- Ongoing, recruitingTherapeutic confirmatory (Phase III)
Risk-benefit analysis of intrathecal morphine administration to patients undergoing surgical treatment of proximal femoral fracture (monocentric, single-blinded, randomized clinical study compared to standard treatment)
This study looks at how well a strong painkiller called morphine, given during surgery, helps people with a broken hip bone. It compares it to standard pain relief to see if it reduces pain and side effects.
For: proximal femur fractureCzechia - Ongoing, recruitingTherapeutic use (Phase IV)
Determining the clinical relevance of the interaction between enzalutamide and the opioid morphine and the DOAC edoxaban to improve rational pharmacological care of patients with prostate cancer
This study looks at how a prostate cancer drug, enzalutamide, might affect other medicines like morphine (for pain) and edoxaban (a blood thinner). The aim is to make sure patients get the best and safest care when taking these drugs together.
For: Prostate cancerNetherlands - Ongoing, recruitingTherapeutic use (Phase IV)
Midazolam and mORPHine to alleviate symptoms at the End of life in patients on acUte geriatric wardS (MORPHEUS study)
The MORPHEUS study looks at how well two medicines, morphine and midazolam, help make older patients in their last days of life more comfortable. Researchers are checking the doses used, how they're given, and any side effects like sickness or restlessness, to improve care at this difficult time.
For: Symptom treatment in the last days of life of geriatric patientsBelgium - AuthorisedPhase III and phase IV (Integrated)
Echo-guided scalp blocks and incidence of postoperative pain in scheduled supratentorial intracranial surgery - ULTRASCALP
This study, called ULTRASCALP, is looking at how well a special type of pain relief, given before brain surgery, helps manage pain afterwards. It aims to see if blocking nerves with ultrasound guidance can reduce the need for strong painkillers and severe pain.
For: supratentorial intracranial surgery with flap creationFrance - AuthorisedTherapeutic confirmatory (Phase III)
MAMI Use of the Methoxyflurane as pain-killer in the prehospital management of Acute Myocardial Infarction
This study is looking at how well two different pain medicines, Penthrox (a liquid you breathe in) and morphine, reduce chest pain in people having a heart attack. It wants to see which one works faster and better before they reach the hospital.
For: Acute Myocardial InfarctionFrance