oplossing voor injectie clinical trials
14 indexed studies · 0 currently recruiting
- Ongoing, recruitingTherapeutic confirmatory (Phase III)
Fentanyl effect on ventilatory pattern under sham postsurgical conditions – an exploratory study in healthy men and women – the FAME study
This study, called FAME, is looking at how a pain medicine called fentanyl affects breathing in healthy adults. Researchers want to understand its effects better to improve safety, especially after operations. It's a key step in understanding how this medicine works.
For: none · healthy subjectsNetherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Influencing Progression of Airway Disease in Primary Antibody Deficiency
This study looks at people with primary antibody deficiency to see if a higher dose of immunoglobulin (Ig) replacement therapy can slow down lung problems. We'll compare lung changes over two years using scans and other health measures. This could help improve treatment for these conditions.
Netherlands - AuthorisedPhase III and phase IV (Integrated)
A randomised, controlled, assessor-blind, parallel groups, multicentre, multinational trial comparing the ovarian response after controlled ovarian stimulation with mixed protocols of follitropin delta (REKOVELLE) and highly purified human menopausal gonadotropin (MENOPUR) in women undergoing an assisted reproductive technology programme
This study is looking at two different hormone medicines, Rekovelle and Menopur, used in fertility treatments like IVF. Researchers want to see which one helps women produce more good-quality eggs. It aims to improve chances of pregnancy for women needing fertility help.
For: Infertility in women undergoing assisted reproductive technologies (ART) such as an in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) cycleItaly · Spain - Ongoing, recruitingPhase III and phase IV (Integrated)
L-NAC for reversal of opioid-induced respiratory depression
This study is looking at a medicine called L-NAC to see if it can help people who have breathing problems after receiving strong pain medication like fentanyl. It aims to find out if L-NAC can help them breathe more easily and safely. Participants will be healthy volunteers.
For: none · healthy subjects onlyNetherlands - Ongoing, recruitingTherapeutic exploratory (Phase II)
Comparison of multiple doses of intramuscular versus intranasal naloxone for reversal of opioid toxicity
This study looks at how well different ways of giving naloxone work to reverse the effects of strong painkillers (opioids) in healthy volunteers. Researchers are comparing injections to a nasal spray to see which is most effective and how many doses are needed.
For: Healthy volunteersNetherlands - AuthorisedTherapeutic use (Phase IV)
High versus low dose serratus anterior plane block after minimally invasive valve surgery: a double-blinded randomized controlled trial
This study looks at different doses of a pain-numbing injection given after heart valve surgery. It aims to see which dose best helps control pain and reduces the need for strong pain medicines, helping patients recover more comfortably.
For: Serratus anterior plane block after an aortic valve replacementBelgium - AuthorisedTherapeutic confirmatory (Phase III)
APECS II: Comparing the efficacy of Pectoral Nerve (PECS II) Block with long-acting liposomal bupivacaine versus levobupivacaine for Mastectomy Surgery: A Multicenter Prospective Randomized Controlled Trial
This study compares two pain medications given during breast cancer surgery (mastectomy) to see which one works better at reducing pain afterwards. It aims to find out if a newer, longer-lasting pain relief注射 (injection) is more effective than a standard one for managing pain in the breast.
For: Postoperative and chronic pain after breast cancer surgeryNetherlands - Ongoing, recruitingTherapeutic use (Phase IV)
Efficacy of Intrathecal Morphine for Postoperative Analgesia with or without Suprainguinal Fascia Iliaca Block After Total Hip Arthroplasty: A Double-Blind Randomized Clinical Trial
This study looks at how well different pain relief methods work after hip replacement surgery, focusing on a strong painkiller given near the spine, sometimes with another pain relief injection. It aims to find the best way to manage pain and help people recover quickly.
For: Total hip arthroplasty under spinal anesthesiaBelgium - AuthorisedTherapeutic confirmatory (Phase III)
Perioperative versus adjuvant FOLFIRINOX for resectable pancreatic cancer: the PREOPANC-3 study
This study looks at treating pancreatic cancer with strong chemotherapy (FOLFIRINOX) either before or after surgery. Researchers want to see if giving it before surgery helps people live longer. It's for adults with pancreatic cancer that hasn't spread and can be removed by surgery.
For: Non-metastatic resectable pancreatic cancerNetherlands · Sweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
THE (COST)EFFECTIVENESS OF NEOADJUVANT FOLFIRINOX VERSUS NEOADJUVANT GEMCITABINE BASED CHEMORADIOTHERAPY AND ADJUVANT GEMCITABINE FOR (BORDERLINE) RESECTABLE PANCREATIC CANCER (PREOPANC-2 STUDY)
This study looks at two different ways to treat pancreatic cancer that can or might be surgically removed. It compares using a specific combination of powerful medicines before surgery to another powerful medicine combined with radiation before surgery, followed by more medicine. The main goal is to see which treatment helps people live longer.
For: non-metastatic (borderline) resectable pancreatic cancerNetherlands - Ongoing, recruitingTherapeutic use (Phase IV)
(ROAR) Reversal of opioid-induced respiratory depression with opioid antagonists - a pharmacokinetic pharmacodynamic modeling study in opioid naïve individuals and chronic opioid users under real-life conditions
This study looks at how medicines called opioid antagonists can reverse breathing problems caused by strong painkillers (opioids). We're testing these medicines in healthy people and those who use opioids, to understand how quickly and effectively they work to help breathing.
For: healthy volunteers · opioid use disorderNetherlands - AuthorisedTherapeutic use (Phase IV)
Head-to-Head Comparison of the Efficacy and Safety of All Commercially Available Botulinum Neurotoxin Type A Products for the Treatment of Glabellar Rhytides: A Multicenter, Triple-Blind, Randomized Controlled Trial
This study is comparing different anti-wrinkle injections to see how well they work and how safe they are for treating frown lines between the eyebrows. It's looking at how long the effects last for real patients.
For: Glabellar frown rhytides (wrinkles).Netherlands - AuthorisedTherapeutic use (Phase IV)
Rapid sequence emergence of general Anaesthesia
This study looks at how quickly people wake up after a general anaesthetic. It compares different medicines used to help you recover quickly, checking when you can breathe on your own and how alert you become.
For: General anesthesiaNetherlands - AuthorisedTherapeutic use (Phase IV)
Intrathecal drug delivery systems versus comprehensive medical management for severe cancer pain: a randomized controlled trial
This study compares different ways to manage severe ongoing cancer pain. It looks at whether special pain pumps (intrathecal drug delivery) work better than standard medical care to improve quality of life for people with cancer.
For: Severe refractory cancer painBelgium