solution pour perfusion clinical trials
27 indexed studies · 0 currently recruiting
- AuthorisedTherapeutic confirmatory (Phase III)
ASPAPY - Aspirin in acute pneumonia in the elderly: a multicenter, double-blind, randomized, placebo-controlled trial
This study is looking at whether aspirin can help older people with severe pneumonia. Researchers want to see if taking aspirin changes how many people die within 90 days after getting pneumonia, compared to a dummy drug.
For: acute pneumoniaFrance - Ongoing, recruitingTherapeutic confirmatory (Phase III)
INCMGA 0012-303: A Phase 3 Global, Multicenter, Double-Blind Randomized Study of Carboplatin-Paclitaxel With INCMGA00012 or Placebo in Participants With Inoperable Locally Recurrent or Metastatic Squamous Cell Carcinoma of the Anal Canal Not Previously Treated With Systemic Chemotherapy (POD1UM-303/InterAACT 2)
This study is testing a new medicine, retifanlimab, alongside standard chemotherapy for anal canal cancer that has spread or come back. Researchers want to see if this new combination helps patients live longer without their cancer getting worse, compared to chemotherapy alone.
For: Squamous Carcinoma of the Anal CanalGermany · France · Norway - AuthorisedTherapeutic exploratory (Phase II)
Phase II study to evaluate the efficacy of 12-month neoadjuvant chemotherapy in terms of disease-free survival in patients with localized digestive neuroendocrine carcinomas - NEONEC D19-01
This study is looking at how well a combination of chemotherapy medicines works before surgery for a specific type of cancer called neuroendocrine carcinoma. It aims to see if this treatment helps people stay cancer-free for longer.
For: Localized digestive Neuroendocrine CarcinomasFrance - Ongoing, recruitingTherapeutic exploratory (Phase II)
Dose Study of Tranexamic Acid in Total Hip Replacement to Reduce Postoperative Hemoglobin Loss. A Phase 2 Randomized Double-blind Monocentric Study. The PRADO study
This study looks at how different doses of a medicine called tranexamic acid can help reduce blood loss during and after hip replacement surgery. It aims to find the safest and most effective amount to use, helping patients recover better.
For: Arthropathy of HipFrance - Ongoing, recruitingTherapeutic exploratory (Phase II)
Multiple Part Clinical Trial of Brentuximab Vedotin in Classical Hodgkin Lymphoma Subjects
This study looks at new ways to treat Hodgkin lymphoma, a type of cancer that affects the immune system. Researchers are testing different combinations of medicines to see how well they work and if they are safe. The main goal is to see if these treatments can make the cancer go away completely.
For: Classical Hodgkin LymphomaSpain · Czechia · Italy - Ongoing, recruitingTherapeutic exploratory (Phase II)
C5691004 _ A dual-cohort, open-label, phase 2 study of brentuximab vedotin and CHP (A+CHP) in the frontline treatment of subjects with peripheral T-cell lymphoma (PTCL) with less than 10% CD30 expression
This study is testing a new way to treat a type of cancer called peripheral T-cell lymphoma (PTCL). Researchers want to see if combining a newer drug (brentuximab vedotin) with standard chemotherapy (CHP) works well for people with a specific type of PTCL.
For: Peripheral T-cell LymphomaSpain · Italy · France - Ongoing, recruitingTherapeutic use (Phase IV)
Randomized Multi-center Clinical Trial to Assess Effectiveness and Safety of Tirofiban Versus Intravenous Aspirin in Patients With Acute Ischemic Stroke Secondary to Tandem Injury, Subject to Recanalization Therapy Through Endovascular Treatment
This study is looking at two different medicines after treatment for a severe type of stroke. It compares a blood-thinning medicine called Tirofiban with aspirin to see which is safer and works better to prevent more problems after the stroke treatment.
For: Acute Ischemic StrokeSpain - Ongoing, recruitingTherapeutic exploratory (Phase II)
Evaluation of the benefit and safety of Localized Tissue Hydration (LTH) in the management of chronic common low back pain: Non-randomized single-center phase II study
This study is looking at a new treatment called Localized Tissue Hydration (LTH) for long-lasting lower back pain. It combines LTH with usual care to see if it helps reduce pain significantly after six months. We want to understand if it's safe and effective for people suffering from chronic back discomfort.
For: chronic common low back painFrance - Ongoing, recruitingTherapeutic use (Phase IV)
Perioperative oral analgesia versus intravenous analgesia for knee arthroscopy, a randomized, double-blinded, non-inferiority trial. OVIKA-trial - S68618
This study, called OVIKA, is looking at the best way to manage pain after a common knee operation. Researchers are comparing pain relief given through an IV drip with pain relief given as tablets to see if tablets work just as well for knee pain.
