- RecruitingPHASE2
Combination of Spartalizumab, mDCF and Radiotherapy in Patients With Metastatic Squamous Cell Anal Carcinoma
This study looks at combining radiotherapy, chemotherapy, and a new anti-cancer drug (spartalizumab) for people with anal cancer that has spread. We want to see if this combination treatment is safe and effective in fighting the cancer.
For: Squamous Cell Anal Carcinoma · Metastatic Squamous Cell CarcinomaFrance - Enrolling by invitation
Sanger Human Cell Atlasing Project
This project aims to create a detailed map of all human cells, like a biological atlas. By understanding what makes each cell type unique, we hope to better understand how our bodies work, how diseases develop, and find new ways to diagnose and treat them. It's a big step towards future medicine.
For: Human Development · Genetic DiseaseUnited Kingdom - Enrolling by invitation
SMS 2: Impact of Cancer Therapy on the Somatic Mutational Landscape of Normal Tissues
This study looks at how cancer treatments, like chemotherapy or radiotherapy, affect tiny changes (mutations) in healthy body cells. We're collecting samples such as blood, cheek swabs, and urine from adult cancer patients to understand these changes better.
For: Somatic Mutation · CancerUnited Kingdom - Enrolling by invitation
SMS - Study of Somatic Mutations Using Genome Sequencing
This study looks at how changes in our genes, called mutations, build up over our lives. Researchers want to understand if things like sunlight, smoking, or medical treatments affect these changes, and how they relate to ageing and health. They will study DNA from different types of samples.
For: Somatic MutationUnited Kingdom - Enrolling by invitation
Exploring the Landscape of Somatic Mutations in Human Tissue
This study looks at tiny changes in the body's cells, called mutations, in both healthy and unhealthy tissues. Scientists want to understand how these changes happen and why some parts of the body are more likely to develop them, which could help prevent diseases like cancer.
For: Somatic MutationUnited Kingdom - Recruiting
Volatile Non-Invasive Biomarkers of Epileptic Seizures
This study looks for tiny molecules in breath and sweat after someone has a suspected seizure. The aim is to find a unique pattern that can help doctors tell the difference between epileptic seizures and other events, and potentially understand how severe a seizure was.
For: Epilepsy · Non-Epileptic SeizureUnited Kingdom - Enrolling by invitation
Investigating the Role of Genetics in Disease Predisposition
This study looks at how tiny changes in the sperm and eggs we inherit can affect our health, especially the risk of certain cancers and rare diseases in our children. Researchers want to understand where these changes come from and how they pass them on.
For: Predisposition, Genetic · Cancer · MutationUnited Kingdom - Enrolling by invitation
Exploring the Landscape of Injury and Repair in the Human Oesophagus
This study looks at tissue samples from people with oesophageal perforations to understand how the body repairs itself and why sometimes this healing process can go wrong, potentially leading to cancer. This could help us learn more about preventing cancer.
For: Perforations to the OesophagusUnited Kingdom - Enrolling by invitation
Investigating How Childhood Tumours and Congenital Disease Develop
This study aims to understand why some children develop certain diseases, like childhood tumours and conditions they are born with. Researchers will look closely at changes in our genetic information (DNA) to find out how these conditions develop from the very beginning of life.
For: Childhood Tumor · Congenital DisordersUnited Kingdom