Ongoing, recruitingHuman Pharmacology (Phase I)- OtherInterventional

A study to learn about the study medicine called PF-08046032 in people with advanced cancers.

This research study is testing a new medicine called PF-08046032. It's for adults, aged 18 and over, who have advanced cancers, including specific types of lymphoma (such as classic Hodgkin lymphoma, peripheral T-cell lymphoma, and diffuse large B-cell lymphoma) or certain solid tumours (like some lung, head and neck cancers, or melanoma). This is an early phase study, meaning the main goal is to find out how the medicine works in the human body, how much of it can be given safely, and to look for any side effects. It's an important step in developing new treatments, but it's not yet known if this medicine will be effective. Both men and women can take part.

At a glance

Status

Ongoing, recruiting

Phase

Human Pharmacology (Phase I)- Other

Sponsor

Pfizer Inc.

Enrolment target

Start

21 Apr 2025

Advanced lymphomas (classic Hodgkin lymphoma [cHL]peripheral T cell lymphoma [PTCL]and diffuse large B cell lymphoma [DLBCL])Solid tumors (eg NSCLC HNSCC and melanoma)

What is this study about?

This study is focused on a new study medicine named PF-08046032. Researchers want to learn more about this medicine in people who have advanced cancer. 'Advanced cancer' means cancer that has spread or is difficult to treat with standard therapies. The study includes people with different types of advanced lymphoma, which is a cancer that starts in infection-fighting cells of the body. It also includes people with certain advanced solid tumours, which are cancers that form a lump, for example, in the lung, head, neck, or skin (melanoma).

This is a very early stage of research, often called a 'Phase I' study. In this phase, the main goals are to understand how the new medicine behaves in the human body. This includes figuring out if it's safe, how much of it can be given without causing too many problems, and what side effects it might have. Researchers will also start to look at how the medicine affects the cancer.

Finding new ways to treat advanced cancers is very important. Studies like this help scientists learn if a new medicine has the potential to become a useful treatment in the future. It's a careful and step-by-step process, focusing first on safety before looking at how well the medicine works.

Key takeaways

Tests a new medicine (PF-08046032) for advanced forms of certain lymphomas and solid tumours.
It's an early-stage study (Phase I) - focusing on safety and how the medicine works in the body.
Open to adults aged 18 and over, both men and women.
Participation involves regular clinic visits, blood tests, and scans.
It's not known if the medicine will be effective, and side effects are possible.
You can stop participating at any time.

Who may be eligible?

To be able to join this study, you must be at least 18 years old. There is no upper age limit, meaning older adults can also take part. The study is open to both men and women.

You would need to have been diagnosed with an advanced cancer. Specifically, this includes certain types of lymphoma, such as classic Hodgkin lymphoma, peripheral T-cell lymphoma, or diffuse large B-cell lymphoma. It also includes various advanced solid tumours, which can affect different parts of the body, like some lung cancers, head and neck cancers, or melanoma (a type of skin cancer).

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Have you been diagnosed with an advanced lymphoma (like classic Hodgkin, PTCL, DLBCL) or an advanced solid tumour (like some lung, head & neck cancers, or melanoma)?
Are you able to travel to study appointments?
Are you able to understand and be willing to follow study instructions?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you would receive the new study medicine, PF-08046032. The study team would closely monitor your health with regular visits to the clinic. These visits might involve blood tests, physical examinations, and possibly scans to see how your body is reacting to the medicine and how your cancer is responding.

The researchers would explain the schedule of these visits and tests, how often you would need to come in, and for how long the study treatment would continue. After stopping the study medicine, there would likely be a period of follow-up visits to check on your health and well-being. The total length of your involvement in the study would be fully explained by the study team.

Potential risks and benefits

Taking part in any clinical study comes with potential benefits and risks. While this new medicine might offer insights into future treatments, it's important to remember that it's in its early stages, and it's not yet known if it will help your cancer. There's a chance you might experience side effects from the medicine, which the study team will explain in detail. However, you are always free to leave the study at any time, for any reason, without it affecting your usual medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Spain

Common questions

What is a 'Phase I' study?

A Phase I study is an early stage of research where scientists first test a new medicine in people. The main goals are to find out if it's safe, what side effects it might cause, and how the body handles it.

What kind of cancers is this study for?

This study is for people with advanced cancers, including certain types of lymphoma (like Hodgkin lymphoma or some non-Hodgkin lymphomas) and various solid tumours that have spread, such as some lung cancers, head and neck cancers, or melanoma.

Will I get better if I join this study?

It's not known if this medicine will make you better. The main aim of this early study is to learn about the safety of the medicine. Any benefits are not guaranteed.

Can I stop participating in the study if I change my mind?

Yes, absolutely. You can withdraw from the study at any time, for any reason, without it affecting your future medical care.

What does 'advanced cancer' mean in this study?

In this study, 'advanced cancer' refers to cancers that have spread from where they started or are difficult to treat with the usual standard medicines.