Radiation Therapy clinical trials
26 indexed studies · 10 currently recruiting
- Active not recruitingPHASE3
Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial)
This study looks at the best treatment for women with a common type of early breast cancer. It compares hormone therapy alone against hormone therapy plus chemotherapy, using a special test to help decide which is best for each woman.
For: Breast Adenocarcinoma · Hormone Receptor Positive · Stage IA Breast Cancer AJCC v7United States · Australia · Canada - Active not recruitingPHASE1
A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer
This study is testing a new drug, AZD1390, alongside standard radiation for brain cancer. It's the first time AZD1390 has been given to patients. The main goal is to check its safety and how the body handles it, especially when combined with different types of radiation.
For: Recurrent Glioblastoma Multiforme · Primary Glioblastoma Multiforme · Brain Neoplasms, MalignantUnited States · Japan · United Kingdom - RecruitingPHASE2
A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)
This study looks at combining nivolumab, an immunotherapy drug, with chemotherapy and then radiation for young people with nasopharyngeal cancer. Researchers want to see if this new treatment can fight the cancer effectively, understand its side effects, and potentially reduce radiation for children.
For: Stage II Nasopharyngeal Carcinoma AJCC v8 · Stage III Nasopharyngeal Carcinoma AJCC v8 · Stage IV Nasopharyngeal Carcinoma AJCC v8United States · Canada · New Zealand - Active not recruitingPHASE3
Immunotherapy (Nivolumab or Brentuximab Vedotin) Plus Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III-IV Classic Hodgkin Lymphoma
This study compares two immunotherapy drugs (nivolumab or brentuximab vedotin) when used with chemotherapy for newly diagnosed, advanced Hodgkin lymphoma. It aims to see which combination works best at shrinking the cancer and keeping it away.
For: Ann Arbor Stage III Hodgkin Lymphoma · Ann Arbor Stage III Lymphocyte-Depleted Classic Hodgkin Lymphoma · Ann Arbor Stage III Mixed Cellularity Classic Hodgkin LymphomaUnited States · Canada · Puerto Rico - RecruitingNA
Treatment of Brain AVMs (TOBAS) Study
The TOBAS Study is looking into the best ways to treat brain AVMs, whether they've caused bleeding or not. Doctors are comparing surgery, radiation, embolization, or simply watching to see which treatments work best to prevent serious problems like stroke.
For: Unruptured Brain Arteriovenous Malformation · Ruptured Brain Arteriovenous Malformation · Arteriovenous MalformationsUnited States · Brazil · Canada - Active not recruitingPHASE3
Phase III Trial of Anaplastic Glioma Without 1p/19q Loss of Heterozygosity (LOH)
This study looks at treating a type of brain tumour called anaplastic glioma. It compares standard radiation treatment with adding a drug called temozolomide. Researchers want to see if adding temozolomide during or after radiation helps people live longer and improves their quality of life.
For: Brain and Central Nervous System TumorsUnited States · Australia · Belgium - Active not recruitingPHASE3
RT or No RT Following Chemotherapy in Treating Patients With Stage III/IV Hodgkin's Disease
This study looks at whether adding radiation after chemotherapy helps people with advanced Hodgkin's disease. Researchers want to see if this combination prevents the disease from coming back or helps people live longer, compared to chemotherapy alone.
For: LymphomaBelgium · Egypt · France - RecruitingNA
ISRT 20 Gy for Indolent Localized Gastrointestinal (GI)-Lymphoma
This study looks at a gentler radiation treatment for a certain type of stomach or gut lymphoma. We want to see if a lower dose is just as good as the usual dose for shrinking the lymphoma and improving patients' lives.
For: Follicular Lymphoma (Gastric or Duodenal) · Marginal Zone Lymphoma (Gastric or Duodenal)Germany - Active not recruiting
Re-irradiation of Recurrent Head and Neck Cancer
This study looks at using a special type of radiation, called proton therapy, for head and neck cancer that has come back in an area already treated with radiation. We're checking how safe it is and how well it controls the cancer, hoping it causes fewer side effects.
For: Head-and-neck CarcinomaGermany - RecruitingNA
Partial Breast Re-irradiation for Breast Cancer
This study looks at a new type of radiation using protons for women who've had breast cancer come back in the same breast after earlier treatment. It checks how safe this new method is and if it causes fewer skin problems.
For: Breast CancersGermany - Active not recruitingPHASE3
Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Hodgkin's Lymphoma
This study looks at different chemotherapy treatments, with or without radiation, for Hodgkin's lymphoma. Researchers want to find the best way to treat this cancer, making sure treatments are effective while reducing side effects.
For: LymphomaBelgium · France · Italy - Active not recruitingPHASE3
Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk Rhabdomyosarcoma
This study looks at new ways to treat a type of cancer called rhabdomyosarcoma. It compares standard chemotherapy with chemotherapy plus a drug called temsirolimus, for patients whose cancer has an average chance of coming back. Researchers want to see if adding temsirolimus helps more.
For: Alveolar Rhabdomyosarcoma · Botryoid-Type Embryonal Rhabdomyosarcoma · Embryonal RhabdomyosarcomaUnited States · Australia · Canada - Active not recruitingPHASE3
Two Studies for Patients With Unfavorable Intermediate Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a Higher Gene Risk Score, The Guidance Trial
This study looks at new ways to treat prostate cancer that hasn't spread but is at medium risk of doing so. It uses a gene test to decide if less or more intense treatment might be better, hoping to reduce side effects or improve outcomes.