For: Postoperative pain relief after knee arthroscopyBelgium - Ongoing, recruitingTherapeutic exploratory (Phase II)
OPTIMUNE-LUNG : INTEGRATIVE ANALYSIS OF THE TUMOR MICROENVIRONMENT AND OPTIMIZATION OF THE IMMUNOTHERAPY DURATION IN NON-SMALL CELL LUNG CANCER PATIENTS
This study looks at how long immunotherapy works for people with advanced lung cancer and how it affects their bodies. We're testing different drug combinations to see which works best and for how long, to improve treatment plans.
For: Patients with locally advanced or metastasic Non-Small Cell Lung Carcinoma.France - Ongoing, recruitingTherapeutic exploratory (Phase II)
PhagoDAIR I : A Pilot, Multicenter, Randomized, Non Comparative, Double-Blind Study of Phage Therapy in Patients with Hip or Knee Prosthetic Joint Infection due to Staphylococcus aureus Treated with DAIR and Antibiotic Therapy.
This study looks at a new treatment called 'phage therapy' for hip or knee joint infections caused by *Staphylococcus aureus* (a common germ). It explores if adding phages to standard treatment (cleaning the joint and antibiotics) helps control the infection better.
For: knee or hip prosthetic joint infection (PJI) due to Staphylococcus aureus · with the indication of DAIR and Suppressive Antibiotics Therapy (SAT)France - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Does high-dose vitamin B3 supplementation prevent major adverse kidney events during septic shock? A multicenter randomized controlled study.
This study looks at whether a high dose of vitamin B3 can help prevent serious kidney problems in very sick patients called "septic shock." It compares vitamin B3 to a dummy treatment to see if it helps reduce deaths or the need for kidney dialysis.
For: adverse kidney events during septic shockFrance - Ongoing, recruitingPhase III and phase IV (Integrated)
Adjunctive DobutAmine in sePtic cardiomyopathy with Tissue hypoperfusion: a randomized controlled multi-center trial
This study looks at treating severe blood poisoning (sepsis) that affects the heart. It tests a drug called Dobutamine to see if it helps improve organ function in people whose hearts aren't pumping enough blood, leading to tissue damage.
For: sepsisFrance - AuthorisedTherapeutic use (Phase IV)
PTX3 genetically stratified randomized double-blinded allocation event-driven clinical trial for antifungal prophylaxis in patients with acute myeloid leukemia
This study looks at different medicines to prevent fungal infections in people with a type of blood cancer called acute myeloid leukaemia. It compares how well these medicines work over 6 months to keep people healthy.
For: Antifungal prophylaxis in patients with acute myeloid leukemiaBelgium · France - AuthorisedTherapeutic confirmatory (Phase III)
Comparison of Landiolol versus standard of care for prevention of mortality in patients hospitalized for a septic shock with hypercontractlity: an open label prospective randomized study
This study compares a new medicine called Landiolol with usual treatment for very sick patients in intensive care with a serious infection (sepsis) and a fast, overworking heart. It aims to see if Landiolol can improve survival at 28 days for these patients.
For: patients hospitalized for a septic shock with hypercontractlityFrance - AuthorisedPhase II and Phase III (Integrated)
Pilot study of the pharmacokinetic profile of paracetamol subcutaneously versus intravenously in patients in a palliative situation
This study is looking at how paracetamol works in the body when given in two different ways to people receiving palliative care. It aims to see if giving paracetamol under the skin is as effective as giving it into a vein for managing pain.
For: Adult patients (> 18 years of age) undergoing palliative care (defined by the WHO as active · comprehensive care given to patients whose condition does not respond to curative treatment) of their disease · able to communicateFrance - AuthorisedTherapeutic exploratory (Phase II)
Pulse corticosteroids or/and Immunoglobulins to treat fulminant Myocarditis: a double-blind randomized controlled adaptive trial (The CORIUM study)
This study looks at new ways to treat a serious heart condition called fulminant myocarditis. Researchers are testing if special medications, corticosteroids and immunoglobulins, can help patients recover better and quicker, focusing on improving heart function and survival.
For: Fulminant myocarditisFrance - AuthorisedTherapeutic confirmatory (Phase III)
ZAMBA: Zoledronic Acid for Modic Back Pain. A randomized, double blind, placebo-controlled, multicenter trial
This study, called ZAMBA, is looking at whether a medicine called zoledronic acid can help people with ongoing back pain. It compares this medicine to a dummy treatment (placebo) to see if it improves daily activities and pain levels over one year.
