Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids

To be considered for this study, you need to be an adult aged between 18 and 75, with a clear diagnosis of asthma for at least a year. Your asthma should not be fully controlled, even though you're using medium or high doses of inhaled steroids along with another type of asthma medicine called a LABA. You would also need to have had a certain number of asthma attacks in the last year, and meet specific blood or breath test results related to your asthma.

There are also some reasons why you might *not* be able to join. For example, if you've recently had a chest infection treated with antibiotics, or if you have other serious lung conditions besides asthma. The study can't include current smokers, or former smokers with a history of heavy smoking, or people with certain heart conditions, active infections like tuberculosis, or a current cancer diagnosis.

Women who could become pregnant would need to have a negative pregnancy test and agree to use effective contraception during the study. Men would also need to use contraception as advised.

If you decide to take part, you would receive either the study medicine, tozorakimab, or a placebo (dummy treatment) by an injection under your skin. You'll have regular visits to the clinic for health checks, to discuss your asthma symptoms, and to have various tests, such as lung function tests and blood tests. You'll also likely be asked to keep a daily diary of your asthma symptoms. The study team will explain everything in detail, including how long you'll be involved and what each visit will entail. All study-related medicines and tests will be provided at no cost.