- recruitingPHASE2
Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids
This study is testing a new medicine, tozorakimab, for adults with asthma that isn't well-controlled. It's looking at how well different doses work and if they are safe, compared to a dummy treatment.
United States · Argentina · Brazil - recruitingPHASE3
A Randomized, Double-Blind, Placebo-Controlled Trial on Efficacy and Safety of Fluticasone Propionate/Albuterol Sulfate Combination in Participants 12 Years and Older With Asthma
This study is testing a new inhaler for people aged 12 and over with asthma. It compares a combination medicine to individual medicines and a dummy inhaler to see how well it works and if it's safe.
United States · Argentina · Bulgaria - active not recruitingPHASE2
Study of Lunsekimig (SAR443765) Compared With Placebo in Adults With High-risk Asthma
This study is looking into a new medication called Lunsekimig for adults with asthma that is hard to control. It compares Lunsekimig to a dummy treatment (placebo) to see if it helps manage asthma better and if it's safe.
United States · Argentina · Belgium - recruitingPHASE4
Therapeutic Relevance of Abnormal Airway Morphology in Asthma
This study looks at why some people with asthma don't get relief from their inhalers. We're using special scans to see if narrow or blocked airways stop medicine from reaching where it needs to go. We'll compare how well inhaled versus oral medicines work for these patients.
Canada - recruitingNA
Improving Quality of Life for Teenagers With Asthma
This study looks at a new way to help teenagers with asthma feel more confident managing their condition. It compares a special asthma consultation with a regular one to see if the new approach improves their quality of life. It aims to help teens control their asthma better.
United Kingdom - recruitingPHASE3
Depemokimab Asthma Imaging and Bronchoscopy Sub-Study
This study looks at a new asthma medicine, Depemokimab, to see how it affects people's lungs. It focuses on those with a specific type of asthma where their airways get inflamed and swollen, causing breathing problems.
United States · Belgium · Canada - recruiting
Evaluation of High Dose Prednisolone Pharmacokinetics in the Acute and Chronic Setting
This study looks at how your body handles prednisolone, a common anti-inflammatory medicine, especially at higher doses. We're trying to understand if prednisolone levels in your blood are consistent and if they change over time, which could help tailor treatment for conditions like asthma or thyroid eye disease.
United Kingdom - recruiting
Pediatric Arm of DZL All Age Asthma Cohort
This study is gathering information on children with asthma. Researchers want to understand why some children keep having asthma symptoms while others grow out of it. The goal is to find better, more personal treatments for asthma in the future.
Germany - active not recruitingPHASE3
Evaluation of Triple Therapy Using Magnetic Resonance Imaging in Asthma
This study looks at a new asthma inhaler with three medicines for people whose asthma isn't well controlled. It uses special scans to see how well air gets into the lungs and aims to improve breathing and lung health.
Canada - recruitingNot Applicable
Investigation of a digital inhaler monitor and smartphone app providing real-time information on inhaler use
This study looks at a 'smart' inhaler system to help people with asthma. It checks if using a digital monitor and app can improve asthma control and if it's helpful for patients and doctors. It's like a practice run for a bigger study.
United Kingdom · England - recruiting
Biobanking for Biomarkers In Respiratory Disease, Allergic Diseases and/or Mast Cell Disorders
This study is building a collection of samples and information from people with allergies, asthma, or mast cell conditions. This 'biobank' will help scientists better understand these conditions and find new ways to diagnose and treat them in the future.
France - recruitingNA
Intragastric Balloon in Obese Patients With Uncontrolled Asthma
This study looks at how an intragastric balloon, plus diet and exercise, helps people with obesity and uncontrolled asthma. We want to see if it improves asthma control compared to just diet and exercise.
France - active not recruitingPHASE2
Long-term Safety and Efficacy Evaluation of Subcutaneous Amlitelimab in Adult Participants With Moderate-to-severe Asthma Who Completed Treatment Period of Previous Amlitelimab Asthma Clinical Study
This study looks at the long-term safety and effectiveness of a drug called amlitelimab for adults with moderate to severe asthma who have used it in a previous study. It will last up to 156 weeks.
United States · Argentina · Brazil - recruitingPHASE3
A Multicentre, Randomised, Double-blind, Parallel Group, Placebo-controlled, Time-to-first Asthma Exacerbation Phase III Efficacy and Safety Study of Benralizumab in Paediatric Patients With Severe Eosinophilic Asthma (DOMINICA)
This study looks at a new medicine called benralizumab for children aged 6 to 18 with severe asthma. It wants to see if the medicine can stop asthma attacks and if it's safe. Half the children get the medicine, and half get a dummy medicine.
