tabletki clinical trials

Effects of single-pill combination of telmisartan/amlodipine and telmisartan/amlodipine/hydrochlorothiazide on 24-hour blood pressure (BP) reduction, 24-h BP variability and office BP control in patients with arterial hypertension – SATELLITE

This study looks at how new combination medicines affect high blood pressure over 24 hours. Researchers want to see how well these pills lower blood pressure and keep it steady throughout the day in people with high blood pressure.

COMPIS - Congenital myopathy intervention study. An open-label, cross over, randomized, controlled study using salbutamol

This study looks at a common asthma medicine, salbutamol (Ventolin), for people with congenital myopathy. It aims to see if salbutamol can improve muscle strength and daily activities over six months compared to not taking the medicine.

Long-term aspirin therapy as a predictor of decreased susceptibility to SARSCoV-2 infection in aspirin-exacerbated respiratory disease

This study looks at whether a special treatment for people with Aspirin-Exacerbated Respiratory Disease (AERD) can reduce their risk of getting COVID-19. They're testing if taking a particular type of aspirin long-term after initial desensitisation changes how certain genes work and makes you less likely to catch the virus.

The effects of 2-week long treatment with naproxen sodium (Nalgesin® Forte) on synovial fluid cytokine and naproxen concentration and clinical outcomes in patients with knee osteoarthritis – ZOOM-IN: A randomized, double-blind, placebo-controlled, parallel, multicenter clinical trial

This study is looking at how a pain relief medicine called naproxen (Nalgesin Forte) affects knee osteoarthritis over two weeks. Researchers are checking how it reduces inflammation and improves symptoms compared to a dummy pill (placebo).

Investigation of pregabalin therapy and complex rehabilitation in treating chronic fatigue associated with post-COVID syndrome

This study is looking into how a medicine called Preato and a special exercise programme might help people in the UK who have long-lasting tiredness (chronic fatigue) after having COVID-19. Researchers will check changes in tiredness and walking ability over six months.

A randomized, double blind, placebo-controlled, dose response, phase II, multicentre trial to evaluate the efficacy and safety of oral AP1189 administered at the doses of 40, 70, or 100 mg for 12 weeks in combination with methotrexate, in DMARD-naïve participants with early rheumatoid arthritis and active inflammation.

This study is testing a new tablet, AP1189, for people recently diagnosed with rheumatoid arthritis who haven't tried other strong medicines yet. It aims to see how well different doses of AP1189 lower inflammation and improve symptoms when taken with another common arthritis medicine.

A phase II efficacy and safety study of cell-free circulating tumor DNA-guided commencement of second-line treatment in patients with DLBCL/HGBCL relapse

This study looks at new ways to decide when to start a second treatment for certain types of lymphoma, using a blood test. It aims to see if this approach is safe and effective in helping patients.

SABINE - The efficacy and Safety of delayed-release Budesonide in children with primary IgA nephropathy - a multicenter, interventional phase III, randomized, placebo-controlled, double-blind study.

This study looks at a new way to treat a kidney condition called IgA nephropathy in children. It compares a special medicine (budesonide) with a dummy medicine (placebo) to see if it can help reduce protein in the urine and is safe.

Dehydroepiandrosterone (DHEA) as augmentation of standard antidepressants in treatment-resistant depression: a randomized controlled trial (DARE-Trial) - A multicenter, randomized, double-blind, placebo-controlled trial with group sequential design

This study is testing a new tablet called DHEA alongside usual antidepressant treatment for people with depression that hasn't improved with other treatments. Researchers want to see if DHEA helps reduce depression symptoms over six weeks and if it's safe to use.

Phase I study of CDK8 inhibitor RVU120 in combination with everolimus in children with recurrent or progressive Group 3 or 4 medulloblastoma; MEDWAY

This study, called MEDWAY, is looking at a new medicine, RVU120, alone and with another drug, everolimus. It's for children with a type of brain cancer called medulloblastoma that has come back or is getting worse. We want to find the safest dose and see how well it works.

A 2-stage, Adaptive, Randomised, Double-blind, Placebo-controlled, Multicentre Study to Evaluate Dose and Treatment Effect of Pentosan Polysulfate Sodium Compared with Placebo in Participants with Knee Osteoarthritis Pain

A randomized, open-label, single dose, cross-over bioavailability study evaluating the drug-drug interaction between Tritace 10, 10 mg, tablets and Tertensif SR 1.5 mg prolonged-release film-coated tablets when co-administered versus the administration of each product alone in two cohorts of healthy volunteers under fasting conditions. Sponsor's Study No.: RAM-IND-DDI-05-23