- recruitingPHASE3
A Study of Efficacy and Safety of Depemokimab Compared With Placebo in Adults and Adolescents With at Risk Type 2 Asthma
This study is testing a new medicine called Depemokimab for people aged 12 and over with a type of asthma that often causes flare-ups. It aims to see if this new medicine can help reduce these flare-ups better than usual treatments or a dummy medicine.
United States · United Kingdom - recruitingTherapeutic exploratory (Phase II)
A randomized, double-blind, placebo-controlled, parallel-group, dose ranging study to assess the efficacy, safety, and tolerability of subcutaneous amlitelimab in adult participants with moderate-to-severe asthma. DRI17509
This study is testing a new medicine, amlitelimab, for adults with moderate to severe asthma. We want to see if it can reduce severe asthma attacks and improve breathing and quality of life over 48 weeks.
Italy · Hungary · Poland - recruitingTherapeutic confirmatory (Phase III)
A prospective multicenter placebo-controlled trial to study the efficacy and safety of Tiotropium in preventing severe asthma exacerbations in partial and uncontrolled preschool asthma.
This study is looking at a new inhaler medicine called Tiotropium for young children with asthma that isn't fully controlled. We want to see if it can help prevent severe asthma attacks, like those needing hospital trips or strong steroid medicines, and if it's safe to use.
Germany - recruitingTherapeutic confirmatory (Phase III)
A randomized, double-blind, parallel group, multi-center study to evaluate the long-term safety of salbutamol rescue medication when administered via metered dose inhalers containing the propellant HFA-152a or reference HFA-134a.
This study is looking at the long-term safety of a common asthma relief inhaler. We're comparing two versions of the inhaler, which help open up your airways, to see if a new ingredient in one of them causes any unexpected side effects over three months.
Spain · France · Greece - recruitingHuman Pharmacology (Phase I)- Other
Comparison of the study drug CHF 1535 formulated with two different propellants to learn about drug levels in blood and safety after inhalation, with and without the use of the AeroChamber Plus® spacer, in healthy volunteers.
This study is testing a new asthma medicine. It will check how different ways of taking the medicine affect its levels in the blood and if it's safe. Healthy adults will take part, using an inhaler, sometimes with a spacer device.
Belgium - recruitingTherapeutic exploratory (Phase II)
A Randomised, Double-blind, Parallel Group, Placebo Controlled, 4-Week, Phase II Study to Evaluate the Effect of AZD4604 on Airway Inflammation and Biomarkers in Adults with Asthma - Artemisia study
This study, called Artemisia, is looking at a new medicine called AZD4604 to see if it can help people with asthma. Researchers want to understand how the medicine affects inflammation in the airways over four weeks, compared to a dummy medicine.
Germany · Denmark · Spain - recruitingHuman Pharmacology (Phase I)- Other
Evaluation of the CHF 5993 concentration in blood, after inhalation with two different devices, (NEXThaler® versus pMDI), with and without Aerochamber spacer device, in healthy volunteers.
This study is looking at how a common asthma medicine gets into the blood when breathed in using different inhalers and a spacer device. It's for healthy adult volunteers and aims to compare two types of inhalers, with and without a spacer, to see which way works best.
Belgium - recruitingHuman Pharmacology (Phase I)- Other
A Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of AZD8630, Administered Once Daily via Inhalation, for 2 Weeks, in Adults with Asthma on Medium-to-high Dose Inhaled Corticosteroids and Long-acting Beta-agonists
This study is looking at a new inhaler medicine, AZD8630, for asthma. It wants to see if the medicine is safe, how it moves through the body, and what effects it has over two weeks. It's for adults whose asthma is already treated with common inhalers.
Germany - recruitingHuman Pharmacology (Phase I)- Other
A Phase Ib, Multicentre, Randomised, Single-blind, Parallel-group, Placebo-controlled, Study to Characterise the Pharmacokinetics and Pharmacodynamics of AZD4604 Administered via the Turbuhaler® Device in Adults with Mild Asthma
This study is testing a new asthma medicine, AZD4604, given through an inhaler. It's for adults with mild asthma to see how the medicine works in the body and what effects it has, compared to a dummy treatment.
Germany - recruitingTherapeutic exploratory (Phase II)
A single-centre, single-dose, open label, non-randomized, parallel group, clinical pharmacology study of CHF 6001 in asthmatic adolescent patients and in asthmatic adult patients as control group
This study is testing a new asthma medicine, CHF 6001, in teenagers and adults with asthma. Researchers want to see how the body handles the medicine and how safe it is. It's an early-stage study to understand the medicine better.
