- RecruitingPHASE3
A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)
This study looks at a medicine called tirzepatide for teenagers aged 12-17 who are overweight and have related health problems. Researchers want to see if it helps with weight and heart health when combined with healthy eating and exercise.
For: Obesity · Weight GainUnited States · Argentina · Australia - RecruitingPHASE3
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)
This study looks at new medicines, retatrutide and tirzepatide, for adults with a type of fatty liver disease called MASLD. It aims to see if these drugs can help prevent serious liver problems. Some participants will receive a dummy drug (placebo) to compare.
For: Metabolic Dysfunction-Associated Steatotic Liver DiseaseUnited States · Argentina · Australia - Active not recruitingPHASE3
A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity
This study is looking at how a medication called Tirzepatide might help people living with obesity. Researchers want to see if it can reduce serious health problems and improve overall health in adults.
For: Obesity · OverweightUnited States · Argentina · Australia - Not yet recruitingPHASE3
A Study of EloraTZP in Adult Participants With Obesity Without Type 2 Diabetes
This study is looking into a new combination treatment called EloraTZP for adults living with obesity. It compares EloraTZP with other existing treatments and a dummy treatment (placebo) to see how safe and effective it is for helping people lose weight. It's for people without type 2 diabetes.
For: ObesityUnited States · Argentina · China - Not yet recruitingPhase II
Weight reduction in asthma programme with tirzepatide
This UK clinical study is testing whether a weekly weight-loss injection called tirzepatide can help improve asthma symptoms in adults living with overweight or obesity. Researchers want to see if losing weight and lowering inflammation can ease chest tightness, improve breathing, and reduce asthma flare-ups over one year.
For: Asthma with obesityUnited Kingdom · England - RecruitingPhase III
IIH-Advance: A randomised clinical trial to determine the effects of weight loss, induced by a weight loss drug (Tirzepatide), in adults with active idiopathic intracranial hypertension
This study looks at whether a weight loss drug, Tirzepatide, can help adults with a condition called Idiopathic Intracranial Hypertension (IIH). IIH causes high pressure in the head, leading to headaches and eye problems. We want to see if losing weight with this drug can improve these symptoms.
For: Idiopathic intracranial hypertensionUnited Kingdom · England · Northern Ireland - RecruitingPHASE3
Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
This study looks at combining two medicines, mirikizumab and tirzepatide, for adults with ulcerative colitis (UC) who are also overweight or obese. The goal is to see if this combination helps UC symptoms improve and also leads to significant weight loss.
For: Ulcerative Colitis · Obesity or OverweightUnited States · Austria · Belgium - Active not recruitingPHASE2
A Study to Assess Efficacy, Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7204239 in Combination With Tirzepatide in Participants With Obesity or Overweight With At Least One Weight-related Comorbidity
This study looks at a new medicine, RO7204239, combined with an existing medicine, tirzepatide, for adults who are overweight or have obesity. It aims to see if this combination helps with weight loss and is safe for people without diabetes.
For: Obesity · Overweight · Overweight With One Weight Related ComorbidityUnited States · Poland · Spain - RecruitingPHASE2, PHASE3
A Clinical Trial Using Tirzepatide to Help Adults With Type 1 Diabetes Automatically Control Their Blood Sugar
This study looks at whether a weekly medicine, tirzepatide, can help adults with type 1 diabetes manage their blood sugar more easily with an insulin pump, especially by reducing or removing the need to count carbs at meals.
For: Type 1 Diabetes · Type 1 Diabetes Mellitus · T1DCanada · Switzerland - RecruitingPHASE3
Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight
This study looks at new medicines, mirikizumab and tirzepatide, for adults with Crohn's disease who are also overweight or have obesity. It wants to see if these treatments are safe and if they help manage Crohn's symptoms and potentially aid weight management.
For: Crohn's Disease · Obesity or OverweightUnited States · Austria · Belgium - Active not recruitingPHASE3
A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin, SGLT2 Inhibitor or Both
This study looks at a new medicine called CagriSema to see how well it lowers blood sugar and helps with weight loss in people with type 2 diabetes. It's compared to another medicine called tirzepatide. Participants will get one of the medicines by chance.
For: Diabetes Mellitus, Type 2United States · Argentina · Australia - Active not recruitingPHASE2
A Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes
This study is looking into a new medicine called tirzepatide. It aims to see if tirzepatide can help people with kidney disease who are also overweight or living with obesity, whether or not they have type 2 diabetes.
For: Overweight · Obesity · Chronic Kidney DiseaseUnited States · Austria · Canada - Active not recruitingPHASE3
A Study of Retatrutide (LY3437943) Compared to Tirzepatide (LY3298176) in Adults Who Have Obesity
This study is looking at two medicines, Retatrutide and Tirzepatide, to see how well and safely they help adults with obesity lose weight. It's comparing them to understand which might be better for weight management.
For: ObesityUnited States · Argentina · Germany - RecruitingPHASE1, PHASE2
A Study to Evaluate ALN-2232 in Participants With Obesity
This study is looking at a new medicine called ALN-2232 for people living with obesity. It will check if the medicine is safe, how well it's tolerated, and if it helps with weight loss, both by itself and when taken with another medicine called tirzepatide.
For: ObesityCanada - Active not recruitingPHASE4
A Study of Tirzepatide Compared With Intensified Conventional Care in Adult Participants With Type 2 Diabetes
This study looks at a new treatment called tirzepatide for people with type 2 diabetes. It's compared to standard care to see how well it works and if it's safe when started early. The goal is to improve blood sugar control for those with type 2 diabetes.
For: Type 2 DiabetesUnited States · Argentina · Canada - Not yet recruitingPHASE4
DECODE - Haemodynamic Effects Of Semaglutide and Tirzepatide - a Series of Pilot Studies
This study looks at how new weight loss drugs, semaglutide and tirzepatide, affect blood vessels and blood pressure. Researchers want to understand if these drugs have direct benefits on the heart and blood system, beyond just helping people lose weight.
For: Cardiovascular DiseasesUnited Kingdom - RecruitingPHASE4
A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK)
This study looks at a new medicine called tirzepatide for adults with obesity but not diabetes. It compares it to standard care to see how well it helps with weight loss and if it can prevent type 2 diabetes over about five years.
For: ObesityUnited Kingdom - RecruitingNA
A Trial Within Cohort Feasibility Study Design Comparing Standard of Care Versus Weight Loss (Achieved Through Tirzepatide) for Obesity-related Hypertension in Young Adults
This study looks at how a new weight loss medicine, Tirzepatide, affects high blood pressure in young adults who are overweight or obese. We want to see if losing weight can help lower blood pressure more effectively than usual care.
For: Hypertension · Obesity & OverweightUnited Kingdom - RecruitingNA
Combination of Biologic and Anti-obesity Therapies in Psoriatic Arthritis
This study looks at how weight loss (using a medication called tirzepatide) or treatment with iksekizumab affects people with psoriatic arthritis who are also overweight or obese. It checks changes in their skin, joints, and fat.
For: Psoriatic Arthritis (PsA) · Obesity & OverweightUnited Kingdom