For: Prostate AdenocarcinomaUnited States · Canada - Active not recruitingPHASE3
Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK-3475-756/KEYNOTE-756)
This study looks at a new drug, pembrolizumab, for early-stage breast cancer. It's for people with a specific type of breast cancer (ER+/HER2-). Researchers want to see if adding pembrolizumab to standard chemotherapy and hormone therapy works better than standard treatment alone.
For: Breast CancerUnited States · Australia · Belgium - Active not recruitingPHASE2
Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer
This study looks at different ways to combine radiation and chemotherapy before surgery for stage 2 or 3 bowel cancer. Doctors hope to shrink tumours, making surgery easier and more successful. It compares various treatment plans to see which works best.
For: Colorectal CancerUnited States · Canada - RecruitingPHASE2
Reducing Respiratory Symptoms of Pulmonary Irradiation in Interstitial Lung Disease
This study looks at new ways to help people with lung cancer and a lung condition called Interstitial Lung Disease (ILD) who are having radiotherapy. It tests if two medicines, NAC and a short course of steroids, can reduce breathing problems after treatment.
For: Lung Cancer · Interstitial Lung DiseaseCanada - Not yet recruitingPHASE2
Study of Radiation Therapy in Combination With Darolutamide + Degarelix in Intermediate Risk Prostate Cancer
This study looks at treating intermediate-risk prostate cancer with radiation and a new hormone therapy. It aims to see if adding the hormone therapy package (darolutamide + degarelix) works better than radiation alone, especially for certain men.
For: Prostate CancerCanada - Active not recruitingPHASE3
A Study to Compare Early Use of Vinorelbine and Maintenance Therapy for Patients With High Risk Rhabdomyosarcoma
This study looks at new ways to treat a type of cancer called rhabdomyosarcoma, which can be aggressive. We're testing if adding a drug called vinorelbine to standard treatment, and then using a 'maintenance' therapy, helps stop the cancer from coming back.
For: Alveolar Rhabdomyosarcoma · Botryoid-Type Embryonal Rhabdomyosarcoma · Embryonal RhabdomyosarcomaUnited States · Australia · Canada - Active not recruitingPHASE3
Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers
This study tests if a new drug, Triapine, added to usual chemotherapy and radiation, works better for advanced cervical or vaginal cancer than the usual treatment alone. It aims to see if this combination helps people live longer and stops cancer from coming back.
For: Advanced Vaginal Adenocarcinoma · Advanced Vaginal Adenosquamous Carcinoma · Advanced Vaginal Squamous Cell CarcinomaUnited States · Canada · Puerto Rico - Active not recruitingPHASE3
Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer
This study compares two ways of giving radiation therapy after breast cancer surgery. It's for women with certain types of stage 2 or 3 breast cancer who have had a mastectomy. The aim is to see if a shorter, stronger radiation treatment is as good, or better, at stopping cancer from coming back.
For: Ductal Breast Carcinoma · Invasive Breast Carcinoma · Lobular Breast CarcinomaUnited States · Canada - RecruitingPHASE3
Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma
This study is giving children and young adults with a type of soft tissue cancer called rhabdomyosarcoma new chemotherapy. It aims to see if less harsh treatment works for those with very low-risk cancer, and if standard treatment works well for others, while also studying patients with specific genetic changes.
For: Embryonal Rhabdomyosarcoma · Fusion-Negative Alveolar Rhabdomyosarcoma · Spindle Cell/Sclerosing RhabdomyosarcomaUnited States · Australia · Canada - Active not recruitingPHASE2
Radiation Therapy With or Without Olaparib in Treating Patients With Inflammatory Breast Cancer
This study looks at whether adding a drug called olaparib to standard radiation therapy helps women with inflammatory breast cancer. Olaparib aims to stop cancer cells from repairing themselves. Researchers want to see if this combination improves recovery and survival.
For: Breast Inflammatory CarcinomaUnited States · Canada · Puerto Rico - RecruitingPHASE3
JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer
This study compares two treatments for early-stage lung cancer: special radiation (SAbR) and a smaller surgery (sublobar resection). It aims to see if SAbR helps people live longer and healthier, especially those who might find full surgery too risky.
For: Non-Small Cell Lung CancerUnited States · Australia · Canada - RecruitingPHASE3
JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC
This study looks at a new treatment called JNJ-90301900 (NBTXR3) combined with standard radiation therapy, sometimes with cetuximab, for older patients with advanced head and neck cancer who can't have platinum chemotherapy.
For: Carcinoma, Squamous CellUnited States · Austria · Belgium - Active not recruitingPHASE2
A Study of GR1014 Cutaneous Gel for the Prevention of Skin Reactions Caused by Radiation Therapy for Breast Cancer
This study tests a new gel, GR1014-CG, to see if it can prevent skin irritation from radiation therapy for breast cancer. Women over 18, who have had breast surgery and need radiation, can join. It checks if the gel is safe and helps reduce redness or soreness.
For: Radiodermatitis; AcuteFrance · United Kingdom - Recruiting
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
The MOMENTUM Study is tracking how a new type of advanced radiotherapy, called MR-Linac, works for people with different cancers. It aims to see if this treatment improves survival, controls cancer better, and enhances quality of life by using highly precise radiation guidance.
For: Oncology · Breast Cancer · Prostate CancerUnited States · Australia · Belgium