For: Low Back PainNorway - AuthorisedPhase I and Phase II (Integrated)- Other
Phase 1 (sequential)/2a (parallel), double-blind, multicenter, randomized, controlled study to evaluate the safety and immunogenicity of two administrations of OVX033 sarbecovirus candidate vaccine, given intramuscularly (IM) at one-month interval, at three dose levels, in comparison to placebo, in subjects aged 18 years and older
This study is testing a new vaccine called OVX033 for sarbecoviruses, which include viruses like the one that causes COVID-19. Participants aged 18 and over will receive the vaccine or a dummy injection, to see how safe it is and how well it helps their immune system fight off these viruses.
For: Sarbecoviruses diseaseFrance - AuthorisedTherapeutic exploratory (Phase II)
A Phase II Proof of Concept Multicenter, Randomized, Double-Blind Study to assess the safety and efficacy of Phage Therapy in Patients with Hip or Knee Prosthetic Joint Infection due to Staphylococcus aureus Treated by DAIR
This study is testing a new way to treat hip or knee joint infections caused by a common germ called Staphylococcus aureus. It's looking at whether using 'phage therapy' – a type of helpful virus – can safely and effectively clear these infections, especially when combined with a procedure to clean the joint.
For: Hip or Knee prosthetic joint infection due to Staphylococcus aureusSpain · Netherlands · France - Ongoing, recruitingTherapeutic exploratory (Phase II)
Phase 2b, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy, immunogenicity and safety of one dose of OVX836 influenza vaccine 480μg, after intramuscular administration in healthy subjects aged 18-59 years
This study is testing a new flu vaccine called OVX836 in healthy adults aged 18 to 59. We want to see how well it prevents the flu, if it's safe, and how the body reacts to it after just one shot. It's a careful study comparing the vaccine to a dummy treatment.
For: Influenza diseaseFrance · Finland · Belgium - AuthorisedPhase III and phase IV (Integrated)
Echo-guided scalp blocks and incidence of postoperative pain in scheduled supratentorial intracranial surgery - ULTRASCALP
This study, called ULTRASCALP, is looking at how well a special type of pain relief, given before brain surgery, helps manage pain afterwards. It aims to see if blocking nerves with ultrasound guidance can reduce the need for strong painkillers and severe pain.
For: supratentorial intracranial surgery with flap creationFrance - AuthorisedTherapeutic exploratory (Phase II)
PALETTE - Adaptive platform trial for personalisation of sepsis treatment in children and adults: a multi-national, treatable traits-guided, adaptive, exploratory, bayesian basket trial
This study is looking for better ways to treat sepsis in adults. It's testing several existing medicines to see if any work well for different types of sepsis. The main goals are to improve survival and help patients recover without needing machines to support their bodies.
For: SepsisFrance - AuthorisedTherapeutic exploratory (Phase II)
SYMBOL CLINICAL : Treatment of severe ocular chemical burns by subconjunctival injection of allogeneic mesenchymal stem cells: a multicentre, single-arm, open-label phase II trial
This study is looking at a new way to treat severe eye burns caused by chemicals. It uses special cells from donors, called mesenchymal stem cells, injected near the eye. Doctors want to see if this treatment can stop the eye from developing a hole in its surface.
For: Patient with severe eye chemical burnsFrance - AuthorisedTherapeutic confirmatory (Phase III)
A multicentre, double-blind, randomized controlled trial of inhaled amikacin versus placebo in critically ill patients with ventilator-associated tracheobronchitis (AMIVAT)
This study looks at a new way to treat lung infections in very sick patients on breathing machines. We want to see if an inhaled antibiotic, amikacin, can stop a mild infection from becoming more serious compared to a dummy treatment.
For: Patients with ventilator-associated tracheobronchitisFrance - AuthorisedTherapeutic confirmatory (Phase III)
Double blind, multicenter, randomized, controlled trial of dexmedetomidine vs placebo in premature neonates receiving invasive ventilation
This study is looking at a new medicine called dexmedetomidine for premature babies who need help breathing. It aims to see if this medicine can reduce the amount of strong pain relief (opioids) these tiny babies need while still keeping them comfortable.
For: Neonatal respiratory distress. Pain and discomfortFrance - AuthorisedTherapeutic confirmatory (Phase III)
Evaluation of the efficacy of iloprost in the management of vaso-occlusive crises in adult patients with sickle cell: a multicentre, randomised, double-blind, placebo-controlled study _ PROSTASICKLE
This study is testing if a drug called iloprost can help people with sickle cell anaemia during painful crises. It aims to see if iloprost can reduce the need for strong painkillers. This is a big study hoping to find a better way to manage these crises.
For: sickle cell anaemia with vaso-occlusive crisisFrance