A Study to Evaluate Brenipatide Compared With Placebo in Adult Participants With Uncontrolled Moderate to Severe Asthma

To join this study, you need to be an adult between 18 and 75 years old who has been diagnosed with asthma by a doctor. Your asthma needs to be moderate to severe and you should have been using a regular asthma controller medicine for at least 12 months. Also, your asthma control score (ACQ-6) needs to be above a certain level at two out of three visits before the study fully begins, showing that your asthma isn't fully under control. Crucially, you must have had at least one severe asthma attack in the past year that required steroid tablets.

There are also reasons why you might not be able to join. For example, if you have asthma caused by your job, or another significant lung condition that isn't asthma, such as emphysema, chronic bronchitis, or certain infections. If you have any other conditions that doctors might confuse with asthma, like vocal cord problems, you wouldn't be able to take part. Also, if you currently have a serious infection, or have had one recently (within 30 days before screening), you wouldn't be able to join.

If you decide to take part in this study, you'll be involved for about 65 weeks in total. This includes a starting period where we check if you're suitable (screening), a time when you'll receive the study medicine, and a follow-up period after the treatment ends. You'll have regular visits to the clinic where you'll have check-ups, answer questions about your asthma, and have some tests done. You'll either receive brenipatide, the new medicine, or a placebo (a dummy medicine). You won't know which one you're getting. Doctors and nurses will monitor your health and breathing closely throughout the study.