- ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of AZD8630, Administered Once Daily via Inhalation, for 2 Weeks, in Adults with Asthma on Medium-to-high Dose Inhaled Corticosteroids and Long-acting Beta-agonists
This study is looking at a new inhaler medicine, AZD8630, for asthma. It wants to see if the medicine is safe, how it moves through the body, and what effects it has over two weeks. It's for adults whose asthma is already treated with common inhalers.
Germany - active not recruitingPHASE4
Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Adult Patients With Uncontrolled Moderate to Severe Asthma
This study is looking at whether a medicine called dupilumab can help adults with moderate to severe asthma keep their lungs working better over time. It compares dupilumab to standard asthma care to see if it can prevent lung function from getting worse. It's a long-term study.
United States · Belgium · Brazil - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A phase I study to evaluate an investigational medicinal product for the treatment of asthma, in healthy adult participants.
This study is testing a new medicine for asthma for the first time in people. It involves healthy adult volunteers and aims to check if the medicine is safe and how it works in the body. This is an early step in developing new treatments for asthma.
Belgium - recruitingPHASE2
Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Glycopyrronium (Bromide) in Children (6 to Less Than 12 Years) With Asthma
This study is looking at a new asthma medicine, glycopyrronium, for children aged 6 to 11. Researchers want to see how well different doses work, how safe they are, and if they can help children breathe easier. This information will help develop a new combination asthma treatment.
Bulgaria · Colombia · Guatemala - enrolling by invitationPHASE2
Long-term Safety and Efficacy Evaluation of Lunsekimig (SAR443765) in Adult Participants With Asthma
This study is looking at the long-term safety and effectiveness of a new medicine called Lunsekimig for adults with asthma. It's for people who have already taken part in a previous study with this medicine and want to continue their treatment.
United States · Argentina · Brazil - recruiting
A Comparison of Diagnostic Testing Modalities in the Assessment of Asthma
This study looks at different ways to diagnose asthma, comparing current guidelines with new tests like Impulse Oscillometry (IOS). We want to find the best and easiest ways to accurately identify asthma in adults, potentially improving how we manage the condition.
United Kingdom - recruitingPHASE2
Therapeutic Equivalence of CHF5993 pMDI 100/6/12.5 µg HFA-152a in Subjects With Mild to Moderate Asthma
This study looks at a new, climate-friendly asthma inhaler. We want to check if it works just as well and is as safe as current inhalers for people with mild to moderate asthma. It's about finding better ways to manage asthma while caring for our planet.
Argentina · Bosnia and Herzegovina · Bulgaria - active not recruitingPHASE1
A Phase 1, Randomized, Double-blind, Placebo-controlled Study Evaluating AMG 691 in Healthy Participants and Participants With Mild-to-Moderate Asthma
This study is testing a new medicine, AMG 691, for safety in healthy people and those with mild-to-moderate asthma. Researchers want to see how the body reacts to single and multiple doses and check for side effects.
United States · Australia · Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Evaluation of the CHF 5993 concentration in blood, after inhalation with two different devices, (NEXThaler® versus pMDI), with and without Aerochamber spacer device, in healthy volunteers.
This study is looking at how a common asthma medicine gets into the blood when breathed in using different inhalers and a spacer device. It's for healthy adult volunteers and aims to compare two types of inhalers, with and without a spacer, to see which way works best.
Belgium - active not recruiting
Wessex Asthma Cohort of Difficult Asthma
This study looks at people with severe asthma treated at Southampton Hospital. It aims to understand why some individuals still struggle with their asthma and how best to help them, using information gathered from regular hospital visits.
United Kingdom - authorisedTherapeutic confirmatory (Phase III)
A double-dummy, double-blind, randomized, active controlled, two-way cross-over study with 12-week treatment duration per period, to evaluate the efficacy and safety of QVM149 (indacaterol acetate / glycopyrronium bromide / mometasone furoate) compared to salmeterol xinafoate/fluticasone propionate in children from 12 years to less than 18 years of age with asthma.
This study is looking at a new asthma inhaler (QVM149) for teenagers aged 12 to 18. Researchers want to see if it works better and is safer than current inhalers to help manage asthma symptoms and improve breathing.
Poland · France · Slovakia - recruiting
The Extended Salford Lung Study ("Ex-SLS") Data Access Project
This study wants to look at the full health history of people who took part in a past asthma study called the Salford Lung Study (SLS). It aims to learn more about how asthma develops and how treatments work over many years, by reviewing their health records.
