- Ongoing, recruitingTherapeutic exploratory (Phase II)
Subcutaneous Methotrexate, Oral Dexamethasone or Oral Montelukast for the Prevention of Infusion Related Reaction Associated with Amivantamab, an EGFR-MET bispecific antibody, Among Post-osimertinib Treated EGFRm NSCLC; SKIPPirr, a Phase 2 Study
This study looks at ways to prevent infusion reactions in people with advanced lung cancer receiving a new combination of medicines. Researchers are testing different medications given before treatment to see if they can reduce side effects when the main cancer drug is given through a drip.
For: EGFR-mutated Advanced or Metastatic Non-small Cell Lung CancerFrance · Spain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2 Randomized, Double-blind, Placebo-controlled, Dose-ranging, Efficacy and Safety study of SAR441566 plus Methotrexate in Adults with Moderate to Severe Rheumatoid Arthritis
This study is testing a new medicine, SAR441566, for people with moderate to severe rheumatoid arthritis who are already taking methotrexate. It aims to see if the new medicine helps reduce arthritis symptoms and if it's safe to use. Patients will either get the new medicine or a dummy medicine.
For: Rheumatoid arthritisSlovakia · Czechia · Germany - Active not recruitingPHASE3
A Study to Compare the Response to Treatment With Abatacept vs Adalimumab, on Background Methotrexate, in Adults With Early, Seropositive, and Shared Epitope-positive Rheumatoid Arthritis and an Inadequate Response to Methotrexate
This study compares two treatments, abatacept and adalimumab, for adults with early, severe rheumatoid arthritis who haven't responded well to methotrexate. It aims to see which treatment is better at reducing arthritis symptoms and improving quality of life.
For: Rheumatoid ArthritisUnited States · Argentina · Australia - RecruitingPHASE2
A Clinical Study of Tulisokibart (MK-7240) to Treat Rheumatoid Arthritis (RA) (MK-7240-014)
This study is testing a new medicine, tulisokibart, for people with rheumatoid arthritis (RA) whose current treatment with methotrexate isn't enough. Researchers want to see if this new medicine, given in different doses, can reduce RA symptoms better than a dummy medicine.
For: Arthritis, RheumatoidUnited States · Canada · Chile - Recruiting
Mind and Skin - the Neurocutaneous Axis in Atopic Eczema
This study, called 'Mind and Skin,' looks at how severe eczema affects the brain, mental health, and thinking abilities in young people aged 12-18. It examines links between inflammation, itching, disturbed sleep, and how new eczema treatments might help.
For: Atopic DermatitisUnited Kingdom - Active not recruiting
Observing Young Patients With Ependymoma Undergoing Standard Combination Chemotherapy
This study looks at how young children with a type of brain tumour called ependymoma respond to standard chemotherapy. It also checks for long-term side effects to help doctors improve treatment for them in the future.
For: Brain and Central Nervous System Tumors · Cognitive/Functional Effects · Long-term Effects Secondary to Cancer Therapy in ChildrenUnited Kingdom - AuthorisedTherapeutic confirmatory (Phase III)
Comparison of neurocognitive outcome in two standard regimen for treatment of low-risk medulloblastoma (COGNITO-MB)
This study compares different standard treatments for a type of childhood brain cancer called medulloblastoma. It looks at how these treatments affect children's thinking and learning abilities, also known as neurocognitive outcome, over time.
For: newly diagnosed · non-metastatic · SHH-activatedFrance · Denmark · Germany - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2a Multicenter, Randomized, Double Blind, Parallel-group, Proof of Concept Study Evaluating the Efficacy and Safety of Nipocalimab and Certolizumab Combination Therapy in Subjects with Active Rheumatoid Arthritis despite Prior Treatment with Advanced Therapies (bDMARD or tsDMARD)
This study is looking at a new combination of two medicines, nipocalimab and certolizumab (Cimzia), for adults with rheumatoid arthritis that hasn't improved with other strong treatments. We want to see if this combination helps reduce symptoms and is safe after 12 weeks.
For: Rheumatoid ArthritisGermany · Poland · Hungary - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2b Multicenter, Randomized, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of JNJ-77242113 for the Treatment of Moderately to Severely Active Ulcerative Colitis
This study is testing a new medicine, JNJ-77242113, for people in the UK with moderate to severe ulcerative colitis. We want to see if it helps reduce symptoms and if it's safe compared to a dummy pill.
For: Ulcerative ColitisCzechia · Spain · Poland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
CO-THEIA (COMBINATION THERAPY WITH METHOTREXATE AND ADALIMUMAB FOR UVEITIS): EFFICACY, SAFETY AND COST-EFFECTIVENESS OF METHOTREXATE, ADALIMUMAB, OR THEIR COMBINATION IN NON INFECTIOUS NON ANTERIOR UVEITIS: A MULTICENTER, RANDOMIZED, PARALLEL 3 ARMS, ACTIVE-CONTROLLED, PHASE 3 OPEN LABEL WITH BLINDED OUTCOME ASSESSMENT STUDY.
