Determination of Lipocalin Type-prostaglandin (L-PGDS) in Blood, Urine, Vaginal Samples and Endometrial Ablation by Enzyme-linked Immunosorbent Assay
This study explores a substance in the body called Lipocalin type-prostaglandin (L-PGDS). Scientists believe L-PGDS might play a role in health conditions such as adenomyosis and endometriosis, which cause problems inside the womb. The goal is to see if measuring L-PGDS in blood, urine, or other samples could help doctors diagnose adenomyosis earlier and more simply, avoiding more invasive procedures. Previous research hints that L-PGDS levels might be lower in women with adenomyosis, and this new study aims to understand this link better. They hope to develop a less uncomfortable way for patients to be diagnosed.
At a glance
What is this study about?
This research study is looking at a specific chemical in the body called Lipocalin type-prostaglandin, or L-PGDS for short. Think of L-PGDS as a messenger that helps control inflammation. We know it plays a part in conditions like asthma or allergies, but doctors haven't fully explored its role in conditions like adenomyosis.
Adenomyosis is a condition where the sort of tissue that normally lines the womb starts growing into the muscular wall of the womb. This can cause pain and heavy periods. The study aims to see if L-PGDS levels are different in women with adenomyosis compared to those who don't have it. If differences are found, it could mean that measuring L-PGDS in straightforward samples like blood or urine might become a way to help diagnose adenomyosis without needing more complex procedures.
Ultimately, the researchers hope that by understanding L-PGDS better, they can find new and easier ways to help women who suffer from adenomyosis. This could lead to quicker diagnoses and better ways to manage the condition in the future.
Key takeaways
- This study investigates L-PGDS, a body chemical, as a potential marker for adenomyosis.
- It aims to find simpler ways to diagnose adenomyosis, possibly using blood or urine tests.
- Participants include women with adenomyosis, women needing hysterectomies for other reasons, and healthy control groups.
- The research helps doctors understand adenomyosis better, leading to future improvements in care.
- Participation involves providing samples and does not include new treatments.
- You can withdraw from the study at any time without affecting your medical care.
Who may be eligible?
This study is looking for women aged 18 to 57. They are particularly interested in women who are still having periods (not gone through menopause).
They are looking for three main groups: women with adenomyosis who are scheduled for a hysterectomy (womb removal), women who need a hysterectomy for other womb-related issues but do not have adenomyosis, and a control group of women aged 18-57 who are generally healthy, have no womb problems, and are having an ultrasound scan as part of fertility treatment for reasons not related to them personally.
You cannot take part if you have certain health conditions like kidney or liver problems, autoimmune diseases, or cancer. Also, you can't join if you've recently taken certain medications like anti-inflammatory painkillers (NSAIDs), steroids, or aspirin in the last 15 days, or if you are currently using certain types of hormone contraception.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you a woman between 18 and 57 years old?
- Are you still having periods (not gone through menopause)?
- Do you *not* have a history of autoimmune diseases, kidney/liver failure, or cancer?
- Have you *not* taken NSAIDs, steroids, or aspirin in the last 15 days?
- Are you *not* currently using estrogen-progestin hormonal contraception?
- For the adenomyosis group: Are you scheduled for a hysterectomy for reasons other than cancer?
What does participation involve?
The detailed involvement for participants isn't fully described in the summary provided. However, generally in studies like this, participants might be asked to provide samples such as blood, urine, or vaginal swabs. Some women might also have samples taken during a scheduled womb removal (hysterectomy) or during an ultrasound scan. There won't be any specific medications given as part of this research, but your current medications will be checked to see if you can take part. The study aims to collect measurements of the L-PGDS chemical. The total duration of your involvement isn't specified but typically involves one or a few visits for sample collection.
Potential risks and benefits
Locations (1)
- CHU de NimesVerified postcodeNîmes, France· Recruiting
Common questions
What is adenomyosis?
Adenomyosis is a condition where the lining tissue of the womb grows into its muscular wall. This can cause heavy periods and pain.
What is L-PGDS?
L-PGDS is a chemical in your body that helps with inflammation. Researchers are looking into whether its levels change in conditions like adenomyosis.
Why are researchers interested in L-PGDS for adenomyosis?
They believe that L-PGDS levels might be different in women with adenomyosis, and if so, it could help develop simpler ways to diagnose the condition, possibly with blood or urine tests.
Will I receive new treatment in this study?
No, this study is observational, meaning it collects information and samples. You will not receive any new or experimental treatments as part of this research.
What kind of samples will be collected?
The study aims to collect blood, urine, and vaginal samples. In some cases, tissue samples might be taken during a planned surgery like a hysterectomy.
How to find out more
Stéphanie HUBERLANT
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
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