A Dose Finding Study With an Anti-TSLP Antibody (GSK5784283) in Adults Aged 18 to 75 Years of Age With Uncontrolled Asthma

To join this study, you need to be between 18 and 75 years old and have been diagnosed with asthma for at least two years. Your asthma should still be active, meaning you've had an asthma flare-up in the past year, and it needs regular treatment with medium or high-dose inhaled steroids.

You also need to be using at least one other regular asthma medication, like a long-acting reliever or other preventative treatments, for at least three months. Your weight needs to be at least 40 kilograms (around 6 stone 4 pounds).

If you're a woman, you can join if you're not pregnant or breastfeeding. You must either be past childbearing age, or if you could still have children, you must be using a very reliable method of contraception throughout the study and for a short time afterwards.

If you decide to take part, you'll be given either the study medicine (GSK5784283) or a placebo (a dummy medicine with no active ingredients). This study involves several visits to the clinic for assessments. These will include checks on your lung function, answering questions about your asthma control, and providing blood and breath samples to look for signs of inflammation. We’ll also be monitoring you closely for any side effects.

The study is divided into two parts. The first part focuses on finding the right dose and will likely involve more frequent check-ups. The second part will look at the longer-term effects and safety of the medicine. The total length of your participation will depend on which part of the study you are in, but it will involve regular follow-up appointments. More detailed information about the schedule will be provided if you’re interested.