- RecruitingPHASE3
High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)
This study looks at new ways to treat high-risk neuroblastoma, a type of cancer, in children and young people. Researchers are testing different combinations of chemotherapy and radiation to find the most effective treatments to help patients live longer and healthier lives.
For: High-Risk Neuroblastoma · Patient With Insufficient Response ChemoimmunotherapyAustralia · Austria · Belgium - RecruitingPHASE1, PHASE2
FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma
This study, FaR-RMS, is for children and adults with a type of cancer called rhabdomyosarcoma. It's looking for better ways to treat both newly diagnosed and returning cancer, using different combinations of medicines and radiotherapy.
For: RhabdomyosarcomaAustralia · Austria · Belgium - Active not recruitingNA
Shortened High-dose Palliative Radiotherapy for Lung Cancer
This study looks at a shorter, more intense course of radiotherapy for advanced lung cancer. It compares a new, quicker treatment with the standard treatment to see if it's safe and works well to help manage symptoms.
For: Stage IV Lung CancerUnited Kingdom - RecruitingPHASE2
Organ Preservation With Durvalumab-based Immunotherapy in Combination With Chemoradiation as Definitive Therapy for Early Stage Esophageal Adenocarcinoma With Indication for Radical Surgery
This study looks at a new way to treat early oesophageal cancer using a combination of immunotherapy (durvalumab), chemotherapy, and radiotherapy. The aim is to help patients avoid major surgery, while still effectively treating their cancer.
For: Esophagus AdenocarcinomaGermany - Active not recruitingPHASE3
Trial of Laryngeal Preservation Comparing Induced CT Followed by RT vs CT Concomitant to RT
This study looks at treating a certain type of throat cancer with chemotherapy and radiotherapy to try and save the voice box. We're comparing two ways of giving chemotherapy to see which works better to keep the voice box working for longer.
For: Head and Neck Squamous Cell CarcinomaFrance - Active not recruitingPHASE1, PHASE2
Glioblastoma Treatment With Irradiation and Olaptesed Pegol (NOX-A12) in MGMT Unmethylated Patients
This study looks at new ways to treat a serious type of brain cancer called glioblastoma. It combines a new drug (olaptesed pegol) with standard treatments like radiotherapy, aiming to improve outcomes for patients where usual chemotherapy isn't expected to work as well.
For: GlioblastomaGermany - Active not recruitingPHASE3
A Study of Adding Apalutamide to Radiotherapy and LHRH Agonist in High-Risk Patients With Hormone-Sensitive Prostate Cancer
This study is looking at whether adding a drug called apalutamide to standard prostate cancer treatments (radiotherapy and hormone therapy) helps men with high-risk prostate cancer live longer without their cancer spreading. It compares the new combination to the standard treatment alone.
For: Prostatic NeoplasmsUnited States · Australia · Austria - Active not recruitingPHASE3
Chemo-radiotherapy Versus Radiotherapy in the Treatment of Salivary Glands and Nasal Tumors (IMRT or Protontherapy)
This study compares chemotherapy combined with radiotherapy against radiotherapy alone for certain head and neck cancers, like those in the salivary glands or nose. It aims to see if adding chemotherapy improves treatment results for these rare cancers.
For: HNSCCFrance - Active not recruitingPHASE2
A Trial Assessing the Effect of Pembrolizumab Combined with Radiotherapy in Patients with Relapsed, Refractory, Specified Stages of Cutaneous T-cell Lymphoma (CTCL) Mycosis Fungoides (MF)/Sezary Syndrome (SS)
This study is testing a new combination of treatments, pembrolizumab (an immunotherapy drug) and radiotherapy, for people with specific types of advanced skin lymphoma (CTCL, Mycosis Fungoides, or Sezary Syndrome) that have returned or not responded to previous treatments.
For: Cutaneous T Cell Lymphoma · Mycosis Fungoides/Sezary SyndromeUnited Kingdom - Active not recruitingPHASE2
Multimodality Treatment in Stage III Non-small Cell Lung Cancer (NSCLC)
This study looks at new ways to treat a type of lung cancer that can be removed by surgery. It combines standard chemotherapy with a new immunotherapy drug (durvalumab) and different types of radiation therapy to see if this mix works better.
For: Non-small Cell Lung Cancer · NSCLCGermany · Switzerland - Active not recruitingPHASE1
A Dose Finding Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed Glioblastoma in Combination With Standard of Care and in Recurrent Glioblastoma as a Single Agent.