United Kingdom - recruitingPHASE1
A Study to Compare the Relative Potency of Salbutamol Administered Via Metered Dose Inhalers (MDI) Containing Propellants HFA-152a to HFA-134a in Mild Asthmatics Aged 18 to 65 Inclusive
This study is looking at two different versions of salbutamol (a common asthma inhaler) delivered through a puffer. We want to see how well they work to prevent asthma symptoms in people with mild asthma, comparing a newer propellant (HFA-152a) with an older one (HFA-134a).
United Kingdom - active not recruitingPHASE1
A Study to Investigate GB-0895 in Adults With Mild to Moderate Asthma or COPD
This study is looking into a new medication called GB-0895 for people with mild to moderate asthma or COPD. Researchers want to see if it's safe, how the body handles it, and if it works. It's an early-stage study to gather basic information.
United States · Germany · United Kingdom - recruitingPHASE2
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma
This study is looking into a new medicine, PF-07275315, for people with moderate to severe asthma who struggle with breathing. We want to see if it's safe and helps improve their daily life.
United States · Argentina · Belgium - recruiting
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.
United Kingdom - active not recruiting
Stem Cell Strategies for the Treatment of Chronic Asthma
This lab study is looking into new ways to treat asthma. Researchers are testing how special cells, called 'stem cells,' might help repair damaged airways and calm inflammation using samples from people with mild, severe, or no asthma.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Comparison of the study drug CHF 1535 formulated with two different propellants to learn about drug levels in blood and safety after inhalation, with and without the use of the AeroChamber Plus® spacer, in healthy volunteers.
This study is testing a new asthma medicine. It will check how different ways of taking the medicine affect its levels in the blood and if it's safe. Healthy adults will take part, using an inhaler, sometimes with a spacer device.
Belgium - recruitingPHASE3
A Study of Efficacy and Safety of Depemokimab Compared With Placebo in Adults and Adolescents With at Risk Type 2 Asthma
This study is testing a new medicine called Depemokimab for people aged 12 and over with a type of asthma that often causes flare-ups. It aims to see if this new medicine can help reduce these flare-ups better than usual treatments or a dummy medicine.
United States · United Kingdom - active not recruitingPHASE4
Benralizumab Airway Remodeling Study in Severe Eosinophilic Asthmatics
This study looks at how a medicine called benralizumab affects the lungs of people with severe asthma. It aims to see if the treatment can improve lung structure and how well the lungs work in people whose asthma isn't controlled by usual medicines.
United States · Canada · Denmark - enrolling by invitationPHASE3
Efficacy and Safety of Subcutaneous Dupilumab in Participants With Asthma/Asthmatic Wheeze Aged 2 to <6 Years (LIBERTY ASTHMA TREKIDS)
This study is testing a new medicine, dupilumab, for children aged 2-5 who have asthma or wheezing that’s hard to control. It aims to see how well it works and if it's safe over time.
United States · Argentina · Brazil - active not recruitingPHASE2
Long-term Safety and Efficacy Evaluation of Subcutaneous Amlitelimab in Adult Participants With Moderate-to-severe Asthma Who Completed Treatment Period of Previous Amlitelimab Asthma Clinical Study
This study looks at the long-term safety and effectiveness of a drug called amlitelimab for adults with moderate to severe asthma who have used it in a previous study. It will last up to 156 weeks.
United States · Argentina · Brazil - recruitingPHASE3
Roll-over Study for Participants Who Have Completed a Previous Clinical Study With Benralizumab (Fasenra) and Benefit From Continued Treatment
This study is for people who have already taken part in a trial for the medicine Benralizumab (Fasenra) for asthma, EGPA, or HES. If the medicine helped them, this study offers a way to continue receiving it while doctors monitor their health and the medicine's long-term effects.
United States · Argentina · Austria - recruitingPHASE3
A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe Asthma
This study looks at a new medicine called Tezepelumab for children aged 5-11 with severe asthma. It compares the medicine to a dummy treatment (placebo) to see if it helps reduce asthma attacks and is safe for children.
United States · Argentina · Brazil - active not recruitingPHASE3
A Multicentre, Randomised, Double-blind, Parallel Group, Placebo-controlled, Time-to-first Asthma Exacerbation Phase III Efficacy and Safety Study of Benralizumab in Paediatric Patients With Severe Eosinophilic Asthma
This study looks at a new medicine called benralizumab for children aged 6 to 18 with severe asthma. It wants to see if the medicine can stop asthma attacks and if it's safe. Half the children get the medicine, and half get a dummy medicine.