Bulgaria - authorisedTherapeutic use (Phase IV)
A pragmatic, phase IV, randomized, open-label, multinational, multicentre, 2-arm parallel group, prospective study comparing efficacy and safety of Single Inhaler ICS/LABA/LAMA (beclometasone/formoterol fumarate/glycopyrronium bromide [87/5/9 pMDI {BD/FF/GB - 100/6/12.5 µg}]) vs Single Inhaler ICS/LABA (beclometasone dipropionate plus formoterol fumarate [200/6 pMDI {BD/FF - 200/6 µg}]) in asthma subjects.
This study compares two inhalers, Trimbow and Fostair, for adults with asthma. It looks at how well they control asthma symptoms and prevent flare-ups over a year, as well as their safety.
Germany · Romania · Italy - recruitingTherapeutic use (Phase IV)
Symptoms control and adhErenCe assessment during treatment with mepolizUmab new pREfilled devices. SECURE
This study looks at how well people with asthma use their medication (Mepolizumab) and how much it helps control their symptoms over six months. It compares different ways of giving the medication, looking at patient diaries and pharmacy records.
France - recruitingHuman Pharmacology (Phase I)- Other
A phase I study to evaluate an investigational medicinal product for the treatment of asthma, in healthy adult participants.
This study is testing a new medicine for asthma for the first time in people. It involves healthy adult volunteers and aims to check if the medicine is safe and how it works in the body. This is an early step in developing new treatments for asthma.
Belgium - recruitingNot Applicable
Investigation of a digital inhaler monitor and smartphone app providing real-time information on inhaler use
This study looks at a 'smart' inhaler system to help people with asthma. It checks if using a digital monitor and app can improve asthma control and if it's helpful for patients and doctors. It's like a practice run for a bigger study.
United Kingdom · England - recruitingHuman Pharmacology (Phase I)- Other
Safety and tolerability of single and multiple ascending doses of lunsekimig (SAR443765) in healthy participants
This study is testing a new medicine, lunsekimig, for asthma. It's a very early-stage trial looking at how safe the medicine is and if people can tolerate different doses. It involves healthy adults and is the first step before testing it in people with asthma.
Belgium - recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
RANDOMISED, CROSSOVER BIOEQUIVALENCE CLINICAL TRIAL OF MONTELUKAST 10 MG CAPSULES VS MONTELUKAST 10 MG FILM-COATED TABLETS, AFTER A SINGLE ORAL DOSE ADMINISTRATION TO HEALTHY VOLUNTEERS UNDER FASTING CONDITIONS.
This study is comparing two ways of taking the asthma medicine montelukast: a capsule and a film-coated tablet. We want to see if the body uses them in the same way when taken by healthy people who haven't eaten, to make sure they work equally well.
Spain - recruitingTherapeutic exploratory (Phase II)
A 52-week, randomised, double blind, multicentre, 2-arm parallel group trial assessing the efficacy and safety of CHF6001 (total daily dose 3200 μg) Dry Powder Inhaler (DPI) add-on to maintenance medium or high dose inhaled corticosteroid in combination with long-acting ß2-agonists in subjects with uncontrolled asthma
This study looks at a new inhaler, CHF6001, for people with asthma that isn't fully controlled. Researchers want to see if adding this new inhaler to their usual medication helps reduce asthma attacks over 52 weeks and is safe.
Italy · Spain · Czechia - recruitingTherapeutic exploratory (Phase II)
A Phase 2 study to evaluate the efficacy and safety of RPT193 in adults with moderate-to-severe T2-high asthma who are partially controlled on inhaled corticosteroid and long-acting beta 2 agonist therapy
This study is testing a new medicine, RPT193, for adults with moderate to severe asthma that's not fully controlled by their usual inhalers. It aims to see how well RPT193 works and if it's safe, helping researchers understand if it could be a future treatment option.
Czechia · Bulgaria · Poland - recruitingPHASE3
Roll-over Study for Participants Who Have Completed a Previous Clinical Study With Benralizumab (Fasenra) and Benefit From Continued Treatment
This study is for people who have already taken part in a trial for the medicine Benralizumab (Fasenra) for asthma, EGPA, or HES. If the medicine helped them, this study offers a way to continue receiving it while doctors monitor their health and the medicine's long-term effects.
United States · Argentina · Austria - recruiting
Exploring the Lived Experience of Young Adults With Severe Asthma
This study explores the daily experiences of young adults (16-25) with severe or uncontrolled asthma in Manchester and Liverpool. We aim to understand their challenges and needs to improve future care and support for this group, which is often overlooked.
United Kingdom - recruitingPHASE2
Xenon-129 and Inert Fluorinated Gas Lung MRI: Study of Healthy Volunteers and Participants With Pulmonary Disease
This study uses special MRI scans with safe gases to look at lungs in people with cystic fibrosis and asthma, and healthy volunteers. The aim is to see how well these new scanning methods work and what they can tell us about lung health.