United States · Argentina · Canada - enrolling by invitationNA
eAMS-Eco: Implementation of a Tool for Climate Conscious Inhaler Prescribing
This study looks at a new computer tool called eAMS-Eco to help doctors choose inhalers for asthma that are better for the environment. It aims to see if this tool can lower carbon emissions from inhalers while still providing good asthma care.
Canada - recruitingNA
Lung Immune Challenge Study: Controlled Exposure to Inhaled Resiquimod (R848)
This study looks at how people's lungs respond to a harmless mist that acts like a virus. It aims to understand lung inflammation better, especially in people with asthma, to help develop new treatments for respiratory infections without causing actual illness.
United Kingdom - active not recruitingPHASE4
Benralizumab Airway Remodeling Study in Severe Eosinophilic Asthmatics
This study looks at how a medicine called benralizumab affects the lungs of people with severe asthma. It aims to see if the treatment can improve lung structure and how well the lungs work in people whose asthma isn't controlled by usual medicines.
United States · Canada · Denmark - not yet recruitingNA
T2 Biomarkers Predictive Value in Occupational Asthma After Cessation of Exposure.
This study looks at whether certain natural body signals, called T2 biomarkers, can predict if people with asthma caused by their job will get better after they stop being exposed to what caused it. They want to see who fully recovers and who doesn't.
France - enrolling by invitation
The Alberta BLOOM Premature Child Study
This study looks at how tiny living things (microbes) in premature babies' guts develop. It aims to understand how these microbes might affect their risk of developing allergies and asthma as they grow up, and what factors influence this development.
Canada - enrolling by invitationNA
The Electronic Asthma Management System in Pharmacies
This study looks at how a new electronic system in pharmacies, called eAMS-Pharm, can help people with asthma manage their condition better. It checks if pharmacists using this system can improve asthma control, medication advice, and referrals for severe asthma, comparing care before and after it's introduced.
Canada - recruitingPHASE3
A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe Asthma
This study looks at a new medicine called Tezepelumab for children aged 5-11 with severe asthma. It compares the medicine to a dummy treatment (placebo) to see if it helps reduce asthma attacks and is safe for children.
United States · Argentina · Brazil - recruitingPHASE2
A Study to Evaluate Brenipatide Compared With Placebo in Adult Participants With Uncontrolled Moderate to Severe Asthma
This study is testing a new medicine, brenipatide, for adults with asthma that isn't well-controlled. We want to see if it's safe and helps improve asthma symptoms compared to a dummy medicine.
United States · Argentina · Brazil - enrolling by invitationNA
Effect of OPEP on Mucus Plugging and Airflow Obstruction in Patients with Moderate-to-severe Asthma
This study looks at how a device called Aerobika helps adults with moderate-to-severe asthma. It aims to see if using it daily can clear mucus and improve breathing, as mucus can make asthma worse.
Canada - not yet recruiting
Investigation of the Effects of Oxidized Antigens on the T-Cell Response and the Epigenetic Reprogramming of Neutrophils in Lung Diseases - OXIGENE -
The OXIGENE study looks at blood from people with lung conditions like asthma or pneumonia. It aims to understand how their immune system works during illness and if certain immune cells change over time. This could help develop better ways to diagnose and treat lung diseases in the future.
Germany - active not recruitingPHASE3
A Study to Test if a Fixed-Dose Combination of Fluticasone Propionate/Albuterol Sulfate is Effective in Preventing Asthma Exacerbations
This study is testing a new combination inhaler (TEV-56248) to see if it can better prevent asthma attacks compared to a standard inhaler (Albuterol). We also want to check how safe it is for people with asthma.
United States · Argentina · Australia - recruitingNA
Effects of Salbutamol in Athletes and Implications for Screening and Sports
This study looks at how a common asthma medicine (salbutamol) affects sports performance in healthy athletes. We want to see if it helps athletes who sometimes have trouble breathing during intense exercise, even if they don't have asthma. Understanding this could help with sports rules.
Canada - active not recruitingPHASE4
REIMAGINE - Real World EvaluatIon of Mepolizumab in Severe Asthma achievinG on Treatment clinIcal remissioN, a prospEctive Study
This study looks at how a medicine called mepolizumab (NUCALA) helps adults with severe asthma achieve better control, sometimes called 'remission'. It's a real-world study, meaning it observes people already using this treatment in their everyday lives to see its effects.