United States · Argentina · France - ongoing, recruitingTherapeutic use (Phase IV)
Symptoms control and adhErenCe assessment during treatment with mepolizUmab new pREfilled devices. SECURE
This study looks at how well people with asthma use their medication (Mepolizumab) and how much it helps control their symptoms over six months. It compares different ways of giving the medication, looking at patient diaries and pharmacy records.
France - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
RANDOMISED, CROSSOVER BIOEQUIVALENCE CLINICAL TRIAL OF MONTELUKAST 10 MG CAPSULES VS MONTELUKAST 10 MG FILM-COATED TABLETS, AFTER A SINGLE ORAL DOSE ADMINISTRATION TO HEALTHY VOLUNTEERS UNDER FASTING CONDITIONS.
This study is comparing two ways of taking the asthma medicine montelukast: a capsule and a film-coated tablet. We want to see if the body uses them in the same way when taken by healthy people who haven't eaten, to make sure they work equally well.
Spain - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2 study to evaluate the efficacy and safety of RPT193 in adults with moderate-to-severe T2-high asthma who are partially controlled on inhaled corticosteroid and long-acting beta 2 agonist therapy
This study is testing a new medicine, RPT193, for adults with moderate to severe asthma that's not fully controlled by their usual inhalers. It aims to see how well RPT193 works and if it's safe, helping researchers understand if it could be a future treatment option.
Czechia · Bulgaria · Poland - ongoing, recruitingTherapeutic exploratory (Phase II)
A 52-week, randomised, double blind, multicentre, 2-arm parallel group trial assessing the efficacy and safety of CHF6001 (total daily dose 3200 μg) Dry Powder Inhaler (DPI) add-on to maintenance medium or high dose inhaled corticosteroid in combination with long-acting ß2-agonists in subjects with uncontrolled asthma
This study looks at a new inhaler, CHF6001, for people with asthma that isn't fully controlled. Researchers want to see if adding this new inhaler to their usual medication helps reduce asthma attacks over 52 weeks and is safe.
Italy · Spain · Czechia - recruiting
Exploring the Lived Experience of Young Adults With Severe Asthma
This study explores the daily experiences of young adults (16-25) with severe or uncontrolled asthma in Manchester and Liverpool. We aim to understand their challenges and needs to improve future care and support for this group, which is often overlooked.
United Kingdom - recruitingPHASE2
Xenon-129 and Inert Fluorinated Gas Lung MRI: Study of Healthy Volunteers and Participants With Pulmonary Disease
This study uses special MRI scans with safe gases to look at lungs in people with cystic fibrosis and asthma, and healthy volunteers. The aim is to see how well these new scanning methods work and what they can tell us about lung health.
Canada - recruiting
Diaphragmatic Function as a Biomarker
This study looks at how your breathing muscles, especially your diaphragm, work if you have lung conditions like asthma or COPD. We want to understand if problems with these muscles are linked to feeling breathless and what that might mean for your health.
Germany - authorisedTherapeutic use (Phase IV)
Therapheutic optimization of omalizumab in allergic severe asthma patients by dose and frequency of administration adjustment
This study is looking at whether adults with severe allergic asthma can take a lower dose of their Xolair (omalizumab) medication and still control their asthma well. Researchers want to see if a 50% dose reduction keeps asthma stable, improves quality of life, and maintains lung function.
Spain - recruitingPHASE2
Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids
This study is testing a new medicine, tozorakimab, for adults with asthma that isn't well-controlled. It's looking at how well different doses work and if they are safe, compared to a dummy treatment.
United States · Argentina · Brazil - recruitingPHASE3
A Randomized, Double-Blind, Placebo-Controlled Trial on Efficacy and Safety of Fluticasone Propionate/Albuterol Sulfate Combination in Participants 12 Years and Older With Asthma
This study is testing a new inhaler for people aged 12 and over with asthma. It compares a combination medicine to individual medicines and a dummy inhaler to see how well it works and if it's safe.
United States · Argentina · Bulgaria - active not recruitingPHASE3
A Study to Test if a Fixed-Dose Combination of Fluticasone Propionate/Albuterol Sulfate is Effective in Preventing Asthma Exacerbations
This study is testing a new combination inhaler (TEV-56248) to see if it can better prevent asthma attacks compared to a standard inhaler (Albuterol). We also want to check how safe it is for people with asthma.
