- Ongoing, recruitingTherapeutic use (Phase IV)
Pulmonary REsistance modification under treatment with Sacubitil/valsartaN in paTients with HeartFailure with reduced ejection fraction
This study looks at how a drug called Entresto affects blood pressure in the lungs and how easily blood flows through them, in people with a type of heart failure where the heart struggles to pump blood.
For: Heart Failure with reduced ejection fraction.Poland - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1b Trial of ARV-471 in Combination with Everolimus in Patients with ER+, HER2– Advanced or Metastatic Breast Cancer
This study is testing a new combination of two drugs, ARV-471 and Everolimus, for advanced breast cancer that has specific characteristics (ER+, HER2-). Doctors want to find the safest dose and see how well patients tolerate this new treatment. It's an early-stage study.
For: HER2– Advanced or Metastatic Breast CancerSpain - Ongoing, recruitingTherapeutic use (Phase IV)
An Interventional, Prospective Open-Label Study of Immunosuppressive Therapies to Mitigate Immune-Mediated Loss of Therapeutic Response to Asfotase Alfa (STRENSIQ®) for Hypophosphatasia (RESTORE)
This study looks at ways to help a medicine called Asfotase Alfa (STRENSIQ®) work better for people with Hypophosphatasia. Sometimes the body fights this medicine, so the study tests other treatments to stop that and improve how well the medicine works.
For: HYPOPHOSPHATASIAFrance - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Danish trial of beta blocker treatment after myocardial infarction without reduced ejection fraction (DANBLOCK)
This study, called DANBLOCK, is looking into whether common heart medications called beta-blockers help people who have had a heart attack but whose heart is still pumping well. It aims to see if these medications can prevent future heart problems and improve overall health.
For: Myocardinal infarctionDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Allogeneic stem cell transplantation vs. conventional therapy as salvage therapy for relapsed / progressive patients with multiple myeloma after a first-line therapy
This study compares a special stem cell treatment to standard care for people with multiple myeloma that has come back or worsened after their first treatment. It aims to see which approach helps people live longer and feel better over five years.
For: multiple myelomaGermany - AuthorisedTherapeutic exploratory (Phase II)
Randomized, controlled, double-blind trial to investigate the effect of colchicin on the endothelial function in patients with CHIP mutations and chronic heart failure with reduced left ventricular function (CHIP-HF)
This study looks at whether a medicine called colchicine can help people with a specific type of heart failure. It compares colchicine to a dummy pill to see impacts on blood vessel health, especially in those with certain genetic changes.
For: Chronic heart failureGermany - AuthorisedPhase III and phase IV (Integrated)
Evaluation of a New Pain Management Regime for Oocyte Pick-Up During Fertility Treatment
This study looks at new ways to manage pain during the egg collection procedure for women having IVF. Researchers want to find out if different medications can make this part of fertility treatment more comfortable and effective.
For: Acute procedural pain associated with oocyte pick-up (oocyte retrieval) in women undergoing IVF/ART.Belgium - AuthorisedTherapeutic use (Phase IV)
The efficacy of pipamperone and aripiprazole on behaviors that challenge in people with intellectual disabilities: A series of N-of-1 cross-over trials
This study looks at how well two medicines, pipamperone and aripiprazole, help people with learning disabilities manage challenging behaviours. It compares how people are doing with and without these medicines to see if they make a positive difference.
For: Behaviors that challengeNetherlands