United States · Belgium · Canada - active not recruitingPHASE4
Symptoms Control and adhErenCe Assessment During Treatment With MepolizUmab New pREfilled Devices
This study looks at how people with severe asthma use a new self-injectable asthma medicine called Mepolizumab. We want to see if using a pre-filled pen at home helps people stick to their treatment compared to having a nurse give injections.
France - recruitingPHASE1
The Safety, Feasibility, and Repeatability of Inhaled ATP Cough Challenges
This study looks at a new way to test how sensitive people are to coughing, especially those with long-term coughs or asthma. We want to make sure this test is safe, easy to do, and gives consistent results for healthy people and those with mild asthma or long-term cough.
Canada - recruiting
InvEstigating oeStrogen Signalling and the Effect upoN the exTracelluar Matrix In pAtients With Obstructive Lung Disease
This study looks at how female hormones, particularly oestrogen, might affect lung conditions like asthma and COPD. Researchers want to understand if changes in oestrogen levels contribute to these diseases and why women might be more affected.
United Kingdom - active not recruiting
Using Exercise-testing to Explore Patient Differences in Severe Asthma
This study looks at why some people with severe asthma still feel very breathless, even when their treatment seems to be working. We'll use exercise tests and compare them to people whose asthma responds well to treatment to understand their differences.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Safety and tolerability of single and multiple ascending doses of lunsekimig (SAR443765) in healthy participants
This study is testing a new medicine, lunsekimig, for asthma. It's a very early-stage trial looking at how safe the medicine is and if people can tolerate different doses. It involves healthy adults and is the first step before testing it in people with asthma.
Belgium - ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomized, double-blind, parallel group, multi-center study to evaluate the long-term safety of salbutamol rescue medication when administered via metered dose inhalers containing the propellant HFA-152a or reference HFA-134a.
This study is looking at the long-term safety of a common asthma relief inhaler. We're comparing two versions of the inhaler, which help open up your airways, to see if a new ingredient in one of them causes any unexpected side effects over three months.
Spain · France · Greece - active not recruitingPHASE2
A Dose Finding Study With an Anti-TSLP Antibody (GSK5784283) in Adults Aged 18 to 75 Years of Age With Uncontrolled Asthma
This study is looking for the right dose of a new medicine, GSK5784283, for adults aged 18 to 75 with asthma that isn't fully controlled by their current treatments. It aims to see how it affects breathing and overall asthma control.
United States · Bulgaria · Canada - ongoing, recruitingTherapeutic exploratory (Phase II)
A single-centre, single-dose, open label, non-randomized, parallel group, clinical pharmacology study of CHF 6001 in asthmatic adolescent patients and in asthmatic adult patients as control group
This study is testing a new asthma medicine, CHF 6001, in teenagers and adults with asthma. Researchers want to see how the body handles the medicine and how safe it is. It's an early-stage study to understand the medicine better.
Bulgaria - active not recruitingNA
Performance and Adherence in Children Using Spacers
This study looks at how children aged 6-18 use their asthma inhalers with a 'Smart Spacer'. It aims to improve asthma control by understanding inhaler use better and seeing if special education helps. We want to make breathing easier for children with asthma.
United Kingdom - authorisedTherapeutic use (Phase IV)
A pragmatic, phase IV, randomized, open-label, multinational, multicentre, 2-arm parallel group, prospective study comparing efficacy and safety of Single Inhaler ICS/LABA/LAMA (beclometasone/formoterol fumarate/glycopyrronium bromide [87/5/9 pMDI {BD/FF/GB - 100/6/12.5 µg}]) vs Single Inhaler ICS/LABA (beclometasone dipropionate plus formoterol fumarate [200/6 pMDI {BD/FF - 200/6 µg}]) in asthma subjects.
This study compares two inhalers, Trimbow and Fostair, for adults with asthma. It looks at how well they control asthma symptoms and prevent flare-ups over a year, as well as their safety.
Germany · Romania · Italy - ongoing, recruitingTherapeutic exploratory (Phase II)
A randomized, double-blind, placebo-controlled, parallel-group, dose ranging study to assess the efficacy, safety, and tolerability of subcutaneous amlitelimab in adult participants with moderate-to-severe asthma. DRI17509
This study is testing a new medicine, amlitelimab, for adults with moderate to severe asthma. We want to see if it can reduce severe asthma attacks and improve breathing and quality of life over 48 weeks.