Canada - recruitingNA
A Randomised Feasibility Study of CPAP in Large Airway Collapse
This study looks at whether a breathing machine called CPAP could help people with a condition called Large Airway Collapse (LAC). We want to see if it's practical to do a bigger study later on, as LAC symptoms often get mistaken for asthma or other breathing problems.
United Kingdom - recruiting
Diaphragmatic Function as a Biomarker
This study looks at how your breathing muscles, especially your diaphragm, work if you have lung conditions like asthma or COPD. We want to understand if problems with these muscles are linked to feeling breathless and what that might mean for your health.
Germany - authorisedTherapeutic use (Phase IV)
Therapheutic optimization of omalizumab in allergic severe asthma patients by dose and frequency of administration adjustment
This study is looking at whether adults with severe allergic asthma can take a lower dose of their Xolair (omalizumab) medication and still control their asthma well. Researchers want to see if a 50% dose reduction keeps asthma stable, improves quality of life, and maintains lung function.
Spain - recruitingPHASE2
Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids
This study is testing a new medicine, tozorakimab, for adults with asthma that isn't well-controlled. It's looking at how well different doses work and if they are safe, compared to a dummy treatment.
United States · Argentina · Brazil - recruitingPHASE3
A Randomized, Double-Blind, Placebo-Controlled Trial on Efficacy and Safety of Fluticasone Propionate/Albuterol Sulfate Combination in Participants 12 Years and Older With Asthma
This study is testing a new inhaler for people aged 12 and over with asthma. It compares a combination medicine to individual medicines and a dummy inhaler to see how well it works and if it's safe.
United States · Argentina · Bulgaria - active not recruitingPHASE3
A Study to Test if a Fixed-Dose Combination of Fluticasone Propionate/Albuterol Sulfate is Effective in Preventing Asthma Exacerbations
This study is testing a new combination inhaler (TEV-56248) to see if it can better prevent asthma attacks compared to a standard inhaler (Albuterol). We also want to check how safe it is for people with asthma.
United States · Argentina · Australia - active not recruitingPHASE2
Study of Lunsekimig (SAR443765) Compared With Placebo in Adults With High-risk Asthma
This study is looking into a new medication called Lunsekimig for adults with asthma that is hard to control. It compares Lunsekimig to a dummy treatment (placebo) to see if it helps manage asthma better and if it's safe.
United States · Argentina · Belgium - recruitingPHASE1
Evaluation of Safety, Side Effects, and How the Drug, Inhaled CHF10136, Is Absorbed, Modified and Removed From the Body in Healthy Adults and Adults With Asthma
This study is testing a new inhaled medicine (CHF10136) for asthma. Researchers want to see if it's safe, how it affects people, and how the body handles it. It involves healthy adults and adults with asthma to understand its early effects.
United Kingdom - recruitingPHASE3
A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe Asthma
This study looks at a new medicine called Tezepelumab for children aged 5-11 with severe asthma. It compares the medicine to a dummy treatment (placebo) to see if it helps reduce asthma attacks and is safe for children.
United States · Argentina · Brazil - recruitingPHASE2
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma
This study is looking into a new medicine, PF-07275315, for people with moderate to severe asthma who struggle with breathing. We want to see if it's safe and helps improve their daily life.
United States · Argentina · Belgium - active not recruitingPHASE3
A Multicentre, Randomised, Double-blind, Parallel Group, Placebo-controlled, Time-to-first Asthma Exacerbation Phase III Efficacy and Safety Study of Benralizumab in Paediatric Patients With Severe Eosinophilic Asthma
This study looks at a new medicine called benralizumab for children aged 6 to 18 with severe asthma. It wants to see if the medicine can stop asthma attacks and if it's safe. Half the children get the medicine, and half get a dummy medicine.
United States · Argentina · France - recruitingPHASE4
Therapeutic Relevance of Abnormal Airway Morphology in Asthma
This study looks at why some people with asthma don't get relief from their inhalers. We're using special scans to see if narrow or blocked airways stop medicine from reaching where it needs to go. We'll compare how well inhaled versus oral medicines work for these patients.
Canada - recruitingNA
Improving Quality of Life for Teenagers With Asthma
This study looks at a new way to help teenagers with asthma feel more confident managing their condition. It compares a special asthma consultation with a regular one to see if the new approach improves their quality of life. It aims to help teens control their asthma better.
United Kingdom - recruitingPHASE3
Depemokimab Asthma Imaging and Bronchoscopy Sub-Study
This study looks at a new asthma medicine, Depemokimab, to see how it affects people's lungs. It focuses on those with a specific type of asthma where their airways get inflamed and swollen, causing breathing problems.
