RecruitingPHASE2INTERVENTIONAL

A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma

This research study is testing a new medicine called PF-07275315 for people living with moderate to severe asthma. Asthma can make breathing difficult and affect everyday activities. The main goal is to understand if this new medicine is safe and if it can help improve asthma symptoms. We are looking for adults aged 18 to 70 who have had moderate to severe asthma for at least a year, and whose asthma isn't well controlled even with their usual treatments. Participants will either receive the study medicine or a placebo (a dummy medicine) through injections at the clinic over 12 weeks. The study involves about 7.5 months and 9 clinic visits in total.

At a glance

Status

Recruiting

Phase

PHASE2

Sponsor

Pfizer

Enrolment target

252

Start

20 May 2025

Estimated completion

31 May 2027

Asthma

What is this study about?

This research study, called "A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma," is looking into a new medicine for people who have asthma that is not well controlled. Asthma is a common condition that can make it hard to breathe, leading to coughing, wheezing, and tightness in the chest. For some people, these symptoms can be quite severe and affect their daily life and activities.

The main purpose of this study is to find out if the new medicine, PF-07275315, is safe to use and if it can help improve asthma symptoms in people with moderate to severe asthma. By understanding how this medicine works and any side effects it might have, we can determine its potential as a future treatment.

We really hope to help people whose asthma isn't currently well managed with their usual medications, giving them a better chance to breathe easier and enjoy a better quality of life. This kind of research is vital for developing new ways to treat conditions like asthma.

Key takeaways

Tests a new medicine (PF-07275315) for moderate to severe asthma.
Aims to find out if the medicine is safe and effective.
Participants will receive injections of the medicine or a placebo.
The study lasts about 7.5 months with 9 clinic visits.
Requires adults aged 18-70 whose asthma isn't well controlled.
You can withdraw from the study at any time.

Who may be eligible?

This study is looking for volunteers who are between 18 and 70 years old. To join, you must have been diagnosed with moderate to severe asthma for at least the past year, and your asthma should not be fully controlled by your current medications.

You also need to have been taking your usual asthma medications consistently for at least the last 12 months. Your lung function will be checked during the screening process to make sure you meet certain requirements.

There are also some conditions that would prevent you from taking part, such as having other serious lung diseases or certain medical or mental health conditions. If you've had recent thoughts of harming yourself, you would not be able to join this study.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you between 18 and 70 years old?
Have you had moderate to severe asthma for at least the past year?
Is your asthma still bothering you, even with your current medication?
Have you been taking your regular asthma medication consistently for at least 12 months?
Have you had at least one asthma attack needing steroid tablets or injections in the last year?

Answer every question to see your result.

What does participation involve?

If you decide to take part, you will be involved in the study for about 7 and a half months in total. During this time, you will have 9 visits to the study clinic.

For 12 weeks of the study, you will receive either the study medicine, PF-07275315, or a placebo (a dummy medicine that looks the same but contains no active drug). Both the medicine and the placebo will be given as injections at the clinic. Neither you nor the study team will know whether you are receiving the active medicine or the placebo – this is a standard way to ensure the study is fair.

Throughout your participation, the study team will monitor your health closely, including your asthma symptoms and any side effects you might experience. Regular check-ups and tests will be done during your clinic visits to assess how you are responding to the treatment. You are free to withdraw from the study at any time.

Potential risks and benefits

Taking part in this study might offer some potential benefits, such as receiving close medical attention for your asthma and potentially gaining access to a new medicine that could improve your symptoms if you receive PF-07275315. However, there's no guarantee that you will personally benefit from taking part. Like all medicines, PF-07275315 may have side effects, which the study team will discuss with you. You might also receive the placebo, which means you won't be getting the active medicine. You are completely free to leave the study at any time, for any reason, without it affecting your medical care.

Locations (132)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

Velocity Clinical Research, Mobile
Verified postcode
Mobile, United States· Recruiting
Chandler Clinical Trials
Verified postcode
Chandler, United States· Recruiting
Antelope Valley Clinical Trials
Verified postcode
Lancaster, United States· Recruiting
NewportNativeMD, Inc.
Verified postcode
Newport Beach, United States· Recruiting
California Medical Research Associates
Verified postcode
Northridge, United States· Recruiting
Allergy and Asthma Associates of Santa Clara Valley Research Center
Verified postcode
San Jose, United States· Recruiting
Allergy & Asthma Clinical Research
Verified postcode
Walnut Creek, United States· Recruiting
Colorado ENT & Allergy
Verified postcode
Colorado Springs, United States· Recruiting
Cpcc-Research Llc
Verified postcode
East Point, United States· Not yet recruiting
Christie Clinic - University
Verified postcode
Champaign, United States· Recruiting
Innovo Research - Christie Clinic
Verified postcode
Champaign, United States· Recruiting
Christie Clinic - Windsor
Verified postcode
Champaign, United States· Recruiting

Common questions

What is PF-07275315?

It's a new medicine being tested to see if it can help people with moderate to severe asthma breathe better and improve their quality of life.

What is a placebo?

A placebo is a substance or treatment that looks exactly like the study medicine but doesn't contain any active drug. It helps us compare the effects of the real medicine accurately.

How will the medicine be given?

The medicine or placebo will be given as injections at the clinic, multiple times over a 12-week period.

How long will I be in the study?

Your total involvement in the study will be about 7 and a half months, with 9 visits to the study clinic.

Can I stop participating if I want to?

Yes, absolutely. You can choose to leave the study at any time, for any reason, and it won't affect your future medical care.

How to find out more

Pfizer CT.gov Call Center

clinicaltrials.gov_inquiries@pfizer.com 1-800-718-1021 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.