This study looks at new ways to treat a serious eye condition called non-infectious uveitis. It compares a combination of two medicines, methotrexate and adalimumab, to using each medicine alone, to see which works best and is safest for patients.
For: Non-infection uveitisSpain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase II, Multicenter Induction Study with an Active Treatment Extension to Evaluate the Efficacy, Safety, and Pharmacokinetics of Vixarelimab in Patients with Moderate to Severe Ulcerative Colitis
This study is testing a new drug, called Vixarelimab, for adults with moderate to severe ulcerative colitis. It aims to see how well it works to reduce symptoms and improve the gut, as well as checking its safety and how the body handles it.
For: Ulcerative Colitis (UC)Belgium · Germany · France - Ongoing, recruitingTherapeutic exploratory (Phase II)
Efficacy and Tolerance of the Combination of Methotrexate and Phototherapy Versus Phototherapy in Adults With Progressive Vitiligo: a Randomized Doubleblind Prospective Study - METVI
This study is testing a new combination treatment for progressive vitiligo, a skin condition causing white patches. It compares light therapy alone with light therapy plus a different medicine called methotrexate. Researchers want to see if the combination works better to reduce the white patches.
For: Vitiligo with new lesions or extension of old lesions during the last 6 monthsFrance - AuthorisedPhase II and Phase III (Integrated)
An International Prospective Study in Children Older than 3 to 5 Years with Clinically Standard-Risk Medulloblastoma with Low-Risk Biological Profile (PNET 5 MB – LR and PNET 5 MB – WNT-HR), average-risk biological profile (PNET 5 MB -SR), or TP53 mutation, and registry for MB ocurring in the context of genetic predisposition
This study is for children aged 3-18 with a type of brain tumour called medulloblastoma. It looks at different ways to treat the tumour, including various chemotherapy drugs, to find the most effective and safest options for different types of medulloblastoma, aiming to improve chances of recovery and quality of life.
For: MedulloblastomaSpain · Netherlands · Czechia - AuthorisedTherapeutic use (Phase IV)
A multicenter, randomized, open-label, blinded-assessor, phase 4 study in patients with early rheumatoid arthritis to compare active conventional therapy versus three biologic treatments, and two de-escalation strategies in patients who respond to treatment.
This study looks at different ways to treat early rheumatoid arthritis, comparing standard treatments with newer biologic medicines. It also explores if medicine doses can be lowered for people who are getting better, aiming to find the most effective and safe long-term approaches.
For: Rheumatoid ArthritisIceland · Denmark · Norway - RecruitingPHASE3
Cardiac Sarcoidosis Randomized Trial
This study compares two treatments for Cardiac Sarcoidosis: a standard dose of Prednisone (a steroid) versus a lower dose of Prednisone combined with Methotrexate. The aim is to find out if the combination treatment is just as effective but causes fewer side effects and improves quality of life.
For: Cardiac Sarcoidosis · SarcoidosisUnited States · Canada · Japan - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Placebo-Controlled, Double-Blind, Parallel Group, Phase 3 Study to Evaluate the Efficacy and Safety of Subcutaneous CT-P13 in Patients with Moderately to Severely Active Rheumatoid Arthritis
This study is looking at a new medicine called CT-P13 for adults with moderate to severe rheumatoid arthritis. Researchers want to see if it helps reduce symptoms and is safe to use. Some people will get the new medicine, and others will get a dummy medicine to compare.
For: Rheumatoid arthritisPoland - AuthorisedTherapeutic exploratory (Phase II)
Prospective Phase II study on Safety and Efficacy of Fludarabine plus Treosulfan (14g) (FT14) conditioning regimen for allogeneic Stem Cell Transplantation (allo-SCT) in Acute Myeloid Leukemia (AML) patients (≥40 <65years)
This study is looking at a new way to prepare people with acute myeloid leukaemia (AML) for a stem cell transplant. It's testing a combination of medicines (Fludarabine and Treosulfan) to see if it's safe and effective for adults aged 40 to 65.
For: Acute Myeloid Leukemia (AML)Italy - AuthorisedTherapeutic confirmatory (Phase III)
LEISURE : Lenalidomide vs methotrexate in difficult-to-treat cutaneous lupus erythematosus (LEISURE trial): An assessor-blinded randomized clinical trial
This study, called LEISURE, is looking at two medicines, methotrexate and lenalidomide, to see which works best for people with severe skin lupus. Doctors want to see if these treatments can significantly reduce skin problems caused by lupus.
For: Cutaneous lupus erythematosusFrance - AuthorisedTherapeutic confirmatory (Phase III)
International Study for Treatment of Childhood Relapsed Precursor B-Cell ALL 2020 - A Randomized Phase III Study Conducted by the Resistant Disease Committee of the International BFM Study Group - IntReALL BCP 2020
This study looks at new ways to treat children with a type of blood cancer called B-cell acute lymphoblastic leukaemia, which has come back after earlier treatment. It compares different drug combinations to find the most effective and safest options for them.
For: Relapsed Acute Lymphoblastic Leukemia (ALL)Netherlands · Czechia · Italy