AuthorisedTherapeutic exploratory (Phase II)Interventional

PALETTE - Adaptive platform trial for personalisation of sepsis treatment in children and adults: a multi-national, treatable traits-guided, adaptive, exploratory, bayesian basket trial

This research, called PALETTE, is a study designed to find better ways to treat sepsis in adults. Sepsis is a very serious condition where the body's response to an infection damages its own tissues and organs. The study is testing several different existing medications, such as Interferon Gamma and Tocilizumab, to see if they can help patients with sepsis. Researchers are trying to figure out if certain medicines work better for specific types of sepsis, almost like finding the right key for a lock. The main things they want to find out are whether these treatments can prevent deaths and help people get better without needing life support machines, like breathing machines, within 28 days.

At a glance

Status

Authorised

Phase

Therapeutic exploratory (Phase II)

Sponsor

Assistance Publique Hopitaux De Paris

Enrolment target

2,000

Start

24 Nov 2025

Sepsis

What is this study about?

Sepsis is an emergency where your body has an extreme reaction to an infection. It can cause organ failure and even be life-threatening. Finding the right treatment quickly is really important, but it can be difficult because not all people with sepsis are the same, and what works for one person might not work for another.

This study, called PALETTE, is designed to look at existing medicines to see if some of them could be particularly helpful for certain people with sepsis. Think of it like trying different keys to unlock a door – some might fit better or work more effectively for different types of sepsis. The researchers want to understand if these medicines can help people recover better and faster.

The main aims of this study are to help more people survive sepsis and to reduce the time they might need machines to help them breathe, or support their heart and kidneys. They're also looking at how quickly people can get back to their normal activities and how their quality of life is affected in the longer term.

Key takeaways

Tests existing medicines for sepsis.
Aims to improve survival and reduce need for life support.
Open to adults aged 18 and older with sepsis.
Involves receiving a new medication alongside standard care.
Looks at long-term recovery and quality of life.

Who may be eligible?

This study is open to adults who are 18 years old or older. You could be considered for this study if you have been diagnosed with sepsis.

There might be specific health conditions or other medications you're taking that could mean this study isn't right for you. The study doctors will carefully check all your health information to make sure it's safe and appropriate for you to take part.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Have you been diagnosed with sepsis?
Are you able to provide consent (or have someone legally able to do so for you)?
Are you willing to have your health monitored over several years?

Answer every question to see your result.

What does participation involve?

If you join the study, you would receive one of the medicines being tested, in addition to the standard care you would already be getting for sepsis. The study team would regularly check on your health and progress. This would involve doctors and nurses looking at how you are recovering, how long you might need life support (like breathing or kidney machines), and how well you are doing over time. This follow-up will continue for several years after you leave the hospital, including checking on your survival rates at 90 days, 1 year, and even 3 years after entering the study. They will also ask about your quality of life and how well you can do your daily activities after you recover.

Potential risks and benefits

Taking part in any medical study has potential benefits and risks. You might benefit from receiving a treatment that could be more effective for your specific type of sepsis than standard care alone. However, there's also a chance that the treatment might not work or could have side effects, as all medications do. The study doctors will monitor you very closely for any side effects. You are always free to leave the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
France

Common questions

What is sepsis?

Sepsis is a life-threatening condition where your body's immune system overreacts to an infection, causing damage to its own tissues and organs.

What kind of medicines are being tested?

The study is testing several existing medicines, such as Interferon Gamma, Tocilizumab, and others, to see if they can improve outcomes for people with sepsis.

What does 'life-supportive therapies' mean?

These are machines or treatments that help your body function when it can't do so on its own, like breathing machines for your lungs or dialysis for your kidneys.

Will I still get my usual sepsis treatment?

Yes, if you join the study, you will receive standard sepsis care in addition to one of the study medications being tested.

How long does the study follow-up last?

The study will follow your health and recovery for a long time, including checking in with you up to three years after you started the study.