United States · Argentina · Australia - active not recruitingPHASE2
Study of Lunsekimig (SAR443765) Compared With Placebo in Adults With High-risk Asthma
This study is looking into a new medication called Lunsekimig for adults with asthma that is hard to control. It compares Lunsekimig to a dummy treatment (placebo) to see if it helps manage asthma better and if it's safe.
United States · Argentina · Belgium - recruitingPHASE4
Therapeutic Relevance of Abnormal Airway Morphology in Asthma
This study looks at why some people with asthma don't get relief from their inhalers. We're using special scans to see if narrow or blocked airways stop medicine from reaching where it needs to go. We'll compare how well inhaled versus oral medicines work for these patients.
Canada - recruitingNA
Improving Quality of Life for Teenagers With Asthma
This study looks at a new way to help teenagers with asthma feel more confident managing their condition. It compares a special asthma consultation with a regular one to see if the new approach improves their quality of life. It aims to help teens control their asthma better.
United Kingdom - recruitingPHASE3
Depemokimab Asthma Imaging and Bronchoscopy Sub-Study
This study looks at a new asthma medicine, Depemokimab, to see how it affects people's lungs. It focuses on those with a specific type of asthma where their airways get inflamed and swollen, causing breathing problems.
United States · Belgium · Canada - recruiting
Evaluation of High Dose Prednisolone Pharmacokinetics in the Acute and Chronic Setting
This study looks at how your body handles prednisolone, a common anti-inflammatory medicine, especially at higher doses. We're trying to understand if prednisolone levels in your blood are consistent and if they change over time, which could help tailor treatment for conditions like asthma or thyroid eye disease.
United Kingdom - recruiting
Pediatric Arm of DZL All Age Asthma Cohort
This study is gathering information on children with asthma. Researchers want to understand why some children keep having asthma symptoms while others grow out of it. The goal is to find better, more personal treatments for asthma in the future.
Germany - active not recruitingPHASE3
Evaluation of Triple Therapy Using Magnetic Resonance Imaging in Asthma
This study looks at a new asthma inhaler with three medicines for people whose asthma isn't well controlled. It uses special scans to see how well air gets into the lungs and aims to improve breathing and lung health.
Canada - active not recruitingPHASE2
A Dose Finding Study With an Anti-TSLP Antibody (GSK5784283) in Adults Aged 18 to 75 Years of Age With Uncontrolled Asthma
This study is looking for the right dose of a new medicine, GSK5784283, for adults aged 18 to 75 with asthma that isn't fully controlled by their current treatments. It aims to see how it affects breathing and overall asthma control.
United States · Bulgaria · Canada - recruitingNot Applicable
Investigation of a digital inhaler monitor and smartphone app providing real-time information on inhaler use
This study looks at a 'smart' inhaler system to help people with asthma. It checks if using a digital monitor and app can improve asthma control and if it's helpful for patients and doctors. It's like a practice run for a bigger study.
United Kingdom · England - recruiting
Biobanking for Biomarkers In Respiratory Disease, Allergic Diseases and/or Mast Cell Disorders
This study is building a collection of samples and information from people with allergies, asthma, or mast cell conditions. This 'biobank' will help scientists better understand these conditions and find new ways to diagnose and treat them in the future.
France - recruitingNA
Intragastric Balloon in Obese Patients With Uncontrolled Asthma
This study looks at how an intragastric balloon, plus diet and exercise, helps people with obesity and uncontrolled asthma. We want to see if it improves asthma control compared to just diet and exercise.
France - enrolling by invitationNA
eAMS-Eco: Implementation of a Tool for Climate Conscious Inhaler Prescribing
This study looks at a new computer tool called eAMS-Eco to help doctors choose inhalers for asthma that are better for the environment. It aims to see if this tool can lower carbon emissions from inhalers while still providing good asthma care.
Canada - recruitingNA
Lung Immune Challenge Study: Controlled Exposure to Inhaled Resiquimod (R848)
This study looks at how people's lungs respond to a harmless mist that acts like a virus. It aims to understand lung inflammation better, especially in people with asthma, to help develop new treatments for respiratory infections without causing actual illness.
United Kingdom - not yet recruitingNA
T2 Biomarkers Predictive Value in Occupational Asthma After Cessation of Exposure.
This study looks at whether certain natural body signals, called T2 biomarkers, can predict if people with asthma caused by their job will get better after they stop being exposed to what caused it. They want to see who fully recovers and who doesn't.
France