- Ongoing, recruitingTherapeutic confirmatory (Phase III)
Rapid rEcognition of COrticosteroid Resistant or sentive Sepsis - RECORDS A Multicentre Concealed‐Allocation Multi-arms Blinded Randomized Controlled Trial to Identify the Best Sepsis Population for Corticotherapy
This study, called RECORDS, is looking for better ways to treat serious infections (sepsis) in intensive care. It's comparing different steroid medicines, like hydrocortisone and betamethasone, to see which works best for patients and helps them recover faster.
For: Patients admitted to the ICU proven or suspected infection as the main diagnosis.France - Ongoing, recruitingTherapeutic confirmatory (Phase III)
HORNbILL. HydrOcortisone and fludRocortisoNe for critical ILLness-related corticosteroid insufficiency
This study looks at treating very unwell patients in intensive care who have a problem with their stress hormones. Researchers are testing if giving certain hormone medicines helps patients get off breathing machines and blood pressure support more quickly. It aims to improve recovery for those with this specific condition.
For: Critically ill patients suffering from CIRCIFrance - AuthorisedTherapeutic confirmatory (Phase III)
Prolonged corticosteroid therapy in scheduled cardiac surgery in intermediate/high-risk patients: a prospective multicenter randomized controlled double-blind placebo-controlled study
This study is looking at whether giving certain steroid medicines before and after heart surgery in people with higher risks helps prevent problems like kidney failure or lung issues. It aims to see if these medicines are safe and effective.
For: high /medium risk cardiac surgery · acute renal failureFrance - AuthorisedTherapeutic exploratory (Phase II)
PALETTE - Adaptive platform trial for personalisation of sepsis treatment in children and adults: a multi-national, treatable traits-guided, adaptive, exploratory, bayesian basket trial
This study is looking for better ways to treat sepsis in adults. It's testing several existing medicines to see if any work well for different types of sepsis. The main goals are to improve survival and help patients recover without needing machines to support their bodies.
For: SepsisFrance - Ongoing, recruitingTherapeutic exploratory (Phase II)
A 12-Week, Phase 2 Open-Label, Sequential Dose Cohort Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of CRN04894 Treatment in Participants with Congenital Adrenal Hyperplasia
For: CONGENITAL ADRENAL HYPERPLASIAGermany · Italy - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER, ADAPTIVE PHASE III TRIAL TO INVESTIGATE EFFICACY AND SAFETY OF VILOBELIMAB IN THE TREATMENT OF ULCERATIVE PYODERMA GANGRENOSUM
For: ulcerative pyoderma gangrenosumBelgium · Hungary · Poland