Type 2 diabetes mellitus research hub
18 indexed studies · 2 currently recruiting
- ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Once Weekly s.c. Administered GL0034 in Adults with Type 2 Diabetes Mellitus Inadequately controlled on Metformin Or Diet and Exercise
This study is testing a new weekly medicine, GL0034, for adults with type 2 diabetes whose blood sugar isn't well controlled by metformin or healthy living. We want to see how well it works, if it's safe, and particularly how it affects tummy issues.
Germany - recruitingPHASE3
Proact: A Study of REACT in Subjects With Type 2 Diabetes Mellitus and Chronic Kidney Disease
This study, called Proact, is investigating a new treatment called REACT (also known as rilparencel) for people with type 2 diabetes and chronic kidney disease. Researchers want to see if this treatment can help kidney function and if it is safe.
United States · Australia · Canada - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Study to Learn if the Study Medicines Called Itraconazole and Cyclosporine Change How the Body Processes the Other Study Medicine Called Danuglipron in Healthy Adults
This study is looking at how two medicines, itraconazole and cyclosporine, might affect how your body uses another new medicine called Danuglipron. It's for healthy adults and is an early-stage study to understand how these drugs interact.
Belgium - not yet recruitingNA
Effect of Beetroot Juice on Cardiovascular and Autonomic Responses to Exercise in Adults With Type 2 Diabetes
This study looks at whether beetroot juice can help adults with Type 2 Diabetes recover better after exercise. It checks how exercise affects blood pressure and heart rate, as well as how helpful beetroot juice might be with these effects.
United Kingdom - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled Clinical Study to Evaluate the Safety and Efficacy of Ertugliflozin (MK-8835/PF-04971729) in Pediatric Participants (ages 10 to 17 years, inclusive) with Type 2 Diabetes Mellitus (MK-8835-059/B1521066)
This study is looking at a new medicine called ertugliflozin for young people aged 10 to 17 with type 2 diabetes. We want to see if it helps control blood sugar and if it's safe compared to a dummy pill.
Poland · Italy · Hungary - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Exploratory Bioavailability of Two Formulations of Gliclazide MR Tablets 120 mg (I.R.I.S.) in Healthy Volunteers Under Fed and Fasting Conditions.
This study is looking at how two different versions of a diabetes medicine called gliclazide MR 120 mg are absorbed by the body. We want to see if food affects how well they work in healthy adults.
Portugal - ongoing, recruitingTherapeutic confirmatory (Phase III)
I8F-MC-GPGN: The Effect of Tirzepatide versus Dulaglutide on Major Adverse Cardiovascular Events in Patients with Type 2 Diabetes (SURPASS-CVOT)
This study compares two medicines, tirzepatide and dulaglutide, for people with type 2 diabetes. It looks at how well they protect against serious heart problems like heart attacks and strokes. It's a big, important study to confirm which medicine is better for your heart.
Slovakia · France · Hungary - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to assess the pharmacokinetics, and glucodynamics of LY3209590 in participants with type 2 diabetes
This study is looking at a new medicine, LY3209590, for people with type 2 diabetes. Researchers want to understand how it works in the body and how it affects blood sugar levels. It's an early-stage study to gather important information about this potential new treatment.
Germany - ongoing, recruitingTherapeutic confirmatory (Phase III)
Effects of Finerenone on Renal Hemodynamics and Oxidative Stress
This study is looking at how a medicine called Kerendia (finerenone) affects the kidneys in people with type 2 diabetes. It aims to see if Kerendia can help improve kidney function by reducing stress on kidney blood vessels, compared to a dummy pill.
Germany - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A research study Looking into blood levels of the medicine NNC0519-0130 in the body of participants with normal or reduced kidney function
This study is looking at a new medicine, NNC0519-0130, for people with Type 2 Diabetes. Researchers want to see how much of the medicine stays in the blood and for how long, especially in people with normal or reduced kidney function. It's an early-stage study to understand the medicine better.
Germany - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A research study comparing different ways of increasing the dose of NNC0519-0130 in participants with overweight or obesity
This study is looking for volunteers to test a new way of giving a medicine called NNC0519-0130. It's for people who are overweight or have obesity and Type 2 diabetes. The aim is to find the best and safest dose.
Austria - ongoing, recruitingTherapeutic use (Phase IV)
Intraclass safety and efficacy comparison among SGLT-2 inhibitors in elderly patients with type 2 diabetes. A pragmatic, phase IV, multicenter, open-label, randomised controlled trial.
This study is looking at how well different diabetes medicines, like Invokana and Forxiga, work and how safe they are for older people with type 2 diabetes. The main goal is to see if these medicines help control blood sugar without causing dangerously low levels.
Italy - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase Ilb, Randomized, Double-blind, Placebo controlled and Open-label Active Comparator Study to Evaluate the Efficacy, Safety, and Tolerability of AZD5004 in Adults with Type 2 Diabetes Mellitus
This study is looking at a new medicine called AZD5004 for adults with Type 2 Diabetes. Researchers want to see how well it lowers blood sugar (HbA1c) and if it's safe, compared to a widely used medicine (Rybelsus) or a dummy pill.
Hungary · Germany · Poland - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase I Randomized, Single-center, Double-blind, Two-period Crossover Trial to Evaluate Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Insulin GZR4 Compared with Insulin Icodec in Participants with Type 2 Diabetes.
This study is testing a new type of insulin, called Insulin GZR4, against another insulin, Insulin Icodec, for people with type 2 diabetes. We want to see how they work in the body, if they are safe, and if people can tolerate them well. It's an early-stage study.
Germany - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Study to Investigate the Response of Participants With Type 2 Diabetes Mellitus on Once-Weekly Retatrutide to Hypoglycemia
This study is looking at how a new weekly medicine called Retatrutide affects people with type 2 diabetes, specifically how their bodies handle low blood sugar levels. It's an early-stage study to understand how this medicine works in people.
Austria - authorisedTherapeutic use (Phase IV)
Impact of GLP1-RAs on inflammation and endothelial biomarkerS in Type 2 diABetes meLlitus patiEnts: STABLE-GLP1 trial.
This study looks at how a diabetes medicine, semaglutide, affects inflammation and blood vessel health in people with Type 2 diabetes. We want to see if adding semaglutide to regular treatment helps reduce harmful effects in the body compared to standard treatment alone.
Italy - ongoing, recruitingPhase I and Phase II (Integrated)- Other
A single-center pilot study to establish a novel hypoglycemic clamp procedure to assess the time to spontaneous recovery from hypoglycemia in people with and without diabetes
This study looks at how people with and without type 2 diabetes recover from low blood sugar. Researchers use a special method to see how much insulin is needed to lower blood sugar and how long it takes for it to naturally return to normal after becoming very low.
Austria - recruitingPhase IV
Initiation and management of DExcom continuous glucose monitoring in primary care in people living with type 2 diabetes on insulin
This study looks at how a glucose monitoring system (Dexcom ONE+) works in UK GP practices for people with type 2 diabetes on insulin. It aims to see if it helps manage blood sugar and fits into routine care.
United Kingdom · England · Ireland