- RecruitingNA
Combination of Biologic and Anti-obesity Therapies in Psoriatic Arthritis
This study looks at how weight loss (using a medication called tirzepatide) or treatment with iksekizumab affects people with psoriatic arthritis who are also overweight or obese. It checks changes in their skin, joints, and fat.
For: Psoriatic Arthritis (PsA) · Obesity & OverweightUnited Kingdom - Active not recruitingPHASE3
A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity
This study is looking at how a medication called Tirzepatide might help people living with obesity. Researchers want to see if it can reduce serious health problems and improve overall health in adults.
For: Obesity · OverweightUnited States · Argentina · Australia - RecruitingPHASE3
A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)
This study looks at a medicine called tirzepatide for teenagers aged 12-17 who are overweight and have related health problems. Researchers want to see if it helps with weight and heart health when combined with healthy eating and exercise.
For: Obesity · Weight GainUnited States · Argentina · Australia - RecruitingPHASE3
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)
This study looks at new medicines, retatrutide and tirzepatide, for adults with a type of fatty liver disease called MASLD. It aims to see if these drugs can help prevent serious liver problems. Some participants will receive a dummy drug (placebo) to compare.
For: Metabolic Dysfunction-Associated Steatotic Liver DiseaseUnited States · Argentina · Australia - RecruitingPHASE4
A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK)
This study looks at a new medicine called tirzepatide for adults with obesity but not diabetes. It compares it to standard care to see how well it helps with weight loss and if it can prevent type 2 diabetes over about five years.
For: ObesityUnited Kingdom - Active not recruitingPHASE4
A Study of Tirzepatide Compared With Intensified Conventional Care in Adult Participants With Type 2 Diabetes
This study looks at a new treatment called tirzepatide for people with type 2 diabetes. It's compared to standard care to see how well it works and if it's safe when started early. The goal is to improve blood sugar control for those with type 2 diabetes.
For: Type 2 DiabetesUnited States · Argentina · Canada - Active not recruitingPHASE2
A Study to Assess Efficacy, Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7204239 in Combination With Tirzepatide in Participants With Obesity or Overweight With At Least One Weight-related Comorbidity
This study looks at a new medicine, RO7204239, combined with an existing medicine, tirzepatide, for adults who are overweight or have obesity. It aims to see if this combination helps with weight loss and is safe for people without diabetes.
For: Obesity · Overweight · Overweight With One Weight Related ComorbidityUnited States · Poland · Spain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
I8F-MC-GPHJ: A Phase 3b, Randomized Controlled Study to Evaluate the Efficacy and Safety of Tirzepatide Compared to Semaglutide 2.4 mg in Adults Who Have Obesity or Overweight with Weight-Related Comorbidities
This study is comparing two medicines, Tirzepatide and Semaglutide, to see which is more effective and safer for helping adults with obesity or overweight, who also have other health issues, to lose weight. It's looking at how much weight people lose and other health changes.
For: Obesity OverweightGermany · Belgium · Poland - Ongoing, recruitingTherapeutic use (Phase IV)
A Phase 4, Randomized, Open-Label, Active-Controlled Study to Investigate the Efficacy and Safety of Switching From Weekly Dulaglutide to Weekly Tirzepatide in Adults With Type 2 Diabetes
This study is looking at how well a new medicine, Tirzepatide, works for adults with type 2 diabetes when they switch from another medicine called Dulaglutide. Researchers want to see if the new medicine helps lower blood sugar and improve other health markers like weight.
For: Type 2 DiabetesRomania · Germany · Belgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
I8F-MC-GPGN: The Effect of Tirzepatide versus Dulaglutide on Major Adverse Cardiovascular Events in Patients with Type 2 Diabetes (SURPASS-CVOT)
This study compares two medicines, tirzepatide and dulaglutide, for people with type 2 diabetes. It looks at how well they protect against serious heart problems like heart attacks and strokes. It's a big, important study to confirm which medicine is better for your heart.
For: Type 2 Diabetes MellitusSlovakia · France · Hungary - Not yet recruitingPHASE4
DECODE - Haemodynamic Effects Of Semaglutide and Tirzepatide - a Series of Pilot Studies
This study looks at how new weight loss drugs, semaglutide and tirzepatide, affect blood vessels and blood pressure. Researchers want to understand if these drugs have direct benefits on the heart and blood system, beyond just helping people lose weight.
For: Cardiovascular DiseasesUnited Kingdom - RecruitingNA
A Trial Within Cohort Feasibility Study Design Comparing Standard of Care Versus Weight Loss (Achieved Through Tirzepatide) for Obesity-related Hypertension in Young Adults
This study looks at how a new weight loss medicine, Tirzepatide, affects high blood pressure in young adults who are overweight or obese. We want to see if losing weight can help lower blood pressure more effectively than usual care.
For: Hypertension · Obesity & OverweightUnited Kingdom - RecruitingPHASE3
Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
This study looks at combining two medicines, mirikizumab and tirzepatide, for adults with ulcerative colitis (UC) who are also overweight or obese. The goal is to see if this combination helps UC symptoms improve and also leads to significant weight loss.
For: Ulcerative Colitis · Obesity or OverweightUnited States · Austria · Belgium