMBD-001, for advanced cancers where a protein called HER3 is active. We want to find the best dose, understand side effects, and see if it helps stop cancer growth, sometimes with another drug called enzalutamide.
United Kingdom - recruiting
Feasibility of Serial Multisite Image-guided Biopsy to Study Breast Cancer Evolution
This study aims to understand how breast cancer changes over time, especially when it spreads. Researchers will take several small tissue samples and blood tests from different areas to see how the cancer evolves. This could help develop better treatments in the future.
United Kingdom - recruitingPHASE2
Investigating Datopotamab Deruxtecan Plus Durvalumab Versus Datopotamab Deruxtecan in Patients With PDL1-negative Metastatic Triple-negative Breast Cancer
This study is testing if a new combination of two drugs, Datopotamab Deruxtecan and Durvalumab, works better than Datopotamab Deruxtecan alone for a specific type of advanced triple-negative breast cancer. It focuses on patients whose cancer doesn't have a marker called PDL1.
United Kingdom