- RecruitingPHASE1, PHASE2
A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)
This study is testing a new drug, neladalkib, for advanced cancers that have a specific genetic change called ALK rearrangement. It's looking at how safe the drug is and if it shrinks tumours in people with certain types of lung cancer and other solid tumours.
For: Locally Advanced Solid Tumor · Metastatic Solid TumorUnited States · Australia · Belgium - RecruitingPHASE1, PHASE2
A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors
This study is testing a new treatment called BNT326, sometimes with other medicines, for people with advanced cancers. It aims to see if these treatments are safe, how well they work, and what dose is best.
For: Advanced Solid TumorUnited States · Australia · Belgium - Active not recruitingPHASE1, PHASE2
First in Human Study of Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia
This study is testing a new drug called ziftomenib for people with a type of blood cancer called acute myeloid leukaemia (AML) that has come back or not responded to previous treatments. It's the first time this drug is being used in people.
For: Advanced Malignant Neoplasm · Acute Myeloid Leukemia · Mixed Lineage LeukemiaUnited States · Belgium · Canada - RecruitingPHASE1
Investigating the Effect of Itraconazole on the Pharmacokinetics of AZD4144 in Healthy Participants
This study is looking at how a new medicine, AZD4144, moves through the body of healthy volunteers. We want to see if another medicine, itraconazole, changes how AZD4144 works. This helps us understand how to use AZD4144 safely in the future.
For: HealthyUnited Kingdom - RecruitingPHASE1
A Drug-drug Interaction Study to Assess the Effect of Phenytoin and Itraconazole on the Pharmacokinetics of Pelabresib in Healthy Participants
This study looks at how a new medicine, pelabresib, interacts with two common drugs, phenytoin and itraconazole, in healthy people. We want to understand how these drugs affect pelabresib's levels in the body and check for safety.
For: Healthy ParticipantsUnited Kingdom