A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Immunogenicity of APG777 in Adults With Asthma

To join this study, you need to be an adult between 18 and 65 years old and have been diagnosed with mild to moderate asthma for at least a year. Your asthma should be reasonably controlled with your current medications, which might include an occasional reliever inhaler, regular preventative inhalers, or other asthma medicines. We'll also check your lung function (how well you can breathe out) and your asthma control score.

There are also some reasons why you might not be able to join. For example, if you've had a severe asthma attack that needed strong steroid tablets or hospital care recently, or if you've ever had a life-threatening asthma attack. You also can't have used certain newer asthma treatments called biologics. If you currently smoke or have smoked a lot in the past (defined as 10 'pack years' or more), or if you have a history of drug or alcohol misuse, you wouldn't be able to take part. Also, women who could become pregnant and men must agree to use effective contraception during the study.

If you decide to take part, the study will last about 52 weeks (just under a year). You'll first go through a 'screening period' to make sure the study is right for you. This will involve health checks, reviewing your medical history, and some tests. If you're eligible, you'll then enter the 'treatment period' where you'll receive either the study drug (APG777) or the placebo. This will involve regular visits to the clinic for assessments, blood tests, and to receive your medication. After the treatment period, there will be a 'follow-up period' to continue monitoring your health and any effects of the study drug.