- Ongoing, recruitingTherapeutic exploratory (Phase II)
A 12-Month, Randomized, Controlled, Open-Label, Dose Escalation Study Evaluating Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of an Anti-CD2 Monoclonal Antibody, TCD601(siplizumab) Compared to Anti-Thymocyte Globulin (rATG), as Induction Therapy in de novo Renal Transplant Recipients
This study looks at a new medicine called TCD601 (siplizumab) for people who have recently had a kidney transplant. It compares TCD601 to a standard treatment to see if it's safe and how well it helps prevent the body from rejecting the new kidney.
For: Renal TransplantationSweden · Spain · Austria - Ongoing, recruitingTherapeutic use (Phase IV)
Duration of peripheral nerve blocks in opioid tolerant individuals - A volunteer blinded matched case-control study
This study looks at how long special pain-blocking injections work in people who regularly use strong painkillers. It compares a pain-numbing medicine to see if it lasts longer in these individuals after an operation.
For: Postoperative painDenmark - Ongoing, recruitingTherapeutic use (Phase IV)
The GOBLET trial: A clinical trial on GOblet cell density after Benzalkonium chloride and preservative-free Latanoprost Eye drop Treatment
This study looks at how different eye drops for glaucoma and high eye pressure affect special cells in your eyes called goblet cells. Doctors want to see if one type of drop is kinder to your eye's surface than another, which could make treatment more comfortable.
For: Ocular hypertension · Primary open angle glaucomaDenmark - Ongoing, recruitingPhase III and phase IV (Integrated)
The effect of combining lidocaine and ropivacaine on the duration and onset time of an ultrasound-guided infraclavicular brachial plexus nerve block. A randomized controlled trial
This study looks at how well a mix of two pain medications, lidocaine and ropivacaine, works for hand surgery. Researchers want to see if combining them makes the numbing effect last longer and start quicker for patients.
For: Patients undergoing hand surgery for antebrachial fractures or arthroplasty/alloplasty of a thumb base joint in the handDenmark - AuthorisedTherapeutic use (Phase IV)
Methadone versus fentanil and oxycodone for post-operative pain reduction in patients undergoing coronary artery bypass grafting and/or valve surgery – a placebo-controlled, double-blind, randomized clinical trial
This study looks at different pain medicines (methadone, fentanyl, and oxycodone) after heart surgery. It wants to find out which one best reduces pain and limits the amount of strong pain relief needed, aiming for fewer problems and a better recovery for patients.
For: Following heart surgery · patients experience poor postoperative pain control and a moderate/high opioid consumptions. This is correlated to adverese events and poor outcome.Denmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Comparison of cocaine, lidocaine/xylometazoline and saline for intranasal analgesia - A blinded triple crossover study
This study is comparing different medicines (cocaine, a mix of lidocaine and xylometazoline, and salt water) given inside the nose to help reduce discomfort during a medical procedure where a breathing tube is put through the nose. It's looking at how much pain people feel.
For: Nasotracheal intubationDenmark - Ongoing, recruitingTherapeutic use (Phase IV)
A blinded randomized study of neostigmine/glycopyrrolate 50 mikrogram/kg or sugammadex 2 mg/kg for reversal of neuromuscular blockade in elderly patients (≥ 75 years)
This study looks at how well two common medicines help older patients (over 75) wake up after keyhole surgery using a robot. We're checking which medicine helps them recover fastest and if they have any problems afterwards.
For: Anaesthesia to laparoscopic robotassisted surgeryDenmark - Ongoing, recruitingPhase III and phase IV (Integrated)
The effect of the Popliteal Plexus Block on the motor function of the leg - a randomized, controlled, blinded study in volunteers
This study looks at how a type of pain relief, called a popliteal plexus block, affects leg movement after knee surgery. Researchers want to see if different pain medications used in the block change how well people can move their ankles after the procedure.
For: Acute post surgical pain after knee surgeryDenmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
Intraoperative clonidine for postoperative pain management in patients undergoing spine surgery: a prospective, randomized, blinded, placebo-controlled trial
This study looks at whether a drug called clonidine, given during spine surgery, can help reduce the amount of strong pain relief (opioids) people need right after their operation. It aims to make recovery more comfortable for patients with back problems.