Italy · Hungary · Poland - ongoing, recruitingTherapeutic confirmatory (Phase III)
A prospective multicenter placebo-controlled trial to study the efficacy and safety of Tiotropium in preventing severe asthma exacerbations in partial and uncontrolled preschool asthma.
This study is looking at a new inhaler medicine called Tiotropium for young children with asthma that isn't fully controlled. We want to see if it can help prevent severe asthma attacks, like those needing hospital trips or strong steroid medicines, and if it's safe to use.
Germany - active not recruiting
Registry of Asthma Patients Initiating DUPIXENT®
This study looks at how a medicine called DUPIXENT® is used by real people with asthma. It helps us understand who uses it and how well it works over time in everyday life, not just in strict research settings.
United States · Canada · Denmark - active not recruitingPHASE2
A Phase 2, Dose Ranging Study Assessing Rocatinlimab in Moderate-to-severe Asthma
This study is looking at a new medicine called rocatinlimab for people aged 18-75 with moderate to severe asthma. It wants to see if the medicine can reduce asthma attacks. Participants will receive either rocatinlimab or a dummy medicine called a placebo.
United States · Argentina · Australia - recruiting
A Trial Evaluating Novel Technologies for the Diagnosis of Asthma The LUNG-TECH Trial
This study, called LUNG-TECH, is looking for new and better ways to diagnose asthma. It aims to test new technologies to see if they can accurately identify asthma in different groups of people, from healthy volunteers to those already suspected of having asthma.
United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
A Randomised, Double-blind, Parallel Group, Placebo Controlled, 4-Week, Phase II Study to Evaluate the Effect of AZD4604 on Airway Inflammation and Biomarkers in Adults with Asthma - Artemisia study
This study, called Artemisia, is looking at a new medicine called AZD4604 to see if it can help people with asthma. Researchers want to understand how the medicine affects inflammation in the airways over four weeks, compared to a dummy medicine.
Germany · Denmark · Spain - not yet recruiting
London Asthma Diagnostics Study
This study looks at new ways to diagnose asthma in adults. Researchers want to see if adding a breathing test called oscillometry helps doctors diagnose asthma more accurately, alongside standard tests. It could lead to better and quicker diagnosis for you.
United Kingdom - active not recruitingPHASE1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Immunogenicity of APG777 in Adults With Asthma
This study is looking into a new medication called APG777 for adults with mild to moderate asthma. It's a first step to see if it's safe and how the body handles it, compared to a dummy drug (placebo).
United States · United Kingdom - recruitingNA
Reducing Chronic Breathlessness in Adults by Following a Self-guided, Internet Based Supportive Intervention (SELF-BREATHE)
This study looks at how a self-guided online tool called SELF-BREATHE helps adults with long-term breathlessness. It aims to see if using this website improves their breathing and quality of life, and if it could be used more widely in the NHS.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase Ib, Multicentre, Randomised, Single-blind, Parallel-group, Placebo-controlled, Study to Characterise the Pharmacokinetics and Pharmacodynamics of AZD4604 Administered via the Turbuhaler® Device in Adults with Mild Asthma
This study is testing a new asthma medicine, AZD4604, given through an inhaler. It's for adults with mild asthma to see how the medicine works in the body and what effects it has, compared to a dummy treatment.
Germany - recruitingPHASE3
Efficacy and Safety of Subcutaneous Dupilumab in Participants With Asthma/Asthmatic Wheeze Aged 2 to <6 Years (LIBERTY ASTHMA TREKIDS)
This study is testing a new medicine, dupilumab, for children aged 2-5 who have asthma or wheezing that’s hard to control. It aims to see how well it works and if it's safe over time.
United States · Argentina · Brazil - recruiting
Study of Inflammatory and Physiological Profiles of Healthy and Diseased Lung
This study looks at how lung diseases like asthma and COPD affect the body. Researchers want to understand these conditions better by studying samples from healthy people and those with lung problems to find better ways to help patients.
United Kingdom - not yet recruiting
Development of the Drug and Alcohol Respiratory Health Test
This study is creating a simple test to check lung health in adults who use certain substances. Many people with substance use disorder have breathing problems that often go unnoticed. This new test aims to find these issues early so people can get the right help.
United Kingdom