- Recruiting
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
The MOMENTUM Study is tracking how a new type of advanced radiotherapy, called MR-Linac, works for people with different cancers. It aims to see if this treatment improves survival, controls cancer better, and enhances quality of life by using highly precise radiation guidance.
For: Oncology · Breast Cancer · Prostate CancerUnited States · Australia · Belgium - Active not recruitingPHASE3
Phase III Trial of Anaplastic Glioma Without 1p/19q Loss of Heterozygosity (LOH)
This study looks at treating a type of brain tumour called anaplastic glioma. It compares standard radiation treatment with adding a drug called temozolomide. Researchers want to see if adding temozolomide during or after radiation helps people live longer and improves their quality of life.
For: Brain and Central Nervous System TumorsUnited States · Australia · Belgium - RecruitingPHASE3
JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer
This study compares two treatments for early-stage lung cancer: special radiation (SAbR) and a smaller surgery (sublobar resection). It aims to see if SAbR helps people live longer and healthier, especially those who might find full surgery too risky.
For: Non-Small Cell Lung CancerUnited States · Australia · Canada - Active not recruitingPHASE3
Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial)
This study looks at the best treatment for women with a common type of early breast cancer. It compares hormone therapy alone against hormone therapy plus chemotherapy, using a special test to help decide which is best for each woman.
For: Breast Adenocarcinoma · Hormone Receptor Positive · Stage IA Breast Cancer AJCC v7United States · Australia · Canada - RecruitingPHASE3
JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC
This study looks at a new treatment called JNJ-90301900 (NBTXR3) combined with standard radiation therapy, sometimes with cetuximab, for older patients with advanced head and neck cancer who can't have platinum chemotherapy.
For: Carcinoma, Squamous CellUnited States · Austria · Belgium - Active not recruitingPHASE3
Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK-3475-756/KEYNOTE-756)
This study looks at a new drug, pembrolizumab, for early-stage breast cancer. It's for people with a specific type of breast cancer (ER+/HER2-). Researchers want to see if adding pembrolizumab to standard chemotherapy and hormone therapy works better than standard treatment alone.
For: Breast CancerUnited States · Australia · Belgium - RecruitingPHASE1
A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer
This study is testing a new drug, AZD1390, alongside standard radiation for brain cancer. It's the first time AZD1390 has been given to patients. The main goal is to check its safety and how the body handles it, especially when combined with different types of radiation.
For: Recurrent Glioblastoma Multiforme · Primary Glioblastoma Multiforme · Brain Neoplasms, MalignantUnited States · Japan · United Kingdom - Active not recruitingPHASE2
A Study of GR1014 Cutaneous Gel for the Prevention of Skin Reactions Caused by Radiation Therapy for Breast Cancer
This study tests a new gel, GR1014-CG, to see if it can prevent skin irritation from radiation therapy for breast cancer. Women over 18, who have had breast surgery and need radiation, can join. It checks if the gel is safe and helps reduce redness or soreness.
For: Radiodermatitis; AcuteFrance · United Kingdom