For: Degenerative spine diseasesDenmark - Ongoing, recruitingTherapeutic use (Phase IV)
Effect of ultrasound guided lateral infraclavicular brachial plexus block with Lidocaine or Ropivacaine for closed reduction of distal radius fractures - A randomized controlled non-inferiority trial
This study looks at two types of numbing medicine (Lidocaine or Ropivacaine) used for reducing broken wrists. Researchers want to see if one is as good as the other in quickly numbing the area using ultrasound guidance, to help set the bone without surgery.
For: Distal radius fractures with need of acute closed reductionDenmark - AuthorisedTherapeutic exploratory (Phase II)
Local Antibiotic Delivery for Community Acquired Pneumonia (LANDCAP 2)
This study is looking at new ways to treat pneumonia, a serious chest infection. We want to see if delivering antibiotics directly to the lungs, or using different antibiotics, helps people recover faster and spend less time in hospital. It's a key step in finding better treatments.
For: Community-acquired pneumoniaDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Prospective, Open-Label, Multicenter Randomized Phase III Study to Compare the Efficacy and Safety of a Combined Regimen of Venetoclax and Obinutuzumab Versus Fludarabine, Cyclophosphamide, and Rituximab (FCR)/ Bendamustine and Rituximab (BR) in FIT Patients with previously untreated Chronic Lymphocytic Leukemia (CLL) without DEL(17P) or TP53 Mutation
This study compares two treatments for newly diagnosed Chronic Lymphocytic Leukemia (CLL). It looks at how well a combination of venetoclax and obinutuzumab works against standard treatments (FCR/BR) to reduce tiny amounts of cancer cells and improve overall health.
For: Chronic Lymphocytic Leukemia (CLL)Spain · France · Italy - Ongoing, recruitingTherapeutic use (Phase IV)
LOW-DOSE DOBUTAMINE INFUSION AND SINGLE-DOSE TOCILIZUMAB IN ACUTE MYOCARDIAL INFARCTION PATIENTS WITH HIGH RISK OF CARDIOGENIC SHOCK DEVELOPMENT (DOBERMANN) - A 2X2 MULTIFACTORIAL, DOUBLE-BLINDED, RANDOMIZED, PLACEBO-CONTROLLED TRIAL
This study, called DOBERMANN, looks at new ways to help patients who have had a heart attack and are at high risk of a serious complication called cardiogenic shock. It tests two medicines to see if they can improve recovery and reduce risks.
For: Acute Myocardial Infarction with increased risk of Cardiogenic ShockDenmark - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
KANDOVA - A two-part Phase Ib/IIa study to evaluate the safety and tolerability of KAND567, in combination with carboplatin therapy, and to determine the Recommended Phase II Dose (RPIID) of KAND567. An open-label, multicenter dose escalation study with an expansion cohort in women with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer.
This study is looking at a new medicine called KAND567, given alongside standard carboplatin chemotherapy, for women with ovarian, fallopian tube, or primary peritoneal cancer that has come back. It aims to see how safe it is and find the best dose.
For: Recurrent epithelial ovarian · fallopian tube · or primary peritoneal cancer.Denmark · Norway · Sweden - Ongoing, recruitingTherapeutic use (Phase IV)
Steroids and/ or Non-steroidal Anti-inflammatory Drugs in the Postoperative Regime After Trabeculectomy. (SNAP)
This study looks at how different eye drops (steroids and anti-inflammatory drugs) affect eye pressure after glaucoma surgery. It aims to find the best way to keep eye pressure low for patients who’ve had an operation to treat their glaucoma.
For: Medically uncontrolled glaucoma that requires filtration surgery.Denmark - AuthorisedTherapeutic exploratory (Phase II)
A randomized, double-blind crossover study to investigate the analgesic efficacy of the bradykinin (B2) antagonist icatibant for propofol injection pain in healthy adult participants.
This study is looking for healthy adults to test a new medicine idea, icatibant, to see if it can reduce the stinging pain sometimes felt when having an injection of propofol, a medicine used for sleep during medical procedures.
For: PainNorway - AuthorisedHuman Pharmacology (Phase I)- Other
Intraperitoneal treatment with fosfomycin, metronidazole and recombinant human granulocyte-macrophage colony-stimulating factor in patients with multi-quadrant peritonitis undergoing abdominal surgery: A randomized placebo-controlled trial (TRIPLE)
This study is testing new treatments for a serious tummy infection called peritonitis. It aims to see if a mix of medicines given during surgery can help patients recover better and reduce problems like further infections or needing more surgery. Researchers want to find the best way to help people get well.
For: peritonitisDenmark