RecruitingPHASE4INTERVENTIONAL

A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK)

This study, called SURMOUNT-REAL UK, is looking into a medication named tirzepatide for adults who are living with obesity and have at least one other weight-related health condition, but do not have diabetes. The researchers want to find out how well tirzepatide helps people lose weight and whether it can lower their risk of developing type 2 diabetes, compared to the usual care they might receive. This is a "real-world" study, meaning it aims to reflect how the treatment might work in everyday life. If you join, your participation would last for about five years.

At a glance

Status

Recruiting

Phase

PHASE4

Sponsor

Eli Lilly and Company

Enrolment target

3,000

Start

24 Nov 2025

Estimated completion

01 Jul 2032

Obesity

What is this study about?

This study is investigating a new medicine called tirzepatide for people in the UK who have obesity but do not have diabetes. Obesity is a condition where you have too much body fat, which can affect your health. The aim of this research is to see how well tirzepatide helps people reduce their weight and whether it can prevent them from developing type 2 diabetes. Type 2 diabetes is a long-term condition that causes a person's blood sugar level to become too high. The study will compare tirzepatide with the standard care that people would normally receive for obesity.

This is a 'real-world' study, which means it will look at how tirzepatide works in everyday life, outside of very strict trial conditions. By doing this, the researchers hope to get a better understanding of its effects for people living with obesity. Understanding whether tirzepatide can help with weight loss and prevent type 2 diabetes could offer new options for managing obesity and improving long-term health.

Taking part in this study would involve a commitment of about five years. During this time, researchers will closely monitor participants' health, weight, and blood sugar levels to see the effects of the treatments being studied. This kind of research is very important for finding new and better ways to help people manage their health conditions.

Key takeaways

This study is for adults with obesity who do not have diabetes.
It tests a new medicine called tirzepatide against standard care.
The main goals are to measure weight loss and prevent type 2 diabetes.
Participation will last for about five years.
You must have tried to lose weight with diet and exercise before.
You cannot have any type of diabetes to join.

Who may be eligible?

To be able to join this study, you need to be an adult (18 years or older) and have a body mass index (BMI) between 30 and 34.9. Your BMI is a number that tells you if your weight is healthy compared to your height. You also need to have a waist-to-height ratio greater than 0.5, which means your waist measurement should be less than half of your height.

Beyond these measurements, you must have at least one other health condition that is linked to your weight. You should also have tried to lose weight before through changes to your diet and physical activity.

However, you cannot join the study if you have any type of diabetes, including type 1 or type 2 diabetes. Also, if your weight has changed by more than 5 kilograms (about 11 pounds) in the 90 days before you were screened for the study, you would not be able to take part.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Is your BMI between 30 and 34.9?
Is your waist measurement less than half your height?
Do you have at least one other health condition related to your weight?
Have you tried to lose weight through diet and exercise?
Do you NOT have type 1 or type 2 diabetes?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you will be involved for about five years (approximately 260 weeks). You will either receive the study medication, tirzepatide, or be on standard care, which is the usual treatment for obesity. You will have regular visits to the clinic where the research team will monitor your health, check your weight, take blood samples to measure your blood sugar and other health markers, and ask you about your general well-being. The study will not only track your weight loss but also keep an eye on whether you develop type 2 diabetes. All visits, tests, and medication related to the study will be provided. You will be given clear instructions on what to do and when to attend these appointments.

Potential risks and benefits

Participating in this study might offer potential benefits, such as receiving a new medication that could help you lose weight and potentially reduce your risk of type 2 diabetes, with close medical supervision. However, like all medications, tirzepatide may have side effects, and it's possible you might not experience any direct benefit yourself. There could also be some risks associated with the assessments, such as blood tests, or from the medication itself. It's important to remember that you can stop taking part in the study at any time, for any reason, without it affecting your usual medical care.

Locations (30)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

P91604 St John's Medical Centre
Verified postcode
Altrincham, United Kingdom· Not yet recruiting
P89008 Ashton Medical Group
Verified postcode
Ashton-under-Lyne, United Kingdom· Recruiting
Y02319 SSP Bolton General Practice
Verified postcode
Bolton, United Kingdom· Not yet recruiting
P83012 Tower Family Healthcare
Verified postcode
Bury, United Kingdom· Not yet recruiting
P91014 Washway Road Medical Centre
Unverified
Cheshire, United Kingdom· Not yet recruiting
P88007 Cheadle Hulme Medical Group (was Cheadle Hulme Health Centre) (Bridge House)
Unverified
Cheshire, United Kingdom· Not yet recruiting
Y02790 SSP Bolton Medical Centre
Verified postcode
Great Lever, United Kingdom· Not yet recruiting
P89002 The Brooke Surgery
Unverified
Hyde SK14, United Kingdom· Recruiting
P84035 Bodey Medical Centre
Verified postcode
Manchester, United Kingdom· Recruiting
P84630 The Arch Medical Practice
Verified postcode
Manchester, United Kingdom· Recruiting
P84678 Didsbury Medical Centre
Verified postcode
Manchester, United Kingdom· Not yet recruiting
P84017 Ladybarn Group Practice
Verified postcode
Manchester, United Kingdom· Not yet recruiting

Common questions

What is obesity?

Obesity is a medical condition where you have excess body fat that can increase your risk of health problems.

What is tirzepatide?

Tirzepatide is a new medication being studied for its effects on weight loss and preventing diabetes.

What does 'standard of care' mean?

Standard of care refers to the usual medical treatments and advice that someone with obesity would receive.

How long will I be in the study?

If you join the study, you will be involved for approximately five years.

Can I leave the study if I change my mind?

Yes, you are free to withdraw from the study at any time, for any reason.

How to find out more

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or

lillytrials@lilly.com 317-615-4559 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.