- RecruitingPHASE1
NG-350A Plus Chemoradiotherapy for Locally Advanced Rectal Cancer
This study is testing a new drug called NG-350A, given into a vein, alongside standard treatment (chemotherapy and radiotherapy) for locally advanced bowel cancer in the back passage (rectum). It aims to see how safe and effective this combination is for adults.
For: Locally Advanced Rectal Cancer (LARC)United States · United Kingdom - RecruitingNA
Partial Volume High-Dose Irradiation in Renal Cell Carcinoma for Intra-TUmoural Control ALongside Current Management
This study looks at a new way to give radiotherapy for kidney cancer, both when it's just in one place or has spread. It compares the usual treatment to a shorter, more intense course to see if it's safe and practical.
For: Renal Cell Carcinoma · Renal Cell Carcinoma MetastaticUnited Kingdom - Active not recruitingPHASE3
Induction Chemotherapy Plus Chemoradiation as First Line Treatment for Locally Advanced Cervical Cancer
This study looks into adding a short course of chemotherapy (Paclitaxel and Carboplatin) before standard chemoradiation for women with locally advanced cervical cancer. The aim is to see if this extra step improves how long women live and if the cancer stays away.
For: Cervical CancerBrazil · India · Italy - Not yet recruitingPHASE3
A Phase III Randomised Control Clinical Trial of Radiotherapy With Radiosensitisation Versus Intravesical Bacillus Calmette-Guerin Therapy for High-risk Non-muscle Invasive Bladder Cancer.
This study compares two ways to treat high-risk bladder cancer that hasn't spread: standard BCG therapy (a medicine put into the bladder) versus a combination of radiotherapy and a special drug to make it work better. It aims to find a more effective and reliable treatment.
For: High-Risk Non-Muscle Invasive Bladder CancerUnited Kingdom - RecruitingPHASE1, PHASE2
FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma
This study, FaR-RMS, is for children and adults with a type of cancer called rhabdomyosarcoma. It's looking for better ways to treat both newly diagnosed and returning cancer, using different combinations of medicines and radiotherapy.
For: RhabdomyosarcomaAustralia · Austria · Belgium - Active not recruitingPHASE3
CompARE: Escalating Treatment of Intermediate and High-risk Oropharyngeal Cancer (OPC)
The CompARE trial is testing new treatments for a type of throat cancer called oropharyngeal cancer. It compares different ways of using radiotherapy, surgery, and immunotherapy to see if they improve survival and quality of life for adults with more advanced forms of this cancer.
For: Oropharyngeal CancerIreland · United Kingdom - RecruitingPHASE1
A Platform Study of Novel Agents in Combination With Radiotherapy in NSCLC
This study looks at combining radiotherapy with new drugs to treat non-small cell lung cancer that hasn't spread widely. Researchers want to find the safest and most effective dose of these new drugs, which help radiotherapy work better by making it harder for cancer cells to repair themselves.
For: Non Small Cell Lung CancerUnited Kingdom - Active not recruitingNA
Shortened High-dose Palliative Radiotherapy for Lung Cancer
This study looks at a shorter, more intense course of radiotherapy for advanced lung cancer. It compares a new, quicker treatment with the standard treatment to see if it's safe and works well to help manage symptoms.
For: Stage IV Lung CancerUnited Kingdom - RecruitingPHASE3
High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)
This study looks at new ways to treat high-risk neuroblastoma, a type of cancer, in children and young people. Researchers are testing different combinations of chemotherapy and radiation to find the most effective treatments to help patients live longer and healthier lives.
For: High-Risk Neuroblastoma · Patient With Insufficient Response ChemoimmunotherapyAustralia · Austria · Belgium - Active not recruitingPHASE3
Study of Pembrolizumab (MK-3475) Versus Placebo in Participants With Esophageal Carcinoma Who Are Receiving Chemotherapy and Radiation Therapy (MK-3475-975/KEYNOTE-975)
This study looks at a new drug, pembrolizumab, for certain types of oesophageal cancer. It compares giving pembrolizumab alongside standard chemotherapy and radiotherapy with giving a dummy drug (placebo) with the same standard treatment. We want to see if the new drug can help people live longer or prevent the cancer from coming back.
For: Esophageal Squamous Cell Carcinoma (ESCC) · Gastroesophageal Junction Carcinoma (GEJC) · Esophageal Adenocarcinoma (EAC)United States · Argentina · Belgium - Active not recruitingPHASE3
Trial Comparing Irradiation Plus Long Term Adjuvant Androgen Deprivation With GnRH Antagonist Versus GnRH Agonist Plus Flare Protection in Patients With Very High Risk Localized or Locally Advanced Prostate Cancer
This study looks at treating advanced prostate cancer with radiation and hormone therapy. It compares two types of hormone therapy to see which is better at stopping the cancer from growing, spreading, or coming back.
For: Prostate CancerBelgium · Denmark · France - Active not recruitingPHASE1
Pembrolizumab in Muscle Invasive/Metastatic Bladder Cancer
This study looks at a new combination treatment for bladder cancer: the drug pembrolizumab and radiotherapy. It aims to see how safe and effective this combination is, and if different doses of pembrolizumab make a difference.
For: Invasive Bladder CancerUnited Kingdom - Active not recruitingPHASE2
A Trial Assessing the Effect of Pembrolizumab Combined with Radiotherapy in Patients with Relapsed, Refractory, Specified Stages of Cutaneous T-cell Lymphoma (CTCL) Mycosis Fungoides (MF)/Sezary Syndrome (SS)
This study is testing a new combination of treatments, pembrolizumab (an immunotherapy drug) and radiotherapy, for people with specific types of advanced skin lymphoma (CTCL, Mycosis Fungoides, or Sezary Syndrome) that have returned or not responded to previous treatments.
For: Cutaneous T Cell Lymphoma · Mycosis Fungoides/Sezary SyndromeUnited Kingdom - Not yet recruitingNA
Understanding the Feasibility of a Co-designed Pre-radiotherapy Exercise Programme - A Single-arm Study
This study looks at a new exercise plan for people with lung cancer having radiotherapy. Participants cycle for 20 minutes before treatment to see if it's helpful and safe. The goal is to make treatment easier for future patients.
For: Lung CancerUnited Kingdom