This study looks at a new treatment called [177Lu]Lu-DOTA-TATE for glioblastoma, a type of brain tumour. It's testing different doses and how well it works, both on its own and with usual treatments, in people recently diagnosed or whose cancer has come back.
For: GlioblastomaUnited States · France · Portugal - RecruitingPHASE3
Study Evaluating the Efficacy and Safety of Darolutamide and Stereotactic Dose Escalated Radiotherapy in Patients With Localized Prostate Cancer and High-risk Features of Relapse
This study is testing new ways to treat prostate cancer that is considered high-risk. It combines a new drug called darolutamide and a special type of radiation therapy with standard treatments to see if they can better stop the cancer from spreading.
For: High Risk Prostate Carcinoma · Prostate CancerFrance · Martinique - Recruiting
Clinical Database of Safe Personalized Adjuvant Breast Radiotherapy Based on Individual Radiosensitivity
This study is looking at how to give breast cancer radiotherapy in a more personal way. It uses a special test to predict side effects, aiming to reduce problems like skin changes, while still treating the cancer effectively, especially for older women with certain types of breast cancer.
For: Breast CancerFrance - RecruitingPHASE3
Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0
This study is testing new medicines for a type of brain tumour called Diffuse Intrinsic Pontine Glioma (DIPG) and similar tumours (Diffuse Midline Gliomas in children and young people over 6 months old). It compares two drugs, Everolimus and ONC201, to see which works best.
For: Diffuse Intrinsic Pontine Glioma · Diffuse Midline Glioma, H3 K27M-Mutant · Diffuse Midline Glioma, H3K27-alteredDenmark · France · Spain - Active not recruitingPHASE1
Pembrolizumab in Muscle Invasive/Metastatic Bladder Cancer
This study looks at a new combination treatment for bladder cancer: the drug pembrolizumab and radiotherapy. It aims to see how safe and effective this combination is, and if different doses of pembrolizumab make a difference.
For: Invasive Bladder CancerUnited Kingdom - RecruitingPHASE2
Nivolumab in Children and Adults With Nasopharyngeal Carcinoma
This study is looking at adding a new drug called Nivolumab to standard chemotherapy for nasopharyngeal cancer. It aims to see if this combination helps more patients achieve a complete response, meaning the cancer is no longer detectable, especially when seen on scans.
For: Nasopharyngeal Carcinoma · Nasopharyngeal Cancer · Nasopharyngeal NeoplasmsGermany - Recruiting
Online Adaptive Stereotactic Body Radiotherapy for Localized Prostate Cancer (X-SMILE)
This study looks at a new way to deliver radiation therapy (SBRT) for prostate cancer, specifically for men who also have urinary issues or an enlarged prostate. It aims to see if this new approach, using weekly treatments guided by scans, is safe and effective.
For: Localized Prostate Carcinoma · Prostate Cancer (Adenocarcinoma) · Prostate HyperplasiaGermany · Switzerland - Active not recruitingPHASE1, PHASE2
AGuIX Nanoparticles With Radiotherapy Plus Concomitant Temozolomide in the Treatment of Newly Diagnosed Glioblastoma
This study looks at a new treatment for a type of brain cancer called glioblastoma. It combines standard treatments (radiotherapy and other medicine) with special ‘nanoparticles’ called AGuIX. The aim is to see if this new combination is safe and effective.
For: GlioblastomaFrance - RecruitingNA
Hyperthermia With Chemoradiotherapy in Rectal Cancer
This study looks at adding heat treatment (hyperthermia) to standard therapy for advanced bowel cancer (rectal cancer). It aims to see if this helps more people avoid surgery and improve recovery.
For: Rectal CancerGermany - Active not recruitingNA
Radiotherapy Omission in Low Risk Ductal in Situ Carcinoma Breast
This study looks at whether some women with a very early form of breast cancer, called DCIS, might not need radiotherapy after surgery. We're trying to find safe ways to avoid extra treatments for those who don't need them, using new biological tests alongside usual checks.
For: DCIS · Breast Cancer · Low Risk DCISFrance - Active not recruitingPHASE2
Radiation During Osimertinib Treatment: a Safety and Efficacy Cohort Study
This study looks at whether it's safe and effective to continue a lung cancer drug called osimertinib (Tagrisso) while also having radiotherapy. It focuses on people with a specific type of lung cancer that has a particular genetic change.