United States · Belgium · Canada - recruiting
Evaluation of High Dose Prednisolone Pharmacokinetics in the Acute and Chronic Setting
This study looks at how your body handles prednisolone, a common anti-inflammatory medicine, especially at higher doses. We're trying to understand if prednisolone levels in your blood are consistent and if they change over time, which could help tailor treatment for conditions like asthma or thyroid eye disease.
United Kingdom - recruiting
Pediatric Arm of DZL All Age Asthma Cohort
This study is gathering information on children with asthma. Researchers want to understand why some children keep having asthma symptoms while others grow out of it. The goal is to find better, more personal treatments for asthma in the future.
Germany - active not recruitingPHASE3
Evaluation of Triple Therapy Using Magnetic Resonance Imaging in Asthma
This study looks at a new asthma inhaler with three medicines for people whose asthma isn't well controlled. It uses special scans to see how well air gets into the lungs and aims to improve breathing and lung health.
Canada - recruiting
Biobanking for Biomarkers In Respiratory Disease, Allergic Diseases and/or Mast Cell Disorders
This study is building a collection of samples and information from people with allergies, asthma, or mast cell conditions. This 'biobank' will help scientists better understand these conditions and find new ways to diagnose and treat them in the future.
France - recruitingNA
Intragastric Balloon in Obese Patients With Uncontrolled Asthma
This study looks at how an intragastric balloon, plus diet and exercise, helps people with obesity and uncontrolled asthma. We want to see if it improves asthma control compared to just diet and exercise.
France - active not recruitingPHASE2
Long-term Safety and Efficacy Evaluation of Subcutaneous Amlitelimab in Adult Participants With Moderate-to-severe Asthma Who Completed Treatment Period of Previous Amlitelimab Asthma Clinical Study
This study looks at the long-term safety and effectiveness of a drug called amlitelimab for adults with moderate to severe asthma who have used it in a previous study. It will last up to 156 weeks.
United States · Argentina · Brazil - enrolling by invitationNA
eAMS-Eco: Implementation of a Tool for Climate Conscious Inhaler Prescribing
This study looks at a new computer tool called eAMS-Eco to help doctors choose inhalers for asthma that are better for the environment. It aims to see if this tool can lower carbon emissions from inhalers while still providing good asthma care.
Canada - recruitingNA
Lung Immune Challenge Study: Controlled Exposure to Inhaled Resiquimod (R848)
This study looks at how people's lungs respond to a harmless mist that acts like a virus. It aims to understand lung inflammation better, especially in people with asthma, to help develop new treatments for respiratory infections without causing actual illness.
United Kingdom - active not recruitingPHASE4
Benralizumab Airway Remodeling Study in Severe Eosinophilic Asthmatics
This study looks at how a medicine called benralizumab affects the lungs of people with severe asthma. It aims to see if the treatment can improve lung structure and how well the lungs work in people whose asthma isn't controlled by usual medicines.
United States · Canada · Denmark - not yet recruitingNA
T2 Biomarkers Predictive Value in Occupational Asthma After Cessation of Exposure.
This study looks at whether certain natural body signals, called T2 biomarkers, can predict if people with asthma caused by their job will get better after they stop being exposed to what caused it. They want to see who fully recovers and who doesn't.
France - enrolling by invitation
The Alberta BLOOM Premature Child Study
This study looks at how tiny living things (microbes) in premature babies' guts develop. It aims to understand how these microbes might affect their risk of developing allergies and asthma as they grow up, and what factors influence this development.
Canada - enrolling by invitationNA
The Electronic Asthma Management System in Pharmacies
This study looks at how a new electronic system in pharmacies, called eAMS-Pharm, can help people with asthma manage their condition better. It checks if pharmacists using this system can improve asthma control, medication advice, and referrals for severe asthma, comparing care before and after it's introduced.
Canada - enrolling by invitationNA
Effect of OPEP on Mucus Plugging and Airflow Obstruction in Patients with Moderate-to-severe Asthma
This study looks at how a device called Aerobika helps adults with moderate-to-severe asthma. It aims to see if using it daily can clear mucus and improve breathing, as mucus can make asthma worse.
Canada - recruitingPHASE2
A Study to Evaluate Brenipatide Compared With Placebo in Adult Participants With Uncontrolled Moderate to Severe Asthma
This study is testing a new medicine, brenipatide, for adults with asthma that isn't well-controlled. We want to see if it's safe and helps improve asthma symptoms compared to a dummy medicine.
United States · Argentina · Brazil - not yet recruiting
Investigation of the Effects of Oxidized Antigens on the T-Cell Response and the Epigenetic Reprogramming of Neutrophils in Lung Diseases - OXIGENE -
The OXIGENE study looks at blood from people with lung conditions like asthma or pneumonia. It aims to understand how their immune system works during illness and if certain immune cells change over time. This could help develop better ways to diagnose and treat lung diseases in the future.
Germany