For: NSCLC · EGFR Positive Non-small Cell Lung Cancer · OligoprogressionGermany - RecruitingPHASE2
Trial of Combined Radiotherapy and Vertebroplasty for Patients With Painful Metastatic Spinal Lesions
This study looks at combining two treatments, radiotherapy and vertebroplasty, for people with painful spinal metastases (cancer that has spread to the spine). We want to see if this combination works better than radiotherapy alone to ease pain and protect the spine.
For: Spinal MetastasesCanada - Active not recruitingPHASE3
Trial Comparing Irradiation Plus Long Term Adjuvant Androgen Deprivation With GnRH Antagonist Versus GnRH Agonist Plus Flare Protection in Patients With Very High Risk Localized or Locally Advanced Prostate Cancer
This study looks at treating advanced prostate cancer with radiation and hormone therapy. It compares two types of hormone therapy to see which is better at stopping the cancer from growing, spreading, or coming back.
For: Prostate CancerBelgium · Denmark · France - RecruitingPHASE1
A Platform Study of Novel Agents in Combination With Radiotherapy in NSCLC
This study looks at combining radiotherapy with new drugs to treat non-small cell lung cancer that hasn't spread widely. Researchers want to find the safest and most effective dose of these new drugs, which help radiotherapy work better by making it harder for cancer cells to repair themselves.
For: Non Small Cell Lung CancerUnited Kingdom - Not yet recruitingPHASE3
A Phase III Randomised Control Clinical Trial of Radiotherapy With Radiosensitisation Versus Intravesical Bacillus Calmette-Guerin Therapy for High-risk Non-muscle Invasive Bladder Cancer.
This study compares two ways to treat high-risk bladder cancer that hasn't spread: standard BCG therapy (a medicine put into the bladder) versus a combination of radiotherapy and a special drug to make it work better. It aims to find a more effective and reliable treatment.
For: High-Risk Non-Muscle Invasive Bladder CancerUnited Kingdom - Active not recruitingPHASE3
CompARE: Escalating Treatment of Intermediate and High-risk Oropharyngeal Cancer (OPC)
The CompARE trial is testing new treatments for a type of throat cancer called oropharyngeal cancer. It compares different ways of using radiotherapy, surgery, and immunotherapy to see if they improve survival and quality of life for adults with more advanced forms of this cancer.
For: Oropharyngeal CancerIreland · United Kingdom - Active not recruitingPHASE3
Induction Chemotherapy Plus Chemoradiation as First Line Treatment for Locally Advanced Cervical Cancer
This study looks into adding a short course of chemotherapy (Paclitaxel and Carboplatin) before standard chemoradiation for women with locally advanced cervical cancer. The aim is to see if this extra step improves how long women live and if the cancer stays away.
For: Cervical CancerBrazil · India · Italy - Active not recruitingPHASE1
NG-350A Plus Chemoradiotherapy for Locally Advanced Rectal Cancer
This study is testing a new drug called NG-350A, given into a vein, alongside standard treatment (chemotherapy and radiotherapy) for locally advanced bowel cancer in the back passage (rectum). It aims to see how safe and effective this combination is for adults.
For: Locally Advanced Rectal Cancer (LARC)United States · United Kingdom - RecruitingNA
Understanding the Feasibility of a Co-designed Pre-radiotherapy Exercise Programme - A Single-arm Study
This study looks at a new exercise plan for people with lung cancer having radiotherapy. Participants cycle for 20 minutes before treatment to see if it's helpful and safe. The goal is to make treatment easier for future patients.
For: Lung CancerUnited Kingdom - RecruitingNA
Partial Volume High-Dose Irradiation in Renal Cell Carcinoma for Intra-TUmoural Control ALongside Current Management
This study looks at a new way to give radiotherapy for kidney cancer, both when it's just in one place or has spread. It compares the usual treatment to a shorter, more intense course to see if it's safe and practical.
For: Renal Cell Carcinoma · Renal Cell Carcinoma MetastaticUnited Kingdom - Active not recruitingPHASE3
Study of Pembrolizumab (MK-3475) Versus Placebo in Participants With Esophageal Carcinoma Who Are Receiving Chemotherapy and Radiation Therapy (MK-3475-975/KEYNOTE-975)
This study looks at a new drug, pembrolizumab, for certain types of oesophageal cancer. It compares giving pembrolizumab alongside standard chemotherapy and radiotherapy with giving a dummy drug (placebo) with the same standard treatment. We want to see if the new drug can help people live longer or prevent the cancer from coming back.
For: Esophageal Squamous Cell Carcinoma (ESCC) · Gastroesophageal Junction Carcinoma (GEJC) · Esophageal Adenocarcinoma (EAC)United States · Argentina · Belgium